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917910-45-3,MFCD20528236
Catalog No.:AA00GU1M

917910-45-3 | 2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanamido}cyclohex-1-ene-1-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$307.00   $215.00
- +
5mg
95%
in stock  
$385.00   $270.00
- +
25mg
95%
in stock  
$681.00   $477.00
- +
100mg
95%
in stock  
$1,554.00   $1,088.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU1M
Chemical Name:
2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanamido}cyclohex-1-ene-1-carboxylic acid
CAS Number:
917910-45-3
Molecular Formula:
C19H22N4O5
Molecular Weight:
386.4018
MDL Number:
MFCD20528236
SMILES:
Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C
Properties
Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
2.3  

Literature

Title: Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

Journal: Journal of medicinal chemistry 20100325

Title: Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53(6):2666-70.

Title: Kim HY, et al. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38(6):1019-32.

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Tags:917910-45-3 Molecular Formula|917910-45-3 MDL|917910-45-3 SMILES|917910-45-3 2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanamido}cyclohex-1-ene-1-carboxylic acid
Catalog No.: AA00GU1M
917910-45-3,MFCD20528236
917910-45-3 | 2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanamido}cyclohex-1-ene-1-carboxylic acid
Pack Size： 1mg
Purity： 98%
in stock
$307.00 $215.00
Pack Size： 5mg
Purity： 95%
in stock
$385.00 $270.00
Pack Size： 25mg
Purity： 95%
in stock
$681.00 $477.00
Pack Size： 100mg
Purity： 95%
in stock
$1,554.00 $1,088.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00GU1M
Chemical Name: 2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanamido}cyclohex-1-ene-1-carboxylic acid
CAS Number: 917910-45-3
Molecular Formula: C19H22N4O5
Molecular Weight: 386.4018
MDL Number: MFCD20528236
SMILES: Oc1ccc(nc1)c1noc(n1)CC(C(=O)NC1=C(CCCC1)C(=O)O)(C)C
Properties
Complexity: 636  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 6  
XLogP3: 2.3  
Literature fold

Title: Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

Journal: Journal of medicinal chemistry20100325

Title: Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53(6):2666-70.

Title: Kim HY, et al. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38(6):1019-32.

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