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Home Amines 939791-38-5
939791-38-5,MFCD14105612
Catalog No.:AA00GU2O

939791-38-5 | N-Methyl-n-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
2mg
98%
in stock  
$24.00   $17.00
- +
5mg
98%
in stock  
$39.00   $28.00
- +
10mg
98%
in stock  
$60.00   $42.00
- +
50mg
98%
in stock  
$169.00   $118.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU2O
Chemical Name:
N-Methyl-n-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate
CAS Number:
939791-38-5
Molecular Formula:
C27H26F3N7O6S2
Molecular Weight:
665.6638
MDL Number:
MFCD14105612
SMILES:
OS(=O)(=O)c1ccccc1.O=C1Nc2c(C1)cc(cc2)Nc1ncc(c(n1)NCc1cccnc1N(S(=O)(=O)C)C)C(F)(F)F
Properties
Computed Properties
 
Complexity:
1040  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  

Literature

Title: Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120501

Title: Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944.

Title: Lim ST, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7(15), 2306-2314.

Title: Canel M, et al. Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res, 2010, 70(22), 9413-9422.

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SDS
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Tags:939791-38-5 Molecular Formula|939791-38-5 MDL|939791-38-5 SMILES|939791-38-5 N-Methyl-n-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate