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936091-26-8,MFCD12922515
Catalog No.:AA00GU48

936091-26-8 | Fedratinib (SAR302503, TG101348)

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Purity
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Price(USD)
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1mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$33.00   $23.00
- +
50mg
98%
in stock  
$300.00   $210.00
- +
100mg
95%
in stock  
$311.00   $218.00
- +
250mg
95%
in stock  
$598.00   $419.00
- +
1g
95%
in stock  
$1,555.00   $1,089.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU48
Chemical Name:
Fedratinib (SAR302503, TG101348)
CAS Number:
936091-26-8
Molecular Formula:
C27H36N6O3S
Molecular Weight:
524.6781
MDL Number:
MFCD12922515
SMILES:
Cc1cnc(nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C)Nc1ccc(cc1)OCCN1CCCC1
Properties
Computed Properties
 
Complexity:
787  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
11  
XLogP3:
4.8  

Downstream Synthesis Route
936092-53-4    50609-01-3   
N-tert-butyl-3-{5-methyl-2-4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino-pyrimidin-4-ylamino}-benzenesulfonamide 

[1]Patent:WO2007/53452,2007,A1.Locationinpatent:Page/Pagecolumn120

[2]Patent:WO2012/60847,2012,A1.Locationinpatent:Page/Pagecolumn43-44

308283-47-8    14394-70-8   
N-tert-butyl-3-{5-methyl-2-4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino-pyrimidin-4-ylamino}-benzenesulfonamide 

[1]Patent:WO2012/60847,2012,A1

[1]CurrentPatentAssignee:SUNYAT-SENUNIVERSITY(CHINA)-CN112110863,2020,A

[1]CurrentPatentAssignee:SUNYAT-SENUNIVERSITY(CHINA)-CN112110863,2020,A

[2]Wei,Mingjie;Liang,Dacheng;Cao,Xiaohui;Luo,Wenjun;Ma,Guojian;Liu,Zeyuan;Li,Le[AngewandteChemie-InternationalEdition,2021,vol.60,#13,p.7397-7404][Angew.Chem.,2021,vol.133,#13,p.7473-7480,8]

[1]CurrentPatentAssignee:SUNYAT-SENUNIVERSITY(CHINA)-CN112110863,2020,ALocationinpatent:Paragraph0167-0172

[2]Wei,Mingjie;Liang,Dacheng;Cao,Xiaohui;Luo,Wenjun;Ma,Guojian;Liu,Zeyuan;Li,Le[AngewandteChemie-InternationalEdition,2021,vol.60,#13,p.7397-7404][Angew.Chem.,2021,vol.133,#13,p.7473-7480,8]

Literature

Title: Differences in gene expression and alterations in cell cycle of acute myeloid leukemia cell lines after treatment with JAK inhibitors.

Journal: European journal of pharmacology 20151015

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150601

Title: Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.

Journal: Nature chemical biology 20140401

Title: Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

Journal: The Biochemical journal 20130901

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Current outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms.

Journal: Molecular diagnosis & therapy 20121001

Title: JAK2 inhibitors and their impact in myeloproliferative neoplasms.

Journal: Hematology (Amsterdam, Netherlands) 20120401

Title: New generation small-molecule inhibitors in myeloproliferative neoplasms.

Journal: Current opinion in hematology 20120301

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Targeting myeloproliferative neoplasms with JAK inhibitors.

Journal: Current opinion in hematology 20110301

Title: JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations.

Journal: Leukemia 20110201

Title: Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis.

Journal: PloS one 20110101

Title: Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells.

Journal: Leukemia 20100701

Title: Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.

Journal: Cancer cell 20100615

Title: Therapeutic potential of JAK2 inhibitors.

Journal: Hematology. American Society of Hematology. Education Program 20090101

Title: TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients.

Journal: Leukemia 20080901

Title: Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

Journal: Cancer cell 20080401

Title: Wernig G, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20.

Title: Geron I, et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 2008 Apr;13(4):321-30.

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Tags:936091-26-8 Molecular Formula|936091-26-8 MDL|936091-26-8 SMILES|936091-26-8 Fedratinib (SAR302503, TG101348)