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Home Other Building Blocks 915759-45-4
915759-45-4,MFCD18206894
Catalog No.:AA00GU4M

915759-45-4 | Way 316606

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$14.00   $10.00
- +
5mg
98+%
in stock  
$35.00   $25.00
- +
10mg
98+%
in stock  
$51.00   $36.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU4M
Chemical Name:
Way 316606
CAS Number:
915759-45-4
Molecular Formula:
C18H19F3N2O4S2
Molecular Weight:
448.4797
MDL Number:
MFCD18206894
SMILES:
O=S(=O)(c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1)NC1CCNCC1
Properties
Computed Properties
 
Complexity:
747  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.7  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.190-201

850568-54-6    915759-45-4   
C29H31F3N2O6S2 

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.190-201

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.190-201

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.190-201

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.190-201

Literature

Title: Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.

Journal: PLoS biology 20180501

Title: Emerging targets in osteoporosis disease modification.

Journal: Journal of medicinal chemistry 20100610

Title: A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.

Journal: Bone 20090601

Title: Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.

Journal: Journal of medicinal chemistry 20090108

Title: Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116.

Title: Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8.

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