Name: Name:GSK2190915
Brand: AABLOCKS
SKU: AA00GU5R
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00GU5R

Chemical Name: GSK2190915

CAS Number: 936350-00-4

Molecular Formula: C38H43N3O4S

Molecular Weight: 637.8307

MDL Number: MFCD10567009

SMILES: CCOc1ccc(cn1)c1ccc(cc1)Cn1c(CC(C(=O)O)(C)C)c(c2c1ccc(c2)OCc1ccc(cn1)C)SC(C)(C)C

Properties

Complexity: 966

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 46

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 1

Rotatable Bond Count: 13

XLogP3: 7.8

Literature fold

Title: 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.

Journal: Journal of medicinal chemistry20111208

Title: Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.

Journal: European journal of pharmacology20100825

Title: Stock NS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3--tert-butylsulfanyl-1--(6-ethoxypyridin-3-yl)benzyl-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. J Med Chem. 2011 Dec 8;54(23):8013-29.

Title: Lorrain DS, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8.

936350-00-4 | GSK2190915