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917111-44-5,MFCD18206787
Catalog No.:AA00GU5Z

917111-44-5 | CYT997

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$12.00   $8.00
- +
5mg
98+%
in stock  
$27.00   $19.00
- +
10mg
98+%
in stock  
$41.00   $29.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU5Z
Chemical Name:
CYT997
CAS Number:
917111-44-5
Molecular Formula:
C24H30N6O2
Molecular Weight:
434.5340
MDL Number:
MFCD18206787
SMILES:
CCC[C@@H](c1cccnc1)Nc1nc(ncc1C)c1ccc(c(c1)OC)NC(=O)NCC
Properties
Computed Properties
 
Complexity:
565  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
3.6  

Literature

Title: The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20111201

Title: CYT997 causes apoptosis in human multiple myeloma.

Journal: Investigational new drugs 20110401

Title: Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent.

Journal: British journal of cancer 20100824

Title: Burns CJ, et al. CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Mol Cancer Ther. 2009 Nov;8(11):3036-45.

Title: Monaghan K, et al. CYT997 causes apoptosis in human multiple myeloma. Invest New Drugs. 2011 Apr;29(2):232-8.

Title: Ya Cao, wt al. Mitochondrial ROS Accumulation Inhibiting JAK2/STAT3 Pathway Is a Critical Modulator of CYT997-induced Autophagy and Apoptosis in Gastric Cancer. J Exp Clin Cancer Res. 2020 Jun 23;39(1):119.

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Tags:917111-44-5 Molecular Formula|917111-44-5 MDL|917111-44-5 SMILES|917111-44-5 CYT997