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863405-60-1,MFCD07048962
Catalog No.:AA00GU8G

863405-60-1 | JW74

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
95%
in stock  
$90.00   $63.00
- +
50mg
≥99%(HPLC)
in stock  
$725.00   $508.00
- +
100mg
98% by HPLC
in stock  
$1,431.00   $1,002.00
- +
500mg
98% by HPLC
in stock  
$4,477.00   $3,134.00
- +
1000mg
98% by HPLC
in stock  
$7,126.00   $4,988.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU8G
Chemical Name:
JW74
CAS Number:
863405-60-1
Molecular Formula:
C24H20N6O2S
Molecular Weight:
456.5196
MDL Number:
MFCD07048962
SMILES:
COc1ccc(cc1)n1c(SCc2onc(n2)c2ccc(cc2)C)nnc1c1ccncc1
Properties
Computed Properties
 
Complexity:
596  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.3  

Literature

Title: [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

Journal: Journal of medicinal chemistry 20120209

Title: Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011 Jan 1;71(1):197-205.

Title: Stratford EW, et al. The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. Cancer Med. 2014 Feb;3(1):36-46.

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SDS
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Tags:863405-60-1 Molecular Formula|863405-60-1 MDL|863405-60-1 SMILES|863405-60-1 JW74
Catalog No.: AA00GU8G
863405-60-1,MFCD07048962
863405-60-1 | JW74
Pack Size： 1mg
Purity： ≥98%
in stock
$46.00 $32.00
Pack Size： 5mg
Purity： 95%
in stock
$90.00 $63.00
Pack Size： 50mg
Purity： ≥99%(HPLC)
in stock
$725.00 $508.00
Pack Size： 100mg
Purity： 98% by HPLC
in stock
$1,431.00 $1,002.00
Pack Size： 500mg
Purity： 98% by HPLC
in stock
$4,477.00 $3,134.00
Pack Size： 1000mg
Purity： 98% by HPLC
in stock
$7,126.00 $4,988.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00GU8G
Chemical Name: JW74
CAS Number: 863405-60-1
Molecular Formula: C24H20N6O2S
Molecular Weight: 456.5196
MDL Number: MFCD07048962
SMILES: COc1ccc(cc1)n1c(SCc2onc(n2)c2ccc(cc2)C)nnc1c1ccncc1
Properties
Complexity: 596  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.3  
Literature fold

Title: [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

Journal: Journal of medicinal chemistry20120209

Title: Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011 Jan 1;71(1):197-205.

Title: Stratford EW, et al. The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. Cancer Med. 2014 Feb;3(1):36-46.

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