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925701-46-8,MFCD18384974
Catalog No.:AA00GU8H

925701-46-8 | KU-60019

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$42.00   $29.00
- +
5mg
99+%
in stock  
$154.00   $108.00
- +
10mg
99+%
in stock  
$199.00   $140.00
- +
50mg
99+%
in stock  
$336.00   $235.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU8H
Chemical Name:
KU-60019
CAS Number:
925701-46-8
Molecular Formula:
C30H33N3O5S
Molecular Weight:
547.6651
MDL Number:
MFCD18384974
SMILES:
O=C(Nc1ccc2c(c1)Cc1c(S2)c(ccc1)c1cc(=O)cc(o1)N1CCOCC1)CN1CC(C)OC(C1)C
Properties
Computed Properties
 
Complexity:
972  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Literature

Title: Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.

Journal: Environmental health perspectives 20160101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.

Journal: The Journal of biological chemistry 20120406

Title: Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.

Journal: Cell cycle (Georgetown, Tex.) 20120315

Title: Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

Journal: Molecular cancer therapeutics 20091001

Title: Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.

Title: McCabe N, et al. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer Res. 2015 Jun 1;75(11):2159-65.

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SDS
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Tags:925701-46-8 Molecular Formula|925701-46-8 MDL|925701-46-8 SMILES|925701-46-8 KU-60019
Catalog No.: AA00GU8H
925701-46-8,MFCD18384974
925701-46-8 | KU-60019
Pack Size： 1mg
Purity： ≥98%
in stock
$42.00 $29.00
Pack Size： 5mg
Purity： 99+%
in stock
$154.00 $108.00
Pack Size： 10mg
Purity： 99+%
in stock
$199.00 $140.00
Pack Size： 50mg
Purity： 99+%
in stock
$336.00 $235.00
Quantity
- +
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Technical Information
Catalog Number: AA00GU8H
Chemical Name: KU-60019
CAS Number: 925701-46-8
Molecular Formula: C30H33N3O5S
Molecular Weight: 547.6651
MDL Number: MFCD18384974
SMILES: O=C(Nc1ccc2c(c1)Cc1c(S2)c(ccc1)c1cc(=O)cc(o1)N1CCOCC1)CN1CC(C)OC(C1)C
Properties
Complexity: 972  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 39  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Literature fold

Title: Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.

Journal: Environmental health perspectives20160101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.

Journal: The Journal of biological chemistry20120406

Title: Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.

Journal: Cell cycle (Georgetown, Tex.)20120315

Title: Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

Journal: Molecular cancer therapeutics20091001

Title: Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.

Title: McCabe N, et al. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer Res. 2015 Jun 1;75(11):2159-65.

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