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866823-73-6,MFCD19440914
Catalog No.:AA00GXDZ

866823-73-6 | Biphenylindanone A

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5mg
≥98%
in stock  
$152.00   $106.00
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10mg
≥98%
in stock  
$263.00   $184.00
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25mg
≥98%
in stock  
$610.00   $427.00
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  • Technical Information
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Technical Information
Catalog Number:
AA00GXDZ
Chemical Name:
Biphenylindanone A
CAS Number:
866823-73-6
Molecular Formula:
C30H30O4
Molecular Weight:
454.5568
MDL Number:
MFCD19440914
SMILES:
Cc1c(OCc2cccc(c2)c2ccc(cc2)C(=O)O)cc2c(c1C)C(=O)C(C2)C1CCCC1
Properties
Computed Properties
 
Complexity:
719  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
7.2  

Literature

Title: Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.

Journal: Journal of medicinal chemistry 20110113

Title: The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100901

Title: Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation.

Journal: Neuroscience 20100616

Title: Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture.

Journal: European journal of pharmacology 20090128

Title: Promise of mGluR2/3 activators in psychiatry.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

Title: A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.

Journal: Molecular pharmacology 20070801

Title: Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20060701

Title: Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.

Journal: Bioorganic & medicinal chemistry letters 20051001

Title: Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site. J Pharmacol Exp Ther. 2008 Jul;326(1):240-51.

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