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87233-62-3,MFCD00923844
Catalog No.:AA00GXTB

87233-62-3 | Emedastine difumarate

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5mg
≥98%
in stock  
$46.00   $32.00
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10mg
≥98%
in stock  
$88.00   $61.00
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50mg
≥98.0%(HPLC)
in stock  
$93.00   $65.00
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250mg
98%
in stock  
$112.00   $78.00
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1g
98%
in stock  
$187.00   $131.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GXTB
Chemical Name:
Emedastine difumarate
CAS Number:
87233-62-3
Molecular Formula:
C25H34N4O9
Molecular Weight:
534.5589
MDL Number:
MFCD00923844
SMILES:
OC(=O)/C=C/C(=O)O.OC(=O)/C=C/C(=O)O.CCOCCn1c(nc2c1cccc2)N1CCCN(CC1)C
Properties
Computed Properties
 
Complexity:
460  
Covalently-Bonded Unit Count:
3  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  

Literature

Title: The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase.

Journal: Acta haematologica 20110101

Title: Contribution of mast cells to cerebral aneurysm formation.

Journal: Current neurovascular research 20100501

Title: Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.

Journal: Acta ophthalmologica 20090801

Title: Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases.

Journal: Expert opinion on pharmacotherapy 20090801

Title: Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis.

Journal: Experimental eye research 20080501

Title: Emedastine difumarate inhibits histamine-induced collagen synthesis in dermal fibroblasts.

Journal: Journal of investigational allergology & clinical immunology 20080101

Title: High-performance liquid chromatography-electrospray ionization-mass spectrometric determination of emedastine difumarate in human plasma and its pharmacokinetics.

Journal: Journal of chromatographic science 20070301

Title: [The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from acute seasonal allergic conjunctivitis].

Journal: Orvosi hetilap 20070211

Title: Emedastine difumarate versus loratadine in chronic idiopathic urticaria: a randomized, double-blind, controlled European multicentre clinical trial.

Journal: European journal of dermatology : EJD 20060101

Title: Estimation of in vivo percutaneous absorption of emedastine from bile excretion data using a deconvolution method.

Journal: Drug metabolism and pharmacokinetics 20051001

Title: Biopharmaceutical considerations on antihistamine effects of topically administered emedastine.

Journal: Journal of pharmaceutical sciences 20050101

Title: [Topical H1 antihistaminics in the therapy of acute conjunctival allergic reactions].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040101

Title: Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus terfenadine in the treatment of seasonal allergic rhinitis.

Journal: Arzneimittel-Forschung 20040101

Title: Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus cetirizine in the treatment of seasonal allergic rhinitis.

Journal: Arzneimittel-Forschung 20040101

Title: Suplatast tosilate inhibits eosinophil production and recruitment into the skin in murine contact sensitivity.

Journal: Clinical immunology (Orlando, Fla.) 20030901

Title: Development of a new dissolution test method for an oral controlled release preparation, the PVA swelling controlled release system (SCRS).

Journal: Journal of controlled release : official journal of the Controlled Release Society 20030605

Title: [Effects of emedastine eyedrops on acute seasonal allergic conjunctivitis in children].

Journal: Orvosi hetilap 20030406

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.

Journal: Skin pharmacology and applied skin physiology 20030101

Title: Pharmacokinetic and mass balance study of unlabelled and (14)C-labelled emedastine difumarate in healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020901

Title: Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways.

Journal: Biological & pharmaceutical bulletin 20020301

Title: Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females.

Journal: Journal of psychopharmacology (Oxford, England) 20020301

Title: Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.

Journal: Clinical therapeutics 20020301

Title: A randomized, double-blind, placebo-controlled comparison of emedastine 0.05% ophthalmic solution with loratadine 10 mg and their combination in the human conjunctival allergen challenge model.

Journal: Clinical therapeutics 20020301

Title: Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes.

Journal: Journal of dermatological science 20020101

Title: Comparison of emedastine 0.05% or nedocromil sodium 2% eye drops and placebo in controlling local reactions in subjects with allergic conjunctivitis.

Journal: European journal of ophthalmology 20020101

Title: Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis.

Journal: American journal of ophthalmology 20010601

Title: VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.

Journal: Japanese journal of pharmacology 20010501

Title: Pharmacokinetics of emedastine difumarate, a new anti-histaminic agent in patients with renal impairment.

Journal: European journal of clinical pharmacology 20010301

Title: Emedastine-ketoconazole: pharmacokinetic and pharmacodynamic interactions in healthy volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20010301

Title: Cost effectiveness of emedastine versus levocabastine in the treatment of allergic conjunctivitis in 7 European countries.

Journal: PharmacoEconomics 20010101

Title: Effect of emedastine difumarate on CC chemokine-elicited eosinophil migration.

Journal: International archives of allergy and immunology 20010101

Title: General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate. 1st communication: effects on the central nervous system.

Journal: Arzneimittel-Forschung 19880101

Title: Pharmacologic analysis of LY188695 (KB-2413), 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate, a potent histamine1 receptor antagonist.

Journal: Agents and actions 19870201

Title: Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10(4):653-64.

Title: Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10(11):1859-67.

Title: Andoh T, et al. Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406(1):149-52.

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