Name: Name:Gemigliptin
Brand: AABLOCKS
SKU: AA00H0FH
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00H0FH

Chemical Name: Gemigliptin

CAS Number: 911637-19-9

Molecular Formula: C18H19F8N5O2

Molecular Weight: 489.3630

MDL Number: MFCD19443742

SMILES: N[C@H](CN1CC(F)(F)CCC1=O)CC(=O)N1CCc2c(C1)nc(nc2C(F)(F)F)C(F)(F)F

Properties

Complexity: 746

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Heavy Atom Count: 33

Hydrogen Bond Acceptor Count: 13

Hydrogen Bond Donor Count: 1

Rotatable Bond Count: 4

XLogP3: 0.7

Literature fold

Title: Effects of ketoconazole and rifampicin on the pharmacokinetics of gemigliptin, a dipeptidyl peptidase-IV inhibitor: a crossover drug-drug interaction study in healthy male Korean volunteers.

Journal: Clinical therapeutics20120501

Title: Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase IV inhibitor LC15-0444 and pioglitazone in healthy volunteers.

Journal: International journal of clinical pharmacology and therapeutics20120101

Title: A multicenter, randomized, placebo-controlled, double-blind phase II trial evaluating the optimal dose, efficacy and safety of LC 15-0444 in patients with type 2 diabetes.

Journal: Diabetes, obesity & metabolism20101201

Title: Pharmacokinetics, pharmacodynamics, and tolerability of the dipeptidyl peptidase IV inhibitor LC15-0444 in healthy Korean men: a dose-block-randomized, double-blind, placebo-controlled, ascending single-dose, Phase I study.

Journal: Clinical therapeutics20081001

Title: Jung E, et al. Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo. Eur J Pharmacol. 2014 Dec 5;744:98-102.

Title: Kim SH, et al. Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo. Eur J Pharmacol. 2016 Oct 5;788:54-64.

911637-19-9 | Gemigliptin