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915385-81-8,MFCD22666355
Catalog No.:AA00H0QJ

915385-81-8 | ABC294640

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$31.00   $22.00
- +
5mg
98%
in stock  
$95.00   $67.00
- +
25mg
98%
in stock  
$331.00   $232.00
- +
100mg
98%
in stock  
$573.00   $401.00
- +
250mg
98%
in stock  
$835.00   $584.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00H0QJ
Chemical Name:
ABC294640
CAS Number:
915385-81-8
Molecular Formula:
C23H25ClN2O
Molecular Weight:
380.9104
MDL Number:
MFCD22666355
SMILES:
Clc1ccc(cc1)C12CC3CC(C1)CC(C2)(C3)C(=O)NCc1ccncc1
Properties
Computed Properties
 
Complexity:
551  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
2  
XLogP3:
4.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:APOGEEBIOTECHNOLOGYCORPORATION;EHPOUDZHIBIOTEKNOLODZHI-US2006/287317,2006,A1Locationinpatent:Page/Pagecolumn34-35

[1]CurrentPatentAssignee:APOGEEBIOTECHNOLOGYCORPORATION;EHPOUDZHIBIOTEKNOLODZHI-US2006/287317,2006,A1Locationinpatent:Page/Pagecolumn34-35

CASUnavailable 
  56531-62-5    915385-81-8 

[1]CurrentPatentAssignee:TIANJINMINXIANGPHARMACEUTICALCOLTD-CN116217468,2023,ALocationinpatent:Paragraph0054-0062

Literature

Title: Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160301

Title: Effect of alkyl chain length on sphingosine kinase 2 selectivity.

Journal: Bioorganic & medicinal chemistry letters 20121115

Title: Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.

Journal: Experimental biology and medicine (Maywood, N.J.) 20120701

Title: Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice.

Journal: Thrombosis and haemostasis 20120301

Title: Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.

Journal: Journal of hepatology 20120101

Title: Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.

Journal: PloS one 20120101

Title: Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.

Journal: Investigational new drugs 20111201

Title: Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.

Journal: Inflammopharmacology 20110401

Title: Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.

Journal: Cancer biology & therapy 20110401

Title: Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.

Journal: Cancer biology & therapy 20110301

Title: Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2.

Journal: Pharmacology 20110101

Title: Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.

Journal: Endocrinology 20101101

Title: Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Journal: Carcinogenesis 20101001

Title: A novel sphingosine kinase inhibitor induces autophagy in tumor cells.

Journal: The Journal of pharmacology and experimental therapeutics 20100501

Title: Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.

Journal: Inflammopharmacology 20100401

Title: Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases.

Journal: Investigative ophthalmology & visual science 20061101

Title: French KJ, et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.

Title: Beljanski V, et al. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. 2011 Dec;29(6):1132-42.

Title: Shi Y, et al. Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol. 2012 Jan;56(1):137-45.

Title: Liu Q, et al. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. 2012;7(7):e41834.

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