64461-82-1,MFCD00798231
Catalog No.:AA00H732

64461-82-1 | Tizanidine HCl

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
98%
in stock  
$6.00   $4.00
- +
100mg
98%
in stock  
$7.00   $5.00
- +
1g
98%
in stock  
$9.00   $7.00
- +
5g
98%
in stock  
$29.00   $21.00
- +
25g
98%
in stock  
$121.00   $85.00
- +
100g
98%
in stock  
$419.00   $294.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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Technical Information
Catalog Number:
AA00H732
Chemical Name:
Tizanidine HCl
CAS Number:
64461-82-1
Molecular Formula:
C19H39N3O
Molecular Weight:
325.5325
MDL Number:
MFCD00798231
SMILES:
OCCC1C2CCN(C1CNC(CCCN(CC)CC)C)CC2
Properties
Properties
 
BP:
391.2°C at 760 mmHg  
Form:
Solid  
MP:
280 °C  
Solubility:
H2O: ~29 mg/mL  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
300  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  

Literature

Title: Eperisone versus tizanidine for treatment of chronic low back pain.

Journal: Minerva medica 20120601

Title: [Pharmacological treatment of spasticity in multiple sclerosis].

Journal: Revue neurologique 20120401

Title: Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.

Journal: Journal of cardiovascular pharmacology and therapeutics 20120301

Title: Medium-latency reflex response elicited from the flexor carpi radialis by radial nerve stimulation.

Journal: Experimental brain research 20120301

Title: Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain.

Journal: Journal of pharmaceutical sciences 20120201

Title: Doxazosin versus tizanidine for treatment of dysfunctional voiding in children: a prospective randomized open-labeled trial.

Journal: Urology 20120201

Title: Tizanidine and tizanidine hydrochloride: on the correct tautomeric form of tizanidine.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120101

Title: Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.

Journal: Audiology & neuro-otology 20120101

Title: Sensitive spectrofluorimetric determination of tizanidine in pharmaceutical preparations, human plasma and urine through derivatization with dansyl chloride.

Journal: Luminescence : the journal of biological and chemical luminescence 20120101

Title: Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.

Journal: Neuroscience 20111027

Title: Tizanidine for alcohol withdrawal treatment.

Journal: Medical hypotheses 20111001

Title: Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20110601

Title: Pharmacotherapy of spasticity in children with cerebral palsy.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20110401

Title: A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.

Journal: General hospital psychiatry 20110101

Title: Development and validation of stability-indicating HPLC method for the simultaneous determination of paracetamol, tizanidine, and diclofenac in pharmaceuticals and human serum.

Journal: Journal of AOAC International 20110101

Title: The effect of robot-assisted lokomotor training on gait recovery: a multivariate analysis.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20110101

Title: Pharmacologic treatment of spasticity in children.

Journal: Seminars in pediatric neurology 20101201

Title: Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101001

Title: Cervical myelopathy from spinal sarcoidosis as the unexpected initial presentation for systemic sarcoidosis.

Journal: Southern medical journal 20100901

Title: Managing spasticity with drugs.

Journal: European journal of physical and rehabilitation medicine 20100901

Title: Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601

Title: Load rather than length sensitive feedback contributes to soleus muscle activity during human treadmill walking.

Journal: Journal of neurophysiology 20100501

Title: Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.

Journal: Clinical neuropharmacology 20100501

Title: Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis.

Journal: Experimental brain research 20100401

Title: Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.

Journal: Journal of clinical pharmacology 20100301

Title: Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

Journal: Neurology 20100126

Title: Drug-induced QT prolongation and sudden death.

Journal: Missouri medicine 20100101

Title: [Therapeutic blockades and reflexotherapy in the complex treatment of tension headache].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Formulation of two-drug controlled release non-biodegradable microparticles for potential treatment of muscles pain and spasm and their simultaneous spectrophotometeric estimation.

Journal: Acta poloniae pharmaceutica 20100101

Title: Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.

Journal: Journal of neuroengineering and rehabilitation 20100101

Title: Spasticity: revisiting the role and the individual value of several pharmacological treatments.

Journal: NeuroRehabilitation 20100101

Title: The addition of tramadol as a second opioid may improve pain relief in severe osteoarthritis: a prospective study.

Journal: Pain practice : the official journal of World Institute of Pain 20100101

Title: [Clinical features of headache of tension type and principles of treatment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: [The use of sirdalud MR in patients with multiple sclerosis].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.

Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20091201

Title: Drug treatments for spasticity.

Journal: Annals of physical and rehabilitation medicine 20091201

Title: [New therapies for spastic movement disorders].

Journal: MMW Fortschritte der Medizin 20091001

Title: Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets.

Journal: AAPS PharmSciTech 20090601

Title: Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study.

Journal: Journal of neurology, neurosurgery, and psychiatry 20090401

Title: Botulinum toxin should be first-line treatment for poststroke spasticity.

Journal: Journal of neurology, neurosurgery, and psychiatry 20090401

Title: Effect of cold application and tizanidine on clonus: clinical and electrophysiological assessment.

Journal: The journal of spinal cord medicine 20090401

Title: Medium-latency reflex response of soleus elicited by peroneal nerve stimulation.

Journal: Experimental brain research 20090201

Title: Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.

Journal: Anesthesiology 20090201

Title: A combined approach of chemical enhancers and sonophoresis for the transdermal delivery of tizanidine hydrochloride.

Journal: Drug delivery 20090201

Title: Pediatric safety of tizanidine: clinical adverse event database and retrospective chart assessment.

Journal: Paediatric drugs 20090101

Title: Prevention of intrathecal baclofen withdrawal syndrome: successful use of a temporary intrathecal catheter.

Journal: Regional anesthesia and pain medicine 20090101

Title: Botulinum toxin type A with oral baclofen versus oral tizanidine: a nonrandomized pilot comparison in patients with cerebral palsy and spastic equinus foot deformity.

Journal: Journal of child neurology 20081201

Title: Relative bioavailability of tizanidine hydrochloride capsule formulation compared with capsule contents administered in applesauce: a single-dose, open-label, randomized, two-way, crossover study in fasted healthy adult subjects.

Journal: Clinical therapeutics 20081201

Title: [Effects of intrathecal ouabain and tizanidine injection for treatment of neuropathic pain in rats].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20081001

Title: Update on tizanidine for muscle spasticity and emerging indications.

Journal: Expert opinion on pharmacotherapy 20080801

Title: Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.

Journal: European journal of pharmacology 20080728

Title: Tizanidine-induced hypotension in patients with liver cirrhosis.

Journal: European journal of clinical pharmacology 20080601

Title: Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis.

Journal: The Annals of pharmacotherapy 20080601

Title: Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo.

Journal: European journal of clinical pharmacology 20080501

Title: [Protocol for tizanidine use in infantile cerebral palsy].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20080501

Title: Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm.

Journal: Journal of the Indian Medical Association 20080501

Title: Alpha-2 agonists decrease expression of morphine-induced conditioned place preference.

Journal: Pharmacology, biochemistry, and behavior 20080201

Title: A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.

Journal: Current medical research and opinion 20080201

Title: A clinically relevant review of tizanidine hydrochloride dose relationships to pharmacokinetics, drug safety and effectiveness in healthy subjects and patients.

Journal: International journal of clinical practice 20080201

Title: Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.

Journal: European journal of clinical pharmacology 20080101

Title: The effects of medical treatment and rehabilitation in a patient with adult tethered cord syndrome in the late postoperative period.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20071201

Title: Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070901

Title: Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation.

Journal: European journal of clinical pharmacology 20070901

Title: Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

Journal: Clinical pharmacology and therapeutics 20070601

Title: Efficacy of neuroprotectors in patients with tension headaches.

Journal: Neuroscience and behavioral physiology 20070601

Title: Relative bioavailability of tizanidine 4-mg capsule and tablet formulations after a standardized high-fat meal: a single-dose, randomized, open-label, crossover study in healthy subjects.

Journal: Clinical therapeutics 20070401

Title: Drug interaction of tizanidine and ciprofloxacin: case report.

Journal: Clinical pharmacology and therapeutics 20061201

Title: The pharmacological management of spasticity.

Journal: The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20061201

Title: Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects.

Journal: British journal of clinical pharmacology 20060901

Title: Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers.

Journal: Clinical therapeutics 20060901

Title: [The usefulness of tizanidine. A one-year follow-up of the treatment of spasticity in infantile cerebral palsy].

Journal: Revista de neurologia 20060801

Title: Non-antiepileptic drugs for trigeminal neuralgia.

Journal: The Cochrane database of systematic reviews 20060719

Title: In-vitro studies of tizanidine controlled-release microcapsular matrices.

Journal: Pakistan journal of pharmaceutical sciences 20060701

Title: Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine.

Journal: European journal of clinical pharmacology 20060601

Title: Tizanidine distribution in a postmortem case.

Journal: Journal of analytical toxicology 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Mediation of late excitation from human hand muscles via parallel group II spinal and group I transcortical pathways.

Journal: The Journal of physiology 20060415

Title: Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review.

Journal: Europa medicophysica 20060301

Title: Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life.

Journal: The journal of headache and pain 20060201

Title: Quantification of tizanidine in human plasma by liquid chromatography coupled to tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.

Journal: Clinical pharmacology and therapeutics 20051001

Title: Pharmacologic interventions for reducing spasticity in cerebral palsy.

Journal: Indian journal of pediatrics 20051001

Title: Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.

Journal: Journal of pharmacological sciences 20050901

Title: Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.

Journal: International journal of clinical practice 20050701

Title: [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20050415

Title: Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form.

Journal: Journal of pharmaceutical and biomedical analysis 20050207

Title: Simultaneous LC determination of tizanidine and rofecoxib in tablets.

Journal: Journal of pharmaceutical and biomedical analysis 20050207

Title: Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20050201

Title: Involuntary jerking of lower half of the body (spinal myoclonus).

Journal: The Journal of the Association of Physicians of India 20050201

Title: Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.

Journal: Clinical pharmacology and therapeutics 20041201

Title: Hypotension due to interaction between lisinopril and tizanidine.

Journal: The Annals of pharmacotherapy 20041101

Title: Drug interaction of tizanidine and fluvoxamine.

Journal: Clinical pharmacology and therapeutics 20041101

Title: [Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia].

Journal: No to hattatsu = Brain and development 20041101

Title: [Pharmacology and upper limb poststroke spasticity: a review. International Society of Prosthetics and Orthotics].

Journal: Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique 20041001

Title: [Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].

Journal: Neurologia (Barcelona, Spain) 20041001

Title: Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.

Journal: Journal of neurosurgery 20041001

Title: Preventive migraine therapy: what is new.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

Title: Tizanidine for the treatment of intention myoclonus: a case series.

Journal: Archives of physical medicine and rehabilitation 20040701

Title: Muscle relaxants in the treatment of myofascial face pain. A literature review.

Journal: Minerva stomatologica 20040601

Title: Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.

Journal: Clinical pharmacology and therapeutics 20040401

Title: Effect of oral tizanidine on local-anesthetic infiltration pain during epidural catheterization.

Journal: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20040401

Title: Efficacy of tizanidine hydrochloride in the treatment of myofascial face pain.

Journal: Minerva medica 20040401

Title: Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.

Journal: British journal of clinical pharmacology 20040301

Title: Modulation of the transmission in group II heteronymous pathways by tizanidine in spastic hemiplegic patients.

Journal: Journal of neurology, neurosurgery, and psychiatry 20040101

Title: Retrospective review of Tizanidine (Zanaflex) overdose.

Journal: Journal of toxicology. Clinical toxicology 20040101

Title: Stability-indicating HPTLC determination of tizanidine hydrochloride in bulk drug and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20031124

Title: Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.

Journal: Anesthesiology 20030601

Title: Continuous intrathecal clonidine and tizanidine in conscious dogs: analgesic and hemodynamic effects.

Journal: Anesthesia and analgesia 20030301

Title: Tizanidine is not a cure for chronic daily headache.

Journal: Headache 20030301

Title: Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats.

Journal: Acta anaesthesiologica Scandinavica 20030301

Title: Eosinophilic exudative pleural effusion after initiation of tizanidine treatment: a case report.

Journal: Pain medicine (Malden, Mass.) 20030301

Title: Modulatory effects of alpha1-,alpha2-, and beta -receptor agonists on feline spinal interneurons with monosynaptic input from group I muscle afferents.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030101

Title: Anti-spasticity medications.

Journal: Saudi medical journal 20030101

Title: Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role?

Journal: CNS drugs 20030101

Title: [Spastic syndrome and main directions of its treatment].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: High-dose tizanidine abuse.

Journal: Psychopharmacology bulletin 20030101

Title: Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias.

Journal: Methods and findings in experimental and clinical pharmacology 20020901

Title: Oral tizanidine, an alpha2-adrenoceptor agonist, reduces the minimum alveolar concentration of sevoflurane in human adults.

Journal: Anesthesia and analgesia 20020801

Title: Determination of tizanidine in human plasma by gas chromatography-mass spectrometry.

Journal: The Analyst 20020701

Title: Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine.

Journal: European journal of pharmacology 20020612

Title: Treatment of spasticity.

Journal: Spinal cord 20020601

Title: Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study.

Journal: Headache 20020601

Title: Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.

Journal: Life sciences 20020503

Title: Low-dose tizanidine with nonsteroidal anti-inflammatory drugs for detoxification from analgesic rebound headache.

Journal: Headache 20020301

Title: Cost-effectiveness comparison of tizanidine and baclofen in the management of spasticity.

Journal: PharmacoEconomics 20020101

Title: Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.

Journal: Anesthesia and analgesia 20011101

Title: Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy.

Journal: Anesthesia and analgesia 20011101

Title: Alpha adrenergic and serotonergic agents in the treatment of spastic hypertonia.

Journal: Physical medicine and rehabilitation clinics of North America 20011101

Title: Prospective assessment of tizanidine for spasticity due to acquired brain injury.

Journal: Archives of physical medicine and rehabilitation 20010901

Title: Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans.

Journal: The Journal of physiology 20010801

Title: Open-label dose-titration safety and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with chronic stroke.

Journal: Stroke 20010801

Title: Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.

Journal: Current neurology and neuroscience reports 20010501

Title: An open-label dose-titration study of the efficacy and tolerability of tizanidine hydrochloride tablets in the prophylaxis of chronic daily headache.

Journal: Headache 20010401

Title: Antagonistic effects of selective alpha1-adrenoceptor antagonists MDL73005EF and tamsulosin and partial agonists clonidine and tizanidine in rat thoracic aorta and rabbit iliac artery.

Journal: The Journal of pharmacy and pharmacology 20010101

Title: Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.

Journal: Journal of child neurology 20001201

Title: Scopolamine-induced convulsions in food given fasted mice: effects of clonidine and tizanidine.

Journal: Epilepsy research 19990601

Title: Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.

Journal: Pharmacology & toxicology 19990101

Title: Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects.

Journal: Anesthesia and analgesia 19960301

Title: A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia.

Journal: Pain 19930601

Title: Development of a simple spasticity quantification method: effects of tizanidine on spasticity in patients with sequelae of cerebrovascular disease.

Journal: The Journal of international medical research 19920201

Title: Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.

Journal: Neuropharmacology 19910601

Title: Antagonists of adenosine and alpha-2-adrenoceptors reverse the anticonvulsant effects of tizanidine in DBA/2 mice.

Journal: Neuropharmacology 19890301

Title: Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39.

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Tags:64461-82-1 Molecular Formula|64461-82-1 MDL|64461-82-1 SMILES|64461-82-1 Tizanidine HCl
Catalog No.: AA00H732
64461-82-1,MFCD00798231
64461-82-1 | Tizanidine HCl
Pack Size: 50mg
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 100mg
Purity: 98%
in stock
$7.00 $5.00
Pack Size: 1g
Purity: 98%
in stock
$9.00 $7.00
Pack Size: 5g
Purity: 98%
in stock
$29.00 $21.00
Pack Size: 25g
Purity: 98%
in stock
$121.00 $85.00
Pack Size: 100g
Purity: 98%
in stock
$419.00 $294.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00H732
Chemical Name: Tizanidine HCl
CAS Number: 64461-82-1
Molecular Formula: C19H39N3O
Molecular Weight: 325.5325
MDL Number: MFCD00798231
SMILES: OCCC1C2CCN(C1CNC(CCCN(CC)CC)C)CC2
Properties
BP: 391.2°C at 760 mmHg  
Form: Solid  
MP: 280 °C  
Solubility: H2O: ~29 mg/mL  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 300  
Covalently-Bonded Unit Count: 2  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 2  
Literature fold

Title: Eperisone versus tizanidine for treatment of chronic low back pain.

Journal: Minerva medica20120601

Title: [Pharmacological treatment of spasticity in multiple sclerosis].

Journal: Revue neurologique20120401

Title: Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.

Journal: Journal of cardiovascular pharmacology and therapeutics20120301

Title: Medium-latency reflex response elicited from the flexor carpi radialis by radial nerve stimulation.

Journal: Experimental brain research20120301

Title: Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain.

Journal: Journal of pharmaceutical sciences20120201

Title: Doxazosin versus tizanidine for treatment of dysfunctional voiding in children: a prospective randomized open-labeled trial.

Journal: Urology20120201

Title: Tizanidine and tizanidine hydrochloride: on the correct tautomeric form of tizanidine.

Journal: Acta crystallographica. Section C, Crystal structure communications20120101

Title: Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.

Journal: Audiology & neuro-otology20120101

Title: Sensitive spectrofluorimetric determination of tizanidine in pharmaceutical preparations, human plasma and urine through derivatization with dansyl chloride.

Journal: Luminescence : the journal of biological and chemical luminescence20120101

Title: Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.

Journal: Neuroscience20111027

Title: Tizanidine for alcohol withdrawal treatment.

Journal: Medical hypotheses20111001

Title: Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride.

Journal: Acta pharmaceutica (Zagreb, Croatia)20110601

Title: Pharmacotherapy of spasticity in children with cerebral palsy.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi20110401

Title: A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.

Journal: General hospital psychiatry20110101

Title: Development and validation of stability-indicating HPLC method for the simultaneous determination of paracetamol, tizanidine, and diclofenac in pharmaceuticals and human serum.

Journal: Journal of AOAC International20110101

Title: The effect of robot-assisted lokomotor training on gait recovery: a multivariate analysis.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference20110101

Title: Pharmacologic treatment of spasticity in children.

Journal: Seminars in pediatric neurology20101201

Title: Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20101001

Title: Cervical myelopathy from spinal sarcoidosis as the unexpected initial presentation for systemic sarcoidosis.

Journal: Southern medical journal20100901

Title: Managing spasticity with drugs.

Journal: European journal of physical and rehabilitation medicine20100901

Title: Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology20100601

Title: Load rather than length sensitive feedback contributes to soleus muscle activity during human treadmill walking.

Journal: Journal of neurophysiology20100501

Title: Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.

Journal: Clinical neuropharmacology20100501

Title: Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis.

Journal: Experimental brain research20100401

Title: Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.

Journal: Journal of clinical pharmacology20100301

Title: Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

Journal: Neurology20100126

Title: Drug-induced QT prolongation and sudden death.

Journal: Missouri medicine20100101

Title: [Therapeutic blockades and reflexotherapy in the complex treatment of tension headache].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20100101

Title: Formulation of two-drug controlled release non-biodegradable microparticles for potential treatment of muscles pain and spasm and their simultaneous spectrophotometeric estimation.

Journal: Acta poloniae pharmaceutica20100101

Title: Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.

Journal: Journal of neuroengineering and rehabilitation20100101

Title: Spasticity: revisiting the role and the individual value of several pharmacological treatments.

Journal: NeuroRehabilitation20100101

Title: The addition of tramadol as a second opioid may improve pain relief in severe osteoarthritis: a prospective study.

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Title: [The use of sirdalud MR in patients with multiple sclerosis].

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Title: Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.

Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society20091201

Title: Drug treatments for spasticity.

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Title: Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets.

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Title: Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study.

Journal: Journal of neurology, neurosurgery, and psychiatry20090401

Title: Botulinum toxin should be first-line treatment for poststroke spasticity.

Journal: Journal of neurology, neurosurgery, and psychiatry20090401

Title: Effect of cold application and tizanidine on clonus: clinical and electrophysiological assessment.

Journal: The journal of spinal cord medicine20090401

Title: Medium-latency reflex response of soleus elicited by peroneal nerve stimulation.

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Title: Relative bioavailability of tizanidine hydrochloride capsule formulation compared with capsule contents administered in applesauce: a single-dose, open-label, randomized, two-way, crossover study in fasted healthy adult subjects.

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Title: Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.

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Title: A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.

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Title: The effects of medical treatment and rehabilitation in a patient with adult tethered cord syndrome in the late postoperative period.

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Title: Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study.

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Title: Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation.

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Title: Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

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Title: Efficacy of neuroprotectors in patients with tension headaches.

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Title: Relative bioavailability of tizanidine 4-mg capsule and tablet formulations after a standardized high-fat meal: a single-dose, randomized, open-label, crossover study in healthy subjects.

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Title: The pharmacological management of spasticity.

Journal: The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses20061201

Title: Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects.

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Title: Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers.

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Title: Tizanidine distribution in a postmortem case.

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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

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Title: Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life.

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Title: Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.

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Title: Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form.

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Title: Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient.

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Journal: The Journal of the Association of Physicians of India20050201

Title: Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.

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Title: Hypotension due to interaction between lisinopril and tizanidine.

Journal: The Annals of pharmacotherapy20041101

Title: Drug interaction of tizanidine and fluvoxamine.

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