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103890-78-4,MFCD00865936
Catalog No.:AA00HA50

103890-78-4 | Lacidipine

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250mg
98%
in stock  
$15.00   $10.00
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1g
98%
in stock  
$16.00   $11.00
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5g
98%
in stock  
$27.00   $19.00
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25g
98%
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$114.00   $80.00
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100g
98%
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$408.00   $286.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00HA50
Chemical Name:
Lacidipine
CAS Number:
103890-78-4
Molecular Formula:
C26H33NO6
Molecular Weight:
455.5433
MDL Number:
MFCD00865936
SMILES:
CCOC(=O)C1=C(C)NC(=C(C1c1ccccc1/C=C/C(=O)OC(C)(C)C)C(=O)OCC)C
Properties
Computed Properties
 
Complexity:
805  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
11  
XLogP3:
4.5  

Literature

Title: Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Journal: Toxicology and applied pharmacology 20161215

Title: Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Journal: Scientific reports 20140101

Title: The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.

Journal: Surgery today 20121101

Title: Discrepant regulation of QT (QTc) interval duration by calcium channel blockade and angiotensin converting enzyme inhibition in experimental hypertension.

Journal: Basic & clinical pharmacology & toxicology 20121001

Title: Considerations in the development of an in vitro dissolution condition for lacidipine tablets: in vivo pharmacokinetic evaluation.

Journal: Drug development and industrial pharmacy 20120901

Title: Vasodilation and hypotension of CZ454, an analogue of lacidipine through inhibiting extracellular calcium influx.

Journal: Arzneimittel-Forschung 20120901

Title: Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis.

Journal: Circulation 20120731

Title: Liquid chromatography-tandem mass spectrometric assay for the light sensitive calcium channel antagonist lacidipine in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20120701

Title: Comparing effects of lacidipine, ramipril, and valsartan against experimentally induced myocardial infarcted rats.

Journal: Cardiovascular toxicology 20120601

Title: Visit-to-visit blood pressure variability in the European Lacidipine Study on Atherosclerosis: methodological aspects and effects of antihypertensive treatment.

Journal: Journal of hypertension 20120601

Title: Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells.

Journal: BMC research notes 20120101

Title: Effect of lacidipine pre-treatment on diabetic neuropathy in rats.

Journal: Archives of physiology and biochemistry 20110201

Title: [Amorphous form in pharmaceutical technological research].

Journal: Acta pharmaceutica Hungarica 20110101

Title: Effects of hypertension and ovariectomy on rat hepatocytes. Are amlodipine and lacidipine protective? (A stereological and histological study).

Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20101201

Title: Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.

Journal: Bioorganic & medicinal chemistry 20101115

Title: Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization.

Journal: International journal of pharmaceutics 20100330

Title: Experimental analyses of synergistic combinations of antibiotics with a recently recognised antibacterial agent, lacidipine.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100201

Title: Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure.

Journal: Vascular pharmacology 20100101

Title: Lacidipine encapsulated gastroretentive microspheres prepared by chemical denaturation for pylorospasm.

Journal: Journal of microencapsulation 20090801

Title: Investigation of effects of Lacidipine, Ramipril and Valsartan on DNA damage and oxidative stress occurred in acute and chronic periods following isoproterenol-induced myocardial infarct in rats.

Journal: Molecular and cellular biochemistry 20090801

Title: Development of high performance liquid chromatography method for lacidipine in rabbit serum: application to pharmacokinetic study.

Journal: Analytica chimica acta 20090126

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20080805

Title: Effects of calcium channel blockers on hyaluronidase-induced capillary vascular permeability.

Journal: Archives of pharmacal research 20080701

Title: Effects of antihypertensive drugs on alcohol-induced functional responses of cultured human endothelial cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080201

Title: Protective effects of amlodipine and lacidipine on ovariectomy-induced bone loss in rats.

Journal: European journal of pharmacology 20080128

Title: Prevalence and incidence of the metabolic syndrome in the European Lacidipine Study on Atherosclerosis (ELSA) and its relation with carotid intima-media thickness.

Journal: Journal of hypertension 20071201

Title: [Relationship between cardiomyocyte protein synthesis and cell viability].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601

Title: Assessment of long-term antihypertensive treatment by clinic and ambulatory blood pressure: data from the European Lacidipine Study on Atherosclerosis.

Journal: Journal of hypertension 20070501

Title: Lercanidipine in the treatment of hypertension.

Journal: The Annals of pharmacotherapy 20070301

Title: Comparative study of the effects of lacidipine and enalapril on the left ventricular cardiomyocyte remodeling in spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20060401

Title: Calcium channel blocker inhibits Western-type diet-evoked atherosclerosis development in ApoE-deficient mice.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Effects of amlodipine and lacidipine on heart rate variability in hypertensive patients with stable angina pectoris and isolated left ventricular diastolic dysfunction.

Journal: International journal of cardiology 20050608

Title: Carotid wall composition in hypertensive patients after 4-year treatment with lacidipine or atenolol: an echoreflectivity study.

Journal: Journal of hypertension 20050601

Title: Effect of amlodipine and lacidipine on left ventricular diastolic and long axis functions in arterial hypertension and stable angina pectoris.

Journal: Acta cardiologica 20050601

Title: Cardiac structural and functional changes during long-term antihypertensive treatment with lacidipine and atenolol in the European Lacidipine Study on Atherosclerosis (ELSA).

Journal: Journal of hypertension 20050501

Title: Different relation between 24-h blood pressure and distensibility at different peripheral arteries. Data from the European Lacidipine Study on Atherosclerosis (ELSA).

Journal: Journal of hypertension 20050301

Title: Calcium channel blockade and preservation of renal graft function in cyclosporine-treated recipients: a prospective randomized placebo-controlled 2-year study.

Journal: Transplantation 20041027

Title: Simple, sensitive and rapid liquid chromatographic/electrospray ionization tandem mass spectrometric method for the quantification of lacidipine in human plasma.

Journal: Journal of mass spectrometry : JMS 20040701

Title: Absolute and relative changes in carotid intima-media thickness and atherosclerotic plaques during long-term antihypertensive treatment: further results of the European Lacidipine Study on Atherosclerosis (ELSA).

Journal: Journal of hypertension 20040601

Title: Reduced progression of atherosclerosis in apolipoprotein E-deficient mice treated with lacidipine is associated with a decreased susceptibility of low-density lipoprotein to oxidation.

Journal: International journal of experimental pathology 20040401

Title: Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine.

Journal: Journal of hypertension 20040301

Title: Development and validation of a liquid chromatographic method for determination of lacidipine residues on surfaces in the manufacture of pharmaceuticals.

Journal: Journal of chromatography. A 20040123

Title: Involvement of the nitric oxide system in the anti-atherosclerotic potential of lacidipine in the ApoE-deficient mouse: a morphological, functional, and electrochemical study.

Journal: Toxicologic pathology 20040101

Title: Lercanidipine vs lacidipine in isolated systolic hypertension.

Journal: Journal of human hypertension 20031101

Title: Antioxidant activity of different dihydropyridines.

Journal: Biochemical and biophysical research communications 20030321

Title: Emerging data on calcium-channel blockers: the COHORT study.

Journal: Clinical cardiology 20030201

Title: Lacidipine, a potential peroxynitrite scavenger: investigation of activity by liquid chromatography and mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Treatment of isolated systolic hypertension: the SHELL study results.

Journal: Blood pressure 20030101

Title: Comparative effects of lercanidipine, lacidipine, and nifedipine gastrointestinal therapeutic system on blood pressure and heart rate in elderly hypertensive patients: the ELderly and LErcanidipine (ELLE) study.

Journal: Archives of gerontology and geriatrics 20030101

Title: Lacidipine: a review of its use in the management of hypertension.

Journal: Drugs 20030101

Title: MRS study of the interaction of dihydropyridines with lipid molecules in phosphatidylcholine vesicles.

Journal: Physiological chemistry and physics and medical NMR 20030101

Title: Mechanisms of plaque stabilization for the dihydropyridine calcium channel blocker amlodipine: review of the evidence.

Journal: Atherosclerosis 20021201

Title: Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial.

Journal: Circulation 20021105

Title: Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives.

Journal: American journal of hypertension 20021101

Title: Oral lacidipine in the treatment of anal fissure.

Journal: Techniques in coloproctology 20020901

Title: Determination of lacidipine from urine by HPTLC using off-line SPE.

Journal: Journal of pharmaceutical and biomedical analysis 20020515

Title: Evidence that lacidipine at nonsustained antihypertensive doses activates nitrogen monoxide system in the endothelium of salt-loaded Dahl-S rats.

Journal: Journal of cardiovascular pharmacology 20020401

Title: Comparative effect of lisinopril and lacidipine on urinary albumin excretion in patients with type 11 diabetic nephropathy.

Journal: African journal of medicine and medical sciences 20020301

Title: Photodegradation studies on lacidipine in solution: basic experiments with a cis-trans reversible photoequilibrium under UV-A radiation exposure.

Journal: Journal of pharmaceutical and biomedical analysis 20020201

Title: Lacidipine inhibits adhesion molecule and oxidase expression independent of blood pressure reduction in angiotensin-induced vascular injury.

Journal: Hypertension (Dallas, Tex. : 1979) 20020201

Title: [Therapeutic efficacy of lacidipine in patients with chronic glomerulonephritis and diabetic nephropathy].

Journal: Likars'ka sprava 20020101

Title: Endothelial dysfunction, hypertension and atherosclerosis. A review of the effects of lacidipine.

Journal: Drugs in R&D 20020101

Title: [Third generation of calcium antagonists: focus on lacidipine].

Journal: Kardiologiia 20020101

Title: [The use of combination therapy with lacidipine and beta-adrenoblockers in patients with hypertension].

Journal: Kardiologiia 20020101

Title: Effects of amlodipine and lacidipine on cardiac remodelling and renin production in salt-loaded stroke-prone hypertensive rats.

Journal: British journal of pharmacology 20011201

Title: [Calcium antagonists lower not only blood pressure. Arteriosclerosis is braked too].

Journal: MMW Fortschritte der Medizin 20011115

Title: Angiotensin-converting enzyme inhibition prevents glomerular-tubule disconnection and atrophy in passive Heymann nephritis, an effect not observed with a calcium antagonist.

Journal: The American journal of pathology 20011101

Title: Semipersonalized psychological evaluation of quality of life in hypertensive patients during a trial with two calcium antagonists: a multicenter Latin-American Study (LASTLHY).

Journal: International journal of clinical pharmacology and therapeutics 20010801

Title: Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients.

Journal: Journal of hypertension 20010801

Title: [ELSA Studies studies progression of atherosclerosis. Calcium antagonist arrests the process more than a beta-blocker].

Journal: MMW Fortschritte der Medizin 20010705

Title: Lacidipine prevents endothelial dysfunction in salt-loaded stroke-prone hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20010401

Title: Lacidipine [correction of Lalsoacidipine] modulates the secretion of matrix metalloproteinase-9 by human macrophages.

Journal: The Journal of pharmacology and experimental therapeutics 20010301

Title: Electrochemical evidence that lacidipine stimulates release of nitrogen monoxide in rat aorta.

Journal: Neuroscience letters 20010209

Title: The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects.

Journal: British journal of clinical pharmacology 20010201

Title: Effect of calcium antagonists on stress-induced rise in blood pressure and heart rate: a double-blind, placebo-controlled study.

Journal: International journal of clinical pharmacology and therapeutics 20010101

Title: Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding.

Journal: Hypertension (Dallas, Tex. : 1979) 19991201

Title: [Preclinical study of the action of a calcium channel blocker during salt load].

Journal: Bulletin de l'Academie nationale de medecine 19970201

Title: Relative efficacy and tolerability of lacidipine and amlodipine in patients with mild-to-moderate hypertension: a randomized double-blind study.

Journal: Journal of cardiovascular pharmacology 19960801

Title: Lacidipine: a calcium antagonist with potent and long-lasting antihypertensive effects in animal studies.

Journal: Journal of cardiovascular pharmacology 19900401

Title: Haemodynamic parameters in hypertensive patients: changes induced by lacidipine and nifedipine.

Journal: Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19891201

Title: Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9.

Title: van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7.

Title: Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7.

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Tags:103890-78-4 Molecular Formula|103890-78-4 MDL|103890-78-4 SMILES|103890-78-4 Lacidipine