Name: Name:Pyrithioxin
Brand: AABLOCKS
SKU: AA00HBIT
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00HBIT

Chemical Name: Pyrithioxin

CAS Number: 1098-97-1

Molecular Formula: C16H20N2O4S2

Molecular Weight: 368.4710

MDL Number: MFCD00151477

SMILES: OCc1c(CSSCc2cnc(c(c2CO)O)C)cnc(c1O)C

NSC Number: 759229

Properties

Complexity: 346

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 24

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 4

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.2

Downstream Synthesis Route

960-71-4

1098-97-1

22638-93-3

[1]Roth;Surborg[ArchivderPharmazieundBerichtederDeutschenPharmazeutischenGesellschaft,1968,vol.301,#9,p.646-659]

98-88-4

1098-97-1

55422-88-3

[1]CurrentPatentAssignee:MERCK&COINC-US3971797,1976,A

373-91-1

1098-97-1

55422-94-1

[1]CurrentPatentAssignee:MERCK&COINC-US3971797,1976,A

Literature fold

Title: Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging.

Journal: Frontiers in aging neuroscience20100101

Title: Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride.

Journal: Drug testing and analysis20090501

Title: Pyritinol for post asphyxial encephalopathy in term babies-- a randomized double-blind controlled trial.

Journal: Indian pediatrics20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Pyritinol reduces nociception and oxidative stress in diabetic rats.

Journal: European journal of pharmacology20080820

Title: Stability-indicating electrochemical methods for the determination of meclophenoxate hydrochloride and pyritinol dihydrochloride using ion-selective membrane electrodes.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20070101

Title: Stability-indicating methods for determination of pyritinol dihydrochloride in the presence of its precursor and degradation product by derivative spectrophotometry.

Journal: Journal of AOAC International20050101

Title: Prolongevity medicine: Antagonic-Stress drug in distress, geriatrics, and related diseases. II. Clinical review--2003.

Journal: Annals of the New York Academy of Sciences20040601

Title: Severe cholestatic hepatitis induced by pyritinol.

Journal: BMJ (Clinical research ed.)20040306

Title: [Current strategies of pathogenetic therapy of Alzheimer's disease].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk20010101

Title: Effect of nicergoline on learning and memory.

Journal: Methods and findings in experimental and clinical pharmacology19880701

Title: Stoica E, et al. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. Eur Neurol. 1975;13(4):285-303.

1098-97-1 | Pyrithioxin