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112901-68-5,MFCD00453866
Catalog No.:AA00HCDD

112901-68-5 | Amifostine trihydrate

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1mg
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$7.00   $5.00
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10mg
97%
in stock  
$13.00   $9.00
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50mg
97%
in stock  
$29.00   $21.00
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100mg
97%
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$45.00   $32.00
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250mg
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$66.00   $47.00
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1g
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$132.00   $93.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HCDD
Chemical Name:
Amifostine trihydrate
CAS Number:
112901-68-5
Molecular Formula:
C5H21N2O6PS
Molecular Weight:
268.2688
MDL Number:
MFCD00453866
SMILES:
NCCCNCCSP(=O)(O)O.O.O.O
Properties
Computed Properties
 
Complexity:
152  
Covalently-Bonded Unit Count:
4  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ALBEMARLECORP-WO2007/53730,2007,A1Locationinpatent:Page/Pagecolumn15-16

[1]CurrentPatentAssignee:ALBEMARLECORP-WO2007/53730,2007,A1Locationinpatent:Page/Pagecolumn14-15

Literature

Title: High glucose inhibits the aspirin-induced activation of the nitric oxide/cGMP/cGMP-dependent protein kinase pathway and does not affect the aspirin-induced inhibition of thromboxane synthesis in human platelets.

Journal: Diabetes 20121101

Title: Postoperative pelvic hypofractionated accelerated radiotherapy with cytoprotection (HypoARC) for high-risk or recurrent prostate cancer.

Journal: Anticancer research 20121001

Title: Meta-analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity.

Journal: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 20121001

Title: [Effect of amifostine on locally advanced non-small cell lung cancer patients treated with radiotherapy: a meta-analysis of randomized controlled trials].

Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer 20120920

Title: Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells.

Journal: International journal of oncology 20120901

Title: A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy.

Journal: International journal of radiation oncology, biology, physics 20120801

Title: Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest.

Journal: Human reproduction (Oxford, England) 20120801

Title: Radiation-induced chronic oxidative renal damage can be reduced by amifostine.

Journal: Medical oncology (Northwood, London, England) 20120601

Title: Medical interventions for the prevention of platinum-induced hearing loss in children with cancer.

Journal: The Cochrane database of systematic reviews 20120516

Title: Effects of amifostine in combination with cyclophosphamide on female reproductive system.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20120501

Title: Reduction of renal uptake of radiolabeled octreotate by amifostine coadministration.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120501

Title: Low-dose antioxidant is sufficient to regulate pulmonary redox equilibration.

Journal: Critical care medicine 20120501

Title: Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: an FTIR microspectroscopic imaging study.

Journal: Archives of biochemistry and biophysics 20120415

Title: Radiation damage and radioprotectants: new concepts in the era of molecular medicine.

Journal: The British journal of radiology 20120401

Title: A new orally active, aminothiol radioprotector-free of nausea and hypotension side effects at its highest radioprotective doses.

Journal: International journal of radiation oncology, biology, physics 20120401

Title: Radiation-induced craniofacial bone growth inhibition: acute and long-term effects on bone histopathology with and without cytoprotection.

Journal: Plastic and reconstructive surgery 20120401

Title: Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

Journal: Plastic and reconstructive surgery 20120401

Title: Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group.

Journal: International journal of radiation oncology, biology, physics 20120101

Title: Protective effect of polysaccharide-protein complex from a polypore mushroom, Phellinus rimosus against radiation-induced oxidative stress.

Journal: Redox report : communications in free radical research 20120101

Title: The histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicity.

Journal: Journal of cancer research and therapeutics 20120101

Title: Addition of amifostine to the CHOP regimen in elderly patients with aggressive non-Hodgkin lymphoma: a phase II trial showing reduction in toxicity without altering long-term survival.

Journal: Hematology/oncology and stem cell therapy 20120101

Title: A phase II study of amifostine in children with myelodysplastic syndrome: a report from the Children's Oncology Group study (AAML0121).

Journal: Pediatric blood & cancer 20111215

Title: Myelodysplastic syndrome in children: changing definitions from FAB 1976 to WHO 2008 classification systems.

Journal: Pediatric blood & cancer 20111215

Title: Protective effect of L-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats.

Journal: Medical oncology (Northwood, London, England) 20111201

Title: Preparation of amifostine polylactide-co-glycolide microspheres and its irradiation protective to mouse through oral administration.

Journal: Drug development and industrial pharmacy 20111201

Title: Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury.

Journal: Critical care medicine 20111201

Title: Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure.

Journal: Cancer biotherapy & radiopharmaceuticals 20111201

Title: Central role of oxidative stress and its signaling pathways in causing and preventing acute lung injury.

Journal: Critical care medicine 20111201

Title: SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.

Journal: Free radical biology & medicine 20111115

Title: Attenuation of sulfur mustard toxicity by S-2(2-aminoethylamino)ethyl phenyl sulfide (DRDE-07) in mouse liver.

Journal: Toxicology mechanisms and methods 20111001

Title: Extended-field irradiation and intracavitary brachytherapy combined with cisplatin and amifostine for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of arm II of Radiation Therapy Oncology Group (RTOG) 0116.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20111001

Title: Antioxidant prophylaxis for cellular injury in ovarian surface epithelium resulting from CO₂ pneumoperitoneum in a laparoscopic rat model.

Journal: Archives of gynecology and obstetrics 20110901

Title: Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip.

Journal: Biofabrication 20110901

Title: Cytotoxicity of gamma-ray in rat immature hippocampal neurons.

Journal: Journal of veterinary science 20110901

Title: Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor.

Journal: Journal of pediatric hematology/oncology 20110801

Title: A Phase I trial: dose escalation of melphalan in the 'BEAM' regimen using amifostine cytoprotection.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20110701

Title: Chemical genoprotection: reducing biological damage to as low as reasonably achievable levels.

Journal: Dento maxillo facial radiology 20110701

Title: Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110620

Title: Bevacizumab, capecitabine, amifostine, and preoperative hypofractionated accelerated radiotherapy (HypoArc) for rectal cancer: a Phase II study.

Journal: International journal of radiation oncology, biology, physics 20110601

Title: Amifostine-related fever-rash during fractionated radiotherapy: diagnostic and predictive role of C-reactive protein.

Journal: American journal of clinical oncology 20110601

Title: [Prediction and bioinformatics analysis of human gene expression profiling regulated by amifostine].

Journal: Zhongguo shi yan xue ye xue za zhi 20110601

Title: Risk of xerostomia in association with the receipt of radiation therapy in older patients with head and neck cancer.

Journal: American journal of therapeutics 20110501

Title: Phosphorylation and cytoplasmic localization of MAPK p38 during apoptosis signaling in bone marrow granulocytes of mice irradiated in vivo and the role of amifostine in reducing these effects.

Journal: Acta histochemica 20110501

Title: Treatment of low-risk prostate cancer with radical hypofractionated accelerated radiotherapy with cytoprotection (HypoARC): an interim analysis of toxicity and efficacy.

Journal: Anticancer research 20110501

Title: Screening of protective effect of amifostine on radiation-induced structural and functional variations in rat liver microsomal membranes by FT-IR spectroscopy.

Journal: Analytical chemistry 20110401

Title: Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver.

Journal: Radiation and environmental biophysics 20110301

Title: Can radiation risks to patients be reduced without reducing radiation exposure? The status of chemical radioprotectants.

Journal: AJR. American journal of roentgenology 20110301

Title: The Children's Oncology Group routinely applies 'lack of efficacy' interim monitoring to its randomized clinical trials.

Journal: The American journal of bioethics : AJOB 20110301

Title: Role of capsaicin-sensitive primary afferent neurons and non-protein sulphydryl groups on gastroprotective effect of amifostine against ethanol-induced gastric damage in rats.

Journal: Digestive diseases and sciences 20110201

Title: Amifostine in the treatment of head and neck cancer: intravenous administration, subcutaneous administration, or none of the above.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

Title: Subcutaneous compared with intravenous administration of amifostine in patients with head and neck cancer receiving radiotherapy: final results of the GORTEC2000-02 phase III randomized trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110110

Title: Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine.

Journal: Biochemical and biophysical research communications 20110107

Title: Efficacy of amifostine in treating patients with idiopathic thrombocytopenia purpura.

Journal: Cell biochemistry and biophysics 20110101

Title: Role of amifostine on acute and late radiation nephrotoxicity: a histopathological study.

Journal: In vivo (Athens, Greece) 20110101

Title: Narrow amifostine dose windows define radioprotection outcome, following fractionated whole-body irradiation of mice.

Journal: In vivo (Athens, Greece) 20110101

Title: N-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

Title: Acute radiation effect in the brain in infant rats: Neurocognitive and histopathological examination.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

Title: Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma.

Journal: International journal of radiation oncology, biology, physics 20101201

Title: Renoprotective potency of amifostine in rat renal ischaemia-reperfusion.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101201

Title: Amifostine enhancement of the anti-cancer effects of paclitaxel in endometrial cancer is TP53-dependent.

Journal: International journal of oncology 20101101

Title: Drde-07: a possible antidote for sulphur mustard toxicity.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20100911

Title: Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit.

Journal: Human & experimental toxicology 20100901

Title: The rat acute-phase protein α2-macroglobulin plays a central role in amifostine-mediated radioprotection.

Journal: Journal of radiological protection : official journal of the Society for Radiological Protection 20100901

Title: Does amifostine have radioprotective effects on salivary glands in high-dose radioactive iodine-treated differentiated thyroid cancer.

Journal: European journal of nuclear medicine and molecular imaging 20100801

Title: A systematic review of dysgeusia induced by cancer therapies.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20100801

Title: Comparative toxic effect of nitrogen mustards (HN-1, HN-2, and HN-3) and sulfur mustard on hematological and biochemical variables and their protection by DRDE-07 and its analogues.

Journal: International journal of toxicology 20100701

Title: Systemic chemotherapy-induced microsatellite instability in the mononuclear cell fraction of women with breast cancer can be reproduced in vitro and abrogated by amifostine.

Journal: The Journal of pharmacy and pharmacology 20100701

Title: Prophylactic efficacy of combination of DRDE-07 and its analogues with amifostine against sulphur mustard induced systemic toxicity.

Journal: Indian journal of experimental biology 20100701

Title: Radioprotection from radiation-induced lymphedema without tumor protection.

Journal: Lymphology 20100601

Title: Radiochemotherapy with cetuximab, cisplatin, and amifostine for locally advanced head and neck cancer: a feasibility study.

Journal: International journal of radiation oncology, biology, physics 20100501

Title: [Drug delivery of CPC/amifostine/cisplatin complex in vitro and its ability in repairing bone defect and eliminating tumor in vivo].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100501

Title: Amifostine protection against induced DNA damage in gamma-irradiated Escherichia coli cells depend on recN DNA repair gene product activity.

Journal: Environmental toxicology 20100401

Title: Radioprotectors and mitigators of radiation-induced normal tissue injury.

Journal: The oncologist 20100401

Title: [In vitro study on physical and chemical properities of calcium phosphate cement/amifostine complex and on vitality of cultured cells].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100401

Title: Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation.

Journal: Journal of veterinary science 20100301

Title: Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.

Journal: Radiation research 20100201

Title: Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100201

Title: Amifostine reduces the seminiferous epithelium damage in doxorubicin-treated prepubertal rats without improving the fertility status.

Journal: Reproductive biology and endocrinology : RB&E 20100101

Title: [Physicochemical and sustained drug release properties of calcium phosphate cement/amifostine/cisplatin complex and its effect in repairing bone defect due to tumor resection in rabbits].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100101

Title: The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A.

Journal: BMC medicine 20100101

Title: Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis.

Journal: Journal of experimental & clinical cancer research : CR 20100101

Title: Amifostine modulates radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients.

Journal: Journal of radiation research 20100101

Title: The preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20100101

Title: Comparison of protective effects of L-carnitine and amifostine on radiation-induced toxicity to growing bone: histopathology and scintigraphy findings.

Journal: Asian Pacific journal of cancer prevention : APJCP 20100101

Title: Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group.

Journal: Cancer 20091215

Title: Hepatoblastoma, cisplatin, and ototoxicity: good news on deaf ears.

Journal: Cancer 20091215

Title: The role of amifostine on late normal tissue damage induced by pelvic radiotherapy with concomitant gemcitabine: an in vivo study.

Journal: Medical oncology (Northwood, London, England) 20091201

Title: Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: an analysis of RTOG 9801.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091201

Title: [Mechanism and problem of amifostine in treating myelodysplastic syndromes].

Journal: Zhongguo shi yan xue ye xue za zhi 20091201

Title: A prospective study of salivary gland function in lymphoma patients receiving head and neck irradiation.

Journal: International journal of radiation oncology, biology, physics 20091115

Title: Amifostine for salivary glands in high-dose radioactive iodine treated differentiated thyroid cancer.

Journal: The Cochrane database of systematic reviews 20091007

Title: Cytoprotective activity of amifostine on cultured human lymphocytes exposed to irinotecan.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

Title: Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer.

Journal: Cancer 20091001

Title: Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.

Journal: Free radical biology & medicine 20090915

Title: Amifostine has the potential to induce haematologic responses and decelerate disease progression in individual patients with low- and intermediate-1-risk myelodysplastic syndromes.

Journal: Leukemia research 20090901

Title: DRDE-07 and its analogues as promising cytoprotectants to nitrogen mustard (HN-2)--an alkylating anticancer and chemical warfare agent.

Journal: Toxicology letters 20090810

Title: Hypofractionated and accelerated radiotherapy with subcutaneous amifostine cytoprotection as short adjuvant regimen after breast-conserving surgery: interim report.

Journal: International journal of radiation oncology, biology, physics 20090715

Title: Differential effect triggered by a heparan mimetic of the RGTA family preventing oral mucositis without tumor protection.

Journal: International journal of radiation oncology, biology, physics 20090715

Title: [Application of bioinformatics analysis to optimize amifostine combination therapeutic regimen of myelodysplastic syndrome].

Journal: Zhonghua yi xue za zhi 20090714

Title: Cytoprotective effects of amifostine in the treatment of childhood malignancies.

Journal: Pediatric blood & cancer 20090701

Title: Protective effects of amifostine and cyclooxygenase-1 inhibitor against normal human epidermal keratinocyte toxicity induced by methotrexate and 5-fluorouracil.

Journal: Basic & clinical pharmacology & toxicology 20090701

Title: The radioprotective effect of alpha2-macroglobulin: a morphological study of rat liver.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20090701

Title: The acute-phase protein alpha2-macroglobulin plays an important role in radioprotection in the rat.

Journal: Shock (Augusta, Ga.) 20090601

Title: Computed tomography assessment of lung density in patients with lung cancer treated with accelerated hypofractionated radio-chemotherapy supported with amifostine.

Journal: American journal of clinical oncology 20090601

Title: Histopathological and scintigraphic comparisons of the protective effects of L-carnitine and amifostine against radiation-induced late renal toxicity in rats.

Journal: Clinical and experimental pharmacology & physiology 20090501

Title: Evaluation of new thiadiazoles and benzothiazoles as potential radioprotectors: free radical scavenging activity in vitro and theoretical studies (QSAR, DFT).

Journal: Free radical biology & medicine 20090415

Title: An outpatient intraperitoneal chemotherapy regimen for advanced ovarian cancer.

Journal: Gynecologic oncology 20090401

Title: Radioprotective effects of kojic acid against mortality induced by gamma irradiation in mice.

Journal: Saudi medical journal 20090401

Title: Amifostine reduces lung vascular permeability via suppression of inflammatory signalling.

Journal: The European respiratory journal 20090301

Title: Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.

Journal: International journal of radiation oncology, biology, physics 20090301

Title: The role of amifostine in the treatment of head and neck cancer with cisplatin-radiotherapy.

Journal: European journal of cancer care 20090301

Title: Radioprotection of osteoblasts by a fractionated dose regimen and amifostine.

Journal: Plastic and reconstructive surgery 20090201

Title: A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesothelioma.

Journal: The Journal of thoracic and cardiovascular surgery 20090201

Title: Effects of amifostine administration prior to irradiation to the submandibular gland in mice: autoradiographic study using 3H-leucine.

Journal: Okajimas folia anatomica Japonica 20090201

Title: Prevention of hearing loss in children receiving cisplatin chemotherapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090110

Title: American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090101

Title: Strategies for managing radiation-induced mucositis in head and neck cancer.

Journal: Seminars in radiation oncology 20090101

Title: Amifostine enhances recovery and expansion of peripheral FAS/CD95+ T- and NK-cell subpopulations during radiotherapy of patients with head-neck cancer.

Journal: International journal of radiation biology 20090101

Title: p53-Induced apoptosis and inhibitors of p53.

Journal: Current medicinal chemistry 20090101

Title: Evaluation of the possible benefits of post-radiotherapy surgery after concomitant chemoradiotherapy with a new radio-sensitizing regimen (irinotecan / CPT-11, interferon A2b and amifostine) for advanced-stage cervical carcinoma. Preliminary results of a pilot phase-II study.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20090101

Title: Antimutagenicity of amifostine against the anticancer drug fotemustine in the Drosophila somatic mutation and recombination (SMART) test.

Journal: Mutation research 20090101

Title: Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits.

Journal: Journal of cardiothoracic surgery 20090101

Title: Auditory late effects of chemotherapy.

Journal: Cancer treatment and research 20090101

Title: Postoperative accelerated radiotherapy with cytoprotection followed by three-dimensional conformal boost in patients with early endometrial/cervical cancer.

Journal: Tumori 20090101

Title: Analysis of the cytoprotective effect of amifostine on the irradiated inner ear of guinea pigs: an experimental study.

Journal: Brazilian journal of otorhinolaryngology 20090101

Title: WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

Journal: Free radical biology & medicine 20081215

Title: Clinically meaningful differences in patient-reported outcomes with amifostine in combination with chemoradiation for locally advanced non-small-cell lung cancer: an analysis of RTOG 9801.

Journal: International journal of radiation oncology, biology, physics 20081201

Title: The effect of N-acetylcysteine on biomarkers for radiation-induced oxidative damage in a rat model.

Journal: Acta medica Okayama 20081201

Title: The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20081101

Title: Randomized phase 2 study of subcutaneous amifostine versus epoetin-alpha given 3 times weekly during concurrent chemotherapy and hyperfractionated radiotherapy for limited-disease small cell lung cancer.

Journal: Cancer 20081001

Title: The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20081001

Title: RLIP76 in defense of radiation poisoning.

Journal: International journal of radiation oncology, biology, physics 20081001

Title: Pharmacologic normal tissue protection in clinical radiation oncology: focus on amifostine.

Journal: Expert opinion on drug metabolism & toxicology 20081001

Title: Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells.

Journal: Plastic and reconstructive surgery 20081001

Title: [Prophylactic effect of amifostine on oxaliplatin-related neurotoxicity in patients with digestive tract tumors].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20081001

Title: Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.

Journal: Hematology (Amsterdam, Netherlands) 20081001

Title: [Short-term curative effect of amifostine combined with rhbeta-EPO on patients with pure erythroid aplasia].

Journal: Zhongguo shi yan xue ye xue za zhi 20081001

Title: Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury.

Journal: International journal of radiation biology 20081001

Title: Emerging drugs for chemotherapy-induced mucositis.

Journal: Expert opinion on emerging drugs 20080901

Title: Amifostine protection against mitomycin-induced chromosomal breakage in fanconi anaemia lymphocytes.

Journal: Molecules (Basel, Switzerland) 20080821

Title: Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine.

Journal: International journal of radiation biology 20080801

Title: Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080801

Title: Amifostine protective effect on cisplatin-treated rat testis.

Journal: Anatomical record (Hoboken, N.J. : 2007) 20080701

Title: Alternate delivery route for amifostine as a radio-/chemo-protecting agent.

Journal: The Journal of pharmacy and pharmacology 20080701

Title: Amifostine use in radiation-induced kidney damage. Preclinical evaluation with scintigraphic and histopathologic parameters.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20080701

Title: Amifostine prior to lethal irradiation prevents allogeneic bone marrow engraftment in mice.

Journal: Bone marrow transplantation 20080601

Title: Prevention and treatment of regimen-related mucosal toxicity.

Journal: Recent patents on anti-cancer drug discovery 20080601

Title: Stevens-Johnson syndrome and toxic epidermal necrolysis induced by amifostine during head and neck radiotherapy.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080501

Title: Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.

Journal: Radiation research 20080501

Title: Cytoprotective efficacy of amifostine against radiation- induced rectal toxicity: objective and subjective grading scales for radiomucositis.

Journal: Molecules (Basel, Switzerland) 20080418

Title: In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro.

Journal: Pediatric nephrology (Berlin, Germany) 20080401

Title: [Amifostine-induced Stevens-Johnson syndrome during radiotherapy].

Journal: Annales de dermatologie et de venereologie 20080401

Title: Preparation of polylactide-co-glycolide and chitosan hybrid microcapsules of amifostine using coaxial ultrasonic atomizer with solvent evaporation.

Journal: The Journal of pharmacy and pharmacology 20080301

Title: Cytogenetic damage induced by radiotherapy. Evaluation of protection by amifostine and analysis of chromosome aberrations persistence.

Journal: International journal of radiation biology 20080301

Title: Radiation-induced craniofacial bone growth inhibition: in vitro cytoprotection in the rabbit orbitozygomatic complex periosteum-derived cell culture.

Journal: Plastic and reconstructive surgery 20080301

Title: Limited cytoprotective effects of amifostine in high-dose radioactive iodine 131-treated well-differentiated thyroid cancer patients: analysis of quantitative salivary scan.

Journal: Thyroid : official journal of the American Thyroid Association 20080301

Title: A pilot study of addition of amifostine to melphalan, carboplatin, etoposide, and cyclophosphamide with autologous hematopoietic stem cell transplantation in pediatric solid tumors-A pediatric blood and marrow transplant consortium study.

Journal: Journal of pediatric hematology/oncology 20080301

Title: Amifostine can differentially modulate DNA double-strand breaks and apoptosis induced by idarubicin in normal and cancer cells.

Journal: Experimental oncology 20080301

Title: Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast.

Journal: Oncogene 20080221

Title: Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.

Journal: Cancer letters 20080218

Title: [Painful hyperexcitability syndrome with oxaliplatin containing chemotherapy. Clinical features, pathophysiology and therapeutic options].

Journal: Schmerz (Berlin, Germany) 20080201

Title: [Therapy of 17 cases of idiopathic thrombocytopenia purpura by amifostine].

Journal: Zhongguo shi yan xue ye xue za zhi 20080201

Title: Hypoxia inducible factor (HIf1alpha and HIF2alpha) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy.

Journal: International journal of radiation biology 20080101

Title: Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score.

Journal: International journal of radiation oncology, biology, physics 20080101

Title: Cytoprotection for radiation-associated normal tissue injury.

Journal: Cancer treatment and research 20080101

Title: Hypofractionated/accelerated radiotherapy with cytoprotection (HypoARC) combined with vinorelbine and liposomal doxorubicin for locally advanced non-small cell lung cancer (NSCLC).

Journal: Anticancer research 20080101

Title: Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland: a pilot study.

Journal: Radiation oncology (London, England) 20080101

Title: Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study.

Journal: Anticancer research 20080101

Title: Efficacy and safety of subcutaneous amifostine in minimizing radiation-induced toxicities in patients receiving combined-modality treatment for squamous cell carcinoma of the head and neck.

Journal: International journal of radiation oncology, biology, physics 20071201

Title: In regard to Münter et Al. Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without amifostine. (Int j radiat oncol biol phys 2007;67:651-659).

Journal: International journal of radiation oncology, biology, physics 20071201

Title: Effects of dexrazoxane and amifostine on evolution of Doxorubicin cardiomyopathy in vivo.

Journal: Experimental biology and medicine (Maywood, N.J.) 20071201

Title: Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents.

Journal: International journal of radiation oncology, biology, physics 20071001

Title: [Curative efficacy of fludarabine combined with rituximab and amifostine on aged patient with B-chronic lymphocytic leukemia].

Journal: Zhongguo shi yan xue ye xue za zhi 20071001

Title: Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070901

Title: In regards to Münter et Al. (Int J Radiat Oncol Biol Phys 2007;67:651-659).

Journal: International journal of radiation oncology, biology, physics 20070901

Title: Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin.

Journal: Pediatric hematology and oncology 20070901

Title: Radioprotection of craniofacial bone growth.

Journal: The Journal of craniofacial surgery 20070901

Title: Cytoprotective agents used in the treatment of patients with cancer.

Journal: Seminars in oncology nursing 20070801

Title: Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats.

Journal: Colloids and surfaces. B, Biointerfaces 20070701

Title: A new intensive induction schedule, including high-dose Idarubicin, high-dose Aracytin and Amifostine, in older AML patients: feasibility and long-term results in 42 patients.

Journal: Experimental hematology 20070701

Title: The DNA-damaging potential of tamoxifen in breast cancer and normal cells.

Journal: Archives of toxicology 20070701

Title: Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs.

Journal: Radiation research 20070701

Title: Amifostine: the first selective-target and broad-spectrum radioprotector.

Journal: The oncologist 20070601

Title: Toxic epidermal necrolysis.

Journal: Clinical journal of oncology nursing 20070601

Title: Daily subcutaneous amifostine administration during irradiation of pediatric head and neck cancers.

Journal: Pediatric blood & cancer 20070501

Title: Amifostine protects rat kidneys during peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate.

Journal: European journal of nuclear medicine and molecular imaging 20070501

Title: Effect of amifostine on response rates in locally advanced non-small-cell lung cancer patients treated on randomized controlled trials: a meta-analysis.

Journal: International journal of radiation oncology, biology, physics 20070501

Title: Clinical trial design limitations in head and neck squamous cell carcinomas.

Journal: Current opinion in oncology 20070501

Title: Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.

Journal: Radiation research 20070401

Title: A sequential procedure for monitoring clinical trials against historical controls.

Journal: Statistics in medicine 20070330

Title: [Role of amifostine against the effect of etoposide on non-Hodgkin lymphoma bone marrow derived mesenchymal stem cells: an in vitro experiment].

Journal: Zhonghua yi xue za zhi 20070327

Title: Phase I North Central Cancer Treatment Group Trial-N9923 of escalating doses of twice-daily thoracic radiation therapy with amifostine and with alternating chemotherapy in limited stage small-cell lung cancer.

Journal: International journal of radiation oncology, biology, physics 20070315

Title: Ifosfamide toxicity in cultured proximal renal tubule cells.

Journal: Pediatric nephrology (Berlin, Germany) 20070301

Title: Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine.

Journal: International journal of radiation oncology, biology, physics 20070301

Title: Management of salivary hypofunction during and after radiotherapy.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301

Title: The effect of amifostine, a cytoprotective agent, on paraquat toxicity in mice.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070301

Title: cDNA microarray study to identify expression changes relevant for apoptosis in K562 cells co-treated with amifostine and imatinib.

Journal: Cancer chemotherapy and pharmacology 20070201

Title: A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer.

Journal: International journal of radiation oncology, biology, physics 20070201

Title: Radical hypofractionated accelerated radiotherapy with cytoprotection for invasive bladder cancer.

Journal: Urology 20070201

Title: [Amifostine used in the treatment of patients with myelodysplastic syndrome].

Journal: Zhongguo shi yan xue ye xue za zhi 20070201

Title: Interventions for preventing neuropathy caused by cisplatin and related compounds.

Journal: The Cochrane database of systematic reviews 20070124

Title: Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis.

Journal: Cancer chemotherapy and pharmacology 20070101

Title: Kojic acid and its manganese and zinc complexes as potential radioprotective agents.

Journal: Bioorganic & medicinal chemistry letters 20070101

Title: Amifostine (Wr-2721) prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.

Journal: Digestive diseases and sciences 20070101

Title: Anaphylactoid reaction from amifostine.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20070101

Title: Concurrent chemoradiotherapy with vinorelbine and a platinum compound followed by consolidation chemotherapy for unresectable stage III non-small cell lung cancer: preliminary results of a phase II study.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20070101

Title: Influence of amifostine on late radiation-toxicity in head and neck cancer--a follow-up study.

Journal: Anticancer research 20070101

Title: Amifostine protects bone marrow from benzene-induced hematotoxicity in mice.

Journal: International journal of toxicology 20070101

Title: Hypofractionated accelerated radiochemotherapy with cytoprotection (Chemo-HypoARC) for inoperable non-small cell lung carcinoma.

Journal: Anticancer research 20070101

Title: A case of Stevens-Johnson syndrome possibly induced by amifostine during radiotherapy.

Journal: Tumori 20070101

Title: Effect of Amifostine to prevent radiotherapy-induced acute and late toxicity in head and neck cancer patients who had normal or mild impaired salivary gland function.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20061201

Title: Maximizing the delivery of intraperitoneal therapy while minimizing drug toxicity and maintaining quality of life.

Journal: Seminars in oncology 20061201

Title: Recombinant human erythropoietin in comparison to amifostine against cisplatin-induced peripheral sensorial neurotoxicity in rats.

Journal: Journal of experimental & clinical cancer research : CR 20061201

Title: Radioprotectants: adding quality of life to survivorship?

Journal: Seminars in oncology nursing 20061101

Title: Amelioration of early radiation effects in oral mucosa (mouse) by intravenous or subcutaneous administration of amifostine.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20061001

Title: Computed tomography (CT) scan evaluation of late toxicity following hypofractionated/accelerated radiotherapy with cytoprotection (HypoARC) in breast cancer patients treated with conservative surgery.

Journal: American journal of clinical oncology 20061001

Title: [Intervention of Amifostine for benzene-induced blood toxicity in mice].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20061001

Title: [Amifostine in treatment of five patients with myelodysplastic syndrome].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20061001

Title: Zebrafish as a 'biosensor'? Effects of ionizing radiation and amifostine on embryonic viability and development.

Journal: Cancer research 20060815

Title: Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53.

Journal: Cancer gene therapy 20060801

Title: Future opportunities in preventing cisplatin induced ototoxicity.

Journal: Cancer treatment reviews 20060801

Title: Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine 5 times weekly: A prospective randomized study in squamous cell head and neck cancer.

Journal: Cancer 20060801

Title: Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses.

Journal: Journal of dental research 20060801

Title: Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study.

Journal: International journal of radiation oncology, biology, physics 20060715

Title: [Model of benzene induced aplastic anemia in mice and pathological changes of intervention of Amifostine].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060701

Title: Amifostine in the management of radiation-induced and chemo-induced mucositis.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060601

Title: An anaphylactoid reaction from amifostine.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060601

Title: Assessment of the radioprotective effects of amifostine and melatonin on human lymphocytes irradiated with gamma-rays in vitro.

Journal: Arhiv za higijenu rada i toksikologiju 20060601

Title: Evaluation, prevention and management of radiotherapy-induced xerostomia in head and neck cancer patients.

Journal: Current opinion in oncology 20060501

Title: Effect of amifostine on the cytotoxicity of daunorubicin and daunoxome in tumor and normal cells.

Journal: Cancer chemotherapy and pharmacology 20060401

Title: Antimutagenic effect of polysaccharide ginsan extracted from Panax ginseng.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060401

Title: [Early effect of amifostine in treating aged patients with idiopathic thrombocytopenia purpura].

Journal: Zhongguo shi yan xue ye xue za zhi 20060401

Title: Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis.

Journal: International journal of radiation oncology, biology, physics 20060301

Title: Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study.

Journal: International journal of radiation oncology, biology, physics 20060301

Title: How to reduce radiation-related toxicity in patients with cancer of the head and neck.

Journal: Current oncology reports 20060301

Title: Amifostine-induced back pain: a case report.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060215

Title: Amifostine administration during radiotherapy for cancer patients with genetic, autoimmune, metabolic and other diseases.

Journal: Anti-cancer drugs 20060201

Title: Established and emerging uses of cytoprotection in head and neck cancer.

Journal: Archives of otolaryngology--head & neck surgery 20060201

Title: Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy.

Journal: Archives of otolaryngology--head & neck surgery 20060201

Title: Managing oral mucositis in patients with hematologic malignancies.

Journal: The journal of supportive oncology 20060201

Title: New approaches to preventing xerostomia.

Journal: The journal of supportive oncology 20060201

Title: Chemoradiotherapy for head and neck cancer: 'local' side effects are actually systemic.

Journal: The journal of supportive oncology 20060201

Title: Trial of amifostine in autologous stem cell transplant.

Journal: Bone marrow transplantation 20060101

Title: Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group Phase II Study 9457--a report from the Children's Oncology Group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060101

Title: Developmental therapeutics for myelodysplastic syndromes.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20060101

Title: Evaluation of analogues of DRDE-07 as prophylactic agents against the lethality and toxicity of sulfur mustard administered through percutaneous route.

Journal: Journal of applied toxicology : JAT 20060101

Title: Cytoprotective effect of amifostine in the treatment of childhood neoplastic diseases--a clinical study including the pharmacoeconomic analysis.

Journal: Pharmacological reports : PR 20060101

Title: Potentiation of the antitumor effect of Merocyanine 540-mediated photodynamic therapy by amifostine and amphotericin B.

Journal: Photochemistry and photobiology 20060101

Title: [Protective effect of amifostine on cisplatin-induced nephrotoxicity and its mechanism].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20060101

Title: The effects of amifostine and dexamethasone on brain tissue lipid peroxidation during oxygen treatment of carbon monoxide-poisoned rats.

Journal: Advances in therapy 20060101

Title: Comparison of uroprotective efficacy of mesna and amifostine in Cyclophosphamide- induced hemorrhagic cystitis in rats.

Journal: Indian journal of cancer 20060101

Title: Individualization of the subcutaneous amifostine dose during hypofractionated / accelerated radiotherapy.

Journal: Anticancer research 20060101

Title: Amifostine improves hemodynamic parameters in doxorubicin-pretreated rabbits.

Journal: Pharmacological reports : PR 20060101

Title: The protective effects of amifostine on adriamycin-induced acute cardiotoxicity in rats.

Journal: The Tohoku journal of experimental medicine 20051201

Title: Radioprotective effect of amifostine on parotid gland functioning is region dependent.

Journal: International journal of radiation oncology, biology, physics 20051201

Title: Cytoprotection by amifostine during autologous stem cell transplantation for advanced refractory hematologic malignancies.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20051201

Title: Commentary: the pharmacological antioxidant amifostine -- implications of recent research for integrative cancer care.

Journal: Integrative cancer therapies 20051201

Title: Management of xerostomia related to radiotherapy for head and neck cancer.

Journal: Oncology (Williston Park, N.Y.) 20051201

Title: Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, phase III trial.

Journal: International journal of radiation oncology, biology, physics 20051115

Title: A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy.

Journal: Cancer research 20051115

Title: Effects of insulin-like growth factor-1 (IGF-1) and amifostine in spinal cord reirradiation.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20051101

Title: Doxorubicin induces apoptosis in germ line stem cells in the immature rat testis and amifostine cannot protect against this cytotoxicity.

Journal: Cancer research 20051101

Title: A potential synergistic anticancer effect of paclitaxel and amifostine on endometrial cancer.

Journal: Cancer research 20051015

Title: Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy--a double-blind, placebo-controlled, randomized phase II study from the Arbeitsgemeinschaft Gynäkologische Onkologoie (AGO) Ovarian Cancer Study Group.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20051001

Title: Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma.

Journal: Cancer 20051001

Title: What should the optimal timing be for amifostine administration relative to radiation and chemotherapy?

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051001

Title: Phase II study of tolerance and efficacy of hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and paclitaxel (taxol) and amifostine (ethyol) in head and neck squamous cell carcinomas: A-3 protocol.

Journal: American journal of clinical oncology 20051001

Title: Adipocyte differentiation in Sod2(-/-) and Sod2(+/+) murine bone marrow stromal cells is associated with low antioxidant pools.

Journal: Experimental hematology 20051001

Title: Amifostine exerts anti-angiogenic activity and suppresses vascular endothelial growth factor secreted by hemopoietic stem/progenitor cells.

Journal: Saudi medical journal 20051001

Title: Radioprotectant combinations spare radiation-induced damage to the physis more than fractionation alone.

Journal: International journal of radiation biology 20051001

Title: Effects of amifostine on glycerol-pretreated rabbit kidneys.

Journal: Basic & clinical pharmacology & toxicology 20050901

Title: Costs of treatment intensification for head and neck cancer: concomitant chemoradiation randomised for radioprotection with amifostine.

Journal: European journal of cancer (Oxford, England : 1990) 20050901

Title: Amifostine and dexrazoxane enhance the rapid loss of bone mass and further deterioration of vertebrae architecture in female rats.

Journal: Calcified tissue international 20050901

Title: Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study.

Journal: Cancer 20050815

Title: Cytoprotective effects of amifostine and cysteamine on cultured normal and tumor cells treated with paclitaxel in terms of mitotic index and 3H-thymidine labeling index.

Journal: Cancer chemotherapy and pharmacology 20050801

Title: Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy.

Journal: International journal of radiation oncology, biology, physics 20050801

Title: [Morphological observation of amifostine's protective effect on radiation induced early middle ear injury].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20050801

Title: Influence of the cyto-protective agent amifostine on the pharmacokinetics of low-dose Paclitaxel.

Journal: Chemotherapy 20050701

Title: Additive apoptotic effect of STI571 with the cytoprotective agent amifostine in K-562 cell line.

Journal: Cancer chemotherapy and pharmacology 20050601

Title: A phase I trial of irinotecan (CPT-11) with amifostine in patients with metastatic colorectal cancer.

Journal: Investigational new drugs 20050601

Title: Phase II multicenter randomized study of amifostine for prevention of acute radiation rectal toxicity: topical intrarectal versus subcutaneous application.

Journal: International journal of radiation oncology, biology, physics 20050601

Title: Radiation-induced craniofacial bone growth inhibition: efficacy of cytoprotection following a fractionated dose regimen.

Journal: Plastic and reconstructive surgery 20050601

Title: [Short-term curative effect of amifostine combined with rhEPO on aged patients wilh myelodysplastic syndrome].

Journal: Zhongguo shi yan xue ye xue za zhi 20050601

Title: Navigating external beam radiation therapy for head and neck cancer.

Journal: Clinical journal of oncology nursing 20050601

Title: Head and neck squamous cell carcinoma: optimizing the therapeutic index.

Journal: Expert review of anticancer therapy 20050601

Title: Determination of WR-1065 in human blood by high-performance liquid chromatography following fluorescent derivatization by a maleimide reagent ThioGlo3.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

Title: Prospective randomised trial of amifostine cytoprotection in myeloma patients undergoing high-dose melphalan conditioned autologous stem cell transplantation.

Journal: Bone marrow transplantation 20050501

Title: A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells.

Journal: Journal of pineal research 20050501

Title: Radiopharmaceutical model using 99mTc-MIBI to evaluate amifostine protection against doxorubicin cardiotoxicity in rats.

Journal: Annals of nuclear medicine 20050501

Title: A randomized phase II study of paclitaxel with carboplatin +/- amifostine as first line treatment in advanced ovarian carcinoma.

Journal: Gynecologic oncology 20050401

Title: Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: radiation therapy oncology group trial 98-01.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050401

Title: Amifostine is a potent radioprotector of salivary glands in radioiodine therapy. Structural and ultrastructural findings.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20050401

Title: Does more aggressive therapy improve outcomes in the treatment of unresectable stage III non-small cell lung cancer?

Journal: Seminars in oncology 20050401

Title: Pulmonary toxicity associated with the treatment of non-small cell lung cancer and the effects of cytoprotective strategies.

Journal: Seminars in oncology 20050401

Title: Treatment-related esophagitis.

Journal: Seminars in oncology 20050401

Title: Mutagen sensitivity may predict lung protection by amifostine for patients with locally advanced non-small cell lung cancer treated by chemoradiotherapy.

Journal: Seminars in oncology 20050401

Title: Reduction of treatment breaks and radiation-induced esophagitis and pneumonitis using amifostine in unresectable non-small cell lung cancer patients receiving definitive concurrent chemotherapy and radiation therapy: a prospective community-based clinical trial.

Journal: Seminars in oncology 20050401

Title: Amifostine in chemoradiation therapy for non-small cell lung cancer: review of experience and design of a phase II trial assessing subcutaneous and intravenous bolus administration.

Journal: Seminars in oncology 20050401

Title: In regard to Boccia et al.: assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP) (INT J RADIAT ONCOL BIOL PHYS 2004;60:302-309).

Journal: International journal of radiation oncology, biology, physics 20050315

Title: Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity.

Journal: Life sciences 20050304

Title: Amifostine (ETHYOL) protects rats from mucositis resulting from fractionated or hyperfractionated radiation exposure.

Journal: International journal of radiation oncology, biology, physics 20050301

Title: Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group.

Journal: Gynecologic oncology 20050301

Title: [Minutes of the 23th meeting of the European Society for Therapeutic Radiology and Oncology (ESTRO). Amsterdam, 24-28 October 2004].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20050301

Title: Radioprotection in mice following oral delivery of amifostine nanoparticles.

Journal: International journal of radiation biology 20050301

Title: Ionizing radiation-induced damage on developing cerebellar granule cells cultures can be prevented by an early amifostine post-treatment.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050201

Title: Combined modality treatment with full-dose chemotherapy and concomitant boost radiotherapy for advanced head and neck carcinoma.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20050101

Title: Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.

Journal: International journal of radiation oncology, biology, physics 20050101

Title: The relationship between the protective effect of amifostine and decreased intercellular adhesion molecule 1 expression.

Journal: American journal of otolaryngology 20050101

Title: The role of radiation therapy in gastrointestinal bleeding.

Journal: The journal of supportive oncology 20050101

Title: Triplet chemotherapy with docetaxel, gemcitabine and liposomal doxorubicin, supported with subcutaneous amifostine and hemopoietic growth factors, in advanced non-small cell lung cancer.

Journal: Anticancer research 20050101

Title: Amifostine has an inhibitory effect on the radiation-induced p53-branched cascade in the immature mouse ovary.

Journal: In vivo (Athens, Greece) 20050101

Title: Pathophysiology and management of radiation-induced xerostomia.

Journal: The journal of supportive oncology 20050101

Title: Induction of caspase 3 activity, bcl-2 bax and p65 gene expression modulation in human acute promyelocytic leukemia HL-60 cells by doxorubicin with amifostine.

Journal: Pharmacological reports : PR 20050101

Title: Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine.

Journal: Pediatric hematology and oncology 20050101

Title: Use of amifostine, a novel cytoprotective, in alpha-amanitin poisoning.

Journal: Clinical toxicology (Philadelphia, Pa.) 20050101

Title: In vivo study to evaluate the protective effects of amifostine on radiation-induced damage of testis tissue.

Journal: Oncology 20050101

Title: [Amifostine otoprotection to cisplatin ototoxicity: a guinea pig study using otoacoustic emission distortion products (DPOEA) and scanning electron microscopy].

Journal: Brazilian journal of otorhinolaryngology 20050101

Title: Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy.

Journal: Pediatric blood & cancer 20041201

Title: [Protective effects of amifostine on hematopoietic stem/progenitor cells against chemotherapeutic damage].

Journal: Zhongguo shi yan xue ye xue za zhi 20041201

Title: The evaluation of amifostine for mucosal protection in patients with advanced loco-regional squamous cell carcinomas of the head and neck (SCCHN) treated with concurrent weekly carboplatin, paclitaxel, and daily radiotherapy (RT).

Journal: Seminars in oncology 20041201

Title: Toxicity and compliance of subcutaneous amifostine in patients undergoing postoperative intensity-modulated radiation therapy for head and neck cancer.

Journal: Seminars in oncology 20041201

Title: A randomized phase II trial of amifostine for head and neck irradiation in lymphoma.

Journal: Seminars in oncology 20041201

Title: A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing.

Journal: Seminars in oncology 20041201

Title: Radiotherapy-induced salivary dysfunction.

Journal: Seminars in oncology 20041201

Title: The role of amifostine in the treatment of carcinoma of the uterine cervix: an update of RTOG-0116 and review of future directions.

Journal: Seminars in oncology 20041201

Title: Open label multicenter trial of subcutaneous amifostine (Ethyol) in the prevention of radiation induced esophagitis and pneumonitis in patients with measurable, unresectable non-small cell lung cancer.

Journal: Seminars in oncology 20041201

Title: Randomized phase II study of amifostine mucosal protection by either subcutaneous injection or rapid IV bolus for patients with inoperable stage II-IIIA/B or stage IV non-small cell lung cancer with oligometastases receiving concurrent radiochemotherapy with carboplatin and paclitaxel followed by optional consolidative chemotherapy: a follow-up study after RTOG 98-01.

Journal: Seminars in oncology 20041201

Title: Can the use of amifostine improve cure rates for patients with advanced non-small cell lung cancer?

Journal: Seminars in oncology 20041201

Title: Phase I study for poor-prognosis lymphoma: augmentation of the 'BEAM' regimen with escalating dose melphalan using amifostine cytoprotection and autologous hematopoietic stem cell transplantation--a preliminary report.

Journal: Seminars in oncology 20041201

Title: Randomized trials of amifostine and radiotherapy: effect on survival?

Journal: Seminars in oncology 20041201

Title: Cytoprotection in acute myelogenous leukemia (AML) therapy.

Journal: Seminars in oncology 20041201

Title: Proceedings of the Fourth International Cytoprotection Investigators' Congress. May 2004. Philadelphia, Pennsylvania, USA.

Journal: Seminars in oncology 20041201

Title: Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.

Journal: Radiation research 20041101

Title: Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).

Journal: International journal of radiation oncology, biology, physics 20041001

Title: The protective effect of amifostine on radiation-induced acute pulmonary toxicity: detection by (99m)Tc-DTPA transalveolar clearances.

Journal: International journal of radiation oncology, biology, physics 20041001

Title: Comment on: 'Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients' Radiother Oncol 70: 261-264, 2004 by Dr Rades et al.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20041001

Title: Study of cisplatin-vinblastine plus amifostine in patients with locally advanced or metastatic non-small cell lung cancer.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20041001

Title: WR-2721 (Amifostine) ameliorates cisplatin-induced hearing loss but causes neurotoxicity in hamsters: dose-dependent effects.

Journal: Journal of the Association for Research in Otolaryngology : JARO 20040901

Title: Oral delivery of spray dried PLGA/amifostine nanoparticles.

Journal: The Journal of pharmacy and pharmacology 20040901

Title: Assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP).

Journal: International journal of radiation oncology, biology, physics 20040901

Title: Combinations of radioprotectants spare radiation-induced damage to the physis.

Journal: Clinical orthopaedics and related research 20040901

Title: A phase II randomized study of topical intrarectal administration of amifostine for the prevention of acute radiation-induced rectal toxicity.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040901

Title: High-dose Cisplatin with amifostine: ototoxicity and pharmacokinetics.

Journal: The Laryngoscope 20040901

Title: Amifostine reduces radiation therapy-induced dry mouth in head and neck cancer patients.

Journal: Oncology (Williston Park, N.Y.) 20040901

Title: Radioprotective effects of amifostine in vitro and in vivo measured with the comet assay.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040801

Title: [Effect of S-2-(3-aminopropylamino) ethyl phosphorothioic acid on apoptosis and proliferation inhibition of HL-60 cell line].

Journal: Zhongguo shi yan xue ye xue za zhi 20040801

Title: Impact on cytoprotective efficacy of intermediate interval between amifostine administration and radiotherapy: a retrospective analysis.

Journal: International journal of radiation oncology, biology, physics 20040715

Title: Amifostine and autologous hematopoietic stem cell support of escalating-dose melphalan: a phase I study.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040701

Title: A randomized trial of amifostine as a cytoprotectant for patients receiving myeloablative therapy for allogeneic hematopoietic stem cell transplantation.

Journal: Bone marrow transplantation 20040701

Title: [Future therapy strategies for salivary gland impairment].

Journal: Refu'at ha-peh veha-shinayim (1993) 20040701

Title: [The protective effect of amifostine on hydroquinone-induced apoptosis in bone marrow].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040601

Title: Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer.

Journal: International journal of radiation oncology, biology, physics 20040501

Title: Effect of melatonin, ascorbic acid, and succinic acid on the cumulative toxic effect of repeated treatment with gammafos (amifostine).

Journal: Bulletin of experimental biology and medicine 20040501

Title: Activity of single-agent melphalan 220-300 mg/m2 with amifostine cytoprotection and autologous hematopoietic stem cell support in non-Hodgkin and Hodgkin lymphoma.

Journal: Bone marrow transplantation 20040401

Title: Oxidative study of patients with total body irradiation: effects of amifostine treatment.

Journal: Bone marrow transplantation 20040401

Title: Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial.

Journal: International journal of radiation oncology, biology, physics 20040401

Title: Amifostine feasibility and efficacy in autologous stem cell transplantation for multiple myeloma.

Journal: Haematologica 20040401

Title: A randomized trial of amifostine and carmustine-containing chemotherapy to assess lung-protective effects.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20040401

Title: Stevens-Johnson syndrome after amifostine during radiotherapy.

Journal: International journal of dermatology 20040401

Title: The potential cardioprotective effects of amifostine in irradiated rats.

Journal: International journal of radiation oncology, biology, physics 20040315

Title: Preparation and in vitro characterization of amifostine biodegradable microcapsules.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20040301

Title: Serious adverse effects of amifostine during radiotherapy in head and neck cancer patients.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20040301

Title: Amifostine as differentiating agent in cord blood and bone marrow cultures from children with hematological disorders.

Journal: Pediatric hematology and oncology 20040301

Title: Comparative study between the interaction of dephosphorylated amifostine (WR-1065) and amoxicilline with pBR322 in absence and presence of cisplatin by AFM.

Journal: International journal of pharmaceutics 20040211

Title: Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20040201

Title: Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040201

Title: The radioprotectors amifostine and sodium selenite do not modify the radiosensitivity of rat rhabdomyosarcomas.

Journal: Onkologie 20040201

Title: Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope.

Journal: Folia morphologica 20040201

Title: Quality of life with well-differentiated thyroid cancer: treatment toxicities and their reduction.

Journal: Thyroid : official journal of the American Thyroid Association 20040201

Title: Amifostine protection against doxorubicin cardiotoxicity in rats.

Journal: Anti-cancer drugs 20040201

Title: Neurophysiological study of peripheral neuropathy after high-dose Paclitaxel: lack of neuroprotective effect of amifostine.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040115

Title: Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha.

Journal: Cancer chemotherapy and pharmacology 20040101

Title: Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine.

Journal: Biopharmaceutics & drug disposition 20040101

Title: Amifostine-induced fever: case report and review of the literature.

Journal: Pharmacotherapy 20040101

Title: Radioprotective effects of amifostine (WR-2721) or cystamine on radiation damage and its repair in rats whole body exposed to fission neutrons.

Journal: Acta medica (Hradec Kralove) 20040101

Title: Heterogeneous planning for homogeneous protocols.

Journal: Medical dosimetry : official journal of the American Association of Medical Dosimetrists 20040101

Title: The potential influence of cell protectors for dose escalation in cancer therapy: an analysis of amifostine.

Journal: Medical dosimetry : official journal of the American Association of Medical Dosimetrists 20040101

Title: The effect of cytoprotective agents in platinum anticancer therapy.

Journal: Metal ions in biological systems 20040101

Title: Amifostine protects against chemotherapy-induced neurotoxicity: an in vitro investigation.

Journal: Anticancer research 20040101

Title: Amifostine stimulates the formation of hematopoietic bone marrow progenitors from B-cell chronic lymphocytic leukemia.

Journal: Acta haematologica 20040101

Title: Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.

Journal: In vivo (Athens, Greece) 20040101

Title: Effects of amifostine on healing of microvascular anastomoses, flap survival, and nerve regeneration with preoperative or postoperative irradiation.

Journal: Microsurgery 20040101

Title: Conformal hypofractionated and accelerated radiotherapy with cytoprotection (HypoARC) for high risk prostatic carcinoma: rationale, technique and early experience.

Journal: Anticancer research 20040101

Title: Outcome of local application of amifostine (WR-1065) on epirubicin-induced oral mucositis. A phase II study.

Journal: Anticancer research 20040101

Title: Tissue levels of WR-1065, the active metabolite of amifostine (Ethyol), are equivalent following intravenous or subcutaneous administration in cynomolgus monkeys.

Journal: Oncology 20040101

Title: Cytoprotection in head and neck cancer: issues in oral care.

Journal: The journal of supportive oncology 20040101

Title: Non-small cell lung cancer: the role of cytoprotection in treating therapy-related toxicity.

Journal: The journal of supportive oncology 20040101

Title: Managing toxicities in pelvic malignancies.

Journal: The journal of supportive oncology 20040101

Title: Prevention of radiation-induced central nervous system toxicity: a role for amifostine?

Journal: Anticancer research 20040101

Title: Lack of cytoprotective effect of amifostine following HLA-identical sibling transplantation for advanced myelodysplastic syndrome (MDS): a pilot study.

Journal: Bone marrow transplantation 20031201

Title: Phase II randomized trial of cisplatin and WR-2721 versus cisplatin alone for metastatic melanoma: an Eastern Cooperative Oncology Group Study (E1686).

Journal: Melanoma research 20031201

Title: Proceedings of the 3rd International Cytoprotection Investigators' Congress. May 15-18, 2003, Nevis, West Indies.

Journal: Seminars in oncology 20031201

Title: Amifostine reduces radiochemotherapy-induced toxicities in patients with locally advanced non-small cell lung cancer.

Journal: Seminars in oncology 20031201

Title: Radioprotective effect of amifostine in radiation pneumonitis.

Journal: Seminars in oncology 20031201

Title: Amifostine: is there evidence of tumor protection?

Journal: Seminars in oncology 20031201

Title: Effects of dose and schedule on the efficacy of ethyol: preclinical studies.

Journal: Seminars in oncology 20031201

Title: Rationale for integrating high-dose rate intraoperative radiation (HDR-IORT) and postoperative external beam radiation with subcutaneous amifostine for the management of stage III/IV head and neck cancer.

Journal: Seminars in oncology 20031201

Title: Feasibility of amifostine administration in conjunction with high-dose rate brachytherapy.

Journal: Seminars in oncology 20031201

Title: Amifostine and external beam radiation therapy and/or high-dose rate brachytherapy in the treatment of localized prostate carcinoma: preliminary results of a phase II trial.

Journal: Seminars in oncology 20031201

Title: Clinical trial of endorectal amifostine for radioprotection in patients with prostate cancer: rationale and early results.

Journal: Seminars in oncology 20031201

Title: Cytoprotection/radioprotection with amifostine: potential role in cervical cancer and early findings in the Radiation Therapy Oncology Group C-0116 trial.

Journal: Seminars in oncology 20031201

Title: Aggressive multimodality therapy for patients with locally advanced esophageal cancer: is there a role for amifostine?

Journal: Seminars in oncology 20031201

Title: The effect of oral mucositis on morbidity and mortality in bone marrow transplant.

Journal: Seminars in oncology 20031201

Title: Phase II randomized study of concomitant chemoradiation using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with newly diagnosed locally advanced squamous cell carcinoma of the head and neck.

Journal: Seminars in oncology 20031201

Title: Ongoing prospective multicenter safety study of the cytoprotectant amifostine given subcutaneously: overview of trial design.

Journal: Seminars in oncology 20031201

Title: Pilot study of subcutaneous amifostine in patients undergoing postoperative intensity modulated radiation therapy for head and neck cancer: preliminary data.

Journal: Seminars in oncology 20031201

Title: Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of amifostine.

Journal: Seminars in oncology 20031201

Title: Myeloprotective effects of different amifostine regimens in rabbits undergoing high-dose treatment with 186rhenium-(tin)1,1- hydroxyethylidene diphosphonate (186Re-HEDP).

Journal: Cancer biotherapy & radiopharmaceuticals 20031201

Title: Serious cutaneous reactions to amifostine.

Journal: Prescrire international 20031201

Title: Radiation-induced cognitive dysfunction: the protective effect of ethyol in young rats.

Journal: International journal of radiation oncology, biology, physics 20031115

Title: Limited access trial using amifostine for protection against cisplatin- and three-hour paclitaxel-induced neurotoxicity: a phase II study of the Gynecologic Oncology Group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20031115

Title: Subcutaneous administration of amifostine (ethyol) is equivalent to intravenous administration in a rat mucositis model.

Journal: International journal of radiation oncology, biology, physics 20031101

Title: Amifostine has antiangiogenic properties in vitro by changing the redox status of human endothelial cells.

Journal: Free radical research 20031101

Title: [Radiation protectants of the crystalline lens].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20031101

Title: Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-small-cell lung cancer.

Journal: International journal of radiation oncology, biology, physics 20031001

Title: Amifostine and chemoradiation therapy: ASCO responds.

Journal: The Lancet. Oncology 20031001

Title: Moist skin care can diminish acute radiation-induced skin toxicity.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20031001

Title: Radioprotective effect of amifostine on cells from cancer prone patients and healthy individuals studied by the G2 and PCC assays.

Journal: International journal of radiation biology 20031001

Title: Assessment of the protective effects of amifostine against cisplatin-induced toxicity.

Journal: The Journal of otolaryngology 20031001

Title: Amifostine does not reduce the toxicity of the fludarabine and cyclophosphamide regimen in patients with chronic lymphocytic leukemia.

Journal: Cancer chemotherapy and pharmacology 20030901

Title: Cisplatin nephrotoxicity affects magnesium and calcium metabolism.

Journal: Medical and pediatric oncology 20030901

Title: Amifostine, in a reduced dose, protects against severe diarrhea associated with weekly fluorouracil and folinic acid chemotherapy in advanced colorectal cancer: a pilot study.

Journal: Journal of pain and symptom management 20030901

Title: Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells.

Journal: Molecular cancer therapeutics 20030901

Title: Amifostine before chemotherapy: improved tolerance profile of the subcutaneous over the intravenous route.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030815

Title: Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030801

Title: Amifostine pretreatment for protection against topotecan-induced hematologic toxicity: results of a multicenter phase III trial in patients with advanced gynecologic malignancies.

Journal: Gynecologic oncology 20030801

Title: Transiently increased bone density after irradiation and the radioprotectant drug amifostine in a rat model.

Journal: American journal of clinical oncology 20030801

Title: [Cytoprotective effects of amifostine in the treatment of tumors].

Journal: Vnitrni lekarstvi 20030801

Title: Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: results of a randomized trial.

Journal: International journal of radiation oncology, biology, physics 20030715

Title: Amifostine does not preferentially stimulate the growth of residual polyclonal progenitor cells in myelodysplastic syndromes.

Journal: Leukemia research 20030701

Title: High frequency of temperature-sensitive mutations of p53 tumor suppressor in acute myeloid leukemia revealed by functional assay in yeast.

Journal: International journal of oncology 20030701

Title: Residual chromosomal damage after radiochemotherapy with and without amifostine detected by 24-color FISH.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030701

Title: Sequential histomorphometric analysis of the growth plate following irradiation with and without radioprotection.

Journal: The Journal of bone and joint surgery. American volume 20030701

Title: Phase III multicenter randomized trial of amifostine as cytoprotectant in first-line chemotherapy in ovarian cancer patients.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030701

Title: Oral candidiasis in head and neck cancer patients receiving radiotherapy with amifostine cytoprotection.

Journal: Oral oncology 20030601

Title: Re: Sodium thiosulfate in cisplatin overdose by Erdlenbruch B et al., Med Pediatr Oncol 2002;38:349-352.

Journal: Medical and pediatric oncology 20030601

Title: Does amifostine have a role in chemoradiation treatment?

Journal: The Lancet. Oncology 20030601

Title: Randomized phase III trial of postoperative radiochemotherapy +/- amifostine in head and neck cancer. Is there evidence for radioprotection?

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030601

Title: Development of investigational radiation modifiers.

Journal: Journal of the National Cancer Institute 20030507

Title: The relationship between local dose and loss of function for irradiated lung.

Journal: International journal of radiation oncology, biology, physics 20030501

Title: Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small-cell lung cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501

Title: Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.

Journal: Thrombosis research 20030415

Title: WR-2721 (amifostine, ethyol) prevents motor and morphological changes induced by neonatal X-irradiation.

Journal: Neurochemistry international 20030401

Title: The radiosensitising effect of gemcitabine and the influence of the rescue agent amifostine in vitro.

Journal: European journal of cancer (Oxford, England : 1990) 20030401

Title: Phase I study of amifostine as a cytoprotector of the gemcitabine/cisplatin combination in patients with advanced solid malignancies.

Journal: Anti-cancer drugs 20030401

Title: Amifostine plus erythropoietin in a patient with low-risk myelodysplastic syndrome.

Journal: Annals of hematology 20030401

Title: Improved tolerability of chemotherapy in soft tissue sarcomas: old and new strategies.

Journal: Expert review of anticancer therapy 20030401

Title: Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo.

Journal: Biochimica et biophysica acta 20030320

Title: p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection.

Journal: British journal of cancer 20030310

Title: Amifostine as radioprotective agent for the rectal mucosa during irradiation of pelvic tumors. A phase II randomized study using various toxicity scales and rectosigmoidoscopy.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030301

Title: Radioactive iodine and the salivary glands.

Journal: Thyroid : official journal of the American Thyroid Association 20030301

Title: The radioprotective activities of turpentine-induced inflammation and alpha2-macroglobulin: the effect of dexamethasone on the radioprotective efficacy of the inflammation.

Journal: Journal of radiation research 20030301

Title: Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.

Journal: Mutation research 20030205

Title: Amifostine inhibits angiogenesis in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20030201

Title: Phase I clinical and pharmacologic study of weekly cisplatin and irinotecan combined with amifostine for refractory solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030201

Title: Amifostine protects lymphocytes during radiotherapy and stimulates expansion of the CD95/Fas and CD31 expressing T-cells, in breast cancer patients.

Journal: Cancer immunology, immunotherapy : CII 20030201

Title: Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols.

Journal: Experimental and molecular pathology 20030201

Title: Induction of apoptosis in bone marrow cells after treatment of mice with WR-2721 and gamma-rays: relationship to the cell cycle.

Journal: Cell biology and toxicology 20030201

Title: Amifostine as chemoprotectant in metastatic breast cancer patients treated with doxorubicin.

Journal: Oncology reports 20030101

Title: Effects of irradiation on the appositional and longitudinal growth of the tibia and fibula of the rat with and without radioprotectant.

Journal: Journal of pediatric orthopedics 20030101

Title: Studies on the radioprotective potency of amifostine on salivary glands of rats during fractionated irradiation: acute and late effects.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20030101

Title: Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy.

Journal: Seminars in radiation oncology 20030101

Title: Effects of amifostine on clonogenic mesenchymal progenitors and hematopoietic progenitors exposed to radiation.

Journal: Journal of pediatric hematology/oncology 20030101

Title: Mucosal injury in patients undergoing hematopoietic progenitor cell transplantation: new approaches to prophylaxis and treatment.

Journal: Bone marrow transplantation 20030101

Title: Amifostine protects against cisplatin-induced nephrotoxicity in a child with medulloblastoma.

Journal: Pediatric hematology and oncology 20030101

Title: Has the time come for routine use of amifostine in clinical radiotherapy practice?

Journal: Acta oncologica (Stockholm, Sweden) 20030101

Title: Effects of amifostine on radiation-induced cardiac damage.

Journal: Acta oncologica (Stockholm, Sweden) 20030101

Title: Efficiency of amifostine as a protection against doxorubicin toxicity in rats during a 12-day treatment.

Journal: Anticancer research 20030101

Title: Six-week induction chemotherapy followed by concomitant chemoradiation therapy in stage IV head and neck cancer: a phase II study with organ-sparing purposes.

Journal: Oncology reports 20030101

Title: Changes in hemopoietic precursors after treatment of low-risk myelodysplasia with amifostine.

Journal: In vivo (Athens, Greece) 20030101

Title: Amifostine and curative intent chemoradiation for compromised cancer patients.

Journal: Anticancer research 20030101

Title: Protection against cisplatin-induced nephrotoxicity by recombinant human erythropoietin.

Journal: Medical oncology (Northwood, London, England) 20030101

Title: Protective effect of amifostine against cisplatin-induced motor neuropathy in rat.

Journal: Medical oncology (Northwood, London, England) 20030101

Title: [Dermatologic reactions to amifostine].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20030101

Title: Variable cytotoxicity of amifostine in malignant and non-malignant cell lines.

Journal: Oncology reports 20030101

Title: Induction of caspase 3 and modulation of some apoptotic genes in human acute promyelocytic leukemia HL-60 cells by carboplatin with amifostine.

Journal: Polish journal of pharmacology 20030101

Title: Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer: a single center randomized study.

Journal: Medical oncology (Northwood, London, England) 20030101

Title: [Current status and perspectives of using radioprotectors in clinical practice].

Journal: Likars'ka sprava 20030101

Title: [Role of etiol (amifostine) in the treatment of patients with malignant lymphoma].

Journal: Likars'ka sprava 20030101

Title: The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron.

Journal: Redox report : communications in free radical research 20030101

Title: Regional pharmacokinetics of amifostine in anesthetized dogs: role of the liver, gastrointestinal tract, lungs, and kidneys.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201

Title: Amifostine reduces mucosal damage after high-dose melphalan conditioning and autologous peripheral blood progenitor cell transplantation for patients with multiple myeloma.

Journal: Bone marrow transplantation 20021201

Title: Amifostine differentially modulates DNA damage evoked by idarubicin in normal and leukemic cells.

Journal: Leukemia research 20021201

Title: Influence of amifostine on reconstitution of lymphocyte subpopulations after conventional- and high-dose chemotherapy in patients with germ cell tumor.

Journal: Annals of hematology 20021201

Title: [Radioprotective effects on head and neck tumors of amifostine--a broad-spectrum cytoprotection].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20021201

Title: Proceedings of the 2nd International Cytoprotection Investigators' Congress. June 6-9, 2002. St Thomas, US Virgin Islands, USA.

Journal: Seminars in oncology 20021201

Title: Preclinical studies on the radioprotective efficacy and pharmacokinetics of subcutaneously administered amifostine.

Journal: Seminars in oncology 20021201

Title: Improved tolerability of amifostine with rapid infusion and optimal patient preparation.

Journal: Seminars in oncology 20021201

Title: Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.

Journal: Seminars in oncology 20021201

Title: Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice.

Journal: Seminars in oncology 20021201

Title: Early results from a phase I/II radiation dose-escalation study with concurrent amifostine and infusional 5-fluorouracil chemotherapy for preoperative treatment of unresectable or locally recurrent rectal carcinoma.

Journal: Seminars in oncology 20021201

Title: Potential for use of amifostine in cervical cancer.

Journal: Seminars in oncology 20021201

Title: A phase III randomized evaluation of amifostine in stage IIIA/IIIB non-small cell lung cancer patients receiving concurrent carboplatin, paclitaxel, and radiation therapy followed by gemcitabine and cisplatin intensification: preliminary findings.

Journal: Seminars in oncology 20021201

Title: Hypofractionated and accelerated radiotherapy with amifostine cytoprotection (HypoARC): a new concept in radiotherapy and encouraging results in breast cancer.

Journal: Seminars in oncology 20021201

Title: The potential of amifostine in high-dose chemotherapy and autologous hematopoietic stem cell transplantation.

Journal: Seminars in oncology 20021201

Title: Preliminary data of the GORTEC 2000-02 phase III trial comparing intravenous and subcutaneous administration of amifostine for head and neck tumors treated by external radiotherapy.

Journal: Seminars in oncology 20021201

Title: Radioprotective effect of amifostine in patients with head and neck squamous cell carcinoma.

Journal: Seminars in oncology 20021201

Title: Tools for optimal tissue sparing in concomitant chemoradiation of advanced head and neck cancer: subcutaneous amifostine and computed tomography-based target delineation.

Journal: Seminars in oncology 20021201

Title: Phase II trial of subcutaneous amifostine in patients undergoing radiation therapy for head and neck cancer.

Journal: Seminars in oncology 20021201

Title: Amifostine does not prevent activation of TGFbeta1 but induces smad 7 activation in megakaryocytes irradiated in vivo.

Journal: American journal of hematology 20021101

Title: DNA damage and repair in BCR/ABL-expressing cells after combined action of idarubicin, STI571 and amifostine.

Journal: Anti-cancer drugs 20021101

Title: Amifostine-induced toxic epidermal necrolysis during radiotherapy: a case report.

Journal: Japanese journal of clinical oncology 20021101

Title: A pilot study on feasibility and efficacy of amifostine preceding high-dose melphalan with autologous stem cell support in myeloma patients.

Journal: Leukemia & lymphoma 20021001

Title: Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity.

Journal: European journal of cancer (Oxford, England : 1990) 20020901

Title: Amifostine aminothiols and protection of keratinocyte apoptosis and DNA damage.

Journal: The Journal of investigative dermatology 20020901

Title: [Reducing late toxicity with amifostine in fractionated irradiation of the rat salivary glands].

Journal: HNO 20020901

Title: Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection.

Journal: British journal of cancer 20020812

Title: Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen.

Journal: American journal of physiology. Lung cellular and molecular physiology 20020801

Title: A pilot study of topical intrarectal application of amifostine for prevention of late radiation rectal injury.

Journal: International journal of radiation oncology, biology, physics 20020801

Title: In regard to Antonadou et al. Randomized trial investigating the effects of daily amifostine in addition to radiation therapy in 146 patients with advanced lung cancers.

Journal: International journal of radiation oncology, biology, physics 20020801

Title: A phase I study of idarubicin dose escalation with amisfostine and high-dose cytarabine in patients with relapsed acute myelogenous leukemia and myelodysplastic syndromes.

Journal: Haematologica 20020801

Title: Effects of WR-2721 and cyclophosphamide on the cell cycle phase specificity of apoptosis in mouse bone marrow.

Journal: Anti-cancer drugs 20020801

Title: Cytoprotective effect of amifostine in radiation-induced acute mucositis - a retrospective analysis.

Journal: Onkologie 20020801

Title: Clinical and biological effects of treatment with amifostine in myelodysplastic syndromes.

Journal: British journal of haematology 20020701

Title: In vivo protection by amifostine and DRDE-07 against sulphur mustard toxicity.

Journal: Human & experimental toxicology 20020701

Title: 2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020615

Title: New liquid chromatographic assay with electrochemical detection for the measurement of amifostine and WR1065.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020605

Title: Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity.

Journal: Radiation research 20020601

Title: Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets.

Journal: International journal of radiation biology 20020601

Title: Flow cytometric detection of apoptotic bone marrow cells with fractional DNA content after application of WR-2721, cyclophosphamide, cisplatin, and exposure of mice to gamma rays.

Journal: Human & experimental toxicology 20020601

Title: [Effect of amifostine on reducing acute toxicity of megachemotherapy of tumors in children].

Journal: Casopis lekaru ceskych 20020524

Title: Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

Title: Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine.

Journal: International journal of radiation oncology, biology, physics 20020501

Title: BNP7787, a novel protector against platinum-related toxicities, does not affect the efficacy of cisplatin or carboplatin in human tumour xenografts.

Journal: European journal of cancer (Oxford, England : 1990) 20020501

Title: No evidence that amifostine influences the plasma pharmacokinetics of topotecan in ovarian cancer patients.

Journal: European journal of clinical pharmacology 20020501

Title: Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine.

Journal: Chemico-biological interactions 20020420

Title: Phase II trial of irinotecan in combination with amifostine in patients with advanced colorectal carcinoma.

Journal: Cancer 20020415

Title: Efficacy of radioprotection in the prevention of radiation-induced craniofacial bone growth inhibition.

Journal: Plastic and reconstructive surgery 20020401

Title: Treatment of anemia in low-risk myelodysplastic syndromes with amifostine. In vitro testing of response.

Journal: Annals of hematology 20020401

Title: Influence of amifostine on toxicity of CHOP in elderly patients with aggressive non-Hodgkin's lymphoma--a phase II study.

Journal: Anti-cancer drugs 20020401

Title: Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer.

Journal: International journal of radiation oncology, biology, physics 20020301

Title: Combined therapy with amifostine plus erythropoietin for the treatment of myelodysplastic syndromes.

Journal: Haematologica 20020301

Title: Bleomycin genotoxicity and amifostine (WR-2721) cell protection in normal leukocytes vs. K562 tumoral cells.

Journal: Biochemical pharmacology 20020301

Title: Amifostine in clinical oncology: current use and future applications.

Journal: Anti-cancer drugs 20020301

Title: Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review.

Journal: Anti-cancer drugs 20020301

Title: Development of biodegradable microcapsules as carrier for oral controlled delivery of amifostine.

Journal: Drug development and industrial pharmacy 20020301

Title: Flow cytometric estimation of the plasma membrane diversity of bone marrow cells in mice treated with WR-2721 and cyclophosphamide.

Journal: Toxicology 20020227

Title: Effects of amifostine on the proliferation and differentiation of megakaryocytic progenitor cells.

Journal: European journal of pharmacology 20020215

Title: New dosing regimens for amifostine: a pilot study to compare the relative bioavailability of oral and subcutaneous administration with intravenous infusion.

Journal: Journal of clinical pharmacology 20020201

Title: Relationships between cytoprotection and mutation prevention by WR-1065.

Journal: Military medicine 20020201

Title: Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines.

Journal: Anti-cancer drugs 20020201

Title: Acute myeloblastic leukemia achieving complete remission with amifostine alone.

Journal: Leukemia & lymphoma 20020201

Title: [Radioprotective effectiveness of amifostine on the salivary glands of the rat during fractionated irradiation].

Journal: HNO 20020201

Title: Inhibition of spontaneous metastases formation by amifostine.

Journal: International journal of cancer 20020110

Title: Radioprotection of head and neck tissue by amifostine.

Journal: Frontiers of radiation therapy and oncology 20020101

Title: Hypofractionated and accelerated radiotherapy with cytoprotection (HypoARC): a short, safe, and effective postoperative regimen for high-risk breast cancer patients.

Journal: International journal of radiation oncology, biology, physics 20020101

Title: Influence of amifostine on the toxicity and pharmacokinetics of docetaxel in metastatic breast cancer patients: a pilot study.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

Title: Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice.

Journal: Environmental and molecular mutagenesis 20020101

Title: Amifostine in simultaneous radiochemotherapy of advanced head and neck cancer.

Journal: Seminars in radiation oncology 20020101

Title: A prospective, nonrandomized study of the impact of amifostine on subsequent hypothyroidism in irradiated patients with head and neck cancers.

Journal: Seminars in radiation oncology 20020101

Title: A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer.

Journal: Seminars in radiation oncology 20020101

Title: Protection of salivary function by intensity-modulated radiation therapy in patients with head and neck cancer.

Journal: Seminars in radiation oncology 20020101

Title: Phase II: trial of twice weekly amifostine in patients with non-small cell lung cancer treated with chemoradiotherapy.

Journal: Seminars in radiation oncology 20020101

Title: Exploring the role of the radioprotector amifostine in locally advanced non-small cell lung cancer: Radiation Therapy Oncology Group trial 98-01.

Journal: Seminars in radiation oncology 20020101

Title: Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II-III non-small cell lung cancer: preliminary results.

Journal: Seminars in radiation oncology 20020101

Title: Radiotherapy or chemotherapy followed by radiotherapy with or without amifostine in locally advanced lung cancer.

Journal: Seminars in radiation oncology 20020101

Title: Phase II evaluation of amifostine as an esophageal mucosal protectant in the treatment of limited-stage small cell lung cancer with chemotherapy and twice-daily radiation.

Journal: Seminars in radiation oncology 20020101

Title: Esophageal cancer and the esophagus: challenges and potential strategies for selective cytoprotection of the tumor-bearing organ during cancer treatment.

Journal: Seminars in radiation oncology 20020101

Title: The potential role of amifostine in the treatment of carcinoma of the uterine cervix: a review.

Journal: Seminars in radiation oncology 20020101

Title: Intrarectal application of amifostine for the prevention of radiation-induced rectal injury.

Journal: Seminars in radiation oncology 20020101

Title: Rationale for a phase I/II radiation dose-escalation study with concurrent amifostine (Ethyol) and infusional 5-FU chemotherapy for preoperative treatment of unresectable or locally recurrent rectal carcinoma.

Journal: Seminars in radiation oncology 20020101

Title: Preclinical modeling of improved amifostine (Ethyol) use in radiation therapy.

Journal: Seminars in radiation oncology 20020101

Title: Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells.

Journal: Seminars in radiation oncology 20020101

Title: New approaches to the treatment of myelodysplasia.

Journal: The oncologist 20020101

Title: [Amifostin in protection of kidney from cisplatinum injury].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020101

Title: Use of amifostine in the therapy of osteosarcoma in children and adolescents.

Journal: Journal of pediatric hematology/oncology 20020101

Title: Amifostine as a radioprotectant.

Journal: Clinical journal of oncology nursing 20020101

Title: Investigation of doxorubicin tissue toxicity: does amifostine provide chemoprotection? An experimental study.

Journal: Anticancer research 20020101

Title: TEL/JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine.

Journal: Acta biochimica Polonica 20020101

Title: Amifostine promotes hemopoietic progenitor cell mobilization in patients with myelodysplastic syndrome.

Journal: Anticancer research 20020101

Title: The cytoprotective effect of amifostine in acute radiation dermatitis: a retrospective analysis.

Journal: European journal of dermatology : EJD 20020101

Title: Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity.

Journal: Experimental lung research 20020101

Title: Radioprotectants: current status and new directions.

Journal: Oncology 20020101

Title: Head and neck cancer: managing xerostomia and other treatment induced side effects.

Journal: ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses 20020101

Title: Amifostine protects blood vessels from the effects of ionizing radiation.

Journal: Anticancer research 20020101

Title: Phosphatidylserine externalization during bone marrow cell death after treatment of mice with WR-2721 and gamma-rays.

Journal: Folia biologica 20020101

Title: Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats.

Journal: Drug metabolism and drug interactions 20020101

Title: A randomized phase II study of amifostine used as stem cell protectant in non-hodgkin lymphoma patients receiving cisplatin-based salvage chemotherapy prior to stem cell transplant.

Journal: Journal of hematotherapy & stem cell research 20011201

Title: Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer.

Journal: International journal of radiation oncology, biology, physics 20011115

Title: Alteration of radiation-induced hematotoxicity by amifostine.

Journal: International journal of radiation oncology, biology, physics 20011115

Title: Radiation therapy and concurrent fixed dose amifostine with escalating doses of twice-weekly gemcitabine in advanced pancreatic cancer.

Journal: International journal of radiation oncology, biology, physics 20011115

Title: A Phase II trial of cisplatin plus WR-2721 (amifostine) for metastatic breast carcinoma: an Eastern Cooperative Oncology Group Study (E8188).

Journal: Cancer 20011115

Title: Blood thiols following amifostine and mesna infusions, a pediatric oncology group study.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20011101

Title: Protective effects of amifostine and its analogues on sulfur mustard toxicity in vitro and in vivo.

Journal: Toxicology and applied pharmacology 20011001

Title: High-dose treatment with (186)Re-HEDP or (153)Sm-EDTMP combined with amifostine in a rabbit model.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011001

Title: The role of amifostine as a radioprotector.

Journal: Oncology (Williston Park, N.Y.) 20011001

Title: Amifostine protects against early but not late toxic effects of doxorubicin in infant rats.

Journal: Cancer research 20010901

Title: Has the outlook improved for amifostine as a clinical radioprotector.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010901

Title: Phase I trial of a twice-daily regimen of amifostine with ifosfamide, carboplatin, and etoposide chemotherapy in children with refractory carcinoma.

Journal: Cancer 20010815

Title: Treatment of patients with myelodysplastic syndrome with amifostine.

Journal: Leukemia research 20010801

Title: Pharmacologic study of paclitaxel administered with or without the cytoprotective agent amifostine, and given as a single agent or in combination with epirubicin and cisplatin in patients with advanced solid tumors.

Journal: American journal of clinical oncology 20010801

Title: [Renal protection with amifostine during intraoperative peritoneal chemohyperthermia (IPCH) with cisplatin (CDDP) for peritoneal carcinosis. Phase 1 study].

Journal: Minerva medica 20010801

Title: Assessment of amifostine as protection from chemotherapy-induced toxicities after conventional-dose and high-dose chemotherapy in patients with germ cell tumor.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010801

Title: Amifostine does not inhibit the toxic effects of anthracycline derivates or mitoxantrone on MDR tumor cell lines.

Journal: Leukemia & lymphoma 20010801

Title: Clinical applications of radioprotectors.

Journal: Expert review of anticancer therapy 20010801

Title: Amifostine does not protect malignant lymphoma cell lines from the cytotoxic effects of various chemotherapeutics in vitro.

Journal: Leukemia & lymphoma 20010701

Title: Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity.

Journal: Toxicology 20010621

Title: Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay.

Journal: Oncogene 20010614

Title: Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model.

Journal: International journal of radiation oncology, biology, physics 20010601

Title: Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone.

Journal: International journal of radiation oncology, biology, physics 20010601

Title: Effect of amifostine on lipid peroxidation caused by cisplatin in rat kidney.

Journal: Journal of chemotherapy (Florence, Italy) 20010601

Title: Phase I-II study of escalating doses of amifostine combined with high-dose cyclophosphamide.

Journal: Cancer chemotherapy and pharmacology 20010601

Title: [Adjuvant chemotherapy of cervix carcinoma--results of a phase II study].

Journal: Zentralblatt fur Gynakologie 20010501

Title: T-cell apoptosis induced by granulocyte colony-stimulating factor is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors.

Journal: Experimental hematology 20010401

Title: Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study.

Journal: Anti-cancer drugs 20010401

Title: [Comments on five clinical trials concerning radiotherapy-induced mucositis in patients with head and neck neoplasms].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20010401

Title: Clarification on the potential of subcutaneous ethyol as a radioprotective agent.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010301

Title: Subcutaneous administration of amifostine: a promising therapeutic option in patients with oxaliplatin-related peripheral sensitive neuropathy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010301

Title: Amifostine: chemotherapeutic and radiotherapeutic protective effects.

Journal: Expert opinion on pharmacotherapy 20010301

Title: In vivo effects of IL-4, IL-10, and amifostine on cytokine production in patients with acute myelogenous leukemia.

Journal: Leukemia & lymphoma 20010301

Title: Preliminary results of amifostine administration in combination with recombinant human erythropoietin in patients with myelodysplastic syndromes.

Journal: Journal of experimental & clinical cancer research : CR 20010301

Title: Phase III randomized trial of amifostine as a radioprotector in head and neck cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010215

Title: A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplantation.

Journal: British journal of cancer 20010201

Title: Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds.

Journal: Experimental hematology 20010201

Title: Amifostine alone and in combination with erythropoietin for the treatment of favorable myelodysplastic syndrome.

Journal: Leukemia research 20010201

Title: Effect of amifostine on toxicities associated with salvage combination chemotherapy.

Journal: The Journal of the Association of Physicians of India 20010201

Title: PBPC mobilization with paclitaxel, ifosfamide, and G-CSF with or without amifostine: results of a prospective randomized trial.

Journal: Transfusion 20010201

Title: [Recommendations of the Working Group 'Supportive Massnahmen in der Onkologie' concerning the Clinical Use of Cytoprotectives].

Journal: Onkologie 20010201

Title: A randomized trial of amifostine as a cytoprotective agent in patients receiving chemotherapy for small cell lung cancer.

Journal: British journal of cancer 20010101

Title: Effects of amifostine in a patient with an advanced-stage myelodysplastic syndrome.

Journal: Annals of hematology 20010101

Title: Economic analysis of amifostine as adjunctive support for patients with advanced head and neck cancer: preliminary results from a randomized phase II clinical trial from Germany.

Journal: Cancer investigation 20010101

Title: Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome.

Journal: Drugs 20010101

Title: Immunocytochemical analysis of apoptotic bone marrow cells after treatment of mice with WR-2721 and chemotherapeutic drugs.

Journal: Folia histochemica et cytobiologica 20010101

Title: Amifostine (Ethyol) as modulator of hepatic and biliary toxicity from intraarterial hepatic chemoembolization: results of a phase I study.

Journal: Hepato-gastroenterology 20010101

Title: Effects of retinoic acid and amifostine on in vitro growth of normal hemopoietic progenitor cells.

Journal: Anticancer research 20010101

Title: Quantitation of interferon regulatory factor transcripts in patients with acute myeloid leukemia.

Journal: Cancer investigation 20010101

Title: Amifostine in combination with erythropoietin and G-CSF promotes multilineage hematopoiesis in patients with myelodysplastic syndrome.

Journal: Leukemia & lymphoma 20010101

Title: [Development of cancer chemotherapy. Cytoprotective agents].

Journal: La Clinica terapeutica 20010101

Title: Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients.

Journal: Medical and pediatric oncology 20010101

Title: WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment.

Journal: International journal of pancreatology : official journal of the International Association of Pancreatology 20010101

Title: High dose daily amifostine and hypofractionated intensively accelerated radiotherapy for locally advanced breast cancer. A phase I/II study and report on early and late sequellae.

Journal: Anticancer research 20010101

Title: Sensitizers and protectors of radiation and chemotherapy.

Journal: Current problems in cancer 20010101

Title: Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation.

Journal: International journal of cancer 20010101

Title: [Application of Ethyol during chemotherapy in patients with impaired kidney function. Description of three cases].

Journal: Medycyna wieku rozwojowego 20010101

Title: Use of amifostine as a chemoprotectant during high-dose chemotherapy in autologous peripheral blood stem cell transplantation.

Journal: Bone marrow transplantation 20001201

Title: Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.

Journal: American journal of clinical oncology 20000801

Title: Amifostine can reduce mucosal damage after high-dose melphalan conditioning for peripheral blood progenitor cellautotransplant: a retrospective study.

Journal: British journal of haematology 20000801

Title: Amifostine plus cisplatin plus vinorelbine in the treatment of advanced non small cell lung cancer: a multicenter phase II study.

Journal: Lung cancer (Amsterdam, Netherlands) 20000601

Title: Systemic inflammatory response syndrome associated with amifostine.

Journal: Medical and pediatric oncology 20000401

Title: Patients with myelodysplastic syndromes benefit from palliative therapy with amifostine, pentoxifylline, and ciprofloxacin with or without dexamethasone.

Journal: Blood 20000301

Title: Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats.

Journal: Cancer chemotherapy and pharmacology 20000101

Title: The use of reduced doses of amifostine to ameliorate nephrotoxicity of cisplatin/ifosfamide-based chemotherapy in patients with solid tumors.

Journal: Anti-cancer drugs 20000101

Title: Experimental model of hepatic venoocclusive disease (VOD) caused by dactinomycin--preliminary report about hepatoprotective effect of amifostine.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20000101

Title: Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-kappaB/Rel transcription factors.

Journal: Blood 19991215

Title: The potential of amifostine: from cytoprotectant to therapeutic agent.

Journal: Haematologica 19991101

Title: Evaluation of uroprotective efficacy of amifostine against cyclophosphamide induced hemorrhagic cystitis.

Journal: Bone marrow transplantation 19990301

Title: Protection of normal tissues from the cytotoxic effects of radiation therapy: focus on amifostine.

Journal: Seminars in radiation oncology 19981001

Title: The efficacy of selenium, WR-2721, and their combination in the prevention of adriamycin-induced cardiotoxicity in rats.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 19980101

Title: Effect of amifostine on toxicities associated with sequential chemotherapy and radiation therapy for unresectable non-small-cell lung cancer: results of a phase II trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19970801

Title: Phase II evaluation of cisplatin and WR2721 for refractory metastatic breast cancer.

Journal: American journal of clinical oncology 19970801

Title: Cytoprotective agents for anthracyclines.

Journal: Seminars in oncology 19960801

Title: Hypotensive mechanisms of amifostine.

Journal: Journal of clinical pharmacology 19960401

Title: Amifostine (Ethyol): dosing, administration and patient management guidelines.

Journal: European journal of cancer (Oxford, England : 1990) 19960101

Title: Organic thiophosphate WR-151327 suppresses expression of HIV in chronically infected cells.

Journal: AIDS research and human retroviruses 19940601

Title: Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil.

Journal: Cancer chemotherapy and pharmacology 19920101

Title: Final report of the phase I trial of single-dose WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid].

Journal: Cancer treatment reports 19861201

Title: Clinical trial of the effect of S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) (NSC 296961) on the toxicity of cyclophosphamide.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19830301

Title: D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.

Title: Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.

Title: Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.

Title: John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

Title: Shao-Ze Wu, et al. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2017;2017:4130824.

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