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145040-37-5,MFCD00871371
Catalog No.:AA00HX9V

145040-37-5 | Candesartan cilexetil

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Purity
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1mg
98%
in stock  
$6.00   $4.00
- +
10mg
98%
in stock  
$8.00   $6.00
- +
50mg
98%
in stock  
$11.00   $8.00
- +
1g
98%
in stock  
$13.00   $9.00
- +
5g
98%
in stock  
$36.00   $25.00
- +
10g
98%
in stock  
$68.00   $48.00
- +
25g
98%
in stock  
$163.00   $114.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00HX9V
Chemical Name:
Candesartan cilexetil
CAS Number:
145040-37-5
Molecular Formula:
C33H34N6O6
Molecular Weight:
610.6597
MDL Number:
MFCD00871371
SMILES:
CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)OC(OC(=O)OC1CCCCC1)C
NSC Number:
758697
Properties
Computed Properties
 
Complexity:
962  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
13  
Undefined Atom Stereocenter Count:
1  
XLogP3:
7  

Literature

Title: Candesartan ameliorates arsenic-induced hypertensive vascular remodeling by regularizing angiotensin II and TGF-beta signaling in rats.

Journal: Toxicology 20161230

Title: Candesartan cilexetil attenuated cardiac remodeling by improving expression and function of mitofusin 2 in SHR.

Journal: International journal of cardiology 20160701

Title: Mitofusin 2 ameliorates aortic remodeling by suppressing ras/raf/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells.

Journal: International journal of cardiology 20150115

Title: Efficacy and safety of 10-mg azilsartan compared with 8-mg candesartan cilexetil in Japanese patients with hypertension: a randomized crossover non-inferiority trial.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20140901

Title: Comparative study of the AT₁ receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers.

Journal: Biochimica et biophysica acta 20121201

Title: Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20120701

Title: LC-MS/MS method for simultaneous estimation of candesartan and hydrochlorothiazide in human plasma and its use in clinical pharmacokinetics.

Journal: Bioanalysis 20120601

Title: Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120501

Title: Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with grade I-II essential hypertension: a randomized, double-blind clinical study.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120501

Title: Fixed-dose combination therapy of candesartan cilexetil and amlodipine besilate for the treatment of hypertension in Japan.

Journal: Expert review of cardiovascular therapy 20120501

Title: Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120401

Title: Acute treatment with candesartan cilexetil, an angiotensin II type 1 receptor blocker, improves insulin sensitivity in high-fructose-diet-fed rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120401

Title: Candesartan cilexetil improves angiotensin II type 2 receptor-mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin-resistant rats.

Journal: Diabetes 20120401

Title: Evaluation of the efficacy and tolerability of combination therapy with candesartan cilexetil and amlodipine besilate compared with candesartan cilexetil monotherapy and amlodipine besilate monotherapy in Japanese patients with mild-to-moderate essential hypertension: a multicenter, 12-week, randomized, double-blind, placebo-controlled, parallel-group study.

Journal: Clinical therapeutics 20120401

Title: Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer.

Journal: The American journal of pathology 20120301

Title: Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet.

Journal: Life sciences 20120227

Title: Candesartan cilexetil in children and adolescents aged 1 to <17 years with hypertension: profile report.

Journal: Paediatric drugs 20120201

Title: Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis.

Journal: Toxicology 20120127

Title: A novel diabetes mellitus mouse model, MAFA-deficient and beta cell-specific MAFK-overexpressing hybrid transgenic mice, developed severe diabetic nephropathy and improved with TCV-116 (candesartan cilexetil) treatment.

Journal: Experimental animals 20120101

Title: Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: Candesartan cilexetil.

Journal: Profiles of drug substances, excipients, and related methodology 20120101

Title: A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

Journal: PloS one 20120101

Title: Pharmacokinetic interaction study with fixed high dose combinations of candesartan cilexetil and hydrochlorothiazide.

Journal: International journal of clinical pharmacology and therapeutics 20111201

Title: Candesartan in the treatment of hypertension: what have we learnt in the last decade?

Journal: Expert opinion on drug safety 20111101

Title: Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia.

Journal: Journal of hypertension 20111101

Title: Efficacy and safety of combination therapy with candesartan cilexetil and pioglitazone hydrochloride in patients with hypertension and type 2 diabetes mellitus.

Journal: Current medical research and opinion 20111101

Title: Investigation and structural elucidation of a process related impurity in candesartan cilexetil by LC/ESI-ITMS and NMR.

Journal: Journal of pharmaceutical and biomedical analysis 20110910

Title: Candesartan cilexetil in the management of blood pressure for acute and recurrent stroke in Japan: the Challenge-Stroke study.

Journal: Expert review of cardiovascular therapy 20110901

Title: Candesartan cilexetil: an update.

Journal: Expert opinion on pharmacotherapy 20110801

Title: Phase IV, 8-week, multicenter, randomized, active treatment-controlled, parallel group, efficacy, and tolerability study of high-dose candesartan cilexetil combined with hydrochlorothiazide in Korean adults with stage II hypertension.

Journal: Clinical therapeutics 20110801

Title: Enhancement of solubility and permeability of Candesartan cilexetil by using different pharmaceutical interventions.

Journal: Current drug delivery 20110701

Title: Reflex systemic sympatho-neural response to brachial adenosine infusion in treated heart failure.

Journal: European journal of heart failure 20110501

Title: Effect of cyclodextrins on the solubility and stability of candesartan cilexetil in solution and solid state.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: [EFFECTIVE data. New effectiveness dimensions in antihypertensive combination therapy].

Journal: MMW Fortschritte der Medizin 20110127

Title: [Focus on compliance. Rapid goal attainment in hypertension].

Journal: MMW Fortschritte der Medizin 20110127

Title: Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20110120

Title: Candesartan cilexetil/hydrochlorothiazide combination treatment versus high-dose candesartan cilexetil monotherapy in patients with mild to moderate cardiovascular risk (CHILI Triple T).

Journal: Vascular health and risk management 20110101

Title: Identification and determination of selected angiotensin II receptor antagonist group drugs by HPLC method.

Journal: Acta poloniae pharmaceutica 20110101

Title: Differential clinical profile of candesartan compared to other angiotensin receptor blockers.

Journal: Vascular health and risk management 20110101

Title: Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

Journal: Bioorganic & medicinal chemistry 20101215

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Positive influence of AT(1) receptor antagonism upon the impaired celiprolol-induced vasodilatation in aorta from spontaneously hypertensive rats.

Journal: European journal of pharmacology 20101010

Title: LC and LC-MS/TOF studies on stress degradation behaviour of candesartan cilexetil.

Journal: Journal of pharmaceutical and biomedical analysis 20100708

Title: Colloid formation by drugs in simulated intestinal fluid.

Journal: Journal of medicinal chemistry 20100527

Title: Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age.

Journal: Journal of hypertension 20100501

Title: Candesartan improves blood pressure control and reduces proteinuria in renal transplant recipients: results from SECRET.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100301

Title: Solid self-microemulsifying formulation for candesartan cilexetil.

Journal: AAPS PharmSciTech 20100301

Title: Hypertension after kidney transplantation: still a SECRET?

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100301

Title: Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters.

Journal: Biopharmaceutics & drug disposition 20100301

Title: [Cross reactivity between ACE inhibitors and angiotensin receptor blockers].

Journal: Lakartidningen 20100201

Title: Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.

Journal: Life sciences 20100102

Title: Candesartan cilexetil/hydrochlorothiazide treatment in high-risk patients with type 2 diabetes mellitus and microalbuminuria: the CHILI T2D study.

Journal: Clinical drug investigation 20100101

Title: Voltammetric determination of candesartan cilexetil in its Cu(II) complex and application to pharmaceutical formulations.

Journal: Journal of AOAC International 20100101

Title: The different isoforms of the receptor for advanced glycation end products are modulated by pharmacological agents.

Journal: Clinical hemorheology and microcirculation 20100101

Title: Candesartan cilexetil: in children and adolescents aged 1 to <17 years with hypertension.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

Title: Angiotensin II receptor blocker candesartan cilexetil, but not hydralazine hydrochloride, protects against mouse cardiac enlargement resulting from undernutrition in utero.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20091001

Title: [Pharmacological and clinical properties of ECARD combination tablets LD & HD, fixed-dose combination of candesartan cilexetil and hydrochlorothiazide].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20091001

Title: Candesartan: widening indications for this angiotensin II receptor blocker?

Journal: Expert opinion on pharmacotherapy 20090801

Title: Effects of candesartan cilexetil 'add-on' treatment in congestive heart failure outpatients in daily practice.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20090601

Title: Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats.

Journal: Journal of hypertension 20090601

Title: Ask the doctor. After being diagnosed with high blood pressure several years ago, I started taking diltiazem and Atacand. The results were good, giving me an average blood pressure of 110/65. I recently developed gastroenteritis and aspiration pneumonia. While I was in the hospital, my blood pressure got so low I was told to stop taking these medications. I have been off them since, and my blood pressure has remained normal, averaging 105/65. How can this be? Will high blood pressure return?

Journal: Harvard heart letter : from Harvard Medical School 20090601

Title: [Pharmacological characteristics of ARB and potential strategy to develop novel ARB].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20090401

Title: Glomerular surface area is normalized in mice born with a nephron deficit: no role for AT1 receptors.

Journal: American journal of physiology. Renal physiology 20090301

Title: Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090201

Title: Relation between cardiovascular complications and blood pressure/blood glucose control in diabetic patients with hypertension receiving long-term candesartan cilexetil therapy: Challenge-DM study.

Journal: Diabetes research and clinical practice 20090201

Title: Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis.

Journal: Journal of pharmacological sciences 20090201

Title: Development and characterization of solid oral dosage form incorporating candesartan nanoparticles.

Journal: Pharmaceutical development and technology 20090101

Title: Relationship between decrease in ambulatory blood pressure and heart rate variability due to the effects of taking olmesartan medoxomil.

Journal: Clinical drug investigation 20090101

Title: Combination therapy with candesartan cilexetil 32 mg and hydrochlorothiazide 25 mg provides the full additive antihypertensive effect of the components: A randomized, double-blind, parallel-group study in primary care.

Journal: Clinical drug investigation 20090101

Title: Candesartan cilexetil in the treatment of chronic heart failure.

Journal: Vascular health and risk management 20090101

Title: Effects of candesartan cilexetil on carotid remodeling in hypertensive diabetic patients: the MITEC study.

Journal: Vascular health and risk management 20090101

Title: Angiotensin II receptor blockage prevents diabetes-induced oxidative damage in rat heart.

Journal: Folia biologica 20090101

Title: Pharmacokinetics and antihypertensive effects of candesartan cilexetil in patients undergoing haemodialysis: an open-label, single-centre study.

Journal: Clinical drug investigation 20090101

Title: Management of hypertension with fixed dose combinations of candesartan cilexetil and hydrochlorothiazide: patient perspectives and clinical utility.

Journal: Vascular health and risk management 20090101

Title: A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.

Journal: Cardiovascular drugs and therapy 20081201

Title: Comparison of the effects of candesartan cilexetil and enalapril maleate on right ventricular myocardial remodeling in dogs with experimentally induced pulmonary stenosis.

Journal: American journal of veterinary research 20081201

Title: Candesartan cilexetil effectively reduces blood pressure in hypertensive children.

Journal: The Annals of pharmacotherapy 20081001

Title: Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20081001

Title: Dual renin-angiotensin blockage and total embryo cryopreservation is not a risk-free strategy in patients at high risk for ovarian hyperstimulation syndrome.

Journal: Fertility and sterility 20080901

Title: Renoprotective effects of angiotensin II receptor blocker, candesartan cilexetil, in patients with stage 4-5 chronic kidney disease.

Journal: Clinical and experimental nephrology 20080801

Title: Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies.

Journal: Journal of hypertension 20080701

Title: Behçet's disease complicated by IgA nephropathy with nephrotic syndrome.

Journal: Clinical and experimental nephrology 20080601

Title: Angiotensin II type 1 receptor antagonist suppress angiogenesis and growth of gastric cancer xenografts.

Journal: Digestive diseases and sciences 20080501

Title: Oligohydramnios and pulmonary hypoplasia: a case in which involvement of an angiotensin II receptor antagonist was suspected.

Journal: The journal of obstetrics and gynaecology research 20080401

Title: Dual blockade of the rennin-angiotensin system versus maximal recommended dose of angiotensin II receptor blockade in chronic glomerulonephritis.

Journal: Clinical and experimental nephrology 20080201

Title: [Importance of a fixed combination of AT1-receptor blockade and hydrochlorothiazide for blood pressure lowering in cardiac risk patients. A postmarketing surveillance study with Candesartan/HCTZ].

Journal: MMW Fortschritte der Medizin 20080117

Title: Angiotensin II AT(1) receptor blockade selectively enhances brain AT(2) receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats.

Journal: Stress (Amsterdam, Netherlands) 20080101

Title: Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis.

Journal: Journal of gastroenterology and hepatology 20071101

Title: Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes.

Journal: Experimental eye research 20070901

Title: Efficacy and tolerability of candesartan cilexetil/hydrochlorothiazide and amlodipine in patients with poorly controlled mild-to-moderate essential hypertension.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20070901

Title: Hydrolysis and transesterification reactions of candesartan cilexetil observed during the solid phase extraction procedure.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

Title: Expression of angiotensin II receptor type 1 is reduced in advanced rat liver fibrosis.

Journal: Digestive diseases and sciences 20070801

Title: [Efficacy of candesartan cilexetil in hypertensive patients with or without diabetes].

Journal: Archives des maladies du coeur et des vaisseaux 20070801

Title: Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070701

Title: Candesartan cilexetil--a review of effects on cardiovascular complications in hypertension and chronic heart failure.

Journal: Current medical research and opinion 20070701

Title: AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers.

Journal: Journal of hepatology 20070601

Title: [ARB: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: Palatability of angiotensin II antagonists among nephropathic children.

Journal: British journal of clinical pharmacology 20070501

Title: [Treatment of high-normal blood pressure with angiotensin receptor blockers. TROPHY Study (Trial of Preventing Hypertension)].

Journal: Der Internist 20070401

Title: [Effects of angiotensin II type 1 receptor blocker on islet of diabetic db/db mice].

Journal: Zhonghua nei ke za zhi 20070401

Title: pH-responsive polymeric micelles of poly(ethylene glycol)-b-poly(alkyl(meth)acrylate-co-methacrylic acid): influence of the copolymer composition on self-assembling properties and release of candesartan cilexetil.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070301

Title: Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis.

Journal: Laboratory investigation; a journal of technical methods and pathology 20070201

Title: Effect of candesartan cilexetil on diabetic and non-diabetic hypertensive patients: meta-analysis of five randomized double-blind clinical trials.

Journal: Vascular health and risk management 20070201

Title: [Effect of candesartan cilexetil with hydrochlorothiazide on blood pressure and ST-segment depression in patients with arterial hypertension].

Journal: Deutsche medizinische Wochenschrift (1946) 20070119

Title: Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC-epsilon expression in the mouse heart.

Journal: Journal of cardiovascular pharmacology 20070101

Title: Developmental activity of the renin-angiotensin system during the 'critical period' modulates later L-NAME-induced hypertension and renal injury.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20070101

Title: A multicentre, 12-week study of imidapril and candesartan cilexetil in patients with mild to moderate hypertension using ambulatory blood pressure monitoring.

Journal: Clinical drug investigation 20070101

Title: Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma.

Journal: European journal of pharmacology 20061215

Title: Carvedilol accelerate elevation of serum potassium in chronic heart failure patients administered spironolactone plus furosemide and either enalapril maleate or candesartan cilexetil.

Journal: Journal of clinical pharmacy and therapeutics 20061201

Title: Effects of benidipine, a long-lasting dihydropyridine-Ca2+ channel blocker, on cerebral blood flow autoregulation in spontaneously hypertensive rats.

Journal: Biological & pharmaceutical bulletin 20061101

Title: Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.

Journal: The Journal of pharmacy and pharmacology 20061101

Title: Candesartan cilexetil in children with hypertension or proteinuria: preliminary data.

Journal: Pediatric nephrology (Berlin, Germany) 20061001

Title: A double-blind, randomized, placebo-controlled multicenter clinical trial to evaluate the effects of the angiotensin II receptor blocker candesartan cilexetil on intimal hyperplasia after coronary stent implantation.

Journal: American heart journal 20061001

Title: Inhibitory effect of candesartan cilexetil on left ventricular remodeling after myocardial infarction.

Journal: International heart journal 20060901

Title: A large scale study of angiotensin II inhibition therapy in an elderly population: the CHANCE study.

Journal: Vascular health and risk management 20060901

Title: Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension.

Journal: Circulation 20060829

Title: [CASE-J].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060801

Title: Treating prehypertension.

Journal: The New England journal of medicine 20060727

Title: Treating prehypertension.

Journal: The New England journal of medicine 20060727

Title: Treating prehypertension.

Journal: The New England journal of medicine 20060727

Title: Treating prehypertension.

Journal: The New England journal of medicine 20060727

Title: Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertension.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20060701

Title: Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice.

Journal: Biochemical and biophysical research communications 20060616

Title: Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus.

Journal: Journal of atherosclerosis and thrombosis 20060601

Title: Pharmacotherapy for prehypertension--mission accomplished?

Journal: The New England journal of medicine 20060420

Title: Feasibility of treating prehypertension with an angiotensin-receptor blocker.

Journal: The New England journal of medicine 20060420

Title: Effect of nos inhibition on retinal arterial and capillary circulation in early arterial hypertension.

Journal: Retina (Philadelphia, Pa.) 20060401

Title: A placebo-controlled comparison of the efficacy and tolerability of candesartan cilexetil, 8 mg, and losartan, 50 mg, as monotherapy in patients with essential hypertension, using 36-h ambulatory blood pressure monitoring.

Journal: International journal of clinical practice 20060401

Title: Effect of Angiotensin II Type 1 receptor blocker on cardiac angiotensin-converting enzyme and chymase-like activities, and cardiac fibrosis in cardiomyopathic hamsters.

Journal: The Journal of veterinary medical science 20060301

Title: Candesartan cilexetil on regular hemodialysis: inability to reduce excessive thirst, but good tolerance and efficacy in hypertensive patients.

Journal: Renal failure 20060101

Title: Candesartan cilexetil: a pharmacoeconomic review of its use in chronic heart failure and hypertension.

Journal: PharmacoEconomics 20060101

Title: Antihypertensive efficacy of olmesartan medoxomil and candesartan cilexetil in achieving 24-hour blood pressure reductions and ambulatory blood pressure goals.

Journal: Clinical drug investigation 20060101

Title: Perspectives on prehypertension.

Journal: Journal of the cardiometabolic syndrome 20060101

Title: [Candesartan Cilexetil (Atacand) induced prolonged severe cholestasis improved by extracorporeal albumin dialysis].

Journal: Gastroenterologie clinique et biologique 20051201

Title: Candesartan reduces urinary fatty acid-binding protein excretion in patients with autosomal dominant polycystic kidney disease.

Journal: The American journal of the medical sciences 20051001

Title: Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan.

Journal: British journal of clinical pharmacology 20050801

Title: Angiotensin blockade inhibits osteopontin expression in non-infarcted myocardium after myocardial infarction.

Journal: Journal of pharmacological sciences 20050701

Title: Long-acting blood pressure reduction by candesartan cilexetil in patients with hypertension.

Journal: Current medical research and opinion 20050601

Title: Evaluation of the effect of candesartan cilexetil on the steady-state pharmacokinetics of tacrolimus in renal transplant patients.

Journal: Biopharmaceutics & drug disposition 20050501

Title: Mechanisms of combined treatment with celiprolol and candesartan for ventricular remodeling in experimental heart failure.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050501

Title: Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models.

Journal: European journal of pharmacology 20050411

Title: Effect of treatment with candesartan or enalapril on subcutaneous small artery structure in hypertensive patients with noninsulin-dependent diabetes mellitus.

Journal: Hypertension (Dallas, Tex. : 1979) 20050401

Title: Treatment with AT(1) receptor blocker restores diabetes-induced alterations in intracellular Ca(2+) transients and contractile function of rat myocardium.

Journal: Archives of biochemistry and biophysics 20050301

Title: Physicians' attitudes towards and reasons for participation in the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial.

Journal: Journal of epidemiology 20050301

Title: Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus.

Journal: Hypertension (Dallas, Tex. : 1979) 20050201

Title: Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.

Journal: Carcinogenesis 20050201

Title: ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure.

Journal: Journal of hypertension 20050201

Title: Effects of candesartan cilexetil and enalapril on inflammatory markers of atherosclerosis in hypertensive patients with non-insulin-dependent diabetes mellitus.

Journal: Journal of hypertension 20050201

Title: Controlled-release nifedipine and candesartan low-dose combination therapy in patients with essential hypertension: the NICE Combi (Nifedipine and Candesartan Combination) Study.

Journal: Journal of hypertension 20050201

Title: Combined effects of ramipril and angiotensin II receptor blocker TCV116 on rat congestive heart failure after myocardial infarction.

Journal: Chinese medical journal 20050120

Title: Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050101

Title: Examination of 209 drugs for inhibition of cytochrome P450 2C8.

Journal: Journal of clinical pharmacology 20050101

Title: The angiotensin II receptor blocker candesartan cilexetil reduces neointima proliferation after coronary stent implantation: a prospective randomized study under intravascular ultrasound guidance.

Journal: American heart journal 20050101

Title: Efficacy and tolerability of candesartan cilexetil vs. amlodipine as assessed by home blood pressure in hypertensive patients.

Journal: International journal of clinical practice 20050101

Title: Candesartan cilexetil: a review of its use in the management of chronic heart failure.

Journal: Drugs 20050101

Title: Effects of angiotensin-II receptor blocker candesartan cilexetil in rats with dilated cardiomyopathy.

Journal: Molecular and cellular biochemistry 20050101

Title: [Investigations of the antihypertensive long-term action of candesartan cilexetil in different dosages under the influence of therapy-free intervals].

Journal: Arzneimittel-Forschung 20050101

Title: Two- and three-drug therapy with candesartan cilexetil (Atacand) successful in patients with severe hypertension.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20050101

Title: Angiotensin receptor gene expression in candesartan mediated neuroprotection.

Journal: Neuroreport 20041203

Title: Beneficial action of candesartan cilexetil plus amlodipine or ACE inhibitors in chronic nondiabetic renal disease.

Journal: Journal of human hypertension 20041201

Title: Disparate systemic and renal blocking properties of angiotensin II antagonists during exogenous angiotensin II administration: implications for treatment.

Journal: Journal of human hypertension 20041201

Title: Combined angiotensin receptor blocker and ACE inhibitor on myocardial fibrosis and left ventricular stiffness in dogs with heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20041201

Title: Candesartan cilexetil in cardiovascular disease.

Journal: Expert review of cardiovascular therapy 20041101

Title: Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade.

Journal: Journal of molecular and cellular cardiology 20041101

Title: [Long-term effects of TCV116 on cardiac function changes after myocardial infarction].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20041101

Title: Anodic adsorptive stripping voltammetry of the antihypertensive drug candesartan cilexetil at a glassy carbon electrode.

Journal: Die Pharmazie 20041101

Title: Effects of AT1 receptor antagonist and spironolactone on cardiac expression of ET-1 mRNA in SHR-SP/Izm.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit model.

Journal: Circulation 20041005

Title: Antiproteinuric effect of candesartan cilexetil in Japanese subjects with type 2 diabetes and nephropathy.

Journal: Diabetes research and clinical practice 20041001

Title: Are angiotensin receptor blockers neuroprotective?

Journal: Current hypertension reports 20040801

Title: Candesartan for the treatment of hypertension and heart failure.

Journal: Expert opinion on pharmacotherapy 20040701

Title: Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced diabetic rats: effects of an ACE inhibitor and an angiotensin II receptor antagonist.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040701

Title: Impaired endothelial function of the retinal vasculature in hypertensive patients.

Journal: Stroke 20040601

Title: Candesartan prevents myocardial fibrosis during progression of congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20040601

Title: Erythema multiforme associated with candesartan cilexetil.

Journal: Southern medical journal 20040601

Title: Fixed combination of candesartan with hydrochlorothiazide in patients with severe primary hypertension.

Journal: Current medical research and opinion 20040501

Title: Effect of long-term angiotensin II type I receptor antagonism on peripheral and coronary vasomotion.

Journal: Cardiovascular drugs and therapy 20040501

Title: Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin II blockade in humans.

Journal: Hypertension (Dallas, Tex. : 1979) 20040401

Title: Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20040401

Title: Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation.

Journal: Journal of hypertension 20040401

Title: Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats.

Journal: Kidney international 20040301

Title: Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR.

Journal: Journal of hypertension 20040301

Title: Angiotensin AT(1) receptor antagonism normalizes retinal blood flow and acetylcholine-induced vasodilatation in normotensive diabetic rats.

Journal: Diabetologia 20040101

Title: Effect of the angiotensin II receptor blocker candesartan on fibrinolysis in patients with mild hypertension.

Journal: Diabetes, obesity & metabolism 20040101

Title: Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist.

Journal: Thorax 20040101

Title: [Effect of angiotensin II receptor antagonist on heart failure].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040101

Title: The CHARM programme raises the profile of candesartan cilexetil in the treatment of chronic health failure.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20040101

Title: CHARM shows improvement in NYHA functional class with candesartan.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20040101

Title: Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig.

Journal: Experimental lung research 20040101

Title: CHARM study in CHF patients with impaired LV function reinforces benefits of candesartan cilexetil (Atacand).

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20040101

Title: Switch from ABCD pretreatment to A-II-A treatment: a multinational, open, centrally randomized, prospective parallel group comparison.

Journal: Drugs under experimental and clinical research 20040101

Title: Attenuation of virus-induced myocardial injury by inhibition of the angiotensin II type 1 receptor signal and decreased nuclear factor-kappa B activation in knockout mice.

Journal: Journal of the American College of Cardiology 20031203

Title: Re: Evaluation of acute candesartan cilexetil therapy in stroke survivors.

Journal: Stroke 20031201

Title: ACCESS study: blood pressure effect?

Journal: Stroke 20031201

Title: The effects of replacing dihydropyridine calcium-channel blockers with angiotensin II receptor blocker on the quality of life of hypertensive patients.

Journal: Blood pressure. Supplement 20031201

Title: Application of first derivative UV-spectrophotometry and ratio derivative spectrophotometry for the simultaneous determination of candesartan cilexetil and hydrochlorothiazide.

Journal: Die Pharmazie 20031101

Title: Use of candesartan cilexetil decreases proteinuria in renal transplant patients with chronic allograft dysfunction.

Journal: Transplantation 20031027

Title: Effects of AT1 receptor block begun late in life on normal cardiac aging in rats.

Journal: Journal of cardiovascular pharmacology 20031001

Title: Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure.

Journal: European journal of heart failure 20031001

Title: Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM.

Journal: European journal of heart failure 20031001

Title: Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme.

Journal: Lancet (London, England) 20030906

Title: Angiotensin II type 1 receptor blockade prevents diastolic heart failure through modulation of Ca(2+) regulatory proteins and extracellular matrix.

Journal: Journal of hypertension 20030901

Title: Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat. The effect of AT1-R blocker on the hepatic fibrosis.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030901

Title: Absence of interactive effects of trans-1,2-cyclohexanediol, a major metabolite of the side-chain of candesartan cilexetil, on digoxin-induced arrhythmias in dogs.

Journal: Journal of pharmacological sciences 20030801

Title: The ACCESS Study: evaluation of Acute Candesartan Cilexetil Therapy in Stroke Survivors.

Journal: Stroke 20030701

Title: Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth.

Journal: The Journal of clinical investigation 20030701

Title: [Additive antiproteinuric effect of angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor in patients with chronic glomerulonephritis].

Journal: Nihon Jinzo Gakkai shi 20030701

Title: Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Journal: Journal of medicinal chemistry 20030605

Title: Dual renin-angiotensin blockade therapy in patients at high risk of early ovarian hyperstimulation syndrome receiving IVF and elective embryo cryopreservation: a case series.

Journal: Human reproduction (Oxford, England) 20030601

Title: Dual blockade with candesartan cilexetil and lisinopril in hypertensive patients with diabetes mellitus: rationale and design.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20030601

Title: Low-dose candesartan cilexetil prevents early kidney damage in type 2 diabetic patients with mildly elevated blood pressure.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030601

Title: Candesartan cilexetil-induced severe hepatotoxicity.

Journal: Journal of clinical gastroenterology 20030301

Title: Acute and 3-month treatment effects of candesartan cilexetil on hemodynamics, neurohormones, and clinical symptoms in patients with congestive heart failure.

Journal: American heart journal 20030301

Title: The regulation of HGF and TGF-beta by an angiotensin II type 1 receptor antagonist in hepatic ischemia-reperfusion injury.

Journal: Transplantation proceedings 20030201

Title: Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels.

Journal: Diabetes research and clinical practice 20030101

Title: Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030101

Title: Outcomes data for Atacand: results of the SCOPE study.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20030101

Title: Candesartan cilexetil induced pustular psoriasis.

Journal: European journal of dermatology : EJD 20030101

Title: CHARM shows benefits of Atacand for symptomatic heart failure.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20030101

Title: Angiotensin II type 1 receptor blockade to control blood pressure in postmenopausal women: influence of hormone replacement therapy.

Journal: Kidney international. Supplement 20021201

Title: Candesartan cilexetil improves left ventricular function, left ventricular hypertrophy, and endothelial function in patients with hypertensive heart disease.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20021101

Title: Cognitive associations of subcortical white matter lesions in older people.

Journal: Annals of the New York Academy of Sciences 20021101

Title: Cardiotoxic interaction of metabolites from a prodrug segment cilexetil (cyclohexyloxy-carbonyloxy-ethyl) with digoxin in the canine failing heart.

Journal: Pharmacological research 20021001

Title: AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade.

Journal: Hypertension (Dallas, Tex. : 1979) 20021001

Title: [Tendency and prospect of the development of new ARBs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001

Title: [Ameliorative effects on retinal disorder in diabetic SHRSP (stroke-prone spontaneously hypertensive rat)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001

Title: [A megatrial of ARB in Japan--CASE-J].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20021001

Title: Antiproteinuric effect of candesartan cilexetil in patients with chronic glomerulonephritis.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20020901

Title: Systemic and regional hemodynamic and cardiac remodeling effects of candesartan in dilated cardiomyopathic hamsters with advanced congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20020801

Title: Prepubertal treatment with angiotensin receptor blocker causes partial attenuation of hypertension and renal damage in adult Dahl salt-sensitive rats.

Journal: Nephron 20020801

Title: Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart.

Journal: Cardiovascular research 20020701

Title: Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20020701

Title: Can hypertension be prevented? The Danish Hypertension Prevention Project and the Trial of Prevention of Hypertension studies.

Journal: Current opinion in cardiology 20020701

Title: Blockade of angiotensin AT1a receptor signaling reduces tumor growth, angiogenesis, and metastasis.

Journal: Biochemical and biophysical research communications 20020607

Title: Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20020601

Title: Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats.

Journal: Journal of hypertension 20020501

Title: Angiotensin II receptor antagonist improves age-related endothelial dysfunction.

Journal: Journal of hypertension 20020301

Title: Renal protective effect of candesartan cilexetil in spontaneously hypercholesterolemic rats.

Journal: Japanese journal of pharmacology 20020301

Title: TCV-116, an angiotensin II type 1 receptor antagonist, reduces hepatic ischemia-reperfusion injury in rats.

Journal: Transplantation 20020227

Title: Interaction of digoxin with antihypertensive drugs via MDR1.

Journal: Life sciences 20020215

Title: Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20020201

Title: Suppression of endotoxin-induced renal tumor necrosis factor-alpha and interleukin-6 mRNA by renin-angiotensin system inhibitors.

Journal: Japanese journal of pharmacology 20020201

Title: Dual blockade of the renin-angiotensin system in diabetic nephropathy: a randomized double-blind crossover study.

Journal: Diabetes care 20020101

Title: Clinical pharmacokinetics of candesartan.

Journal: Clinical pharmacokinetics 20020101

Title: Candesartan cilexetil plus hydrochlorothiazide combination: a review of its use in hypertension.

Journal: Drugs 20020101

Title: Candesartan cilexetil: an update of its use in essential hypertension.

Journal: Drugs 20020101

Title: Switching from ACE inhibitors, beta-blockers, calcium antagonists or diuretics to candesartan improves efficacy and tolerability.

Journal: Blood pressure 20020101

Title: Acute precipitants of congestive heart failure exacerbations.

Journal: Archives of internal medicine 20011022

Title: Autoregulated glomerular filtration rate during candesartan treatment in hypertensive type 2 diabetic patients.

Journal: Kidney international 20011001

Title: TCV-116 stimulates eNOS and caveolin-1 expression and improves coronary microvascular remodeling in normotensive and angiotensin II-induced hypertensive rats.

Journal: Atherosclerosis 20011001

Title: [Review of randomized trials of angiotensin receptor blockers in the treatment of patients with congestive heart failure].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011001

Title: Persistent cardiovascular effects of chronic renin-angiotensin system inhibition following withdrawal in adult spontaneously hypertensive rats.

Journal: Journal of hypertension 20010801

Title: Functional role of endogenous endothelin-1 in congestive heart failure treated with angiotensin II receptor antagonist.

Journal: The Japanese journal of physiology 20010801

Title: A forced titration study of antihypertensive efficacy of candesartan cilexetil in comparison to losartan: CLAIM Study II.

Journal: Journal of human hypertension 20010701

Title: The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats.

Journal: Diabetologia 20010701

Title: Effects of TCV-116 on expression of NOS and adrenomedullin in failing heart of Dahl salt-sensitive rats.

Journal: Atherosclerosis 20010601

Title: [Change from ACE inhibitor, Ca-antagonist or beta-blocker to candesartan cilexetil: better efficacy and tolerance. SWITCH study (German study segment)].

Journal: Deutsche medizinische Wochenschrift (1946) 20010511

Title: A candesartan cilexetil/hydrochlorothiazide combination tablet provides effective blood pressure control in hypertensive patients inadequately controlled on monotherapy.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20010501

Title: Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis.

Journal: Journal of the American Society of Nephrology : JASN 20010401

Title: Effects of quinapril on expression of eNOS, ACE, and AT1 receptor in deoxycorticosterone acetate-salt hypertensive rats.

Journal: American journal of hypertension 20010401

Title: Involvement of angiotensin II in progression of renal injury in rats with genetic non-insulin-dependent diabetes mellitus (Wistar fatty rats).

Journal: Japanese journal of pharmacology 20010401

Title: Comparative effects of candesartan cilexetil and amlodipine in patients with mild systemic hypertension. Comparison of Candesartan and Amlodipine for Safety, Tolerability and Efficacy (CASTLE) Study Investigators.

Journal: The American journal of cardiology 20010315

Title: Effects of AT1 receptor antagonist on proteoglycan gene expression in hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010301

Title: Role of angiotensin II type 1 receptor in the leucocytes and endothelial cells of brain microvessels in the pathogenesis of hypertensive cerebral injury.

Journal: Journal of hypertension 20010301

Title: Discordant responses to two classes of drugs acting on the renin-angiotensin system.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20010301

Title: Angiotensin II type 1 receptor blockers.

Journal: Circulation 20010213

Title: Comparison of candesartan versus enalapril in essential hypertension. Italian Candesartan Study Group.

Journal: American journal of hypertension 20010201

Title: Candesartan cilexetil reduces graft arteriosclerosis in aortic transplantation model in rat.

Journal: Transplant immunology 20010201

Title: Efficacy and tolerability of angiotensin II type 1 receptor antagonists in dialysis patients using AN69 dialysis membranes.

Journal: Kidney & blood pressure research 20010101

Title: Effects of TCV-116 on endothelin-1 and PDGF A-chain expression in angiotensin II-induced hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010101

Title: Effect of prolonged nitric oxide synthesis inhibition on plasma fibrinogen concentration in rats.

Journal: Japanese journal of pharmacology 20010101

Title: Antihypertensive treatment in elderly patients aged 75 years or over: a 24-week study of the tolerability of candesartan cilexetil in relation to hydrochlorothiazide.

Journal: Drugs & aging 20010101

Title: The effect duration of candesartan cilexetil once daily, in comparison with enalapril once daily, in patients with mild to moderate hypertension.

Journal: Blood pressure 20010101

Title: Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis.

Journal: BMC nephrology 20010101

Title: Antihypertensive efficacy of candesartan in comparison to losartan: the CLAIM study.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20010101

Title: Differential effect of chronic inhibition of calcium channel and angiotensin II type 1-receptor on aldosterone synthesis in spontaneously hypertensive rats.

Journal: The Journal of steroid biochemistry and molecular biology 20001001

Title: KRH-594, a new angiotensin AT1 receptor antagonist, ameliorates nephropathy and hyperlipidaemia in diabetic spontaneously hypertensive rats.

Journal: Clinical and experimental pharmacology & physiology 20000401

Title: Overexpression of insulin-like growth factor-I in hearts of rats with isoproterenol-induced cardiac hypertrophy.

Journal: Journal of cardiovascular pharmacology 19991101

Title: Angiotensin II stimulates intercellular adhesion molecule-1 (ICAM-1) expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo.

Journal: Circulation 19991012

Title: Role of angiotensin II, endothelin-1, and nitric oxide in HgCl2-induced acute renal failure.

Journal: Toxicology and applied pharmacology 19981001

Title: Candesartan prevents the progression of mesangioproliferative nephritis in rats.

Journal: Kidney international. Supplement 19971201

Title: Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 19960701

Title: Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 19960601

Title: Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

Journal: Journal of medicinal chemistry 19960202

Title: Regulation of neuronal nitric oxide synthase in rat adrenal medulla.

Journal: Hypertension (Dallas, Tex. : 1979) 19950301

Title: Pfeffer, M.A., et al., Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet, 2003. 362(9386): p. 759-66.

Title: Wada, T., et al., Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res, 1996. 19(2): p. 75-81.

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Tags:145040-37-5 Molecular Formula|145040-37-5 MDL|145040-37-5 SMILES|145040-37-5 Candesartan cilexetil