Catalog No.:AA00HXVV

1523404-29-6 | (S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

Name: Name:(S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
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SKU: AA00HXVV
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1mg

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$255.00 $179.00

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5mg

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10mg

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$1,332.00 $933.00

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25mg

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$3,066.00 $2,147.00

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50mg

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA00HXVV

Chemical Name:

(S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

CAS Number:

1523404-29-6

Molecular Formula:

C18H25F3N4O3

Molecular Weight:

402.4113

MDL Number:

MFCD28411355

SMILES:

O=C(C(C)C)CN1c2nc(cc(=O)n2CC[C@H]1C(F)(F)F)N1CCOC[C@H]1C

Properties

Computed Properties

Complexity:

705

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Rotatable Bond Count:

XLogP3:

Downstream Synthesis Route

16075-42-6

1523404-29-6

[1]JournalofMedicinalChemistry,2015,vol.58,p.376-400

Literature

Title: Pasquier B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido,2-apyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015 Jan 8;58(1):376-400.

Title: Jim Baggen, et al. Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2. Nat Genet. 2021 Mar 8.

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SDS