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27220-47-9,MFCD00800993
Catalog No.:AA00I52U

27220-47-9 | Econazole

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5g
98%
in stock  
$29.00   $20.00
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25g
98%
in stock  
$45.00   $32.00
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100g
98%
in stock  
$95.00   $67.00
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500g
98%
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$261.00   $183.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I52U
Chemical Name:
Econazole
CAS Number:
27220-47-9
Molecular Formula:
C18H15Cl3N2O
Molecular Weight:
381.6835
MDL Number:
MFCD00800993
SMILES:
C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
NSC Number:
187789
Properties
Computed Properties
 
Complexity:
379  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.3  

Literature

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Title: Design and synthesis of 1H-1,2,3-triazoles derived from econazole as antitubercular agents.

Journal: Bioorganic & medicinal chemistry letters 20121115

Title: Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels.

Journal: British journal of pharmacology 20121101

Title: Effect of methoxychlor on Ca(2+) movement and viability in MDCK renal tubular cells.

Journal: Basic & clinical pharmacology & toxicology 20121001

Title: Effect of diindolylmethane on Ca2+ homeostasis and viability in PC3 human prostate cancer cells.

Journal: Journal of receptor and signal transduction research 20121001

Title: Investigation of 2,6-diisopropylphenol (propofol)-evoked Ca2+ movement and cell death in human glioblastoma cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120901

Title: Enhanced transdermal delivery of 18β-glycyrrhetic acid via elastic vesicles: in vitro and in vivo evaluation.

Journal: Drug development and industrial pharmacy 20120701

Title: Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses.

Journal: Mycopathologia 20120701

Title: Distribution, behavior and fate of azole antifungals during mechanical, biological, and chemical treatments in sewage treatment plants in China.

Journal: The Science of the total environment 20120601

Title: Enantiomeric determination of azole antifungals in wastewater and sludge by liquid chromatography-tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20120601

Title: Carvacrol-induced [Ca2+]i rise and apoptosis in human glioblastoma cells.

Journal: Life sciences 20120515

Title: Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20120501

Title: 3,3'-Diindolylmethane alters Ca2+ homeostasis and viability in MG63 human osteosarcoma cells.

Journal: Basic & clinical pharmacology & toxicology 20120401

Title: Binding free energies of inhibitors to iron porphyrin complex as a model for Cytochrome P450.

Journal: Biopolymers 20120401

Title: TRPC-Mediated Current Is Not Involved in Endocannabinoid-Induced Short-Term Depression in Cerebellum.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120401

Title: The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.

Journal: Antimicrobial agents and chemotherapy 20120301

Title: Effect of m-3m3FBS on Ca2+ handling and viability in OC2 human oral cancer cells.

Journal: Acta physiologica Hungarica 20120301

Title: Medical interventions for fungal keratitis.

Journal: The Cochrane database of systematic reviews 20120215

Title: Sulfur mustard primes human neutrophils for increased degranulation and stimulates cytokine release via TRPM2/p38 MAPK signaling.

Journal: Toxicology and applied pharmacology 20120101

Title: Ultrasound-enhanced surfactant-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography for determination of ketoconazole and econazole nitrate in human blood.

Journal: Analytical and bioanalytical chemistry 20120101

Title: Antifungal resistance and new strategies to control fungal infections.

Journal: International journal of microbiology 20120101

Title: 1-[2-(2,4-Dichloro-benz-yloxy)-2-(furan-2-yl)eth-yl]-1H-benzotriazole.

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: Animal model of dermatophytosis.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide.

Journal: International journal of nanomedicine 20120101

Title: A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy.

Journal: Skin pharmacology and physiology 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: 1-[2-(2,5-Dichloro-benz-yloxy)-2-phenyl-eth-yl]-1H-benzotriazole.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Effect of thymol on Ca2+ homeostasis and viability in human glioblastoma cells.

Journal: European journal of pharmacology 20111116

Title: The role of the membrane potential in chondrocyte volume regulation.

Journal: Journal of cellular physiology 20111101

Title: The ability of the mouse lymphoma TK assay to detect aneugens.

Journal: Mutagenesis 20111101

Title: Paroxetine-induced Ca2+ movement and death in OC2 human oral cancer cells.

Journal: The Chinese journal of physiology 20111031

Title: The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules.

Journal: Journal of chromatography. A 20111028

Title: Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells.

Journal: Archives of toxicology 20111001

Title: In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation.

Journal: The Journal of pharmacy and pharmacology 20111001

Title: Periocular rash.

Journal: JAMA 20110921

Title: Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation.

Journal: Pharmaceutical development and technology 20110801

Title: A prototype antifungal contact lens.

Journal: Investigative ophthalmology & visual science 20110801

Title: Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.

Journal: Antimicrobial agents and chemotherapy 20110801

Title: Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for ocular drug delivery.

Journal: International journal of pharmaceutics 20110715

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Determination of azoles in sewage sludge from Spanish wastewater treatment plants by liquid chromatography-tandem mass spectrometry.

Journal: Journal of separation science 20110601

Title: Investigation of carvedilol-evoked Ca²+ movement and death in human oral cancer cells.

Journal: Journal of receptor and signal transduction research 20110601

Title: Inhibition of bone resorption by econazole in rat osteoclast-like cells through suppressing TRPV5.

Journal: Archives of pharmacal research 20110601

Title: Effect of methoxychlor on Ca2+ handling and viability in OC2 human oral cancer cells.

Journal: Basic & clinical pharmacology & toxicology 20110501

Title: Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.

Journal: Current drug targets 20110501

Title: Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans.

Journal: Archives of biochemistry and biophysics 20110501

Title: Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Journal: Toxicology and applied pharmacology 20110501

Title: Effect of diallyl disulfide on Ca2+ movement and viability in PC3 human prostate cancer cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401

Title: Asymmetric chemoenzymatic synthesis of miconazole and econazole enantiomers. The importance of chirality in their biological evaluation.

Journal: The Journal of organic chemistry 20110401

Title: Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein.

Journal: Journal of endocrinological investigation 20110301

Title: Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Common features of periocular tinea.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110301

Title: Structure of Ralstonia eutropha flavohemoglobin in complex with three antibiotic azole compounds.

Journal: Biochemistry 20110222

Title: ABC50 modulates sensitivity of HL60 leukemic cells to endoplasmic reticulum (ER) stress-induced cell death.

Journal: Biochemical pharmacology 20110215

Title: Chemical inhibitors of the calcium entry channel TRPV6.

Journal: Pharmaceutical research 20110201

Title: Functional expression and characterization of CYP51 from dandruff-causing Malassezia globosa.

Journal: FEMS yeast research 20110201

Title: Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.

Journal: Biochimica et biophysica acta 20110101

Title: Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.

Journal: Biochimica et biophysica acta 20110101

Title: Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care.

Journal: BMC public health 20110101

Title: [Determination of hemolytic activity and in vitro antifungal susceptibility of Trichophyton rubrum clinical strains].

Journal: Mikrobiyoloji bulteni 20110101

Title: Treatment of asymptomatic vaginal candidiasis in pregnancy to prevent preterm birth: an open-label pilot randomized controlled trial.

Journal: BMC pregnancy and childbirth 20110101

Title: Antifungal testing and high-throughput screening of compound library against Geomyces destructans, the etiologic agent of geomycosis (WNS) in bats.

Journal: PloS one 20110101

Title: Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis.

Journal: Arzneimittel-Forschung 20110101

Title: Fungal keratitis.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20110101

Title: Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Liposome technology for industrial purposes.

Journal: Journal of drug delivery 20110101

Title: In vitro antifungal susceptibility testing of Scopulariopsis brevicaulis strains using agar diffusion method.

Journal: Wiadomosci parazytologiczne 20110101

Title: Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance.

Journal: PloS one 20110101

Title: Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug.

Journal: PloS one 20110101

Title: Antibacterial treatment of bacterial vaginosis: current and emerging therapies.

Journal: International journal of women's health 20110101

Title: Effect of thymol on Ca2+ homeostasis and viability in MG63 human osteosarcoma cells.

Journal: Pharmacology 20110101

Title: Molecular docking of azole drugs and their analogs on CYP121 of Mycobacterium tuberculosis.

Journal: Bioinformation 20110101

Title: Development of a simple liquid chromatography-tandem mass spectrometry method for multiresidue determination of antifungal drugs in chicken tissues.

Journal: Journal of AOAC International 20110101

Title: Biochemistry of the phagosome: the challenge to study a transient organelle.

Journal: TheScientificWorldJournal 20110101

Title: Models of latent tuberculosis: their salient features, limitations, and development.

Journal: Journal of laboratory physicians 20110101

Title: Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin.

Journal: Journal of pharmaceutical and biomedical analysis 20101215

Title: Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20101201

Title: First case of Trichophyton soudanense isolated in Tunisia.

Journal: Mycopathologia 20101101

Title: Econazole nitrate-loaded MCM-41 for an antifungal topical powder formulation.

Journal: Journal of pharmaceutical sciences 20101101

Title: Independent effects of the broccoli-derived compound sulforaphane on Ca²⁺ influx and apoptosis in Madin-Darby canine renal tubular cells.

Journal: The Chinese journal of physiology 20100831

Title: Comparison of a glucose consumption based method with the CLSI M38-A method for testing antifungal susceptibility of Trichophyton rubrum and Trichophyton mentagrophytes.

Journal: Chinese medical journal 20100701

Title: Effect of m-3M3FBS on Ca²⁺ movement in PC3 human prostate cancer cells.

Journal: The Chinese journal of physiology 20100630

Title: Effect of nortriptyline on Ca²⁺ handling in SIRC rabbit corneal epithelial cells.

Journal: The Chinese journal of physiology 20100630

Title: Antimycotic effectiveness against dermatophytes: comparison of two in vitro tests.

Journal: Veterinary research communications 20100601

Title: Rapid analysis of aerosol drugs using nano extractive electrospray ionization tandem mass spectrometry.

Journal: The Analyst 20100601

Title: 1-[2-(4-Chloro-benz-yloxy)-2-phenyl-ethyl]-1H-benzotriazole.

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: Determination of commonly used azole antifungals in various waters and sewage sludge using ultra-high performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20100521

Title: Antimicrobial activity of topical skin pharmaceuticals - an in vitro study.

Journal: Acta dermato-venereologica 20100501

Title: Structural basis of human CYP51 inhibition by antifungal azoles.

Journal: Journal of molecular biology 20100409

Title: Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.

Journal: Journal of medicinal chemistry 20100325

Title: Otomycosis: Diagnosis and treatment.

Journal: Clinics in dermatology 20100304

Title: Screening of antimycotics in Swedish sewage treatment plants--waters and sludge.

Journal: Water research 20100101

Title: Keratitis caused by the recently described new species Aspergillus brasiliensis: two case reports.

Journal: Journal of medical case reports 20100101

Title: Candidal colonization, strain diversity, and antifungal susceptibility among adult diabetic patients.

Journal: Annals of Saudi medicine 20100101

Title: Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.

Journal: Genome biology 20100101

Title: Multidrug resistant yeasts in synanthropic wild birds.

Journal: Annals of clinical microbiology and antimicrobials 20100101

Title: Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Prevention and treatment of intertrigo in large skin folds of adults: a systematic review.

Journal: BMC nursing 20100101

Title: Current and developing therapeutic agents in the treatment of Chagas disease.

Journal: Drug design, development and therapy 20100101

Title: Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid.

Journal: Scientia pharmaceutica 20100101

Title: Calcium mobilization by the plant estrogen ferutinin does not induce blood platelet aggregation.

Journal: Pharmacological reports : PR 20100101

Title: 1-[2-(2,6-Dichloro-benz-yloxy)-2-(2-fur-yl)eth-yl]-1H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.

Journal: The Journal of biological chemistry 20091218

Title: Prevention, treatment and rehabilitation.

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Title: Managing corneal disease: focus on suppurative keratitis.

Journal: Community eye health 20091201

Title: 1-[2-(2,4-Dichloro-benz-yloxy)-2-(2-fur-yl)eth-yl]-1H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: Effect of m-3M3FBS on Ca(2+) movement in Madin-Darby canine renal tubular cells.

Journal: Human & experimental toxicology 20091001

Title: Infectious keratitis caused by Aspergillus tubingensis.

Journal: Cornea 20090901

Title: Synthesis and evaluation of different fatty acid esters formulated into Precirol ATO-Based lipid nanoparticles as vehicles for topical delivery.

Journal: Chemical & pharmaceutical bulletin 20090701

Title: The antifungal agent itraconazole induces the accumulation of high mannose glycoproteins in macrophages.

Journal: The Journal of biological chemistry 20090619

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Title: Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells.

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Title: Micromolar Zn(2+) potentiates the cytotoxic action of submicromolar econazole in rat thymocytes: possible disturbance of intracellular Ca(2+) and Zn(2+) homeostasis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601

Title: Di(2-ethylhexyl)phthalate stimulates Ca(2+) entry, chemotaxis and ROS production in human granulocytes.

Journal: Toxicology letters 20090522

Title: Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels.

Journal: The European respiratory journal 20090501

Title: Evaluation of solid lipid microparticles produced by spray congealing for topical application of econazole nitrate.

Journal: The Journal of pharmacy and pharmacology 20090501

Title: Extensive tinea versicolor mimicking Pityriasis rubra pilaris.

Journal: Journal of drugs in dermatology : JDD 20090501

Title: Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090302

Title: Physicochemical properties of antifungal drug-cyclodextrin complexes prepared by supercritical carbon dioxide and by conventional techniques.

Journal: Journal of pharmaceutical and biomedical analysis 20090220

Title: Improved bioequivalence assessment of topical dermatological drug products using dermatopharmacokinetics.

Journal: Pharmaceutical research 20090201

Title: Aurintricarboxylic acid inhibits influenza virus neuraminidase.

Journal: Antiviral research 20090201

Title: The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis.

Journal: Lipids 20090201

Title: High-throughput phase-distribution method to determine drug-cyclodextrin binding constants.

Journal: Journal of pharmaceutical sciences 20090101

Title: Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system.

Journal: Tuberculosis (Edinburgh, Scotland) 20090101

Title: Determination of azole antifungal medicines using zero-order and derivative UV spectrophotometry.

Journal: Acta poloniae pharmaceutica 20090101

Title: Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology.

Journal: Drugs 20090101

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Journal: PloS one 20090101

Title: Capacitative Ca2+ entry during Ca2+ undershoot in bovine airway smooth muscle.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

Journal: Molecular pain 20090101

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

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Title: How do azoles inhibit cytochrome P450 enzymes? A density functional study.

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Title: 1-[2-(2,4-Dichloro-benz-yloxy)-2-phenyl-ethyl]-1H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.

Journal: Antimicrobial agents and chemotherapy 20081001

Title: 1-[2-(4-Bromo-benz-yloxy)-2-phenyl-ethyl]-1H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online 20081001

Title: Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.

Journal: The American journal of geriatric pharmacotherapy 20080801

Title: 1-[2-(2,6-Dichloro-benz-yloxy)-2-(2-fur-yl)eth-yl]-1H-benzimidazole.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: 1-[2-(4-Fluoro-benz-yloxy)-2-phenyl-ethyl]-1H-benzimidazole.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: 1-[2-(3,4-Dichloro-benz-yloxy)-2-phenyl-ethyl]-1H-benzimidazole.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: 1-{2-Phenyl-2-[4-(trifluoro-meth-yl)-benzyl-oxy]eth-yl}-1H-benzimidazole.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.

Journal: Journal of medicinal chemistry 20080710

Title: Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.

Journal: Microbiology (Reading, England) 20080701

Title: 1-Phenyl-2-(1H-1,2,4-triazol-1-yl)ethanol.

Journal: Acta crystallographica. Section E, Structure reports online 20080701

Title: 2-(1H-Benzimidazol-1-yl)-1-phenyl-ethanone.

Journal: Acta crystallographica. Section E, Structure reports online 20080701

Title: Imidazole antifungals, but not triazole antifungals, increase membrane Zn2+ permeability in rat thymocytes Possible contribution to their cytotoxicity.

Journal: Toxicology 20080627

Title: Econazole-polycarbophil, a new delivery system for topical therapy: microbiological and clinical results on vaginal candidiasis.

Journal: Journal of chemotherapy (Florence, Italy) 20080601

Title: Development and validation of a method for quantitative determination of econazole nitrate in cream formulation by capillary zone electrophoresis.

Journal: Journal of chromatography. A 20080530

Title: Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient.

Journal: Medical mycology 20080501

Title: Mitochondrial regulation by c-Myc and hypoxia-inducible factor-1 alpha controls sensitivity to econazole.

Journal: Molecular cancer therapeutics 20080301

Title: Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.

Journal: The Journal of biological chemistry 20080222

Title: Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201

Title: Novel chemotherapy for tuberculosis: chemotherapeutic potential of econazole- and moxifloxacin-loaded PLG nanoparticles.

Journal: International journal of antimicrobial agents 20080201

Title: Medical interventions for fungal keratitis.

Journal: The Cochrane database of systematic reviews 20080123

Title: Medical management approach to infectious keratitis.

Journal: Indian journal of ophthalmology 20080101

Title: Topical fenticonazole in dermatology and gynaecology: current role in therapy.

Journal: Drugs 20080101

Title: Econazole-evoked [Ca2+]i rise and non-Ca2+-triggered cell death in rabbit corneal epithelial cells (SIRC).

Journal: Journal of receptor and signal transduction research 20080101

Title: Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

Journal: PloS one 20080101

Title: Herbal excipients in novel drug delivery systems.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Mechanisms of carvedilol-induced [Ca2+] i rises and death in human hepatoma cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20071101

Title: Fungal keratitis in London: microbiological and clinical evaluation.

Journal: Cornea 20071001

Title: Chemotherapeutic evaluation of alginate nanoparticle-encapsulated azole antifungal and antitubercular drugs against murine tuberculosis.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20070901

Title: [Establishment and application of a murine transplant model of bone marrow purging of metastatic breast cancer cells in vitro].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070901

Title: Enantioselective separation of azole compounds by EKC. Reversal of migration order of enantiomers with CD concentration.

Journal: Electrophoresis 20070801

Title: Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in-vitro characterization, ex-vivo and in-vivo studies.

Journal: The Journal of pharmacy and pharmacology 20070801

Title: Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.

Journal: PLoS pathogens 20070601

Title: [The relationship between Candida albicans 25S intron genotypes and antifungal susceptibilities].

Journal: Mikrobiyoloji bulteni 20070401

Title: Enantiomeric separation of several antimycotic azole drugs using supercritical fluid chromatography.

Journal: Journal of chromatography. A 20070316

Title: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: A new environmentally resistant cell type from Dictyostelium.

Journal: Microbiology (Reading, England) 20070201

Title: High-throughput method for lipophilicity measurement.

Journal: Analytical chemistry 20070201

Title: Near infrared spectrometry for the quantification of human dermal absorption of econazole nitrate and estradiol.

Journal: Pharmaceutical research 20070101

Title: Discontinued drugs in 2005: anti-infectives.

Journal: Expert opinion on investigational drugs 20070101

Title: Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea pig model.

Journal: Biological & pharmaceutical bulletin 20070101

Title: TRPM2.

Journal: Handbook of experimental pharmacology 20070101

Title: [The clinical and pathogenic characteristics of keratitis caused by Alternaria alternata].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20070101

Title: [Tinea nigra palmaris: a clinical case in Argentina].

Journal: Revista Argentina de microbiologia 20070101

Title: Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts.

Journal: Experimental & molecular medicine 20061231

Title: Antimycobacterial activity of econazole against multidrug-resistant strains of Mycobacterium tuberculosis.

Journal: International journal of antimicrobial agents 20061201

Title: Increase in anticoagulant effect of warfarin in a patient using econazole cream.

Journal: Journal of the American Academy of Dermatology 20061101

Title: A parenteral econazole formulation using a novel micelle-to-liposome transfer method: in vitro characterization and tumor growth delay in a breast cancer xenograft model.

Journal: Pharmaceutical research 20061101

Title: Inhibition of Ca2+ influx is required for mitochondrial reactive oxygen species-induced endoplasmic reticulum Ca2+ depletion and cell death in leukemia cells.

Journal: Molecular pharmacology 20061001

Title: Effects of Ca2+ channel blockers on store-operated Ca2+ channel currents of Kupffer cells after hepatic ischemia/reperfusion injury in rats.

Journal: World journal of gastroenterology 20060807

Title: Cloning and characterization of CYP51 from Mycobacterium avium.

Journal: American journal of respiratory cell and molecular biology 20060801

Title: What's your diagnosis? Nine-year-old girl with a pubic rash gone incognito.

Journal: Journal of pediatric and adolescent gynecology 20060801

Title: Azole antifungals as novel chemotherapeutic agents against murine tuberculosis.

Journal: FEMS microbiology letters 20060801

Title: Single-dose sertaconazole vaginal tablet treatment of vulvovaginal candidiasis.

Journal: Journal of the Chinese Medical Association : JCMA 20060601

Title: Econazole attenuates cytotoxicity of 1-methyl-4-phenylpyridinium by suppressing mitochondrial membrane permeability transition.

Journal: Brain research bulletin 20060531

Title: The potential of azole antifungals against latent/persistent tuberculosis.

Journal: FEMS microbiology letters 20060501

Title: Near-infrared spectrometry for the quantification of dermal absorption of econazole nitrate and 4-cyanophenol.

Journal: Pharmaceutical research 20060401

Title: Antimycotic influence of beta-cyclodextrin complexes--in vitro measurements using laser nephelometry in microtiter plates.

Journal: International journal of pharmaceutics 20060327

Title: What is the best way to treat tinea cruris?

Journal: The Journal of family practice 20060301

Title: A screening method for chiral selectors that does not require covalent attachment.

Journal: Journal of the American Chemical Society 20060222

Title: TRPV6 potentiates calcium-dependent cell proliferation.

Journal: Cell calcium 20060201

Title: Signaling pathways influencing SLF and c-kit-mediated survival and proliferation.

Journal: Immunologic research 20060101

Title: Molecular properties of econazole and sulconazole relevant to bioavailability.

Journal: Acta poloniae pharmaceutica 20060101

Title: [Diagnosis at a glance. Leisure athlete with itchy back].

Journal: MMW Fortschritte der Medizin 20051208

Title: [Congenital cutaneous candidiasis: a case report and review].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20051201

Title: Athlete's foot.

Journal: Clinical evidence 20051201

Title: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20051001

Title: The role of TRPM channels in cell death.

Journal: Pflugers Archiv : European journal of physiology 20051001

Title: In vitro and ex vivo antimycobacterial potential of azole drugs against Mycobacterium tuberculosis H37Rv.

Journal: FEMS microbiology letters 20051001

Title: Nano-encapsulation of azole antifungals: potential applications to improve oral drug delivery.

Journal: International journal of pharmaceutics 20050914

Title: Effects of econazole on Ca2+ levels in and the growth of human prostate cancer PC3 cells.

Journal: Clinical and experimental pharmacology & physiology 20050901

Title: Econazole induces increases in free intracellular Ca2+ concentrations in human osteosarcoma cells.

Journal: Human & experimental toxicology 20050901

Title: Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.

Journal: Microbiology (Reading, England) 20050601

Title: [Experimental study on apoptosis in leukemia cells induced by econazole].

Journal: Zhongguo shi yan xue ye xue za zhi 20050601

Title: Signaling pathways in the biphasic effect of ANG II on Na+/H+ exchanger in T84 cells.

Journal: The Journal of membrane biology 20050501

Title: Cytochrome P450 products and arachidonic acid-induced, non-store-operated, Ca2+ entry in cultured bovine endothelial cells.

Journal: Endothelium : journal of endothelial cell research 20050101

Title: Poliosis associated with treatment of fungal endophthalmitis.

Journal: Orbit (Amsterdam, Netherlands) 20041201

Title: In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis.

Journal: Chemotherapy 20041201

Title: Concurrent use of 5% natamycin and 2% econazole for the management of fungal keratitis.

Journal: Cornea 20041101

Title: Synthesis, antimicrobial activity and molecular modeling studies of halogenated 4-[1H-imidazol-1-yl(phenyl)methyl]-1,5-diphenyl-1H-pyrazoles.

Journal: Bioorganic & medicinal chemistry 20041015

Title: The calcium influx pathway in rat olfactory ensheathing cells shows TRPC channel pharmacology.

Journal: Brain research 20041008

Title: Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041001

Title: P2Y2-receptor-mediated activation of a contralateral, lanthanide-sensitive calcium entry pathway in the human airway epithelium.

Journal: British journal of pharmacology 20040901

Title: Imidazole analogues of fluoxetine, a novel class of anti-Candida agents.

Journal: Journal of medicinal chemistry 20040729

Title: Usage of antifungal drugs for therapy of genital Candida infections, purchased as over-the-counter products or by prescription: I. Analyses of a unique database.

Journal: Infectious diseases in obstetrics and gynecology 20040601

Title: Epidermal growth factor inhibits 14C-alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells: involvement of PLC/PKC, p44/42 MAPK, and cPLA2.

Journal: Journal of cellular physiology 20040501

Title: Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid.

Journal: FEBS letters 20040423

Title: Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors.

Journal: Chemico-biological interactions 20040415

Title: Antioxidative natural product protect against econazole-induced liver injuries.

Journal: Toxicology 20040301

Title: Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.

Journal: The Journal of biological chemistry 20040220

Title: Dermatophyte-related granular parakeratosis.

Journal: The American Journal of dermatopathology 20040201

Title: Co-isolation of Trichosporon inkin and Candida parapsilosis from a scalp white piedra case.

Journal: Medical mycology 20040201

Title: Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells.

Journal: Pflugers Archiv : European journal of physiology 20040101

Title: A population-based case-control teratological study of vaginal econazole treatment during pregnancy.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20031210

Title: Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery.

Journal: Biochemical pharmacology 20031201

Title: Experimental evaluation of antifungal and antiseptic agents against Rhodotorula spp.

Journal: Mycoses 20031201

Title: The role of calcium channels in substance P-induced contractile response in the rat iris.

Journal: Peptides 20031201

Title: Identification and prediction of promiscuous aggregating inhibitors among known drugs.

Journal: Journal of medicinal chemistry 20031009

Title: A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis.

Journal: The British journal of ophthalmology 20031001

Title: Enlarging pigmented patches on the hand.

Journal: International journal of dermatology 20031001

Title: Candidemia and the susceptibility pattern of Candida isolates in blood.

Journal: Saudi medical journal 20031001

Title: Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria.

Journal: International journal of dermatology 20030901

Title: Intracellular mediators of granulysin-induced cell death.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030901

Title: Effects of Toona sinensis leaf extract on lipolysis in differentiated 3T3-L1 adipocytes.

Journal: The Kaohsiung journal of medical sciences 20030801

Title: Ligand-activated signal transduction in the 2-cell embryo.

Journal: Biology of reproduction 20030701

Title: Effects of cytochrome P450 inhibitors on agonist-induced Ca2+ responses and production of NO and PGI2 in vascular endothelial cells.

Journal: Molecular and cellular biochemistry 20030601

Title: A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030501

Title: Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects.

Journal: Journal of veterinary pharmacology and therapeutics 20030201

Title: [The problem of otomycosis treatment].

Journal: Voenno-meditsinskii zhurnal 20030201

Title: Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane.

Journal: Journal of pharmaceutical sciences 20030101

Title: [Vulvovaginal candidiasis and sensitivity of pathogens to antimycotics].

Journal: Ceska gynekologie 20030101

Title: Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5-dichlorophenylcarbamate) chiral stationary phase.

Journal: Biomedical chromatography : BMC 20030101

Title: Effect of epidermal growth factor on phosphate uptake in renal proximal tubule cells: involvement of PKC, MAPK, and cPLA2.

Journal: Kidney & blood pressure research 20030101

Title: Ciclopiroxolamine: in vitro antifungal activity against clinical yeast isolates.

Journal: International journal of antimicrobial agents 20021101

Title: Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.

Journal: Microbiology (Reading, England) 20021001

Title: Sensitivity of myeloid leukemia cells to calcium influx blockade: application to bone marrow purging.

Journal: Experimental hematology 20021001

Title: Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.

Journal: The Journal of pharmacology and experimental therapeutics 20020901

Title: Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulum.

Journal: Journal of bioenergetics and biomembranes 20020801

Title: Assessing pregnancy risks of azole antifungals using a high throughput aromatase inhibition assay.

Journal: Endocrine research 20020801

Title: Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells.

Journal: Clinical and experimental pharmacology & physiology 20020701

Title: Bradykinin induces a calcium-store- dependent calcium influx in mouse mesangial cells.

Journal: Nephron 20020601

Title: Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.

Journal: Planta medica 20020601

Title: Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.

Journal: The Biochemical journal 20020515

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Purging of contaminating breast cancer cells from hematopoietic progenitor cell preparations using activation enhanced cell death.

Journal: Breast cancer research and treatment 20020401

Title: (2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species.

Journal: European journal of medicinal chemistry 20020301

Title: Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis.

Journal: Journal of oral science 20020301

Title: [Candidal vulvovaginitis: an epidemiological survey among immigrant prostitutes].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20020301

Title: Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography.

Journal: Journal of chromatography. A 20020301

Title: Comparative study of the enantiomeric resolution of chiral antifungal drugs econazole, miconazole and sulconazole by HPLC on various cellulose chiral columns in normal phase mode.

Journal: Journal of pharmaceutical and biomedical analysis 20020115

Title: Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.

Journal: British journal of pharmacology 20011001

Title: In vitro activity of 6 antifungal agents on candida species isolated as causative agents from vaginal and other clinical specimens.

Journal: Saudi medical journal 20011001

Title: Sertaconazole: in-vitro antifungal activity against vaginal and other superficial yeast isolates.

Journal: Journal of chemotherapy (Florence, Italy) 20011001

Title: Fendiline mobilizes intracellular Ca2+ in Chang liver cells.

Journal: Clinical and experimental pharmacology & physiology 20010901

Title: Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs.

Journal: Fresenius' journal of analytical chemistry 20010801

Title: Mechanisms and modulation of formyl-methionyl-leucyl-phenylalanine (fMLP)-induced Ca2+ mobilization in human neutrophils.

Journal: International immunopharmacology 20010701

Title: Fatty acids inhibit anion secretion in rat colon: apical and basolateral action sites.

Journal: Pflugers Archiv : European journal of physiology 20010701

Title: [Invasive rhinocerebral aspergillosis occurred during myelosuppressive phase after chemotherapy: a case report and literature review].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010701

Title: Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis.

Journal: Biochemical pharmacology 20010615

Title: Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron.

Journal: American journal of physiology. Endocrinology and metabolism 20010601

Title: Comparison of in vitro activities of amphotericin, clotrimazole, econazole, miconazole, and nystatin against Fusarium oxysporum.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20010501

Title: Antifungal and immunomodulating activities of 1,4-benzothiazine azole derivatives: review.

Journal: Journal of chemotherapy (Florence, Italy) 20010201

Title: [New developments in medical mycology].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20010201

Title: Systemic Candida infection in University hospital 1997-1999: the distribution of Candida biotypes and antifungal susceptibility patterns.

Journal: Mycopathologia 20010101

Title: Cellular mechanism of calcification and its prevention in glutaraldehyde treated vascular tissue.

Journal: Zeitschrift fur Kardiologie 20010101

Title: [Antifungal drug susceptibility of Candida causing oropharyngeal candidiasis in HIV infected patients].

Journal: Dakar medical 20010101

Title: Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis.

Journal: FEMS microbiology letters 20001115

Title: Synergy between 6-amino-2-n-pentylthiobenzothiazole and ergosterol biosynthesis-inhibiting antimycotics against Candida albicans in vitro.

Journal: International journal of antimicrobial agents 20000701

Title: In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp.

Journal: The Journal of antimicrobial chemotherapy 19951001

Title: In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.

Journal: Mycopathologia 19920401

Title: Antifungal activity of the allylamine derivative terbinafine in vitro.

Journal: Antimicrobial agents and chemotherapy 19870901

Title: Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones.

Journal: Journal of medicinal chemistry 19870801

Title: Thienpont D, et al. Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic. Arzneimittelforschung. 1975 Feb;25(2):224-30.

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Tags:27220-47-9 Molecular Formula|27220-47-9 MDL|27220-47-9 SMILES|27220-47-9 Econazole