Home Amines 29608-49-9
29608-49-9,MFCD01679060
Catalog No.:AA00I5E9

29608-49-9 | 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)

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1g
98%
in stock  
$24.00   $17.00
- +
5g
97%
in stock  
$37.00   $26.00
- +
100g
98%
in stock  
$710.00   $497.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I5E9
Chemical Name:
6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)
CAS Number:
29608-49-9
Molecular Formula:
C28H37F2N7O6S2
Molecular Weight:
669.7635
MDL Number:
MFCD01679060
SMILES:
CS(=O)(=O)O.CS(=O)(=O)O.C=CCNc1nc(nc(n1)NCC=C)N1CCN(CC1)C(c1ccc(cc1)F)c1ccc(cc1)F
Properties
Computed Properties
 
Complexity:
694  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  

Literature

Title: Pharmacological Treatment of Hypoxemia during One-lung Ventilation.

Journal: Anesthesiology 20110801

Title: Almitrine-Raubasine combination for dementia.

Journal: The Cochrane database of systematic reviews 20110316

Title: Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry.

Journal: Drug testing and analysis 20090601

Title: [Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].

Journal: Terapevticheskii arkhiv 20080101

Title: Low-tidal-volume ventilation.

Journal: The New England journal of medicine 20071213

Title: [Clinical research of effect of Yishen Yangnao capsule on vascular dementia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation.

Journal: British journal of anaesthesia 20050901

Title: Treatment of hypoxemia during one-lung ventilation using intravenous almitrine.

Journal: Anesthesia and analgesia 20040301

Title: Assessment of the therapeutic activity of a combination of almitrine and raubasine on functional rehabilitation following ischaemic stroke.

Journal: Current medical research and opinion 20040301

Title: Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy.

Journal: Anaesthesia and intensive care 20031001

Title: Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia.

Journal: Respiratory medicine 20030601

Title: Selective pulmonary vasodilation in acute respiratory distress syndrome.

Journal: Critical care medicine 20030401

Title: Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study.

Journal: Respiration; international review of thoracic diseases 20030101

Title: pO2 - Do we treat the right thing?

Journal: Respiration; international review of thoracic diseases 20030101

Title: Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20021201

Title: Primary alveolar hypoventilation and response to the respiratory stimulant almitrine.

Journal: Internal medicine journal 20021201

Title: Treatment of hypoxaemia during one-lung ventilation with almitrine.

Journal: Lancet (London, England) 20020413

Title: The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.

Journal: Anesthesia and analgesia 20020401

Title: [Effect of almitrine/raubasine on cerebral metabolism in the elderly].

Journal: Presse medicale (Paris, France : 1983) 20020330

Title: Effects of almitrine on diaphragm contractile properties in young and old rats.

Journal: Respiration; international review of thoracic diseases 20020101

Title: An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue.

Journal: Respiration; international review of thoracic diseases 20020101

Title: High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine?

Journal: Intensive care medicine 20011101

Title: [Comparative changes in PaO2 in moderately hypoxemic COPD patients treated with almitrine versus placebo for one year].

Journal: Revue des maladies respiratoires 20010901

Title: Association of oral almitrine and medroxyprogesterone acetate: effect on arterial blood gases in chronic obstructive pulmonary disease.

Journal: Respiratory medicine 20010701

Title: Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury.

Journal: Intensive care medicine 20010301

Title: Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury.

Journal: Anesthesiology 20010301

Title: Effect of almitrine on upper airway muscle contraction in young and old rats.

Journal: European journal of pharmacology 20010126

Title: Right ventricular response to high-dose almitrine infusion in patients with severe hypoxemia related to acute respiratory distress syndrome.

Journal: Critical care medicine 20010101

Title: Peripheral neuropathy in patients treated with almitrine dimesylate.

Journal: Lancet (London, England) 19850601

Title: [Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases].

Journal: Annales de l'anesthesiologie francaise 19800101

Title: López-López JR, et al. Effects of Almitrine bismesylate on the ionic currents of chemoreceptor cells from the carotid body. Mol Pharmacol. 1998 Feb;53(2):330-9.

Title: Bee D, et al. An analysis of the action of an analogue of Almitrine bismesylate in the rat model of hypoxic lung disease. Exp Physiol. 1992 Nov;77(6):819-28.

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Tags:29608-49-9 Molecular Formula|29608-49-9 MDL|29608-49-9 SMILES|29608-49-9 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)