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312-84-5,MFCD00004269
Catalog No.:AA00I5RT

312-84-5 | D-Serine

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1g
95%
in stock  
$6.00   $4.00
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5g
95%
in stock  
$7.00   $5.00
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10g
98%
in stock  
$9.00   $6.00
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25g
95%
in stock  
$12.00   $8.00
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100g
95%
in stock  
$14.00   $10.00
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500g
98%
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$42.00   $29.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I5RT
Chemical Name:
D-Serine
CAS Number:
312-84-5
Molecular Formula:
C3H7NO3
Molecular Weight:
105.0926
MDL Number:
MFCD00004269
SMILES:
OC[C@H](C(=O)O)N
Properties
Properties
 
BP:
394.8°C at 760 mmHg  
Form:
Solid  
MP:
220 °C  
Refractive Index:
1.4368 (estimate)  
Solubility:
H2O: 0.1 g/mL, clear, colorless  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
72.6  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-3.1  

Literature

Title: Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101

Title: Functional roles of endogenous D-serine in the chronic pain-induced plasticity of NMDAR-mediated synaptic transmission in the central amygdala of mice.

Journal: Neuroscience letters 20120627

Title: An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.

Journal: PloS one 20120101

Title: Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

Journal: Analytical biochemistry 20111215

Title: The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.

Journal: British journal of pharmacology 20111201

Title: N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain.

Journal: European journal of pain (London, England) 20110501

Title: D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).

Journal: Journal of neuroscience research 20100601

Title: Total synthesis of the large non-ribosomal peptide polytheonamide B.

Journal: Nature chemistry 20100401

Title: [Interaction between gabapentin and D-serin in the formalin orofacial test].

Journal: Investigacion clinica 20091201

Title: Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20091001

Title: Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.

Journal: Journal of medicinal chemistry 20090827

Title: AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.

Journal: Nature chemical biology 20090301

Title: EAAT1 and D-serine expression are early features of human retinal development.

Journal: Experimental eye research 20070501

Title: D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension.

Journal: Kidney international 20060901

Title: Neurotransmitter transporters and their impact on the development of psychopharmacology.

Journal: British journal of pharmacology 20060101

Title: Biochemical characterization of biocontrol agents used for control of root pathogens.

Journal: Communications in agricultural and applied biological sciences 20060101

Title: Preferred stereoselective brain uptake of d-serine--a modulator of glutamatergic neurotransmission.

Journal: Nuclear medicine and biology 20051101

Title: The vanG glycopeptide resistance operon from Enterococcus faecalis revisited.

Journal: Molecular microbiology 20031101

Title: Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain.

Journal: The European journal of neuroscience 20031001

Title: Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.

Journal: The EMBO journal 20030616

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon.

Journal: Biochemical and biophysical research communications 20020222

Title: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.

Journal: The Journal of biological chemistry 20010518

Title: Resistance to D-cycloserine in the tubercle bacilli: mutation rate and transport of alanine in parental cells and drug-resistant mutants.

Journal: Applied microbiology 19710501

Title: Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.

Title: MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25.

Title: Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.

Title: Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.

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