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37739-05-2,MFCD00078574
Catalog No.:AA00I7CX

37739-05-2 | 2-Chloro-N-cyclopentyladenosine

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10mg
≥98%
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$48.00   $33.00
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50mg
≥98%
in stock  
$153.00   $107.00
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100mg
≥98%
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$258.00   $180.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I7CX
Chemical Name:
2-Chloro-N-cyclopentyladenosine
CAS Number:
37739-05-2
Molecular Formula:
C15H20ClN5O4
Molecular Weight:
369.8034
MDL Number:
MFCD00078574
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1
Properties
Computed Properties
 
Complexity:
471  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
1.8  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2000,vol.43,p.250-260

[2]Journalofmedicinalchemistry,1991,vol.34,p.3388-3390

[3]Patent:WO2005/117910,2005,A2.Locationinpatent:Page/Pagecolumn129

[4]Patent:WO2006/125211,2006,A1.Locationinpatent:Page/Pagecolumn36-37

[5]Patent:WO2006/125190,2006,A1.Locationinpatent:Page/Pagecolumn38

[6]Patent:WO2010/127210,2010,A1.Locationinpatent:Page/Pagecolumn35

[7]Patent:US2014/275128,2014,A1.Locationinpatent:Paragraph0177

[8]Patent:WO2018/67424,2018,A1.Locationinpatent:Paragraph0211

[9]Patent:WO2018/94148,2018,A1.Locationinpatent:Paragraph0187

[10]Patent:WO2019/173682,2019,A1.Locationinpatent:Paragraph0292

[1]Patent:WO2017/120508,2017,A1.Locationinpatent:Paragraph0179

[2]Patent:WO2019/173682,2019,A1.Locationinpatent:Paragraph0275

Literature

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Journal: Journal of molecular and cellular cardiology 20121101

Title: Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.

Journal: Kidney international 20121001

Title: Role of A1 receptors in renal sympathetic neurotransmission in the mouse kidney.

Journal: American journal of physiology. Renal physiology 20121001

Title: Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Journal: Journal of medicinal chemistry 20120927

Title: Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120919

Title: Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.

Journal: Journal of medicinal chemistry 20120913

Title: Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes.

Journal: Journal of cellular physiology 20120901

Title: Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats.

Journal: Head & neck 20120801

Title: Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.

Journal: Journal of medicinal chemistry 20120726

Title: Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.

Journal: American journal of physiology. Renal physiology 20120715

Title: Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.

Journal: Brain research 20120612

Title: The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.

Journal: Autophagy 20120601

Title: Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1 receptor-mediated coincident signaling.

Journal: American journal of physiology. Renal physiology 20120215

Title: Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120215

Title: Acute down-regulation of adenosine A(1) receptor activity in status epilepticus.

Journal: Epilepsia 20120101

Title: The antinociceptive effect of electroacupuncture at different depths of acupoints and under the needling surface.

Journal: Chinese medicine 20120101

Title: Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Sex differences and the effects of ovariectomy on the β-adrenergic contractile response.

Journal: American journal of physiology. Heart and circulatory physiology 20110901

Title: Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning.

Journal: American journal of physiology. Heart and circulatory physiology 20110601

Title: Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.

Journal: European journal of pharmacology 20110115

Title: A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA 'Ecstasy'-induced striatal dopamine release.

Journal: European journal of pharmacology 20110110

Title: Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach.

Journal: The Journal of pharmacology and experimental therapeutics 20110101

Title: Autocrine signaling via A(1) adenosine receptors causes downregulation of M(2) receptors in adult rat atrial myocytes in vitro.

Journal: Pflugers Archiv : European journal of physiology 20110101

Title: Chronic pharmacological preconditioning against ischemia.

Journal: Clinical hemorheology and microcirculation 20110101

Title: Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.

Journal: Molecular and cellular biochemistry 20101201

Title: Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.

Journal: American journal of physiology. Heart and circulatory physiology 20100701

Title: Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100701

Title: Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes.

Journal: Clinical and experimental pharmacology & physiology 20100301

Title: Adenosine A1 receptor blockage mediates theophylline-associated seizures.

Journal: Epilepsia 20100301

Title: Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.

Journal: Hearing research 20100201

Title: The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.

Journal: Brain research 20100108

Title: Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091201

Title: Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes.

Journal: Biochimica et biophysica acta 20091201

Title: Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.

Journal: Journal of cardiovascular pharmacology 20090901

Title: Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.

Journal: American journal of physiology. Heart and circulatory physiology 20090801

Title: [Metallothionein mediates cardioprotection induced by delayed preconditioning with adenosine A1 receptor agonist in rabbits].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090701

Title: Regulation of somatostatin release by adenosine in the mouse stomach.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA.

Journal: Basic research in cardiology 20090301

Title: Adenosine A1 and A3 receptor agonists inhibit nonadrenergic, noncholinergic relaxations in the guinea pig isolated trachea.

Journal: Respiration; international review of thoracic diseases 20090101

Title: Drug-eluting stent for delivery of signal pathway-specific 1,3-dipropyl-8-cyclopentyl xanthine.

Journal: Molecular pharmaceutics 20090101

Title: Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms.

Journal: Acta anaesthesiologica Scandinavica 20081101

Title: Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.

Journal: Journal of medicinal chemistry 20080925

Title: Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.

Journal: Journal of medicinal chemistry 20080724

Title: Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction.

Journal: Neuroscience 20080717

Title: Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats.

Journal: Clinical science (London, England : 1979) 20080701

Title: Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist.

Journal: Alcoholism, clinical and experimental research 20080701

Title: Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080601

Title: Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080601

Title: Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.

Journal: The journal of sexual medicine 20080501

Title: Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21.

Journal: Physiological genomics 20080422

Title: Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20080101

Title: 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.

Journal: Bioorganic & medicinal chemistry 20080101

Title: Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: Adenosine reduces the reverse mode of the Na+/Ca(2+) exchanger in ferret cardiac fibres.

Journal: Canadian journal of physiology and pharmacology 20080101

Title: Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats.

Journal: Molecular pain 20080101

Title: Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors.

Journal: American journal of physiology. Renal physiology 20071201

Title: The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat.

Journal: Pain 20071001

Title: G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.

Journal: The Journal of physiology 20070601

Title: The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart.

Journal: Interactive cardiovascular and thoracic surgery 20070601

Title: Role of NO and COX pathways in mediation of adenosine A1 receptor-induced renal vasoconstriction.

Journal: Experimental biology and medicine (Maywood, N.J.) 20070501

Title: Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.

Journal: European journal of anaesthesiology 20070301

Title: Adenosine enhances cytosolic phosphorylation potential and ventricular contractility in stunned guinea pig heart: receptor-mediated and metabolic protection.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20070301

Title: Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat.

Journal: World journal of gastroenterology 20070128

Title: The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.

Journal: American journal of physiology. Heart and circulatory physiology 20070101

Title: Differential effect of serum from bipolar versus schizophrenic patients on spontaneous acetylcholine release at mammalian neuromuscular junction.

Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20061201

Title: Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs.

Journal: The Journal of physiology 20060901

Title: Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.

Journal: Neuroscience 20060811

Title: Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction.

Journal: Biochemical pharmacology 20060314

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Journal: Nature reviews. Drug discovery 20060301

Title: Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20060101

Title: Anesthetic preconditioning as the alternative to ischemic preconditioning.

Journal: The Journal of thoracic and cardiovascular surgery 20060101

Title: Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.

Journal: Journal of medicinal chemistry 20051229

Title: Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS.

Journal: American journal of physiology. Heart and circulatory physiology 20051101

Title: A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Indirect activation of adenosine A1 receptors in cultured rat hippocampal neurons by volatile anaesthetics.

Journal: European journal of anaesthesiology 20050901

Title: Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent.

Journal: American journal of physiology. Heart and circulatory physiology 20050801

Title: Pretreatment with an adenosine A1 receptor agonist and lidocaine: a possible alternative to myocardial ischemic preconditioning.

Journal: The Journal of thoracic and cardiovascular surgery 20050801

Title: Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte homeostasis after mitochondrial respiratory chain injury.

Journal: American journal of physiology. Heart and circulatory physiology 20050601

Title: New adenosine A2A receptor antagonists: actions on Parkinson's disease models.

Journal: European journal of pharmacology 20050411

Title: Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.

Journal: Neuroscience letters 20050316

Title: The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes.

Journal: Biochemical pharmacology 20050315

Title: Role of A1 adenosine receptors in regulation of vascular tone.

Journal: American journal of physiology. Heart and circulatory physiology 20050301

Title: Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.

Journal: The Journal of clinical investigation 20050301

Title: Modulating effect of adenosine deaminase on function of adenosine A1 receptors.

Journal: Acta pharmacologica Sinica 20050201

Title: 2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model.

Journal: Pharmacological reports : PR 20050101

Title: Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.

Journal: European journal of pharmacology 20040919

Title: Comparative analysis of putative agonist-binding modes in the human A1 adenosine receptor.

Journal: Chembiochem : a European journal of chemical biology 20040607

Title: Presynaptic inhibition of spontaneous acetylcholine release induced by adenosine at the mouse neuromuscular junction.

Journal: British journal of pharmacology 20040501

Title: Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.

Journal: Circulation 20040413

Title: Role of adenosine receptor activation in antioxidant enzyme regulation during ischemia-reperfusion in the isolated rat heart.

Journal: Antioxidants & redox signaling 20040401

Title: 2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.

Journal: Bioorganic & medicinal chemistry letters 20040322

Title: Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040301

Title: A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion.

Journal: American journal of physiology. Renal physiology 20040201

Title: Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation.

Journal: American journal of physiology. Heart and circulatory physiology 20031001

Title: Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030801

Title: Comparison of effects of MgCl2 and Gpp(NH)p on antagonist and agonist radioligand binding to adenosine A1 receptors.

Journal: Acta pharmacologica Sinica 20030801

Title: Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy.

Journal: Epilepsia 20030701

Title: A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus.

Journal: British journal of pharmacology 20030601

Title: N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.

Journal: Journal of medicinal chemistry 20030410

Title: Modulation of agonist responses at the A(1) adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state.

Journal: Biochemical pharmacology 20021015

Title: Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology.

Journal: Brain research 20021004

Title: Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Journal: Journal of medicinal chemistry 20020926

Title: Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy.

Journal: Neuroscience letters 20020906

Title: Reperfusion duration paradox with late myocardial preconditioning in rabbits.

Journal: European journal of pharmacology 20020823

Title: Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain.

Journal: Neuroscience letters 20020816

Title: Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

Journal: Cardiovascular research 20020815

Title: Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.

Journal: Cardiovascular research 20020815

Title: Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway.

Journal: American journal of physiology. Heart and circulatory physiology 20020701

Title: Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

Journal: British journal of pharmacology 20020601

Title: Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.

Journal: The American journal of pathology 20020601

Title: 2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor.

Journal: European journal of pharmacology 20020517

Title: Preconditioning of rat hearts by adenosine A1 or A3 receptor activation.

Journal: European journal of pharmacology 20020426

Title: Human A(2A) adenosine receptors: high-affinity agonist binding to receptor-G protein complexes containing Gbeta(4).

Journal: Molecular pharmacology 20020201

Title: Nitric oxide as a mediator of delayed pharmacological (A(1) receptor triggered) preconditioning; is eNOS masquerading as iNOS?

Journal: Cardiovascular research 20020201

Title: Mechanisms of glutamate release in the rat spinal cord slices during metabolic inhibition.

Journal: Journal of neurotrauma 20020201

Title: Lipopolysaccharide binds to and activates A(1) adenosine receptors on human pulmonary artery endothelial cells.

Journal: Journal of endotoxin research 20020101

Title: Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat.

Journal: Neuroscience 20020101

Title: Molecular modeling the human A1 adenosine receptor and study of the mechanisms of its selective ligand binding.

Journal: Doklady. Biochemistry and biophysics 20020101

Title: Mechanisms of delayed preconditioning with A1 adenosine receptor activation in porcine coronary smooth muscle cells.

Journal: Polish journal of pharmacology 20020101

Title: Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201

Title: Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20011001

Title: Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors.

Journal: Cardiovascular research 20010901

Title: 5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.

Journal: Journal of medicinal chemistry 20010830

Title: Delayed or second window preconditioning induced by adenosine A1 receptor activation is independent of early generation of nitric oxide or late induction of inducible nitric oxide synthase.

Journal: Journal of cardiovascular pharmacology 20010801

Title: Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.

Journal: Journal of molecular and cellular cardiology 20010601

Title: 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.

Journal: Neuropharmacology 20010401

Title: A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.

Journal: Circulation research 20010316

Title: Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons.

Journal: Circulation 20010306

Title: Adenosine-induced late preconditioning in mouse hearts: role of p38 MAP kinase and mitochondrial K(ATP) channels.

Journal: American journal of physiology. Heart and circulatory physiology 20010301

Title: Antiarrhythmic effects of adenosine on ischemia-induced ventricular fibrillation.

Journal: Journal of critical care 20010301

Title: Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning.

Journal: Cardiovascular research 20010301

Title: Antiadrenergic effects of adenosine in pressure overload hypertrophy.

Journal: Hypertension (Dallas, Tex. : 1979) 20010301

Title: Seizure activity produces differential changes in adenosine A1 receptors within rat hippocampus.

Journal: Neurochemical research 20010301

Title: Role of adenosine and glycogen in ischemic preconditioning of rat hearts.

Journal: European journal of pharmacology 20010223

Title: The calcium-dependent [3H]acetylcholine release from synaptosomes of brown trout (Salmo trutta) optic tectum is inhibited by adenosine A1 receptors: effects of enucleation on A1 receptor density and cholinergic markers.

Journal: Brain research 20010216

Title: Characterization of a G protein-coupled receptor for nicotinic acid.

Journal: Molecular pharmacology 20010201

Title: Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes.

Journal: Journal of molecular and cellular cardiology 20010101

Title: Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.

Journal: Molecular and cellular biochemistry 20010101

Title: [Comparative characteristics of A1-receptor agonists as neuroprotective agents].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.

Journal: Circulation 20000822

Title: N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.

Journal: Journal of medicinal chemistry 20000127

Title: Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.

Journal: Molecular pharmacology 19991001

Title: Mechanisms of inhibitory effects of zinc and cadmium ions on agonist binding to adenosine A1 receptors in rat brain.

Journal: Biochemical pharmacology 19990815

Title: Identification of the adenine binding site of the human A1 adenosine receptor.

Journal: The Journal of biological chemistry 19990205

Title: 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.

Journal: Journal of medicinal chemistry 19980507

Title: Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19980101

Title: 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.

Journal: Journal of medicinal chemistry 19941014

Title: Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.

Journal: The Journal of pharmacology and experimental therapeutics 19931101

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SDS
Tags:37739-05-2 Molecular Formula|37739-05-2 MDL|37739-05-2 SMILES|37739-05-2 2-Chloro-N-cyclopentyladenosine