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3918-87-4,MFCD00243055
Catalog No.:AA00I7NK

3918-87-4 | H-Phe-ala-oh

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1g
95%
in stock  
$37.00   $26.00
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5g
95%
in stock  
$100.00   $70.00
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10g
95%
in stock  
$185.00   $130.00
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25g
95%
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$444.00   $311.00
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100g
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$1,389.00   $973.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I7NK
Chemical Name:
H-Phe-ala-oh
CAS Number:
3918-87-4
Molecular Formula:
C12H16N2O3
Molecular Weight:
236.2670
MDL Number:
MFCD00243055
SMILES:
N[C@H](C(=O)N[C@H](C(=O)O)C)Cc1ccccc1
Properties
Computed Properties
 
Complexity:
275  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
-2.9  

Downstream Synthesis Route

[1]Oya,Masanao;Takahashi,Tomoko[BulletinoftheChemicalSocietyofJapan,1981,vol.54,#9,p.2705-2707]

(S)-2-(S)-2-((S)-2-Oxo-4-phenyl-oxazolidin-3-yl)-3-phenyl-propionylamino-propionicacid 
  3918-87-4 

[1]Ojima,Iwao;Chen,Hauh-JyunC.;Qiu,Xiaogang[Tetrahedron,1988,vol.44,#17,p.5307-5318]

N-(S)-1-((S)-1-Carboxy-ethylcarbamoyl)-2-phenyl-ethyl-phthalamicacid 
  3918-87-4    88-99-3 

[1]Costello,ColleenA.;Kreuzman,AdamJ.;Zmijewski,MiltonJ.[TetrahedronLetters,1996,vol.37,#42,p.7469-7472]

773-64-8    3918-87-4   
(S)-2-(S)-3-Phenyl-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionylamino-propionicacid 

[1]Scozzafava,Andrea;Supuran,ClaudiuT[BioorganicandMedicinalChemistryLetters,2002,vol.12,#19,p.2667-2672]

16629-19-9    3918-87-4   
(S)-2-(S)-3-Phenyl-2-(thiophene-2-sulfonylamino)-propionylamino-propionicacid 

[1]Scozzafava,Andrea;Supuran,ClaudiuT[BioorganicandMedicinalChemistryLetters,2002,vol.12,#19,p.2667-2672]

Literature

Title: Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.

Journal: Bioorganic & medicinal chemistry 20110801

Title: Phe-Ala-based diazaspirocyclic lactam as nucleator of type II' β-turn.

Journal: The Journal of organic chemistry 20110204

Title: Single-conformation ultraviolet and infrared spectroscopy of model synthetic foldamers: beta-peptides Ac-beta3-hPhe-beta3-hAla-NHMe and Ac-beta3-hAla-beta3-hPhe-NHMe.

Journal: Journal of the American Chemical Society 20080409

Title: Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20080314

Title: Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.

Journal: Journal of medicinal chemistry 20060615

Title: Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues.

Journal: The Journal of organic chemistry 20050722

Title: Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.

Journal: Journal of medicinal chemistry 20050630

Title: Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations.

Journal: Journal of medicinal chemistry 20040212

Title: Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: P3 cap modified Phe*-Ala series BACE inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions.

Journal: Bioorganic & medicinal chemistry letters 20021007

Title: Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line.

Journal: FEBS letters 20011123

Title: Kinetic analysis of the conjugation of ubiquitin to picornavirus 3C proteases catalyzed by the mammalian ubiquitin-protein ligase E3alpha.

Journal: The Journal of biological chemistry 20011026

Title: N-end rule specificity within the ubiquitin/proteasome pathway is not an affinity effect.

Journal: The Journal of biological chemistry 20011019

Title: L-Phenylalanyl-L-alanine dihydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010501

Title: Facchin G, et al. Experimental and theoretical studies of copper complexes with isomeric dipeptides as novel candidates against breast cancer. J Inorg Biochem. 2016;162:52‐61.

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