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Title: Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors.
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Title: Assessment of amsacrine binding with DNA using UV-visible, circular dichroism and Raman spectroscopic techniques.
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Title: Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair.
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Title: Intensive consolidation therapy compared with standard consolidation and maintenance therapy for adults with acute myeloid leukaemia aged between 46 and 60 years: final results of the randomized phase III study (AML 8B) of the European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups.
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Title: A novel tetrahydrobenzoangelicin with dark and photo biological activity.
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Title: Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives.
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Title: Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen.
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Title: The cadmium-mercaptoacetic acid complex contributes to the genotoxicity of mercaptoacetic acid-coated CdSe-core quantum dots.
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Title: Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery.
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Title: A clinical study of Nirgundi Ghana Vati and Matra Basti in the management of Gridhrasi with special reference to sciatica.
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Title: Randomized placebo-controlled trial of Mustadi Ghanavati in hyperlipidemia.
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Title: Fludarabine, amsacrine, high-dose cytarabine and 12 Gy total body irradiation followed by allogeneic hematopoietic stem cell transplantation is effective in patients with relapsed or high-risk acute lymphoblastic leukemia.
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Title: Population dynamics of methicillin-susceptible and -resistant Staphylococcus aureus in remote communities.
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Title: Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings.
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Title: DNA-targeting pyrroloquinoline-linked butenone and chalcones: synthesis and biological evaluation.
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Title: Genistein inhibition of topoisomerase IIalpha expression participated by Sp1 and Sp3 in HeLa cell.
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Title: Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+.
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Title: Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.
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Title: Impact of age, leukocyte count and day 21-bone marrow response to chemotherapy on the long-term outcome of children with philadelphia chromosome-positive acute lymphoblastic leukemia in the pre-imatinib era: results of the FRALLE 93 study.
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Title: Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks.
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Title: An experimental and theoretical study of dipole moments of N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide.
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Title: Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.
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Title: Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia.
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Title: Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents.
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Title: Discovery of a new anilino-3H-pyrrolo[3,2-f]quinoline derivative as potential anti-cancer agent.
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Title: Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives.
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Title: Development and validation of bioanalytical method for the determination of asulacrine in plasma by liquid chromatography.
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Title: Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death.
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Title: Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
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Title: 3,5-bis(3'-indolyl)pyrazoles, analogues of marine alkaloid nortopsentin: synthesis and antitumor properties.
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Title: The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.
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Title: Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A.
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Title: Decitabine in the treatment of myelodysplastic syndromes.
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Title: Generation and identification of reactive metabolites by electrochemistry and immobilized enzymes coupled on-line to liquid chromatography/mass spectrometry.
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Title: Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
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Title: Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure.
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Title: Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia: a trial by the Acute Leukemia French Association (ALFA) Group.
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Title: Autologous stem cell transplantation after complete remission and first consolidation in acute myeloid leukemia patients aged 61-70 years: results of the prospective EORTC-GIMEMA AML-13 study.
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Title: Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature.
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Journal: Journal of medicinal chemistry 20031218
Title: A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia.
Journal: Blood 20031215
Title: Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?
Journal: Current medicinal chemistry 20031201
Title: More efficient mobilisation of peripheral blood stem cells with HiDAC+AMSA+G-CSF than with mini-ICE+G-CSF in patients with AML.
Journal: Bone marrow transplantation 20031201
Title: [Topotecan-based combined chemotherapy for refractory or relapsed hematologic malignancies].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20031101
Title: Stem cell transplantation after salvage therapy with high-dose cytarabine and amsacrine in adults with high-risk leukaemia.
Journal: Bone marrow transplantation 20030801
Title: Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia.
Journal: British journal of haematology 20030801
Title: Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.
Journal: Anti-cancer drugs 20030801
Title: Acute pericarditis and pleural effusion complicating cytarabine chemotherapy.
Journal: Onkologie 20030801
Title: A preliminary evaluation of a new selective agar supplemented with desferrioxamine for detection of methicillin-resistant Staphylococcus aureus.
Journal: The Journal of hospital infection 20030701
Title: In vitro chemosensitivity testing of selected myeloid cells in acute myeloid leukemia.
Journal: Leukemia & lymphoma 20030501
Title: Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Journal: The Journal of biological chemistry 20030411
Title: Amino acid substitutions at position 43 of NaeI endonuclease. Evidence for changes in NaeI structure.
Journal: The Journal of biological chemistry 20030314
Title: Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
Journal: Journal of medicinal chemistry 20030313
Title: Salvage therapy in refractory acute myeloid leukemia: prediction of outcome based on analysis of prognostic factors.
Journal: Leukemia research 20030301
Title: Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission.
Journal: Blood 20030215
Title: Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.
Journal: Mutation research 20030205
Title: Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2.
Journal: Biochimica et biophysica acta 20030103
Title: [Effect of etoposide and amsacrine on mitotic progression of GM-130 and Hep-2 cell lines. The flow cytometry assay].
Journal: Tsitologiia 20030101
Title: Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Favorable outcome with STI571 (imatinib mesylate) and allogeneic stem cell transplantation in a case of Ph+ chemorefractory acute lymphocytic leukaemia.
Journal: Bone marrow transplantation 20021201
Title: Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
Journal: Journal of medicinal chemistry 20021010
Title: Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.
Journal: The Biochemical journal 20020901
Title: Point of attachment and sequence of immobilized peptide-acridine conjugates control affinity for nucleic acids.
Journal: Journal of the American Chemical Society 20020724
Title: Tetrakis-acridinyl peptide: a novel fluorometric reagent for nucleic acid analysis based on the fluorescence dequenching upon DNA binding.
Journal: The Analyst 20020701
Title: A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.
Journal: Biochemistry 20020625
Title: Increased expression of beta 2-microglobulin in multidrug-resistant tumour cells.
Journal: British journal of cancer 20020617
Title: Impact of addition of maintenance therapy to intensive induction and consolidation chemotherapy for childhood acute myeloblastic leukemia: results of a prospective randomized trial, LAME 89/91. Leucámie Aiqüe Myéloïde Enfant.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020615
Title: High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.
Journal: Carcinogenesis 20020601
Title: Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.
Journal: British journal of cancer 20020506
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine.
Journal: Biochemical pharmacology 20020215
Title: Phase I study of the combination of losoxantrone and cyclophosphamide in patients with refractory solid tumours.
Journal: British journal of cancer 20020212
Title: Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Journal: Blood 20020101
Title: Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination.
Journal: International journal of cancer 20020101
Title: A study of amsalog (CI-921) administered orally on a 5-day schedule, with bioavailability and pharmacokinetically guided dose escalation.
Journal: Cancer chemotherapy and pharmacology 20020101
Title: A rare case of adenoviral fulminant hepatic necrosis after chemotherapy.
Journal: Pediatric hematology and oncology 20020101
Title: Compatibility and stability of 5-HT3 receptor antagonists: a pharmacology review.
Journal: Oncology nursing forum 20020101
Title: Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.
Journal: Molecular cancer therapeutics 20020101
Title: Partial purification of mitochondrial DNA topoisomerase II from Plasmodium falciparum and its sensitivity to inhibitors.
Journal: The Southeast Asian journal of tropical medicine and public health 20011201
Title: Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences.
Journal: Current medicinal chemistry. Anti-cancer agents 20011101
Title: Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).
Journal: Biochemical pharmacology 20011015
Title: Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines.
Journal: Japanese journal of cancer research : Gann 20011001
Title: Co-amplification of dhfr and a homologue of hmsh3 in a Chinese hamster methotrexate-resistant cell line correlates with resistance to a range of chemotherapeutic drugs.
Journal: Cancer chemotherapy and pharmacology 20011001
Title: FAB M4 and high CD14 surface expression is associated with high cellular resistance to Ara-C and daunorubicin: implications for clinical outcome in acute myeloid leukaemia.
Journal: European journal of haematology 20011001
Title: Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta.
Journal: British journal of cancer 20010901
Title: Altered topoisomerase IIalpha and multidrug resistance-associated protein levels during drug selection: adaptations to increasing drug pressure.
Journal: Japanese journal of cancer research : Gann 20010901
Title: Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells.
Journal: Biochemical pharmacology 20010901
Title: Amsacrine and cisplatin in poor prognosis patients with metastatic transitional cell carcinoma of the urothelium: a phase-II study.
Journal: European urology 20010901
Title: Reciprocal control of expression of mRNAs for osteoclast differentiation factor and OPG in osteogenic stromal cells by genistein: evidence for the involvement of topoisomerase II in osteoclastogenesis.
Journal: Endocrinology 20010801
Title: Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes.
Journal: British journal of clinical pharmacology 20010801
Title: Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha.
Journal: Gene 20010711
Title: Novel pyrrolo[3,2-f]quinolines: synthesis and antiproliferative activity.
Journal: Bioorganic & medicinal chemistry 20010701
Title: Expression of drug resistance genes in VP-16 and mAMSA-selected human carcinoma cells.
Journal: Japanese journal of cancer research : Gann 20010701
Title: Hypophosphorylation of topoisomerase IIalpha in etoposide (VP-16)-resistant human carcinoma cell lines associated with carboxy-terminal truncation.
Journal: Japanese journal of cancer research : Gann 20010701
Title: Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
Journal: Journal of medicinal chemistry 20010607
Title: Atp-bound topoisomerase ii as a target for antitumor drugs.
Journal: The Journal of biological chemistry 20010511
Title: Repair of topoisomerase-mediated DNA damage in bacteriophage T4.
Journal: Genetics 20010501
Title: Improved efficiency of remission induction facilitates autologous BMT harvesting and improves overall survival in adults with AML: 108 patients treated at a single institution.
Journal: Bone marrow transplantation 20010501
Title: Selection of an unnatural peptide library for dsDNA binding.
Journal: Current medicinal chemistry 20010401
Title: A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule.
Journal: Cancer chemotherapy and pharmacology 20010401
Title: Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
Journal: Cytometry 20010301
Title: Pretreatment leukaemia cell drug resistance is correlated to clinical outcome in acute myeloid leukaemia.
Journal: European journal of haematology 20010301
Title: Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon.
Journal: American journal of clinical pathology 20010201
Title: Analysis of cleavage complexes using reactive inhibitor derivatives.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: Cell-cycle analysis of drug-treated cells.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: Targeting DNA through-covalent interactions of reversible binding drugs.
Journal: Methods in enzymology 20010101
Title: Inhibition of apoptotic proteins causes multidrug resistance in renal carcinoma cells.
Journal: Anticancer research 20010101
Title: DNA binding properties of the indolocarbazole antitumor drug NB-506.
Journal: Anti-cancer drug design 20010101
Title: Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells.
Journal: Molecular pharmacology 20000401
Title: Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.
Journal: Mutation research 20000320
Title: 1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication.
Journal: Antiviral research 20000201
Title: Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs.
Journal: Cancer chemotherapy and pharmacology 20000101
Title: [Studies on programmed cell death induced by amsacrine and expression of bcl-2 in leukemia cell lines].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 19970901
Title: Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
Journal: Biochemistry 19970311
Title: [Venous protection of acute leukemia treatment with amsacrine].
Journal: Zhonghua hu li za zhi = Chinese journal of nursing 19960901
Title: Steroid-free chemotherapy decreases the risk of hepatitis flare-up in hepatitis B virus carriers with non-Hodgkin's lymphoma.
Journal: Blood 19960201
Title: Induction of small intestinal adenocarcinomas in Wistar rats administered amsacrine.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 19941001
Title: Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.
Journal: Antimicrobial agents and chemotherapy 19930701
Title: Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
Journal: Toxicology letters 19930401
Title: Inhibitors of human immunodeficiency virus integrase.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930315
Title: Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.
Journal: Cancer 19910915
Title: Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.
Journal: Cancer research 19910901
Title: Daunorubicin, amsacrine, and sinus arrest.
Journal: The Western journal of medicine 19910401
Title: Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.
Journal: European journal of cancer (Oxford, England : 1990) 19910101
Title: Preventing amsacrine-induced cardiac arrhythmias.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19871201
Title: Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
Journal: Cancer chemotherapy and pharmacology 19860101
Title: Sequentially administered 5-azacitidine and amsacrine in refractory adult acute leukemia: a phase I-II trial of the Southeastern Cancer Study Group.
Journal: Cancer treatment reports 19850101
Title: Prevention of amsacrine-induced phlebitis with heparin.
Journal: Clinical pharmacy 19820101
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