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Title: Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans.
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Title: 7-Methylguanine: protonation, formation of linkage isomers with trans-(NH3)2Pt(II), and base pairing properties.
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Title: Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer.
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Title: Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.
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Title: Direct analysis of 5-methylcytosine and 5-methyl-2'-deoxycytidine in human urine by isotope dilution LC-MS/MS: correlations with N-methylated purines and oxidized DNA lesions.
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Title: DNA glycosylases: in DNA repair and beyond.
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Title: Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.
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Title: DNA alkylation lesions and their repair in human cells: modification of the comet assay with 3-methyladenine DNA glycosylase (AlkD).
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Title: Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction.
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Title: DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells.
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Title: Aberrant expression of N-methylpurine-DNA glycosylase influences patient survival in malignant gliomas.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Identification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulation.
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Title: Identification of novel human damage response proteins targeted through yeast orthology.
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Title: Characterization of a conserved interaction between DNA glycosylase and ParA in Mycobacterium smegmatis and M. tuberculosis.
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Title: Conventional and unconventional mechanisms for capping viral mRNA.
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Title: Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex.
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Title: Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?
Journal: International journal of environmental research and public health 20111001
Title: N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
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Title: Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.
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Title: Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA.
Journal: The Journal of biological chemistry 20110415
Title: Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.
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Title: Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.
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Title: Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.
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Title: A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.
Journal: British journal of cancer 20110301
Title: Structure-based mutational analysis of eIF4E in relation to sbm1 resistance to pea seed-borne mosaic virus in pea.
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Title: Metabolism, genomics, and DNA repair in the mouse aging liver.
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Title: NNK-Induced Lung Tumors: A Review of Animal Model.
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Title: Knockdown of midgut genes by dsRNA-transgenic plant-mediated RNA interference in the hemipteran insect Nilaparvata lugens.
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Title: Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage.
Journal: Genes & genetic systems 20110101
Title: Oxidative DNA Damage in Blood of CVD Patients Taking Detralex.
Journal: The open cardiovascular medicine journal 20110101
Title: Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
Journal: PloS one 20110101
Title: Nicotinamide inhibits alkylating agent-induced apoptotic neurodegeneration in the developing rat brain.
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Title: A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA.
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Title: Combinatorial effect of fish oil (Maxepa) and 1alpha,25-dihydroxyvitamin D(3) in the chemoprevention of DMBA-induced mammary carcinogenesis in rats.
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Title: A complex small RNA repertoire is generated by a plant/fungal-like machinery and effected by a metazoan-like Argonaute in the single-cell human parasite Toxoplasma gondii.
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Title: Alkylation of sperm DNA is associated with male factor infertility and a reduction in the proportion of oocytes fertilised during assisted reproduction.
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Title: Pt(II) complexes of unsubstituted guanine and 7-methylguanine.
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Title: Synthesis of a hetero subunit RNA modification enzyme by the wheat germ cell-free translation system.
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Title: Transgenerational adaptation of Arabidopsis to stress requires DNA methylation and the function of Dicer-like proteins.
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Title: Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.
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Title: Selective Incision of the alpha-N-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV.
Journal: Journal of nucleic acids 20100101
Title: Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines.
Journal: Journal of nucleic acids 20100101
Title: Effect of n3-methyladenine and an isosteric stable analogue on DNA polymerization.
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Title: Early Steps in the DNA Base Excision Repair Pathway of a Fission Yeast Schizosaccharomyces pombe.
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Title: Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.
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Title: Modification of urinary N7-methylguanine excretion in smokers by glutathione-S-transferase M1 polymorphism.
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Title: Separation and identification of purine nucleosides in the urine of patients with malignant cancer by reverse phase liquid chromatography/electrospray tandem mass spectrometry.
Journal: Journal of mass spectrometry : JMS 20090501
Title: A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma.
Journal: British journal of cancer 20090421
Title: O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.
Journal: British journal of cancer 20090421
Title: Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa.
Journal: Carcinogenesis 20090401
Title: Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine.
Journal: Cancer science 20090401
Title: Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).
Journal: Biochemistry 20090310
Title: Toward a molecular equivalent dose: use of the medaka model in comparative risk assessment.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090301
Title: Biomarkers of induced active and passive smoking damage.
Journal: International journal of environmental research and public health 20090301
Title: Time course evaluation of N-nitrosodialkylamines-induced DNA alkylation and oxidation in liver of mosquito fish.
Journal: Mutation research 20090115
Title: Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair.
Journal: BMC microbiology 20090101
Title: Deciphering peculiar protein-protein interacting modules in Deinococcus radiodurans.
Journal: Biology direct 20090101
Title: Mesoionic heterocyclic compounds as candidate messenger RNA cap analogue inhibitors of the influenza virus RNA polymerase cap-binding activity.
Journal: Antiviral chemistry & chemotherapy 20090101
Title: Adaptive response to DNA-damaging agents in natural Saccharomyces cerevisiae populations from 'Evolution Canyon', Mt. Carmel, Israel.
Journal: PloS one 20090101
Title: Neopterin, a marker of immune response, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine.
Journal: Analytical biochemistry 20081215
Title: Repeated measurements of urinary methylated/oxidative DNA lesions, acute toxicity, and mutagenicity in coke oven workers.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081201
Title: Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081201
Title: Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade.
Journal: International journal of molecular sciences 20081101
Title: Overexpression, purification and characterization of functional calf purine nucleoside phosphorylase (PNP).
Journal: Protein expression and purification 20081001
Title: Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival.
Journal: DNA repair 20081001
Title: Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine.
Journal: Journal of the American Chemical Society 20080903
Title: A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax.
Journal: The Journal of biological chemistry 20080808
Title: Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.
Journal: Molecular pharmacology 20080801
Title: Stacking efficiency and flexibility analysis of aromatic amino acids in cap-binding proteins.
Journal: Proteins 20080601
Title: Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501
Title: Synthesis and biological evaluation of trimethyl-substituted cap analogs.
Journal: Bioorganic & medicinal chemistry letters 20080201
Title: The Argonaute protein family.
Journal: Genome biology 20080101
Title: Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate.
Journal: Mutation research 20071201
Title: Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases.
Journal: International journal of cancer 20071001
Title: Triazene compounds: mechanism of action and related DNA repair systems.
Journal: Pharmacological research 20071001
Title: Lung cancer risk and variation in MGMT activity and sequence.
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Title: Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents.
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Title: Methylation: a regulator of HIV-1 replication?
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Title: Kinetics of C. elegans DcpS cap hydrolysis studied by fluorescence spectroscopy.
Journal: Nucleosides, nucleotides & nucleic acids 20070101
Title: Base excision repair and the role of MUTYH.
Journal: Hereditary cancer in clinical practice 20070101
Title: Decreasing urinary PAH metabolites and 7-methylguanine after smoking cessation.
Journal: International archives of occupational and environmental health 20060801
Title: Theoretical study of the ground and excited states of 7-methyl guanine and 9-methyl guanine: comparison with experiment.
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Title: Probing the mechanism of purine nucleoside phosphorylase by steady-state kinetic studies and ligand binding characterization determined by fluorimetric titrations.
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Title: Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403
Title: Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060401
Title: Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells.
Journal: Chemico-biological interactions 20060325
Title: Synergistic DNA damage and lipid peroxidation in cultured human white blood cells exposed to 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and ultraviolet A.
Journal: Environmental and molecular mutagenesis 20060301
Title: A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD.
Journal: Molecular microbiology 20060301
Title: The efficiency of hypoxanthine excision by alkyladenine DNA glycosylase is altered by changes in nearest neighbor bases.
Journal: DNA repair 20050928
Title: Structure, reactivity and solution behaviour of [Re(ser)(7-MeG)(CO)(3)] and [Re(ser)(3-pic)(CO)(3)]: 'nucleoside-mimicking' complexes based on the fac-[Re(CO)(3)](+) moiety.
Journal: Dalton transactions (Cambridge, England : 2003) 20050907
Title: Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050501
Title: Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences.
Journal: Biochemistry 20050215
Title: Lack of EGF receptor contributes to drug sensitivity of human germline cells.
Journal: British journal of cancer 20050131
Title: Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases.
Journal: Chemical research in toxicology 20050101
Title: Analysis of 7-methylguanine using isotope dilution and gas chromatography/electron-capture negative chemical ionization mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with on-line solid-phase extraction.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Metal ion complexes of macrocyclic polyamines enhance both the phosphate hydrolysis and imidazole ring opening of RNA 5'-cap structure.
Journal: Chemistry & biodiversity 20050101
Title: The combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20041201
Title: Simultaneous HPLC analysis of 8-hydroxydeoxyguanosine and 7-methylguanine in urine from humans and rodents.
Journal: Analytical biochemistry 20041115
Title: Thermodynamics of mRNA 5' cap binding by eukaryotic translation initiation factor eIF4E.
Journal: Biochemistry 20041026
Title: DNA methylation, cell proliferation, and histopathology in rats following repeated inhalation exposure to dimethyl sulfate.
Journal: Inhalation toxicology 20040801
Title: Interspecies dose extrapolation for inhaled dimethyl sulfate: a PBPK model-based analysis using nasal cavity N7-methylguanine adducts.
Journal: Inhalation toxicology 20040801
Title: Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents.
Journal: Carcinogenesis 20040701
Title: A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity.
Journal: The Analyst 20040601
Title: Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.
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Title: Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells.
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Title: The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N6-ethenoadenine as preferred substrates.
Journal: The Journal of biological chemistry 20040402
Title: Head-to-head (HH) and head-to-tail (HT) conformers of cis-bis guanine ligands bound to the [Re(CO)3]+ core.
Journal: Inorganic chemistry 20040322
Title: Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment.
Journal: The Journal of biological chemistry 20040312
Title: Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
Title: Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
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Journal: Cytogenetic and genome research 20040101
Title: Investigations into the biological relevance of in vitro clastogenic and aneugenic activity.
Journal: Cytogenetic and genome research 20040101
Title: Insertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap.
Journal: The Journal of biological chemistry 20031219
Title: DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters.
Journal: Biochemistry 20031209
Title: Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines.
Journal: Biochemistry 20031028
Title: Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases.
Journal: The EMBO journal 20031001
Title: Purine and pyrimidine metabolites in children's urine.
Journal: Clinica chimica acta; international journal of clinical chemistry 20030901
Title: Charge distribution in 7-methylguanine regarding cation-pi interaction with protein factor eIF4E.
Journal: Biophysical journal 20030901
Title: tRNA-guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis.
Journal: Bioorganic chemistry 20030801
Title: Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Journal: Chemical research in toxicology 20030601
Title: Formation of DNA adducts and induction of lacI mutations in Big Blue Rat-2 cells treated with temozolomide: implications for the treatment of low-grade adult and pediatric brain tumors.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030601
Title: Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
Journal: The Journal of biological chemistry 20030530
Title: A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage.
Journal: Molecular microbiology 20030401
Title: K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts.
Journal: Chemical research in toxicology 20030401
Title: The role of human alkyladenine glycosylase in cellular resistance to the chloroethylnitrosoureas.
Journal: Carcinogenesis 20030301
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Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse.
Journal: Nutrition and cancer 20030101
Title: Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
Journal: Biochemistry 20021022
Title: Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
Journal: Glia 20021001
Title: Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes.
Journal: DNA repair 20020806
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Journal: Current medicinal chemistry 20020701
Title: Excision of 8-methylguanine site-specifically incorporated into oligonucleotide substrates by the AlkA protein of Escherichia coli.
Journal: DNA repair 20020621
Title: The 'cap-binding slot' of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap.
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Title: Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
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Title: Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution.
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Title: The in vivo levels of DNA alkylation products in human lymphocytes are not age dependent: an assay of 7-methyl- and 7-(2-hydroxyethyl)-guanine DNA adducts.
Journal: Carcinogenesis 20020201
Title: Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats.
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Title: Monitoring for DNA damage of humans occupationally exposed to methyl bromide.
Journal: Anticancer research 20020101
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Title: Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
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Title: Metabolism of the beta-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-beta-hydroxypropylpropylamine and N-nitroso-beta-oxopropylpropylamine.
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Title: Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon.
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