64506-49-6,MFCD00868207
Catalog No.:AA00IBAW

64506-49-6 | Sofalcone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%(HPLC)
in stock  
$66.00   $46.00
- +
500mg
98%(HPLC)
in stock  
$129.00   $90.00
- +
1g
98%(HPLC)
in stock  
$237.00   $166.00
- +
100g
97%
in stock  
$484.00   $339.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IBAW
Chemical Name:
Sofalcone
CAS Number:
64506-49-6
Molecular Formula:
C27H30O6
Molecular Weight:
450.5235
MDL Number:
MFCD00868207
SMILES:
OC(=O)COc1cc(OCC=C(C)C)ccc1C(=O)/C=C/c1ccc(cc1)OCC=C(C)C
Properties
Computed Properties
 
Complexity:
706  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
12  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
6.2  

Literature

Title: Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20110715

Title: Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.

Journal: Biochemical and biophysical research communications 20100730

Title: Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist.

Journal: Journal of gastroenterology and hepatology 20100501

Title: Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: implication of heme-oxygenase-1 induction.

Journal: Biochemical and biophysical research communications 20090417

Title: Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study.

Journal: Hepato-gastroenterology 20090101

Title: Analysis of sofalcone in human plasma by high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin.

Journal: World journal of gastroenterology 20050321

Title: Gastroprotective effects of flavonoids in plant extracts.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050301

Title: [A case of drug eruption due to solon].

Journal: Arerugi = [Allergy] 20020401

Title: [New therapeutic approaches to peptic ulcer using mucosal protective agents].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: [Sofalcone].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020201

Title: Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.

Journal: Drugs under experimental and clinical research 20010101

Title: Onda K, et al. Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension. 2015 Apr;65(4):855-62.

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Tags:64506-49-6 Molecular Formula|64506-49-6 MDL|64506-49-6 SMILES|64506-49-6 Sofalcone
Catalog No.: AA00IBAW
64506-49-6,MFCD00868207
64506-49-6 | Sofalcone
Pack Size: 100mg
Purity: 98%(HPLC)
in stock
$66.00 $46.00
Pack Size: 500mg
Purity: 98%(HPLC)
in stock
$129.00 $90.00
Pack Size: 1g
Purity: 98%(HPLC)
in stock
$237.00 $166.00
Pack Size: 100g
Purity: 97%
in stock
$484.00 $339.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00IBAW
Chemical Name: Sofalcone
CAS Number: 64506-49-6
Molecular Formula: C27H30O6
Molecular Weight: 450.5235
MDL Number: MFCD00868207
SMILES: OC(=O)COc1cc(OCC=C(C)C)ccc1C(=O)/C=C/c1ccc(cc1)OCC=C(C)C
Properties
Complexity: 706  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 12  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 6.2  
Literature fold

Title: Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20110715

Title: Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.

Journal: Biochemical and biophysical research communications20100730

Title: Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist.

Journal: Journal of gastroenterology and hepatology20100501

Title: Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: implication of heme-oxygenase-1 induction.

Journal: Biochemical and biophysical research communications20090417

Title: Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study.

Journal: Hepato-gastroenterology20090101

Title: Analysis of sofalcone in human plasma by high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070901

Title: Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin.

Journal: World journal of gastroenterology20050321

Title: Gastroprotective effects of flavonoids in plant extracts.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20050301

Title: [A case of drug eruption due to solon].

Journal: Arerugi = [Allergy]20020401

Title: [New therapeutic approaches to peptic ulcer using mucosal protective agents].

Journal: Nihon rinsho. Japanese journal of clinical medicine20020201

Title: [Sofalcone].

Journal: Nihon rinsho. Japanese journal of clinical medicine20020201

Title: Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.

Journal: Drugs under experimental and clinical research20010101

Title: Onda K, et al. Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension. 2015 Apr;65(4):855-62.

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