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66309-69-1,MFCD20488053
Catalog No.:AA00IBID

66309-69-1 | Cefotiam dihydrochloride

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25mg
in stock  
$147.00   $103.00
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1g
≥ 98% (Assay: Anhydrous basis)
in stock  
$231.00   $162.00
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5g
≥ 98% (Assay: Anhydrous basis)
in stock  
$839.00   $588.00
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25g
≥ 98% (Assay: Anhydrous basis)
in stock  
$3,071.00   $2,150.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IBID
Chemical Name:
Cefotiam dihydrochloride
CAS Number:
66309-69-1
Molecular Formula:
C18H25Cl2N9O4S3
Molecular Weight:
598.5500
MDL Number:
MFCD20488053
SMILES:
CN(CCn1nnnc1SCC1=C(C(=O)O)N2[C@H](SC1)[C@@H](C2=O)NC(=O)Cc1csc(n1)N)C.Cl.Cl
Properties
Computed Properties
 
Complexity:
848  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
10  

Literature

Title: Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: [Antimicrobial prophylaxis in radical prostatectomy : single dose versus 1-day treatment].

Journal: Hinyokika kiyo. Acta urologica Japonica 20101001

Title: Detection of specific IgE antibodies to cefotiam-HSA conjugate by ELISA in a nurse with occupational anaphylaxis.

Journal: Allergy 20100601

Title: Severe ulcerated 'bodybuilding acne' caused by anabolic steroid use and exacerbated by isotretinoin.

Journal: International wound journal 20100601

Title: Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands.

Journal: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20090917

Title: [Two cases of emphysematous pyelonephritis successfully treated by transurethral catheterization].

Journal: Hinyokika kiyo. Acta urologica Japonica 20090501

Title: Systemic use of antibiotics does not prevent postoperative infection in elective colorectal surgery: a randomized controlled trial.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090201

Title: Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.

Journal: American journal of physiology. Renal physiology 20080701

Title: Penetration and exposure of cefotiam into the peritoneal fluid of abdominal surgery patients after intravenous administration.

Journal: Journal of chemotherapy (Florence, Italy) 20080601

Title: Postmortem diagnosis of fatal anaphylaxis during intravenous administration of therapeutic and diagnostic agents: evaluation of clinical laboratory parameters and immunohistochemistry in three cases.

Journal: Legal medicine (Tokyo, Japan) 20080501

Title: Quantitative prediction of oral absorption of PEPT1 substrates based on in vitro uptake into Caco-2 cells.

Journal: International journal of pharmaceutics 20080416

Title: Development of breakpoints of cephems for intraabdominal infections based on pharmacokinetics and pharmacodynamics in the peritoneal fluid of patients.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080401

Title: Malakoplakia of the kidney.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20080201

Title: Prophylactic antibiotics given within 24 hours of surgery, compared with antibiotics given for 72 hours perioperatively, increased the rate of methicillin-resistant Staphylococcus aureus isolated from surgical site infections.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080201

Title: Spermatic cord abscess with concurrent prostatic abscess involving the seminal vesicle.

Journal: Radiation medicine 20080201

Title: Randomized prospective comparison of fosfomycin and cefotiam for prevention of postoperative infection following urological surgery.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20071001

Title: [Fundamental study on the selection of antimicrobial prophylactic agents in abdominal surgery].

Journal: The Japanese journal of antibiotics 20070801

Title: Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3.

Journal: American journal of physiology. Renal physiology 20070701

Title: In vitro activity of cefotiam against oxacillin-resistant Staphylococcus epidermidis strains--reevaluation of beta-lactam antibiotics efficiency on MRSE.

Journal: The Japanese journal of antibiotics 20070601

Title: Antibiotic prophylaxis in cerebrospinal fluid shunting: reassessment of Cefotiam penetration into human CSF.

Journal: Zentralblatt fur Neurochirurgie 20070201

Title: Antibiotic prophylaxis in radical prostatectomy: 1-day versus 4-day treatments.

Journal: International journal of urology : official journal of the Japanese Urological Association 20061201

Title: [Role of Ph-SA in enhancing bactericidal activity of beta-lactam antibiotics].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060101

Title: [Intraocular penetration of cefotiam hydrochloride, a kind of cephalosporin after filtration surgery in rabbit eyes].

Journal: Nippon Ganka Gakkai zasshi 20050901

Title: The significance of the intraoperative repeated dosing of antimicrobials for preventing surgical wound infection in colorectal surgery.

Journal: Surgery today 20050101

Title: Camel bite: an unusual type of head injury in an infant.

Journal: Journal of pediatric surgery 20041001

Title: Flupenthixol and cefotiam: effects on vitamin A metabolism in rats.

Journal: The British journal of nutrition 20041001

Title: [Efficacy of cefotiam hexetil in acute maxillary sinusitis, with a short five day vs ten day treatment].

Journal: Medecine et maladies infectieuses 20041001

Title: Accidental intrathecal infusion of cefotiam: clinical presentation and management.

Journal: European journal of clinical pharmacology 20040701

Title: Unexpected impaired consciousness in RA: a rare complication of SIADH induced by increased IL-6.

Journal: Clinical and experimental rheumatology 20040101

Title: [Surveillance of susceptibility of clinical isolates to cefmetazole between 2000 and 2002].

Journal: The Japanese journal of antibiotics 20031201

Title: Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.

Journal: Pharmaceutical research 20030901

Title: Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats.

Journal: Anesthesiology 20030701

Title: [Antimicrobial activity of fosfomycin against beta-lactamase-producing methicillin-sensitive Staphylococcus aureus and methicillin-sensitive coagulase-negative staphylococci].

Journal: The Japanese journal of antibiotics 20030401

Title: Successful treatment of a Salmonella aortic arch aneurysm.

Journal: The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20030201

Title: [A questionnaire survey on the theory of postoperative infection prophylaxis in otorhinolaryngology].

Journal: The Japanese journal of antibiotics 20030201

Title: [Prophylactic antibiotics in lumbar disc surgery: analysis of 1,030 procedures].

Journal: Zentralblatt fur Neurochirurgie 20030101

Title: Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients.

Journal: Arzneimittel-Forschung 20030101

Title: [A questionnaire survey on antimicrobial chemotherapy for acute peritonitis].

Journal: The Japanese journal of antibiotics 20021201

Title: [A questionnaire survey on the theory of postoperative infection prophylaxis in urology].

Journal: The Japanese journal of antibiotics 20021001

Title: Pharmacokinetics of antibiotic prophylaxis in major orthopedic surgery and blood-saving techniques.

Journal: Orthopedics 20010701

Title: [Immunological properties of S-1090, cefmatilen hydrochloride hydrate].

Journal: The Journal of toxicological sciences 20010501

Title: Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010101

Title: Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses.

Journal: Dermatology (Basel, Switzerland) 19960101

Title: [Potential nephrotoxicity of 2nd generation cephalosporins: cefuroxime versus cefotiam].

Journal: Infection 19930101

Title: [Postmarketing survey on the clinical use of cefotiam].

Journal: The Japanese journal of antibiotics 19830801

Title: Nephrotoxicity of cefotiam (CGP 14221/E) in rats and rabbits.

Journal: Archives of toxicology 19810901

Title: Comparison of amino acids bathing the oxyntic gland area in the stimulation of gastric secretion.

Journal: Gastroenterology 19760101

Title: Iwahi T, et, al. Comparative activities of cefotiam and cefazolin against urinary tract infections with Proteus mirabilis in mice. Antimicrob Agents Chemother. 1980 Aug;18(2):257-63.

Title: Watt B, et, al. In-vitro activity of cefotiam against bacteria of clinical interest. J Antimicrob Chemother. 1982 Nov;10(5):391-5.

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