74536-44-0,MFCD08704232
Catalog No.:AA00ICGF

74536-44-0 | (2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
95%
in stock  
$18.00   $13.00
- +
10g
97%
in stock  
$28.00   $20.00
- +
25g
95%
in stock  
$40.00   $28.00
- +
100g
95%
in stock  
$127.00   $89.00
- +
500g
98%
in stock  
$411.00 $288.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ICGF
Chemical Name:
(2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
CAS Number:
74536-44-0
Molecular Formula:
C13H18N2O6
Molecular Weight:
298.2918
MDL Number:
MFCD08704232
SMILES:
O=C1CC[C@H](N1)C(=O)O.OCc1c(CO)cnc(c1O)C
Properties
Computed Properties
 
Complexity:
297  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
3  

Literature

Title: Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease.

Journal: Human psychopharmacology 20111201

Title: [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.

Journal: Archives of pharmacal research 20100701

Title: Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

Journal: Archives of biochemistry and biophysics 20090815

Title: [Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090301

Title: [Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

Title: Acute alcohol intoxication.

Journal: European journal of internal medicine 20081201

Title: Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.

Journal: Chemico-biological interactions 20070830

Title: Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.

Journal: Chinese medical journal 20070120

Title: A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.

Journal: Substance abuse treatment, prevention, and policy 20060101

Title: [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].

Journal: Orvosi hetilap 20051120

Title: Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.

Journal: Farmaco (Societa chimica italiana : 1989) 20050401

Title: [Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].

Journal: Voprosy onkologii 20050101

Title: [Antioxidants in liver protection].

Journal: Orvosi hetilap 20040704

Title: [Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040701

Title: Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20030801

Title: [Reproductive toxicity of metadoxine in rats].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20030501

Title: Metadoxine in the treatment of acute and chronic alcoholism: a review.

Journal: International journal of immunopathology and pharmacology 20030101

Title: A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).

Journal: The Journal of international medical research 20030101

Title: Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.

Journal: Alcoholism, clinical and experimental research 20020301

Title: Efficacy of metadoxine in the management of acute alcohol intoxication.

Journal: The Journal of international medical research 20020101

Title: Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.

Journal: Pharmacological research 20011101

Title: [Metadoxyl in combined treatment of alcohol damage to the liver].

Journal: Klinicheskaia meditsina 20010101

Title: Yang YM, et al. Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. Arch Biochem Biophys. 2009 Aug 15;488(2):91-9.

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Related Products of 74536-44-0
Tags:74536-44-0 Molecular Formula|74536-44-0 MDL|74536-44-0 SMILES|74536-44-0 (2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Catalog No.: AA00ICGF
74536-44-0,MFCD08704232
74536-44-0 | (2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Pack Size: 5g
Purity: 95%
in stock
$18.00 $13.00
Pack Size: 10g
Purity: 97%
in stock
$28.00 $20.00
Pack Size: 25g
Purity: 95%
in stock
$40.00 $28.00
Pack Size: 100g
Purity: 95%
in stock
$127.00 $89.00
Pack Size: 500g
Purity: 98%
in stock
$411.00 $288.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00ICGF
Chemical Name: (2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
CAS Number: 74536-44-0
Molecular Formula: C13H18N2O6
Molecular Weight: 298.2918
MDL Number: MFCD08704232
SMILES: O=C1CC[C@H](N1)C(=O)O.OCc1c(CO)cnc(c1O)C
Properties
Complexity: 297  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 5  
Rotatable Bond Count: 3  
Literature fold

Title: Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease.

Journal: Human psychopharmacology20111201

Title: [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology20110101

Title: Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.

Journal: Archives of pharmacal research20100701

Title: Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

Journal: Archives of biochemistry and biophysics20090815

Title: [Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology20090301

Title: [Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology20090101

Title: Acute alcohol intoxication.

Journal: European journal of internal medicine20081201

Title: Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.

Journal: Chemico-biological interactions20070830

Title: Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.

Journal: Chinese medical journal20070120

Title: A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.

Journal: Substance abuse treatment, prevention, and policy20060101

Title: [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].

Journal: Orvosi hetilap20051120

Title: Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.

Journal: Farmaco (Societa chimica italiana : 1989)20050401

Title: [Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].

Journal: Voprosy onkologii20050101

Title: [Antioxidants in liver protection].

Journal: Orvosi hetilap20040704

Title: [Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]20040701

Title: Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.

Journal: Liver international : official journal of the International Association for the Study of the Liver20030801

Title: [Reproductive toxicity of metadoxine in rats].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]20030501

Title: Metadoxine in the treatment of acute and chronic alcoholism: a review.

Journal: International journal of immunopathology and pharmacology20030101

Title: A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).

Journal: The Journal of international medical research20030101

Title: Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.

Journal: Alcoholism, clinical and experimental research20020301

Title: Efficacy of metadoxine in the management of acute alcohol intoxication.

Journal: The Journal of international medical research20020101

Title: Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.

Journal: Pharmacological research20011101

Title: [Metadoxyl in combined treatment of alcohol damage to the liver].

Journal: Klinicheskaia meditsina20010101

Title: Yang YM, et al. Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. Arch Biochem Biophys. 2009 Aug 15;488(2):91-9.

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