Home Other Building Blocks 761423-87-4
761423-87-4,MFCD19443744
Catalog No.:AA00ICMN

761423-87-4 | Ipragliflozin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$7.00   $5.00
- +
10mg
98%
in stock  
$9.00   $7.00
- +
25mg
98%
in stock  
$12.00   $8.00
- +
50mg
98%
in stock  
$15.00   $11.00
- +
250mg
98%(HPLC)
in stock  
$56.00   $39.00
- +
1g
97%
in stock  
$137.00   $96.00
- +
5g
97%
in stock  
$502.00   $352.00
- +
10g
97%
in stock  
$834.00   $584.00
- +
25g
97%
in stock  
$1,640.00   $1,148.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ICMN
Chemical Name:
Ipragliflozin
CAS Number:
761423-87-4
Molecular Formula:
C21H21FO5S
Molecular Weight:
404.4518
MDL Number:
MFCD19443744
SMILES:
OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2cc3c(s2)cccc3)F)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
525  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
2.5  

Upstream Synthesis Route

[1]Patent:EP2105442,2009,A1,.Locationinpatent:Page/Pagecolumn13

[2]Patent:CN108276396,2018,A,.Locationinpatent:Paragraph0041;0052;0053;0068;0083

[3]BioorganicandMedicinalChemistry,2012,vol.20,#10,p.3263-3279

[4]Patent:EP2009010,2008,A1,.Locationinpatent:Page/Pagecolumn6-7

[1]Patent:EP2105442,2009,A1,.Locationinpatent:Page/Pagecolumn15

[2]Patent:CN107459500,2017,A,.Locationinpatent:Paragraph0024;0025

[1]Patent:CN105541816,2016,A,.Locationinpatent:Paragraph0032;0033;0034

[1]BioorganicandMedicinalChemistry,2012,vol.20,#10,p.3263-3279

[2]BeilsteinJournalofOrganicChemistry,2017,vol.13,p.1064-1070

[3]Patent:CN108276396,2018,A,

[1]BeilsteinJournalofOrganicChemistry,2017,vol.13,p.1064-1070

[2]BeilsteinJournalofOrganicChemistry,2017,vol.13,p.1064-1070

Downstream Synthesis Route

[1]Patent:CN108276396,2018,A.Locationinpatent:Paragraph0041;0070;0085;0054;0055

[2]BeilsteinJournalofOrganicChemistry,2017,vol.13,p.1064-1070

[3]Patent:EP2009010,2008,A1.Locationinpatent:Page/Pagecolumn7

[1]Patent:EP2105442,2009,A1.Locationinpatent:Page/Pagecolumn13

[2]Patent:CN108276396,2018,A.Locationinpatent:Paragraph0041;0052;0053;0068;0083

[3]BioorganicandMedicinalChemistry,2012,vol.20,p.3263-3279

[4]Patent:EP2009010,2008,A1.Locationinpatent:Page/Pagecolumn6-7

[1]Patent:EP2105442,2009,A1.Locationinpatent:Page/Pagecolumn15

[2]Patent:CN107459500,2017,A.Locationinpatent:Paragraph0024;0025

Literature

Title: Pharmacological aspects of the safety of gliflozins.

Journal: Pharmacological research 20170401

Title: Efficacy, safety, and tolerability of ipragliflozin in Asian patients with type 2 diabetes mellitus and inadequate glycemic control with metformin: Results of a phase 3 randomized, placebo-controlled, double-blind, multicenter trial.

Journal: Journal of diabetes investigation 20160501

Title: Pharmacokinetics, Pharmacodynamics and Clinical Use of SGLT2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease.

Journal: Clinical pharmacokinetics 20150701

Title: No pharmacokinetic interaction between ipragliflozin and sitagliptin, pioglitazone, or glimepiride in healthy subjects.

Journal: Diabetes, obesity & metabolism 20121001

Title: Combination treatment with ipragliflozin and metformin: a randomized, double-blind, placebo-controlled study in patients with type 2 diabetes mellitus.

Journal: Clinical therapeutics 20120801

Title: Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Journal: Bioorganic & medicinal chemistry 20120515

Title: Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120401

Title: Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice.

Journal: Journal of pharmacological sciences 20120101

Title: Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus.

Journal: Diabetes technology & therapeutics 20111201

Title: Effect of Ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects.

Journal: Clinical drug investigation 20111201

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SDS
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