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85-00-7,MFCD00211319
Catalog No.:AA00IDF4

85-00-7 | 6,7-Dihydrodipyrido[1,2-a:2',1'-c]pyrazine-5,8-diium bromide

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10mg
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25mg
98%(HPLC)
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IDF4
Chemical Name:
6,7-Dihydrodipyrido[1,2-a:2',1'-c]pyrazine-5,8-diium bromide
CAS Number:
85-00-7
Molecular Formula:
C12H12Br2N2
Molecular Weight:
344.0451
MDL Number:
MFCD00211319
SMILES:
c1cc[n+]2c(c1)c1cccc[n+]1CC2.[Br-].[Br-]
UN Number:
2781
Properties
Computed Properties
 
Complexity:
183  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  

Downstream Synthesis Route
50-31-7    85-00-7   
2C7H2Cl3O2(1-)*C12H12N2(2+) 

[1]Patent:CN107517986,2017,A.Locationinpatent:Paragraph0037;0038

55335-06-3    85-00-7   
2C7H3Cl3NO3(1-)*C12H12N2(2+) 

[1]Patent:CN107517986,2017,A.Locationinpatent:Paragraph0039;0040

94-74-6    85-00-7   
C12H12N2(2+)*2C9H8ClO3(1-) 

[1]Patent:CN107517986,2017,A.Locationinpatent:Paragraph0029;0030

1918-00-9    85-00-7   
2C8H5Cl2O3(1-)*C12H12N2(2+) 

[1]Patent:CN107517986,2017,A.Locationinpatent:Paragraph0033;0034

Literature

Title: Mitochondrial bioenergetics and locomotor activity are altered in zebrafish (Danio rerio) after exposure to the bipyridylium herbicide diquat.

Journal: Toxicology letters 20180201

Title: Diquat-induced cellular pyridine nucleotide redox changes and alteration of metabolic enzyme activities in colonic carcinoma cells.

Journal: Chemico-biological interactions 20170225

Title: Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice.

Journal: PloS one 20160101

Title: Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2.

Journal: Oxidative medicine and cellular longevity 20160101

Title: L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells.

Journal: The Journal of nutrition 20151001

Title: Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.

Journal: Archives of toxicology 20150101

Title: Pyrosequencing-based transcriptomic resources in the pond snail Lymnaea stagnalis, with a focus on genes involved in molecular response to diquat-induced stress.

Journal: Ecotoxicology (London, England) 20121101

Title: Nrf2 protects against diquat-induced liver and lung injury.

Journal: Free radical research 20121001

Title: Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in weaned pigs.

Journal: Animal : an international journal of animal bioscience 20120601

Title: Investigate the chronic neurotoxic effects of diquat.

Journal: Neurochemical research 20120501

Title: Effect of diquat-induced oxidative stress on iron metabolism in male Fischer-344 rats.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20111201

Title: Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20111201

Title: Electrochemical analysis of proton and electron transfer equilibria of the reducible moieties in humic acids.

Journal: Environmental science & technology 20111001

Title: Rapid fluorescence determination of diquat herbicide in food grains using quantum dots as new reducing agent.

Journal: Analytica chimica acta 20110429

Title: Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401

Title: Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.

Journal: Free radical biology & medicine 20110401

Title: Monolithic spin column extraction and GC-MS for the simultaneous assay of diquat, paraquat, and fenitrothion in human serum and urine.

Journal: Analytical and bioanalytical chemistry 20110401

Title: Hepatic response to oxidative injury in long-lived Ames dwarf mice.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101

Title: Wheat bran protects Fischer-344 rats from diquat-induced oxidative stress by activating antioxidant system: selenium as an antioxidant.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Biological monitoring of pesticide exposures in residents living near agricultural land.

Journal: BMC public health 20110101

Title: Diquat derivatives: highly active, two-dimensional nonlinear optical chromophores with potential redox switchability.

Journal: Journal of the American Chemical Society 20100804

Title: Competitive and non-competitive adsorption/desorption of paraquat, diquat and difenzoquat in vineyard-devoted soils.

Journal: Journal of hazardous materials 20100615

Title: The poison pen: bedside diagnosis of urinary diquat.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100301

Title: Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100201

Title: The expression of melanin-based plumage is separately modulated by exogenous oxidative stress and a melanocortin.

Journal: Proceedings. Biological sciences 20090907

Title: Long-lived ames dwarf mice are resistant to chemical stressors.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20090801

Title: Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.

Journal: Free radical biology & medicine 20090801

Title: Determination of diquat by flow injection-chemiluminescence.

Journal: Analytical and bioanalytical chemistry 20090601

Title: Quaternary herbicides retention by the amendment of acid soils with a bentonite-based waste from wineries.

Journal: Journal of hazardous materials 20090530

Title: Effect of organic matter and iron oxides on quaternary herbicide sorption-desorption in vineyard-devoted soils.

Journal: Journal of colloid and interface science 20090515

Title: Evaluation of diquat against an acute experimental infection of Flavobacterium columnare in channel catfish, Ictalurus punctatus (Rafinesque).

Journal: Journal of fish diseases 20090501

Title: Combined photobacterium toxicity of herbicide mixtures containing one insecticide.

Journal: Chemosphere 20090401

Title: Effects of diquat and fomesafen applied alone and in combination with a nonylphenol polyethoxylate adjuvant on Lemna minor in aquatic indoor microcosms.

Journal: Ecotoxicology and environmental safety 20090301

Title: Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090301

Title: Determination of quaternary ammonium herbicides in soils. Comparison of digestion, shaking and microwave-assisted extractions.

Journal: Journal of chromatography. A 20080704

Title: The in vivo gene expression signature of oxidative stress.

Journal: Physiological genomics 20080612

Title: Occurrence and downslope mobilization of quaternary herbicide residues in vineyard-devoted soils.

Journal: Bulletin of environmental contamination and toxicology 20080501

Title: Toxicity of carbaryl, diquat dibromide, and fluoranthene, individually and in mixture, to larval grass shrimp, Palaemonetes pugio.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20080501

Title: Capillary electrophoretic analysis of organic pollutants.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia.

Journal: Free radical biology & medicine 20071101

Title: Hepatotoxicity related to paraquat and diquat absorption through intact skin.

Journal: Digestive diseases and sciences 20071101

Title: Influence of copper on the adsorption and desorption of paraquat, diquat, and difenzoquat in vineyard acid soils.

Journal: Journal of agricultural and food chemistry 20070725

Title: Protective effects of wheat bran against diquat toxicity in male Fischer-344 rats.

Journal: Bioscience, biotechnology, and biochemistry 20070701

Title: Rapid and sensitive HPLC method for the simultaneous determination of paraquat and diquat in human serum.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070501

Title: Melatonin reduces mortality and oxidatively mediated hepatic and renal damage due to diquat treatment.

Journal: Journal of pineal research 20070301

Title: Inclusion complexation of diquat and paraquat by the hosts cucurbit[7]uril and cucurbit[8]uril.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice.

Journal: Toxicology and applied pharmacology 20061215

Title: Relationship between body iron stores and diquat toxicity in male Fischer-344 rats.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201

Title: Comparative genotoxicity of the herbicides Roundup, Stomp and Reglone in plant and mammalian test systems.

Journal: Mutagenesis 20061101

Title: LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061002

Title: Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion.

Journal: Archives of biochemistry and biophysics 20061001

Title: Biochemical effects of nonylphenol polyethoxylate adjuvant, Diquat herbicide and their mixture on the three-spined stickleback (Gasterosteus aculeatus L.).

Journal: Marine environmental research 20060701

Title: Aquatic herbicides and herbicide contaminants: In vitro cytotoxicity and cell-cycle analysis.

Journal: Environmental toxicology 20060601

Title: Gene expression patterns in rainbow trout, Oncorhynchus mykiss, exposed to a suite of model toxicants.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20060525

Title: Bis(meta-phenylene)-32-crown-10-based cryptand/diquat inclusion [2]complexes.

Journal: Chemical communications (Cambridge, England) 20060514

Title: Effect of heparin on viologen-stimulated enzymatic NADH depletion.

Journal: Chemical research in toxicology 20060501

Title: Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.

Journal: Journal of bacteriology 20050501

Title: Does the effect of herbicide pulse exposure on aquatic plants depend on Kow or mode of action?

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20050210

Title: Toxicity of redox cycling pesticides in primary mesencephalic cultures.

Journal: Antioxidants & redox signaling 20050101

Title: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis.

Journal: The Journal of biological chemistry 20041231

Title: Determination of paraquat and diquat in human body fluids by high-performance liquid chromatography/tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20041001

Title: Effects of aquatic herbicides on primary productivity of phytoplankton in the laboratory.

Journal: Bulletin of environmental contamination and toxicology 20040501

Title: Effect of different chemical and mechanical defolation methods on the skin quality of potatoes.

Journal: Communications in agricultural and applied biological sciences 20040101

Title: Use of adjuvant-enhanced formulations to increase bipyridylium-herbicide effectiveness.

Journal: Communications in agricultural and applied biological sciences 20040101

Title: Analysis of bipyridylium herbicides by capillary zone electrophoresis.

Journal: Journal of capillary electrophoresis and microchip technology 20030101

Title: Simultaneous determination of pesticides using a four-band disposable optical capillary immunosensor.

Journal: Analytical chemistry 20021201

Title: Nuclear and nucleolar glutathione reductase, peroxidase, and transferase activities in livers of male and female Fischer-344 rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020901

Title: Analysis of the herbicides paraquat, diquat and difenzoquat in drinking water by micellar electrokinetic chromatography using sweeping and cation selective exhaustive injection.

Journal: Journal of chromatography. A 20020628

Title: Pathways involved in mild gastrointestinal inflammation induced by a low level exposure to a food contaminant.

Journal: Digestive diseases and sciences 20020601

Title: Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes.

Journal: Journal of biochemistry 20020401

Title: Effect of diquat on the antioxidant system and cell growth in human neuroblastoma cells.

Journal: Toxicology and applied pharmacology 20020115

Title: In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice.

Journal: Methods in enzymology 20020101

Title: Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling.

Journal: The Journal of biological chemistry 20011116

Title: Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive oxygen and nitrogen species in mouse hepatocytes.

Journal: The Biochemical journal 20011101

Title: Quantification of copper in biological materials by use of electron spin resonance.

Journal: Clinical chemistry 20011001

Title: Spectra interference between diquat and paraquat by second derivative spectrophotometry.

Journal: Forensic science international 20010915

Title: Separation and quantification of paraquat and diquat in serum and urine by capillary electrophoresis.

Journal: Biomedical chromatography : BMC 20010801

Title: Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation.

Journal: Pain 20010501

Title: Studies of pesticides by collision-induced dissociation, postsource-decay, matrix-assisted laser desorption/ionization time of flight mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20010501

Title: Determination of quaternary ammonium pesticides by liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. A 20010420

Title: Sample stacking with matrix removal for the determination of paraquat, diquat and difenzoquat in water by capillary electrophoresis.

Journal: Journal of chromatography. A 20010406

Title: Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver.

Journal: Laboratory investigation; a journal of technical methods and pathology 20010201

Title: Effects of diquat, an aquatic herbicide, on the development of mallard embryos.

Journal: Journal of toxicology and environmental health. Part A 20010112

Title: Application of calorimetry to microbial biodegradation studies of agrochemicals in oxisols.

Journal: Journal of environmental quality 20010101

Title: Formation of gas-phase clusters monitored during electrospray mass spectrometry: a study of quaternary ammonium pesticides.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress.

Journal: Free radical biology & medicine 19990901

Title: Upregulation of glucose-6-phosphate dehydrogenase in response to hepatocellular oxidative stress: studies with diquat.

Journal: Journal of biochemical toxicology 19951201

Title: The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver.

Journal: Toxicology and applied pharmacology 19950901

Title: Effects of chemically induced maternal toxicity on prenatal development in the rat.

Journal: Teratology 19901201

Title: Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.

Journal: Free radical research communications 19860101

Title: Acute diquat intoxication. Interest of its repeated determination in urine and the evaluation of renal proximal tubule integrity.

Journal: Journal of toxicology. Clinical toxicology 19840101

Title: Assessment of the mutagenic properties of diquat and paraquat in the murine dominant lethal test.

Journal: Mutation research 19740601

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Tags:85-00-7 Molecular Formula|85-00-7 MDL|85-00-7 SMILES|85-00-7 6,7-Dihydrodipyrido[1,2-a:2',1'-c]pyrazine-5,8-diium bromide |Heterocyclic_Building_Blocks