850649-62-6,MFCD09833195
Catalog No.:AA00IDG5

850649-62-6 | Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, monobenzoate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
97%
in stock  
$6.00   $4.00
- +
100mg
97%
in stock  
$8.00   $6.00
- +
1g
97%
in stock  
$28.00   $20.00
- +
5g
97%
in stock  
$96.00   $68.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IDG5
Chemical Name:
Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, monobenzoate
CAS Number:
850649-62-6
Molecular Formula:
C25H27N5O4
Molecular Weight:
461.5130
MDL Number:
MFCD09833195
SMILES:
OC(=O)c1ccccc1.N#Cc1ccccc1Cn1c(cc(=O)n(c1=O)C)N1CCC[C@H](C1)N
Properties
Computed Properties
 
Complexity:
726  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route
850649-61-5    65-85-0   
Alogliptinbenzoate 

[1]Patent:CN107954978,2018,A.Locationinpatent:Paragraph0045

[2]Patent:CN109232532,2019,A.Locationinpatent:Paragraph0049;0098-0105;0106;0149-0154;0155;0198-0203

[3]Patent:CN109810094,2019,A.Locationinpatent:Paragraph0021;0022

[4]Patent:CN110128401,2019,A.Locationinpatent:Paragraph0075-0081

[5]Patent:US2017/81305,2017,A1.Locationinpatent:Paragraph0417-0418

[6]Patent:WO2015/92807,2015,A1.Locationinpatent:Sheet8;9

[7]Patent:CN103980249,2016,B.Locationinpatent:Paragraph0014;0038;0041

[8]Patent:CN104086527,2016,B.Locationinpatent:Paragraph0052;0064-0066;0076

[9]Patent:CN103524483,2016,B.Locationinpatent:Paragraph0021-0023

[10]Patent:CN106336396,2017,A.Locationinpatent:Paragraph0120-0125

[11]Patent:US2007/66635,2007,A1.Locationinpatent:Page/Pagecolumn15

[12]Patent:WO2010/72680,2010,A1.Locationinpatent:Page/Pagecolumn17-18

[13]Patent:CN103923063,2016,B.Locationinpatent:Paragraph0045

[14]Patent:CN104193726,2016,B.Locationinpatent:Paragraph0056-0057

[15]Patent:CN106366068,2017,A.Locationinpatent:Paragraph0019

[1]CurrentPatentAssignee:CHANGZHOUSIYAOPHARMACEUTICALSCOLTD-CN107540656,2018,ALocationinpatent:Paragraph0039;0040;0071-0073;0074-0076

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2009/275750,2009,A1Locationinpatent:Page/Pagecolumn23-24

[1]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECHCOP-CN106632242,2017,ALocationinpatent:Paragraph0012;0025

[2]CurrentPatentAssignee:BEIJINGDOCTORANTETECHDEV-CN105367546,2016,ALocationinpatent:Paragraph0015

[3]CurrentPatentAssignee:MAPIPHARMALTD.-WO2010/109468,2010,A1Locationinpatent:Page/Pagecolumn28

850649-61-5    65-85-0   
alogliptinbenzoate 

[1]Patent:WO2013/46229,2013,A1.Locationinpatent:Page/Pagecolumn20

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-EP2682110,2014,A1

[2]CurrentPatentAssignee:HARMANFINOCHEMLIMITED;KADAM,VijayTrimbak;BUDDHALA,RajasekharRao;SINGAMPALLLI,SriHah;MINHAS,HarpreetSingh;MINHAS,GurpreetSingh-WO2015/92807,2015,A1

[3]CurrentPatentAssignee:BEIJINGDOCTORANTETECHDEV-CN105367546,2016,A

[4]CurrentPatentAssignee:ZHEJIANGYONGNINGPHARMA-CN103819450,2016,B

[5]CurrentPatentAssignee:ANHUINEWSTARPHARMACEUTICALDEV-CN103980249,2016,B

[6]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-US2016/340333,2016,A1

[7]CurrentPatentAssignee:SUZHOULANXITEBIOTECHNOLOGYCOLTD-CN103524483,2016,B

[8]CurrentPatentAssignee:JIANGSUDEYUANPHARMACEUTICAL-CN104193726,2016,B

[9]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECHCOP-CN106632242,2017,A

[10]CurrentPatentAssignee:HEFEILIFEONPHARMACEUTICAL-CN106336396,2017,A

[11]CurrentPatentAssignee:CHANGZHOUSIYAOPHARMACEUTICALSCOLTD-CN107540656,2018,A

[12]CurrentPatentAssignee:CHANGZHOUSUNLIGHTPHARM-CN107954978,2018,A

[13]CurrentPatentAssignee:UNIVJINLINMEDICAL-CN108912093,2018,A

[14]CurrentPatentAssignee:CHONGQINGKERUINANHAIPHARMACEUTICAL-CN109232532,2019,A

[15]CurrentPatentAssignee:CISENPHARMACEUTICALCO.,LTD.-CN112250664,2021,A

[16]CurrentPatentAssignee:CHONGQINGCHEMICALINDVOCATIONALCOLLENGE-CN112341432,2021,A

[17]CurrentPatentAssignee:CHONGQINGCHEMICALINDVOCATIONALCOLLENGE-CN112341432,2021,A

Literature

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Journal: Chemical research in toxicology 20150518

Title: Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations.

Journal: Journal of molecular modeling 20140401

Title: Novel serine protease dipeptidyl peptidase IV inhibitor: alogliptin.

Journal: Mini reviews in medicinal chemistry 20121101

Title: Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results.

Journal: Journal of clinical pharmacology 20121001

Title: Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study.

Journal: Diabetes, obesity & metabolism 20121001

Title: Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.

Journal: American journal of physiology. Renal physiology 20121001

Title: Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial.

Journal: Endocrine 20120601

Title: Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.

Journal: The Journal of clinical endocrinology and metabolism 20120501

Title: An update in incretin-based therapy: a focus on dipeptidyl peptidase--4 inhibitors.

Journal: Current diabetes reviews 20120501

Title: DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.

Journal: Diabetes & metabolism 20120401

Title: Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study.

Journal: Diabetologia 20120401

Title: Alogliptin benzoate for the treatment of type 2 diabetes.

Journal: Expert opinion on pharmacotherapy 20120301

Title: Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study.

Journal: Diabetes, obesity & metabolism 20111201

Title: Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis.

Journal: Circulation 20111122

Title: Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study.

Journal: Diabetes, obesity & metabolism 20111101

Title: Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension.

Journal: Current medical research and opinion 20111101

Title: EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome.

Journal: American heart journal 20111001

Title: Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study.

Journal: Current medical research and opinion 20110901

Title: DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice.

Journal: Journal of cardiovascular pharmacology 20110801

Title: Small molecule dipeptidylpeptidase IV inhibitors under investigation for diabetes mellitus therapy.

Journal: Expert opinion on investigational drugs 20110601

Title: An analysis of the impact of FDA's guidelines for addressing cardiovascular risk of drugs for type 2 diabetes on clinical development.

Journal: Contemporary clinical trials 20110501

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Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501

Title: [A compounding agent of alogliptin and pioglitazone].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501

Title: Effects of chronic administration of alogliptin on the development of diabetes and β-cell function in high fat diet/streptozotocin diabetic mice.

Journal: Diabetes, obesity & metabolism 20110401

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Journal: Drugs of today (Barcelona, Spain : 1998) 20110201

Title: Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.

Journal: Hospital practice (1995) 20110201

Title: Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice.

Journal: Biochemical and biophysical research communications 20110107

Title: The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes.

Journal: European journal of medicinal chemistry 20110101

Title: [Pharmacological and clinical profile of alogliptin benzoate (NESINA®)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110101

Title: Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways.

Journal: Vascular pharmacology 20110101

Title: Treatment of streptozotocin-induced diabetic rats with alogliptin: effect on vascular and neural complications.

Journal: Experimental diabetes research 20110101

Title: Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.

Journal: PloS one 20110101

Title: DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes.

Journal: Atherosclerosis 20101201

Title: DPP-4 inhibitors: what may be the clinical differentiators?

Journal: Diabetes research and clinical practice 20101101

Title: Initial combination therapy with alogliptin and pioglitazone in drug-naïve patients with type 2 diabetes.

Journal: Diabetes care 20101101

Title: Alogliptin: a novel molecule for improving glycemic control in type II diabetes mellitus.

Journal: Current diabetes reviews 20101101

Title: Alogliptin: a review of its use in the management of type 2 diabetes mellitus.

Journal: Drugs 20101022

Title: Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions.

Journal: Clinical pharmacokinetics 20100901

Title: Managing type 2 diabetes in the primary care setting: beyond glucocentricity.

Journal: The American journal of the medical sciences 20100801

Title: Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice.

Journal: Diabetes, obesity & metabolism 20100301

Title: The physiologic role of incretin hormones: clinical applications.

Journal: The Journal of the American Osteopathic Association 20100301

Title: Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics 20100101

Title: Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.

Journal: Vascular health and risk management 20100101

Title: Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia.

Journal: Diabetes, obesity & metabolism 20091201

Title: Alogliptin use in elderly people: a pooled analysis from phase 2 and 3 studies.

Journal: Journal of the American Geriatrics Society 20091101

Title: Coadministration of pioglitazone or glyburide and alogliptin: pharmacokinetic drug interaction assessment in healthy participants.

Journal: Journal of clinical pharmacology 20091001

Title: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study.

Journal: Current medical research and opinion 20091001

Title: A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure.

Journal: Life sciences 20090717

Title: Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice.

Journal: British journal of pharmacology 20090601

Title: Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.

Journal: Bioorganic & medicinal chemistry 20090301

Title: DPP4 inhibitors: from sitagliptin monotherapy to the new alogliptin-pioglitazone combination therapy.

Journal: Advances in therapy 20090301

Title: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy.

Journal: Diabetes, obesity & metabolism 20090201

Title: Alogliptin: a new, highly selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.

Journal: Expert opinion on pharmacotherapy 20090201

Title: The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice.

Journal: European journal of pharmacology 20090114

Title: Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study.

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Journal: The Diabetes educator 20090101

Title: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study.

Journal: Diabetes care 20081201

Title: Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.

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Title: Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.

Journal: European journal of pharmacology 20080707

Title: Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes.

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Title: Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes.

Journal: Clinical therapeutics 20080301

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Title: Hao FL, et, al. The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells. Biomed Pharmacother. 2019 Jan;109:181-187.

Title: Asakawa T, et, al. A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure. Life Sci. 2009 Jul 17;85(3-4):122-6.

Title: Moritoh Y, et al. The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice. Eur J Pharmacol. 2009 Jan 14;602(2-3):448-54.

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Tags:850649-62-6 Molecular Formula|850649-62-6 MDL|850649-62-6 SMILES|850649-62-6 Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, monobenzoate
Catalog No.: AA00IDG5
850649-62-6,MFCD09833195
850649-62-6 | Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, monobenzoate
Pack Size: 50mg
Purity: 97%
in stock
$6.00 $4.00
Pack Size: 100mg
Purity: 97%
in stock
$8.00 $6.00
Pack Size: 1g
Purity: 97%
in stock
$28.00 $20.00
Pack Size: 5g
Purity: 97%
in stock
$96.00 $68.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00IDG5
Chemical Name: Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, monobenzoate
CAS Number: 850649-62-6
Molecular Formula: C25H27N5O4
Molecular Weight: 461.5130
MDL Number: MFCD09833195
SMILES: OC(=O)c1ccccc1.N#Cc1ccccc1Cn1c(cc(=O)n(c1=O)C)N1CCC[C@H](C1)N
Properties
Complexity: 726  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 34  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
850649-61-5    65-85-0   
Alogliptinbenzoate 

[1]Patent:CN107954978,2018,A.Locationinpatent:Paragraph0045

[2]Patent:CN109232532,2019,A.Locationinpatent:Paragraph0049;0098-0105;0106;0149-0154;0155;0198-0203

[3]Patent:CN109810094,2019,A.Locationinpatent:Paragraph0021;0022

[4]Patent:CN110128401,2019,A.Locationinpatent:Paragraph0075-0081

[5]Patent:US2017/81305,2017,A1.Locationinpatent:Paragraph0417-0418

[6]Patent:WO2015/92807,2015,A1.Locationinpatent:Sheet8;9

[7]Patent:CN103980249,2016,B.Locationinpatent:Paragraph0014;0038;0041

[8]Patent:CN104086527,2016,B.Locationinpatent:Paragraph0052;0064-0066;0076

[9]Patent:CN103524483,2016,B.Locationinpatent:Paragraph0021-0023

[10]Patent:CN106336396,2017,A.Locationinpatent:Paragraph0120-0125

[11]Patent:US2007/66635,2007,A1.Locationinpatent:Page/Pagecolumn15

[12]Patent:WO2010/72680,2010,A1.Locationinpatent:Page/Pagecolumn17-18

[13]Patent:CN103923063,2016,B.Locationinpatent:Paragraph0045

[14]Patent:CN104193726,2016,B.Locationinpatent:Paragraph0056-0057

[15]Patent:CN106366068,2017,A.Locationinpatent:Paragraph0019

1246610-75-2    65-85-0    850649-62-6 

[1]CurrentPatentAssignee:CHANGZHOUSIYAOPHARMACEUTICALSCOLTD-CN107540656,2018,ALocationinpatent:Paragraph0039;0040;0071-0073;0074-0076

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2009/275750,2009,A1Locationinpatent:Page/Pagecolumn23-24

1246610-74-1    65-85-0    850649-62-6 

[1]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECHCOP-CN106632242,2017,ALocationinpatent:Paragraph0012;0025

[2]CurrentPatentAssignee:BEIJINGDOCTORANTETECHDEV-CN105367546,2016,ALocationinpatent:Paragraph0015

[3]CurrentPatentAssignee:MAPIPHARMALTD.-WO2010/109468,2010,A1Locationinpatent:Page/Pagecolumn28

850649-61-5    65-85-0   
alogliptinbenzoate 

[1]Patent:WO2013/46229,2013,A1.Locationinpatent:Page/Pagecolumn20

22115-41-9    850649-62-6 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-EP2682110,2014,A1

[2]CurrentPatentAssignee:HARMANFINOCHEMLIMITED;KADAM,VijayTrimbak;BUDDHALA,RajasekharRao;SINGAMPALLLI,SriHah;MINHAS,HarpreetSingh;MINHAS,GurpreetSingh-WO2015/92807,2015,A1

[3]CurrentPatentAssignee:BEIJINGDOCTORANTETECHDEV-CN105367546,2016,A

[4]CurrentPatentAssignee:ZHEJIANGYONGNINGPHARMA-CN103819450,2016,B

[5]CurrentPatentAssignee:ANHUINEWSTARPHARMACEUTICALDEV-CN103980249,2016,B

[6]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-US2016/340333,2016,A1

[7]CurrentPatentAssignee:SUZHOULANXITEBIOTECHNOLOGYCOLTD-CN103524483,2016,B

[8]CurrentPatentAssignee:JIANGSUDEYUANPHARMACEUTICAL-CN104193726,2016,B

[9]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECHCOP-CN106632242,2017,A

[10]CurrentPatentAssignee:HEFEILIFEONPHARMACEUTICAL-CN106336396,2017,A

[11]CurrentPatentAssignee:CHANGZHOUSIYAOPHARMACEUTICALSCOLTD-CN107540656,2018,A

[12]CurrentPatentAssignee:CHANGZHOUSUNLIGHTPHARM-CN107954978,2018,A

[13]CurrentPatentAssignee:UNIVJINLINMEDICAL-CN108912093,2018,A

[14]CurrentPatentAssignee:CHONGQINGKERUINANHAIPHARMACEUTICAL-CN109232532,2019,A

[15]CurrentPatentAssignee:CISENPHARMACEUTICALCO.,LTD.-CN112250664,2021,A

[16]CurrentPatentAssignee:CHONGQINGCHEMICALINDVOCATIONALCOLLENGE-CN112341432,2021,A

[17]CurrentPatentAssignee:CHONGQINGCHEMICALINDVOCATIONALCOLLENGE-CN112341432,2021,A

Literature fold

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology20150518

Title: Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations.

Journal: Journal of molecular modeling20140401

Title: Novel serine protease dipeptidyl peptidase IV inhibitor: alogliptin.

Journal: Mini reviews in medicinal chemistry20121101

Title: Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results.

Journal: Journal of clinical pharmacology20121001

Title: Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study.

Journal: Diabetes, obesity & metabolism20121001

Title: Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.

Journal: American journal of physiology. Renal physiology20121001

Title: Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial.

Journal: Endocrine20120601

Title: Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.

Journal: The Journal of clinical endocrinology and metabolism20120501

Title: An update in incretin-based therapy: a focus on dipeptidyl peptidase--4 inhibitors.

Journal: Current diabetes reviews20120501

Title: DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.

Journal: Diabetes & metabolism20120401

Title: Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study.

Journal: Diabetologia20120401

Title: Alogliptin benzoate for the treatment of type 2 diabetes.

Journal: Expert opinion on pharmacotherapy20120301

Title: Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study.

Journal: Diabetes, obesity & metabolism20111201

Title: Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis.

Journal: Circulation20111122

Title: Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study.

Journal: Diabetes, obesity & metabolism20111101

Title: Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension.

Journal: Current medical research and opinion20111101

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