[1]Patent:CN107954978,2018,A.Locationinpatent:Paragraph0045
[2]Patent:CN109232532,2019,A.Locationinpatent:Paragraph0049;0098-0105;0106;0149-0154;0155;0198-0203
[3]Patent:CN109810094,2019,A.Locationinpatent:Paragraph0021;0022
[4]Patent:CN110128401,2019,A.Locationinpatent:Paragraph0075-0081
[5]Patent:US2017/81305,2017,A1.Locationinpatent:Paragraph0417-0418
[6]Patent:WO2015/92807,2015,A1.Locationinpatent:Sheet8;9
[7]Patent:CN103980249,2016,B.Locationinpatent:Paragraph0014;0038;0041
[8]Patent:CN104086527,2016,B.Locationinpatent:Paragraph0052;0064-0066;0076
[9]Patent:CN103524483,2016,B.Locationinpatent:Paragraph0021-0023
[10]Patent:CN106336396,2017,A.Locationinpatent:Paragraph0120-0125
[11]Patent:US2007/66635,2007,A1.Locationinpatent:Page/Pagecolumn15
[12]Patent:WO2010/72680,2010,A1.Locationinpatent:Page/Pagecolumn17-18
[13]Patent:CN103923063,2016,B.Locationinpatent:Paragraph0045
[14]Patent:CN104193726,2016,B.Locationinpatent:Paragraph0056-0057
[15]Patent:CN106366068,2017,A.Locationinpatent:Paragraph0019
[1]CurrentPatentAssignee:CHANGZHOUSIYAOPHARMACEUTICALSCOLTD-CN107540656,2018,ALocationinpatent:Paragraph0039;0040;0071-0073;0074-0076
[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2009/275750,2009,A1Locationinpatent:Page/Pagecolumn23-24
[1]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECHCOP-CN106632242,2017,ALocationinpatent:Paragraph0012;0025
[2]CurrentPatentAssignee:BEIJINGDOCTORANTETECHDEV-CN105367546,2016,ALocationinpatent:Paragraph0015
[3]CurrentPatentAssignee:MAPIPHARMALTD.-WO2010/109468,2010,A1Locationinpatent:Page/Pagecolumn28
[1]Patent:WO2013/46229,2013,A1.Locationinpatent:Page/Pagecolumn20
[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-EP2682110,2014,A1
[2]CurrentPatentAssignee:HARMANFINOCHEMLIMITED;KADAM,VijayTrimbak;BUDDHALA,RajasekharRao;SINGAMPALLLI,SriHah;MINHAS,HarpreetSingh;MINHAS,GurpreetSingh-WO2015/92807,2015,A1
[3]CurrentPatentAssignee:BEIJINGDOCTORANTETECHDEV-CN105367546,2016,A
[4]CurrentPatentAssignee:ZHEJIANGYONGNINGPHARMA-CN103819450,2016,B
[5]CurrentPatentAssignee:ANHUINEWSTARPHARMACEUTICALDEV-CN103980249,2016,B
[6]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-US2016/340333,2016,A1
[7]CurrentPatentAssignee:SUZHOULANXITEBIOTECHNOLOGYCOLTD-CN103524483,2016,B
[8]CurrentPatentAssignee:JIANGSUDEYUANPHARMACEUTICAL-CN104193726,2016,B
[9]CurrentPatentAssignee:HANGZHOUBIOSINCERITYPHARMATECHCOP-CN106632242,2017,A
[10]CurrentPatentAssignee:HEFEILIFEONPHARMACEUTICAL-CN106336396,2017,A
[11]CurrentPatentAssignee:CHANGZHOUSIYAOPHARMACEUTICALSCOLTD-CN107540656,2018,A
[12]CurrentPatentAssignee:CHANGZHOUSUNLIGHTPHARM-CN107954978,2018,A
[13]CurrentPatentAssignee:UNIVJINLINMEDICAL-CN108912093,2018,A
[14]CurrentPatentAssignee:CHONGQINGKERUINANHAIPHARMACEUTICAL-CN109232532,2019,A
[15]CurrentPatentAssignee:CISENPHARMACEUTICALCO.,LTD.-CN112250664,2021,A
[16]CurrentPatentAssignee:CHONGQINGCHEMICALINDVOCATIONALCOLLENGE-CN112341432,2021,A
[17]CurrentPatentAssignee:CHONGQINGCHEMICALINDVOCATIONALCOLLENGE-CN112341432,2021,A
Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
Journal: Chemical research in toxicology 20150518
Title: Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations.
Journal: Journal of molecular modeling 20140401
Title: Novel serine protease dipeptidyl peptidase IV inhibitor: alogliptin.
Journal: Mini reviews in medicinal chemistry 20121101
Title: Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results.
Journal: Journal of clinical pharmacology 20121001
Title: Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study.
Journal: Diabetes, obesity & metabolism 20121001
Title: Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.
Journal: American journal of physiology. Renal physiology 20121001
Title: Alogliptin as an initial therapy in patients with newly diagnosed, drug naïve type 2 diabetes: a randomized, control trial.
Journal: Endocrine 20120601
Title: Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.
Journal: The Journal of clinical endocrinology and metabolism 20120501
Title: An update in incretin-based therapy: a focus on dipeptidyl peptidase--4 inhibitors.
Journal: Current diabetes reviews 20120501
Title: DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.
Journal: Diabetes & metabolism 20120401
Title: Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study.
Journal: Diabetologia 20120401
Title: Alogliptin benzoate for the treatment of type 2 diabetes.
Journal: Expert opinion on pharmacotherapy 20120301
Title: Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study.
Journal: Diabetes, obesity & metabolism 20111201
Title: Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis.
Journal: Circulation 20111122
Title: Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study.
Journal: Diabetes, obesity & metabolism 20111101
Title: Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension.
Journal: Current medical research and opinion 20111101
Title: EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome.
Journal: American heart journal 20111001
Title: Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study.
Journal: Current medical research and opinion 20110901
Title: DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice.
Journal: Journal of cardiovascular pharmacology 20110801
Title: Small molecule dipeptidylpeptidase IV inhibitors under investigation for diabetes mellitus therapy.
Journal: Expert opinion on investigational drugs 20110601
Title: An analysis of the impact of FDA's guidelines for addressing cardiovascular risk of drugs for type 2 diabetes on clinical development.
Journal: Contemporary clinical trials 20110501
Title: [Alogliptin].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501
Title: [A compounding agent of alogliptin and pioglitazone].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501
Title: Effects of chronic administration of alogliptin on the development of diabetes and β-cell function in high fat diet/streptozotocin diabetic mice.
Journal: Diabetes, obesity & metabolism 20110401
Title: Alogliptin for the treatment of type 2 diabetes.
Journal: Drugs of today (Barcelona, Spain : 1998) 20110201
Title: Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.
Journal: Hospital practice (1995) 20110201
Title: Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice.
Journal: Biochemical and biophysical research communications 20110107
Title: The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes.
Journal: European journal of medicinal chemistry 20110101
Title: [Pharmacological and clinical profile of alogliptin benzoate (NESINA®)].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110101
Title: Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways.
Journal: Vascular pharmacology 20110101
Title: Treatment of streptozotocin-induced diabetic rats with alogliptin: effect on vascular and neural complications.
Journal: Experimental diabetes research 20110101
Title: Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.
Journal: PloS one 20110101
Title: DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes.
Journal: Atherosclerosis 20101201
Title: DPP-4 inhibitors: what may be the clinical differentiators?
Journal: Diabetes research and clinical practice 20101101
Title: Initial combination therapy with alogliptin and pioglitazone in drug-naïve patients with type 2 diabetes.
Journal: Diabetes care 20101101
Title: Alogliptin: a novel molecule for improving glycemic control in type II diabetes mellitus.
Journal: Current diabetes reviews 20101101
Title: Alogliptin: a review of its use in the management of type 2 diabetes mellitus.
Journal: Drugs 20101022
Title: Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions.
Journal: Clinical pharmacokinetics 20100901
Title: Managing type 2 diabetes in the primary care setting: beyond glucocentricity.
Journal: The American journal of the medical sciences 20100801
Title: Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice.
Journal: Diabetes, obesity & metabolism 20100301
Title: The physiologic role of incretin hormones: clinical applications.
Journal: The Journal of the American Osteopathic Association 20100301
Title: Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.
Journal: International journal of clinical pharmacology and therapeutics 20100101
Title: Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.
Journal: Vascular health and risk management 20100101
Title: Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia.
Journal: Diabetes, obesity & metabolism 20091201
Title: Alogliptin use in elderly people: a pooled analysis from phase 2 and 3 studies.
Journal: Journal of the American Geriatrics Society 20091101
Title: Coadministration of pioglitazone or glyburide and alogliptin: pharmacokinetic drug interaction assessment in healthy participants.
Journal: Journal of clinical pharmacology 20091001
Title: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study.
Journal: Current medical research and opinion 20091001
Title: A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure.
Journal: Life sciences 20090717
Title: Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice.
Journal: British journal of pharmacology 20090601
Title: Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice.
Journal: The Journal of pharmacology and experimental therapeutics 20090501
Title: Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
Journal: Bioorganic & medicinal chemistry 20090301
Title: DPP4 inhibitors: from sitagliptin monotherapy to the new alogliptin-pioglitazone combination therapy.
Journal: Advances in therapy 20090301
Title: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy.
Journal: Diabetes, obesity & metabolism 20090201
Title: Alogliptin: a new, highly selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Journal: Expert opinion on pharmacotherapy 20090201
Title: The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice.
Journal: European journal of pharmacology 20090114
Title: Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study.
Journal: International journal of clinical practice 20090101
Title: New therapeutic horizons: mapping the future of glycemic control with incretin-based therapy.
Journal: The Diabetes educator 20090101
Title: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study.
Journal: Diabetes care 20081201
Title: Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys.
Journal: European journal of pharmacology 20080728
Title: Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.
Journal: European journal of pharmacology 20080707
Title: Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes.
Journal: Current opinion in investigational drugs (London, England : 2000) 20080401
Title: Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes.
Journal: Clinical therapeutics 20080301
Title: Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects.
Journal: Clinical therapeutics 20080301
Title: Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV.
Journal: Current topics in medicinal chemistry 20080101
Title: Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV.
Journal: Journal of medicinal chemistry 20070517
Title: Feng J, et, al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300.
Title: Ta NN, et, al. DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis. 2010 Dec;213(2):429-35.
Title: Hao FL, et, al. The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells. Biomed Pharmacother. 2019 Jan;109:181-187.
Title: Asakawa T, et, al. A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure. Life Sci. 2009 Jul 17;85(3-4):122-6.
Title: Moritoh Y, et al. The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice. Eur J Pharmacol. 2009 Jan 14;602(2-3):448-54.