Home Other Building Blocks 850879-09-3
850879-09-3,MFCD16038298
Catalog No.:AA00IDGG

850879-09-3 | Amuvatinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$132.00   $93.00
- +
10mg
99%
in stock  
$264.00   $185.00
- +
25mg
98%
in stock  
$291.00   $204.00
- +
100mg
98%
in stock  
$497.00   $348.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IDGG
Chemical Name:
Amuvatinib
CAS Number:
850879-09-3
Molecular Formula:
C23H21N5O3S
Molecular Weight:
447.5095
MDL Number:
MFCD16038298
SMILES:
S=C(N1CCN(CC1)c1ncnc2c1oc1c2cccc1)NCc1ccc2c(c1)OCO2
Properties
Computed Properties
 
Complexity:
678  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.5  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.

Journal: Nature genetics 20120801

Title: The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombination.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20111001

Title: MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer.

Journal: BMC cancer 20090101

Title: The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells.

Journal: Radiation oncology (London, England) 20090101

Title: A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors.

Journal: Oncogene 20070607

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