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859-18-7,MFCD00167245
Catalog No.:AA00IDQE

859-18-7 | Lincomycin hydrochloride

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Purity
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1g
95
in stock  
$67.00   $47.00
- +
5g
95
in stock  
$232.00   $163.00
- +
25g
95%
in stock  
$443.00   $310.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IDQE
Chemical Name:
Lincomycin hydrochloride
CAS Number:
859-18-7
Molecular Formula:
C18H35ClN2O6S
Molecular Weight:
442.9983
MDL Number:
MFCD00167245
SMILES:
CCC[C@H]1CN([C@@H](C1)C(=O)N[C@@H]([C@H]1O[C@H](SC)[C@@H](C([C@H]1O)O)O)[C@H](O)C)C.Cl
Properties
Computed Properties
 
Complexity:
499  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
7  

Literature

Title: In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-α-D-gluco-octose as a key intermediate in lincomycin A biosynthesis.

Journal: Journal of the American Chemical Society 20140122

Title: Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.

Journal: Journal of the American Chemical Society 20121024

Title: Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms.

Journal: Water research 20121015

Title: Effect of chronic exposure to acetaminophen and lincomycin on Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa, and potential mechanisms of endocrine disruption.

Journal: Chemosphere 20120901

Title: Gene expression of ribosomal protein mRNA in Chironomus riparius: effects of endocrine disruptor chemicals and antibiotics.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120801

Title: Identification of the unknown transformation products derived from lincomycin using LC-HRMS technique.

Journal: Journal of mass spectrometry : JMS 20120601

Title: Antibiotic and antimicrobial peptide combinations: synergistic inhibition of Pseudomonas fluorescens and antibiotic-resistant variants.

Journal: Research in microbiology 20120201

Title: Optimisation and validation of a quantitative and confirmatory method for residues of macrolide antibiotics and lincomycin in kidney by liquid chromatography coupled to mass spectrometry.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101

Title: An efficient intergeneric conjugation of DNA from Escherichia coli to mycelia of the lincomycin-producer Streptomyces lincolnensis.

Journal: International journal of molecular sciences 20120101

Title: Evaluation of inhibition relief operations for mesophilic anaerobic bio-liquefaction of lincomycin manufacturing biowaste.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20120101

Title: Soil persistence and fate of carbamazepine, lincomycin, caffeine, and ibuprofen from wastewater reuse.

Journal: Journal of environmental quality 20120101

Title: Altered turnover of β-carotene and Chl a in Arabidopsis leaves treated with lincomycin or norflurazon.

Journal: Plant & cell physiology 20110701

Title: Oxidation of antibiotics during water treatment with potassium permanganate: reaction pathways and deactivation.

Journal: Environmental science & technology 20110415

Title: Timing the switch to phototrophic growth: a possible role of GUN1.

Journal: Plant signaling & behavior 20110401

Title: A flow injection chemiluminescence method for the determination of lincomycin in serum using a diperiodato-cuprate (III)-luminol system.

Journal: Luminescence : the journal of biological and chemical luminescence 20110101

Title: [Methodic approaches to treatment of the chronic generalized parodontitis in elderly and senile patients].

Journal: Advances in gerontology = Uspekhi gerontologii 20110101

Title: Effect of extender supplementation with various antimicrobial agents on viability of Brucella ovis and Actinobacillus seminis in cryopreserved ovine semen.

Journal: Theriogenology 20101101

Title: Short flashes and continuous light have similar photoinhibitory efficiency in intact leaves.

Journal: Journal of experimental botany 20101001

Title: Development of a competitive indirect ELISA for the determination of lincomycin in milk, eggs, and honey.

Journal: Journal of agricultural and food chemistry 20100922

Title: Heat stress results in loss of chloroplast Cu/Zn superoxide dismutase and increased damage to Photosystem II in combined drought-heat stressed Lotus japonicus.

Journal: Physiologia plantarum 20100901

Title: A sensitive and specific enzyme-linked immunosorbent assay for the detection of lincomycin in food samples.

Journal: Journal of the science of food and agriculture 20100901

Title: Clinical, histologic, and bacteriologic findings in dairy cows with digital dermatitis (footwarts) one month after topical treatment with lincomycin hydrochloride or oxytetracycline hydrochloride.

Journal: Journal of the American Veterinary Medical Association 20100901

Title: Oxidation kinetics of antibiotics during water treatment with potassium permanganate.

Journal: Environmental science & technology 20100815

Title: The Arabidopsis plastid-signalling mutant gun1 (genomes uncoupled1) shows altered sensitivity to sucrose and abscisic acid and alterations in early seedling development.

Journal: Journal of experimental botany 20100801

Title: Stevens-Johnson syndrome associated with furosemide: a case report.

Journal: Journal of pharmacy practice 20100801

Title: Comparison of the effects of different nutrient media on production of heat-stable enterotoxin-b by Escherichia coli.

Journal: Veterinary microbiology 20100729

Title: Interaction of weakly bound antibiotics neomycin and lincomycin with bovine and human serum albumin: biophysical approach.

Journal: Journal of biochemistry 20100701

Title: Reaction of lincosamide antibiotics with manganese oxide in aqueous solution.

Journal: Environmental science & technology 20100615

Title: Characterization of antimicrobial resistance in Enterococcus spp. recovered from a commercial beef processing plant.

Journal: Foodborne pathogens and disease 20100301

Title: Antibiotic prescription for the treatment of endodontic pathology: a survey among Lithuanian dentists.

Journal: Medicina (Kaunas, Lithuania) 20100101

Title: Antimicrobial resistance in Clostridium perfringens isolates from broilers in Belgium.

Journal: Veterinary research communications 20091201

Title: Lincomycin-induced over-expression of mature recombinant cholera toxin B subunit and the holotoxin in Escherichia coli.

Journal: Protein expression and purification 20091001

Title: Role of interlayer hydration in lincomycin sorption by smectite clays.

Journal: Environmental science & technology 20090815

Title: Lincomycin, rational selection of high producing strain and improved fermentation by amino acids supplementation.

Journal: Bioprocess and biosystems engineering 20090601

Title: Study of the depletion of lincomycin residues in honey extracted from treated honeybee (Apis mellifera L.) colonies and the effect of the shook swarm procedure.

Journal: Analytica chimica acta 20090401

Title: Peripheral blood leukocyte subpopulation of dairy cows with digital dermatitis and effect of hoof trimming with antibiotic treatment.

Journal: The Journal of veterinary medical science 20090401

Title: HPLC-fluorescence detection method for determination of key intermediates of the lincomycin biosynthesis in fermentation broth.

Journal: Analytical and bioanalytical chemistry 20090301

Title: Biochemical characterization of L-DOPA 2,3-dioxygenase, a single-domain type I extradiol dioxygenase from lincomycin biosynthesis.

Journal: Archives of biochemistry and biophysics 20081115

Title: Tolerance to antimicrobial agents and persistence of Escherichia coli and cyanobacteria.

Journal: Biochemistry. Biokhimiia 20080701

Title: Characterization of Staphylococcus species isolated from raw milk and milk products (lben and jben) in North Morocco.

Journal: Journal of infection in developing countries 20080601

Title: Post operative penicillin-non-susceptible Streptococcus pneumoniae meningitis and septic shock in a child.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080401

Title: Effects and interactions in an environmentally relevant mixture of pharmaceuticals.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080301

Title: Influence of antibiotic therapy on serum levels of reactive oxygen species in ovariectomized bitches.

Journal: Journal of veterinary pharmacology and therapeutics 20080201

Title: [Distribution and characteristics of Bacillus bacteria associated with hydrobionts and the waters of the Peter the Great Bay, Sea of Japan].

Journal: Mikrobiologiia 20080101

Title: Lincomycin protects mice from septic shock in beta-glucan-indomethacin model.

Journal: Biological & pharmaceutical bulletin 20071201

Title: Airborne antibiotic concentrations in a swine feeding operation.

Journal: Journal of agricultural safety and health 20071101

Title: Effects of tiamulin, neomycin, tetracycline, fluorophenicol, penicillin G, Linco-Spectin, erythromycin and oxytetracycline on controlling bacterial contaminations of the river buffalo (Buballus bubalis) semen.

Journal: Pakistan journal of biological sciences : PJBS 20070915

Title: A bacterial transgene for catalase protects translation of d1 protein during exposure of salt-stressed tobacco leaves to strong light.

Journal: Plant physiology 20070901

Title: Photosystem II damage induced by chemically generated singlet oxygen in tobacco leaves.

Journal: Physiologia plantarum 20070901

Title: Signals from chloroplasts converge to regulate nuclear gene expression.

Journal: Science (New York, N.Y.) 20070504

Title: A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt: hot water extraction followed by liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Susceptibility of bacterial pathogens against lincomycin/spectinomycin (1/2), penicillin G/neomycin (1/1), and penicillin G/dihydrostreptomycin (1/1) as determined in the BfT-GermVet monitoring program 2004-2006.

Journal: Berliner und Munchener tierarztliche Wochenschrift 20070101

Title: Hybridization analysis and mapping of the celesticetin gene cluster revealed genes shared with lincomycin biosynthesis.

Journal: Folia microbiologica 20070101

Title: Simultaneous determination of lincomycin and five macrolide antibiotic residues in honey by liquid chromatography coupled to electrospray ionization mass spectrometry (LC-MS/MS).

Journal: Food additives and contaminants 20061101

Title: Electrochemical study of lincomycin on a multi-wall carbon nanotubes modified glassy carbon electrode and its determination in tablets.

Journal: Journal of pharmaceutical and biomedical analysis 20060607

Title: [Vaginal colonization of the Streptococcus agalactiae in pregnant woman in Tunisia: risk factors and susceptibility of isolates to antibiotics].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20060501

Title: Development and validation of a gradient HPLC method for the determination of clindamycin and related compounds in a novel tablet formulation.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: Presence of 'PSI free' LHCI and monomeric LHCII and subsequent effects on fluorescence characteristics in lincomycin treated maize.

Journal: Planta 20060401

Title: First experience on the effect of in-feed lincomycin for the control of proliferative enteropathy in growing pigs.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20060401

Title: Programmed cell death in plants: effect of protein synthesis inhibitors and structural changes in pea guard cells.

Journal: Biochemistry. Biokhimiia 20060401

Title: HPLC determination of lincomycin in premixes and feedstuffs with solid-phase extraction on HLB OASIS and LC-MS/MS confirmation.

Journal: Journal of pharmaceutical and biomedical analysis 20060303

Title: Biodegradability and toxicity of pharmaceuticals in biological wastewater treatment plants.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101

Title: 3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin.

Journal: Bioorganic & medicinal chemistry 20050901

Title: Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation.

Journal: The Plant journal : for cell and molecular biology 20050801

Title: Macrolides and lincomycin susceptibility of Mycoplasma hyorhinis and variable mutation of domain II and V in 23S ribosomal RNA.

Journal: The Journal of veterinary medical science 20050801

Title: Cellular energization protects the photosynthetic machinery against salt-induced inactivation in Synechococcus.

Journal: Biochimica et biophysica acta 20050630

Title: Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA.

Journal: FEMS microbiology letters 20050615

Title: Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets.

Journal: Domestic animal endocrinology 20050501

Title: Management of diabetic foot in a Jordanian hospital.

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20050501

Title: Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate.

Journal: Environmental toxicology and chemistry 20050401

Title: Drug resistance and pulsed-field gel electrophoresis patterns of Lactococcus garvieae isolates from cultured Seriola (yellowtail, amberjack and kingfish) in Japan.

Journal: Letters in applied microbiology 20050101

Title: The nuclear genes Lhcb and HEMA1 are differentially sensitive to plastid signals and suggest distinct roles for the GUN1 and GUN5 plastid-signalling pathways during de-etiolation.

Journal: The Plant journal : for cell and molecular biology 20041201

Title: Antibiotic sensitivity patterns among Indian strains of avian Pasteurella multocida.

Journal: Tropical animal health and production 20041101

Title: Lack of pharmacokinetic interaction between lincomycin and aspirin in healthy goats.

Journal: Journal of veterinary pharmacology and therapeutics 20041001

Title: l-3,4-Dihydroxyphenyl alanine-extradiol cleavage is followed by intramolecular cyclization in lincomycin biosynthesis.

Journal: European journal of biochemistry 20040901

Title: Crystal and molecular structure and absolute configuration of lincomycin hydrochloride monohydrate.

Journal: Carbohydrate research 20040823

Title: Lincomycin, clindamycin and their applications.

Journal: Applied microbiology and biotechnology 20040501

Title: Larval Apis mellifera L. (Hymenoptera: Apidae) mortality after topical application of antibiotics and dusts.

Journal: Journal of economic entomology 20040401

Title: [intraocular Lincomycin causes retinal toxic retinochoroiditis].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20040401

Title: Quantitative analysis of lincomycin in animal tissues and bovine milk by liquid chromatography electrospray ionization tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20040218

Title: Lincomycin, cultivation of producing strains and biosynthesis.

Journal: Applied microbiology and biotechnology 20040201

Title: [The use of macrolides, lincomycin and tiamulin as animal feed drugs for pigs in Schleswig-Holstein].

Journal: Berliner und Munchener tierarztliche Wochenschrift 20040101

Title: Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications.

Journal: Advances in applied microbiology 20040101

Title: [Moraxella catarrhalis in chronic and relapsing respiratory tract infections in children].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101

Title: [Interaction of aminoglycosides and the other antibiotic on selected bacterial strains].

Journal: Medycyna doswiadczalna i mikrobiologia 20040101

Title: [Clinical basis of provocative detoxicating etiotropic therapy of chronic toxoplasmosis in pediatric cases].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101

Title: Inhibition of Bacillus subtilis aprE expression by lincomycin at the posttranscriptional level through inhibition of ppGpp synthesis.

Journal: Journal of biochemistry 20031101

Title: In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin.

Journal: Research in veterinary science 20030801

Title: [Therapeutic effect of some antibiotics on experimental staphylococcal infection and its correlation with in vitro activity of antibiotics in sub-inhibitory concentration against Staphylococcus aureus strains].

Journal: Medycyna doswiadczalna i mikrobiologia 20030101

Title: [Efficacy of treatment of chronic destructive forms of apical periodontitis using oral decontamination antibiotic therapy].

Journal: Stomatologiia 20030101

Title: Multiple plastid signals regulate the expression of the pea plastocyanin gene in pea and transgenic tobacco plants.

Journal: The Plant journal : for cell and molecular biology 20021201

Title: Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients.

Journal: Journal of Korean medical science 20020801

Title: Determination of clindamycin in animal plasma by high-performance liquid chromatography combined with electrospray ionization mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20020801

Title: Analysis of a formulation containing lincomycin and spectinomycin by liquid chromatography with pulsed electrochemical detection.

Journal: Journal of pharmaceutical and biomedical analysis 20020620

Title: Effects of altered plasma alpha1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis.

Journal: Journal of veterinary pharmacology and therapeutics 20020601

Title: Evaluation of tiamulin and lincomycin for the treatment of broiler breeders experimentally infected with the intestinal spirochaete Brachyspira pilosicoli.

Journal: Avian pathology : journal of the W.V.P.A 20020601

Title: Effects of altered plasma alpha-1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis.

Journal: Journal of veterinary pharmacology and therapeutics 20011201

Title: [Homologous recombination in Streptomyces lincolnensis B48].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20011001

Title: Comparison of valnemulin and lincomycin in the treatment of digital dermatitis by individually applied topical spray.

Journal: The Veterinary record 20010908

Title: Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin.

Journal: Molecules and cells 20010831

Title: Enzymatic glycosylation of lincomycin.

Journal: Bioscience, biotechnology, and biochemistry 20010801

Title: Antibacterial effect of antibiotic solution on cellular viability in canine veins.

Journal: Artificial organs 20010601

Title: The effect of organic acids on the control of porcine post-weaning diarrhoea.

Journal: Research in veterinary science 20010601

Title: Intestinal spirochete infections of chickens: a review of disease associations, epidemiology and control.

Journal: Animal health research reviews 20010601

Title: Sensitive and specific determination of clindamycin in human serum and bone tissue applying liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010505

Title: Copper(II)-lincomycin: complexation pattern and oxidative activity.

Journal: Journal of inorganic biochemistry 20010401

Title: Optimization of the resistance of arterial allografts to infection: comparative study with synthetic prostheses.

Journal: Annals of vascular surgery 20010301

Title: Characterization of nine Pasteurella multocida isolates from avian cholera outbreaks in Indonesia.

Journal: Avian diseases 20010101

Title: Sideroblastic anaemia associated with lincomycin therapy.

Journal: Postgraduate medical journal 19831201

Title: Acute interstitial nephritis associated with gentamicin and lincomycin therapy.

Journal: Postgraduate medical journal 19800601

Title: Further observations in lincomycin-induced cholelithiasis in guinea-pigs.

Journal: The Journal of pathology 19800601

Title: [Hypokalemia during carbenicillin treatment].

Journal: Ugeskrift for laeger 19800310

Title: [Cardiorespiratory arrest due to intraperitoneal absorption of Lincocin].

Journal: Minerva anestesiologica 19790301

Title: [Letter: Cardiac arrest following the rapid intravenous injection of lincomycin].

Journal: La Nouvelle presse medicale 19750524

Title: The spectrum of colitis associated with lincomycin and clindamycin therapy.

Journal: The Journal of infectious diseases 19750501

Title: Lincomycin-curare interaction.

Journal: Anesthesia and analgesia 19750101

Title: Lincomycin-induced cardiac arrest: a case report and laboratory investigation.

Journal: Anesthesia and analgesia 19740101

Title: Clindamycin-associated colitis.

Journal: JAMA 19730319

Title: [Treatment of surgical infections with lincomycin and 7-chlor-lincomycin].

Journal: Arzneimittel-Forschung 19700101

Title: Lincomycin in larger doses.

Journal: JAMA 19681125

Title: STUDIES ON THE BIOSYNTHESIS OF LINCOMYCIN. II. ANTIBIOTIC U-11,973, N-DEMETHYL LINCOMYCIN.

Journal: Biochemistry 19650401

Title: Griaznova, N.S., et al., [Effect of lincomycin and other protein synthesis inhibitors on the metabolism of Actinomyces roseolus, a producer of lincomycin Antibiotiki, 1980. 25(4): p. 250-6.

Title: Hummel, H., W. Piepersberg, and A. Bock, Analysis of lincomycin resistance mutations in Escherichia coli. Mol Gen Genet, 1979. 169(3): p. 345-7.

Title: Champney, W.S. and C.L. Tober, Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol, 2000. 41(2): p. 126-35.

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Tags:859-18-7 Molecular Formula|859-18-7 MDL|859-18-7 SMILES|859-18-7 Lincomycin hydrochloride