908-54-3,MFCD00058386
Catalog No.:AA00IG7U

908-54-3 | bis(2-acetamidoacetic acid); 4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
50mg
98%
in stock  
$23.00   $16.00
- +
100mg
98%
in stock  
$42.00   $29.00
- +
250mg
98%
in stock  
$61.00   $43.00
- +
1g
≥98%
in stock  
$69.00   $48.00
- +
5g
≥98%
in stock  
$218.00   $152.00
- +
25g
95%
in stock  
$760.00   $532.00
- +
100g
95%
in stock  
$2,090.00 $1,463.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IG7U
Chemical Name:
bis(2-acetamidoacetic acid); 4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide
CAS Number:
908-54-3
Molecular Formula:
C22H29N9O6
Molecular Weight:
515.5224
MDL Number:
MFCD00058386
SMILES:
NC(=N)c1ccc(cc1)NN=Nc1ccc(cc1)C(=N)N.CC(=O)NCC(=O)O.CC(=O)NCC(=O)O
Properties
Properties
 
Form:
Solid  
MP:
202 °C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
500  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
9  

Downstream Synthesis Route
908-54-3    108-46-3   
C13H12N4O2*H2O 

[1]ChemicalCommunications,2016,vol.52,p.4191-4194

908-54-3    108-95-2   
C13H12N4O*H(1+) 

[1]ChemicalCommunications,2016,vol.52,p.4191-4194

7647-01-0   
cis-Pt(N-hydroxymethyl-3,5-dimethylpyrazole)2I2 
  7732-18-5    908-54-3   
C52H68N22O4Pt2(2+)*2H2O*4ClH 

[1]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1006-1023

7647-01-0   
cis-Pt(3,5-dimethylpyrazole)2I2 
  7732-18-5    908-54-3   
C48H60N22Pt2(2+)*2H2O*4ClH 

[1]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1006-1023

7647-01-0   
cis-Pt(3,4-dimethylpyrazole)2I2 
  7732-18-5    908-54-3   
C48H60N22Pt2(2+)*2H2O*4ClH 

[1]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1006-1023

Literature

Title: Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20141201

Title: Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso).

Journal: Veterinary parasitology 20121221

Title: Involvement of mitochondrial genes of Babesia gibsoni in resistance to diminazene aceturate.

Journal: The Journal of veterinary medical science 20120901

Title: Purification of plasmid DNA from clarified and non-clarified Escherichia coli lysates by berenil pseudo-affinity chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro.

Journal: The Japanese journal of veterinary research 20120801

Title: Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso.

Journal: Veterinary parasitology 20120608

Title: Energetics of ligand binding to the DNA minor groove.

Journal: Physical chemistry chemical physics : PCCP 20120428

Title: Highly debilitating natural Trypanosoma vivax infections in Brazilian calves: epidemiology, pathology, and probable transplacental transmission.

Journal: Parasitology research 20120101

Title: Validation of an HPLC method for the simultaneous determination of diminazene diaceturate and phenazone in injectable veterinary granules and bulk powders.

Journal: Pakistan journal of pharmaceutical sciences 20120101

Title: Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali.

Journal: Parasites & vectors 20120101

Title: High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.

Journal: PLoS neglected tropical diseases 20111201

Title: Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.

Journal: Experimental physiology 20111001

Title: Genital lesions in male red fronted gazelles (Gazella rufifrons) experimentally infected with Trypanosoma brucei and the effect of melarsamine hydrochloride (Cymelarsan®) and diminazene aceturate (Berenil®) in its treatment.

Journal: Theriogenology 20110901

Title: CBFB and MYH11 in inv(16)(p13q22) of acute myeloid leukemia displaying close spatial proximity in interphase nuclei of human hematopoietic stem cells.

Journal: Genes, chromosomes & cancer 20110901

Title: Serial haematology results in transfused and non-transfused dogs naturally infected with Babesia rossi.

Journal: Journal of the South African Veterinary Association 20110901

Title: Experimental infection with Rangelia vitalii in dogs: acute phase, parasitemia, biological cycle, clinical-pathological aspects and treatment.

Journal: Experimental parasitology 20110801

Title: Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.

Journal: Acta tropica 20110701

Title: Diminazene aceturate associated with sodium selenite and vitamin E in the treatment of Trypanosoma evansi infection in rats.

Journal: Experimental parasitology 20110701

Title: Specific berenil-DNA interactions: an approach for separation of plasmid isoforms by pseudo-affinity chromatography.

Journal: Analytical biochemistry 20110515

Title: The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.

Journal: Asian Pacific journal of tropical medicine 20110501

Title: Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate.

Journal: The Japanese journal of veterinary research 20101101

Title: Babesia canis and Babesia rossi co-infection in an untraveled Nigerian dog.

Journal: Veterinary parasitology 20101029

Title: Efficacy of Cymelarsan and Diminasan against Trypanosoma equiperdum infections in mice and horses.

Journal: Veterinary parasitology 20100804

Title: Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro.

Journal: The Journal of veterinary medical science 20100601

Title: Structural binding evidence of the trypanocidal drugs berenil and pentacarinate active principles to a serine protease model.

Journal: International journal of biological macromolecules 20100601

Title: Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.

Journal: Eukaryotic cell 20100201

Title: Use of a doxycycline-enrofloxacin-metronidazole combination with/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni.

Journal: Acta veterinaria Scandinavica 20100101

Title: The effects of hairpin loops on ligand-DNA interactions.

Journal: The journal of physical chemistry. B 20091029

Title: Structure and inhibition of human diamine oxidase.

Journal: Biochemistry 20091020

Title: Effects of melarsamine hydrochloride (Cymelarsan) and diminazene aceturate (Berenil) on the pathology of experimental Trypanosoma brucei infection in red fronted gazelles (Gazella rufifrons).

Journal: Veterinary parasitology 20090707

Title: Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys.

Journal: Tropical medicine & international health : TM & IH 20090701

Title: Five-fold increase in Trypanosoma congolense isolates resistant to diminazene aceturate over a seven-year period in Eastern Zambia.

Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20081201

Title: Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses.

Journal: Tropical animal health and production 20080801

Title: Enhancement of hydrophilic drug loading and release characteristics through micellization with new carboxymethyldextran-PEG block copolymers of tunable charge density.

Journal: International journal of pharmaceutics 20080522

Title: Prevalence of bovine trypanosomosis and trypanocidal drug sensitivity studies on Trypanosoma congolense in Wolyta and Dawero zones of southern Ethiopia.

Journal: Veterinary parasitology 20080325

Title: Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs.

Journal: Veterinary parasitology 20080214

Title: Acute phase response in mice experimentally infected with Trypanosoma congolense: a molecular gauge of parasite-host interaction.

Journal: Veterinary parasitology 20080125

Title: Microarray analysis of the in vivo sequence preferences of a minor groove binding drug.

Journal: BMC genomics 20080101

Title: Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.

Journal: Journal of natural products 20071001

Title: Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.

Journal: The Onderstepoort journal of veterinary research 20070301

Title: Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system.

Journal: Veterinary parasitology 20070131

Title: Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121

Title: SSCP analysis of the P2 purine transporter TcoAT1 gene of Trypanosoma congolense leads to a simple PCR-RFLP test allowing the rapid identification of diminazene resistant stocks.

Journal: Acta tropica 20061101

Title: DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

Journal: Journal of medicinal chemistry 20060615

Title: Study on the susceptibility of Sahel goats to experimental Trypanosoma vivax infection.

Journal: Veterinary parasitology 20060430

Title: Quantitative analysis of DNA-porphyrin interactions.

Journal: Biopolymers 20060405

Title: Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.

Journal: Tropical medicine & international health : TM & IH 20060201

Title: Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.

Journal: Experimental parasitology 20060101

Title: A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.

Journal: Parasitology 20060101

Title: The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.

Journal: Drug delivery 20060101

Title: Comparative application of wavelet approaches to absorption and ratio spectra for the simultaneous determination of diminazene aceturate and phenazone in veterinary granules for injection.

Journal: Die Pharmazie 20051201

Title: The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride.

Journal: The Onderstepoort journal of veterinary research 20051201

Title: Acquired resistance to berenil in a cloned isolate of Trypanosoma evansi is associated with upregulation of a novel gene, TeDR40.

Journal: Parasitology 20051101

Title: Thermodynamic evaluation and modeling of proton and water exchange associated with benzamidine and berenil binding to beta-trypsin.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20051101

Title: Diminazene aceturate resistance on the virulence of Trypanosoma brucei for rats.

Journal: Journal of comparative pathology 20051101

Title: Synthesis of a novel PEG-block-poly(aspartic acid-stat-phenylalanine) copolymer shows potential for formation of a micellar drug carrier.

Journal: International journal of pharmaceutics 20050613

Title: Semicarbazide-functionalized Si(111) surfaces for the site-specific immobilization of peptides.

Journal: Langmuir : the ACS journal of surfaces and colloids 20050215

Title: Transition models to assess risk factors for new and persistent trypanosome infections in cattle-analysis of longitudinal data from the Ghibe Valley, southwest Ethiopia.

Journal: The Journal of parasitology 20041201

Title: Knowledge and attitudes of cattle owners regarding trypanosomosis control in tsetse-infested areas of Uganda.

Journal: Journal of the South African Veterinary Association 20041201

Title: Degradation of berenil (diminazene aceturate) in acidic aqueous solution.

Journal: The Journal of pharmacy and pharmacology 20041001

Title: Trypanocidal failure suggested by PCR results in cattle field samples.

Journal: Acta tropica 20040901

Title: Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda.

Journal: The Onderstepoort journal of veterinary research 20040901

Title: Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay.

Journal: Mutagenesis 20040701

Title: Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation.

Journal: Journal of medicinal chemistry 20040422

Title: Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage.

Journal: The Journal of biological chemistry 20040402

Title: Application of field methods to assess isometamidium resistance of trypanosomes in cattle in western Ethiopia.

Journal: Acta tropica 20040401

Title: The effects of diminazene aceturate and ceftriaxone on ram sperm.

Journal: Theriogenology 20040115

Title: A large-scale trial to evaluate the efficacy of a 1% pour-on formulation of cyfluthrin (Cylence, Bayer) in controlling bovine trypanosomosis in Eastern Zambia.

Journal: Tropical animal health and production 20040101

Title: RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate.

Journal: Experimental parasitology 20040101

Title: Efficacy of Trypan: a diminazene based drug as antileishmanial agent.

Journal: Acta tropica 20040101

Title: The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes.

Journal: Chemico-biological interactions 20031215

Title: Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter.

Journal: Parasitology 20031201

Title: The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.

Journal: Journal of the South African Veterinary Association 20030901

Title: Chemotherapy of surra in horses and mules with diminazene aceturate.

Journal: Veterinary parasitology 20030102

Title: The pathogenicity of diminazene aceturate-resistant Trypanosoma brucei in rats after treatment with the drug.

Journal: Journal of comparative pathology 20030101

Title: The rare human fragile site 16B.

Journal: Cytogenetic and genome research 20030101

Title: Liquid chromatographic determination of diminazene diaceturate (Berenil) in raw bovine milk.

Journal: Journal of AOAC International 20030101

Title: Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

Journal: Biochemistry 20021217

Title: Determination of diminazene aceturate in pharmaceutical formulations by HPLC and identification of related substances by LC/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20021107

Title: Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda.

Journal: Acta tropica 20021001

Title: Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate.

Journal: Journal of drug targeting 20020801

Title: Inhibition of DNA replication by berenil in plasmids containing Poly(dA)poly(dT) sequences.

Journal: Plasmid 20020301

Title: Effect of strand orientation on the interaction of berenil with DNA triple helices.

Journal: European biophysics journal : EBJ 20020201

Title: Discriminating small molecule DNA binding modes by single molecule force spectroscopy.

Journal: FEBS letters 20020116

Title: Inhibition of DNA replication by berenil of bacterial plasmids containing poly(dA)-poly(dT) sequences. 2D gel analysis of replicative intermediates.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020101

Title: Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy.

Journal: Veterinary parasitology 20011213

Title: Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia.

Journal: Veterinary parasitology 20010831

Title: Heterogeneous DNA binding modes of berenil.

Journal: Biochimica et biophysica acta 20010628

Title: Concentration-dependent inhibition of sheep erythrocyte ghost plasma membrane Ca2+-ATPase activity by Berenil.

Journal: Journal of veterinary pharmacology and therapeutics 20010601

Title: DNA minor-groove recognition by small molecules.

Journal: Natural product reports 20010601

Title: Effect of clindamycin therapy on phagocytic and oxidative activity profiles of spleen mononuclear cells in Babesia rodhaini-infected mice.

Journal: The Journal of veterinary medical science 20010501

Title: Validation of a polymerase chain reaction assay for monitoring the therapeutic efficacy of diminazene aceturate in trypanosome-infected sheep.

Journal: Veterinary parasitology 20010320

Title: Cytokines and the acute phase response in post-treatment reactive encephalopathy of Trypanosoma brucei brucei infected mice.

Journal: Parasitology international 20010301

Title: Enhanced lipid peroxide levels in the erythrocytes of calves with haemoglobinuria.

Journal: Veterinary research communications 20010101

Title: In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.

Journal: Drugs under experimental and clinical research 20010101

Title: Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer.

Journal: Biochemistry 19961203

Title: Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19880801

Title: Kuriakose S, et al. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS One. 2012;7(11):e48696.

Title: Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21(2):342-5.

Title: Castardeli C, et al. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218.

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Related Products of 908-54-3
Tags:908-54-3 Molecular Formula|908-54-3 MDL|908-54-3 SMILES|908-54-3 bis(2-acetamidoacetic acid); 4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide
Catalog No.: AA00IG7U
908-54-3,MFCD00058386
908-54-3 | bis(2-acetamidoacetic acid); 4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide
Pack Size: 1mg
Purity: 98%
in stock
$7.00 $5.00
Pack Size: 50mg
Purity: 98%
in stock
$23.00 $16.00
Pack Size: 100mg
Purity: 98%
in stock
$42.00 $29.00
Pack Size: 250mg
Purity: 98%
in stock
$61.00 $43.00
Pack Size: 1g
Purity: ≥98%
in stock
$69.00 $48.00
Pack Size: 5g
Purity: ≥98%
in stock
$218.00 $152.00
Pack Size: 25g
Purity: 95%
in stock
$760.00 $532.00
Pack Size: 100g
Purity: 95%
in stock
$2,090.00 $1,463.00
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Technical Information
Catalog Number: AA00IG7U
Chemical Name: bis(2-acetamidoacetic acid); 4-[(2E)-3-(4-carbamimidoylphenyl)triaz-2-en-1-yl]benzene-1-carboximidamide
CAS Number: 908-54-3
Molecular Formula: C22H29N9O6
Molecular Weight: 515.5224
MDL Number: MFCD00058386
SMILES: NC(=N)c1ccc(cc1)NN=Nc1ccc(cc1)C(=N)N.CC(=O)NCC(=O)O.CC(=O)NCC(=O)O
Properties
Form: Solid  
MP: 202 °C  
Storage: Inert atmosphere;2-8℃;  
Complexity: 500  
Covalently-Bonded Unit Count: 3  
Heavy Atom Count: 37  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 9  
Rotatable Bond Count: 9  
Downstream Synthesis Route
908-54-3    108-46-3   
C13H12N4O2*H2O 

[1]ChemicalCommunications,2016,vol.52,p.4191-4194

908-54-3    108-95-2   
C13H12N4O*H(1+) 

[1]ChemicalCommunications,2016,vol.52,p.4191-4194

7647-01-0   
cis-Pt(N-hydroxymethyl-3,5-dimethylpyrazole)2I2 
  7732-18-5    908-54-3   
C52H68N22O4Pt2(2+)*2H2O*4ClH 

[1]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1006-1023

7647-01-0   
cis-Pt(3,5-dimethylpyrazole)2I2 
  7732-18-5    908-54-3   
C48H60N22Pt2(2+)*2H2O*4ClH 

[1]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1006-1023

7647-01-0   
cis-Pt(3,4-dimethylpyrazole)2I2 
  7732-18-5    908-54-3   
C48H60N22Pt2(2+)*2H2O*4ClH 

[1]JournalofEnzymeInhibitionandMedicinalChemistry,2018,vol.33,p.1006-1023

Literature fold

Title: Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.

Journal: Arteriosclerosis, thrombosis, and vascular biology20141201

Title: Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso).

Journal: Veterinary parasitology20121221

Title: Involvement of mitochondrial genes of Babesia gibsoni in resistance to diminazene aceturate.

Journal: The Journal of veterinary medical science20120901

Title: Purification of plasmid DNA from clarified and non-clarified Escherichia coli lysates by berenil pseudo-affinity chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120901

Title: Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro.

Journal: The Japanese journal of veterinary research20120801

Title: Field detection of resistance to isometamidium chloride and diminazene aceturate in Trypanosoma vivax from the region of the Boucle du Mouhoun in Burkina Faso.

Journal: Veterinary parasitology20120608

Title: Energetics of ligand binding to the DNA minor groove.

Journal: Physical chemistry chemical physics : PCCP20120428

Title: Highly debilitating natural Trypanosoma vivax infections in Brazilian calves: epidemiology, pathology, and probable transplacental transmission.

Journal: Parasitology research20120101

Title: Validation of an HPLC method for the simultaneous determination of diminazene diaceturate and phenazone in injectable veterinary granules and bulk powders.

Journal: Pakistan journal of pharmaceutical sciences20120101

Title: Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali.

Journal: Parasites & vectors20120101

Title: High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.

Journal: PLoS neglected tropical diseases20111201

Title: Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.

Journal: Experimental physiology20111001

Title: Genital lesions in male red fronted gazelles (Gazella rufifrons) experimentally infected with Trypanosoma brucei and the effect of melarsamine hydrochloride (Cymelarsan®) and diminazene aceturate (Berenil®) in its treatment.

Journal: Theriogenology20110901

Title: CBFB and MYH11 in inv(16)(p13q22) of acute myeloid leukemia displaying close spatial proximity in interphase nuclei of human hematopoietic stem cells.

Journal: Genes, chromosomes & cancer20110901

Title: Serial haematology results in transfused and non-transfused dogs naturally infected with Babesia rossi.

Journal: Journal of the South African Veterinary Association20110901

Title: Experimental infection with Rangelia vitalii in dogs: acute phase, parasitemia, biological cycle, clinical-pathological aspects and treatment.

Journal: Experimental parasitology20110801

Title: Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.

Journal: Acta tropica20110701

Title: Diminazene aceturate associated with sodium selenite and vitamin E in the treatment of Trypanosoma evansi infection in rats.

Journal: Experimental parasitology20110701

Title: Specific berenil-DNA interactions: an approach for separation of plasmid isoforms by pseudo-affinity chromatography.

Journal: Analytical biochemistry20110515

Title: The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.

Journal: Asian Pacific journal of tropical medicine20110501

Title: Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate.

Journal: The Japanese journal of veterinary research20101101

Title: Babesia canis and Babesia rossi co-infection in an untraveled Nigerian dog.

Journal: Veterinary parasitology20101029

Title: Efficacy of Cymelarsan and Diminasan against Trypanosoma equiperdum infections in mice and horses.

Journal: Veterinary parasitology20100804

Title: Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro.

Journal: The Journal of veterinary medical science20100601

Title: Structural binding evidence of the trypanocidal drugs berenil and pentacarinate active principles to a serine protease model.

Journal: International journal of biological macromolecules20100601

Title: Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.

Journal: Eukaryotic cell20100201

Title: Use of a doxycycline-enrofloxacin-metronidazole combination with/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni.

Journal: Acta veterinaria Scandinavica20100101

Title: The effects of hairpin loops on ligand-DNA interactions.

Journal: The journal of physical chemistry. B20091029

Title: Structure and inhibition of human diamine oxidase.

Journal: Biochemistry20091020

Title: Effects of melarsamine hydrochloride (Cymelarsan) and diminazene aceturate (Berenil) on the pathology of experimental Trypanosoma brucei infection in red fronted gazelles (Gazella rufifrons).

Journal: Veterinary parasitology20090707

Title: Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys.

Journal: Tropical medicine & international health : TM & IH20090701

Title: Five-fold increase in Trypanosoma congolense isolates resistant to diminazene aceturate over a seven-year period in Eastern Zambia.

Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy20081201

Title: Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses.

Journal: Tropical animal health and production20080801

Title: Enhancement of hydrophilic drug loading and release characteristics through micellization with new carboxymethyldextran-PEG block copolymers of tunable charge density.

Journal: International journal of pharmaceutics20080522

Title: Prevalence of bovine trypanosomosis and trypanocidal drug sensitivity studies on Trypanosoma congolense in Wolyta and Dawero zones of southern Ethiopia.

Journal: Veterinary parasitology20080325

Title: Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs.

Journal: Veterinary parasitology20080214

Title: Acute phase response in mice experimentally infected with Trypanosoma congolense: a molecular gauge of parasite-host interaction.

Journal: Veterinary parasitology20080125

Title: Microarray analysis of the in vivo sequence preferences of a minor groove binding drug.

Journal: BMC genomics20080101

Title: Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.

Journal: Journal of natural products20071001

Title: Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.

Journal: The Onderstepoort journal of veterinary research20070301

Title: Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system.

Journal: Veterinary parasitology20070131

Title: Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20061121

Title: SSCP analysis of the P2 purine transporter TcoAT1 gene of Trypanosoma congolense leads to a simple PCR-RFLP test allowing the rapid identification of diminazene resistant stocks.

Journal: Acta tropica20061101

Title: DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

Journal: Journal of medicinal chemistry20060615

Title: Study on the susceptibility of Sahel goats to experimental Trypanosoma vivax infection.

Journal: Veterinary parasitology20060430

Title: Quantitative analysis of DNA-porphyrin interactions.

Journal: Biopolymers20060405

Title: Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania.

Journal: Tropical medicine & international health : TM & IH20060201

Title: Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays.

Journal: Experimental parasitology20060101

Title: A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.

Journal: Parasitology20060101

Title: The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.

Journal: Drug delivery20060101

Title: Comparative application of wavelet approaches to absorption and ratio spectra for the simultaneous determination of diminazene aceturate and phenazone in veterinary granules for injection.

Journal: Die Pharmazie20051201

Title: The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride.

Journal: The Onderstepoort journal of veterinary research20051201

Title: Acquired resistance to berenil in a cloned isolate of Trypanosoma evansi is associated with upregulation of a novel gene, TeDR40.

Journal: Parasitology20051101

Title: Thermodynamic evaluation and modeling of proton and water exchange associated with benzamidine and berenil binding to beta-trypsin.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas20051101

Title: Diminazene aceturate resistance on the virulence of Trypanosoma brucei for rats.

Journal: Journal of comparative pathology20051101

Title: Synthesis of a novel PEG-block-poly(aspartic acid-stat-phenylalanine) copolymer shows potential for formation of a micellar drug carrier.

Journal: International journal of pharmaceutics20050613

Title: Semicarbazide-functionalized Si(111) surfaces for the site-specific immobilization of peptides.

Journal: Langmuir : the ACS journal of surfaces and colloids20050215

Title: Transition models to assess risk factors for new and persistent trypanosome infections in cattle-analysis of longitudinal data from the Ghibe Valley, southwest Ethiopia.

Journal: The Journal of parasitology20041201

Title: Knowledge and attitudes of cattle owners regarding trypanosomosis control in tsetse-infested areas of Uganda.

Journal: Journal of the South African Veterinary Association20041201

Title: Degradation of berenil (diminazene aceturate) in acidic aqueous solution.

Journal: The Journal of pharmacy and pharmacology20041001

Title: Trypanocidal failure suggested by PCR results in cattle field samples.

Journal: Acta tropica20040901

Title: Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda.

Journal: The Onderstepoort journal of veterinary research20040901

Title: Micronuclei induced by aneugens and clastogens in mononucleate and binucleate cells using the cytokinesis block assay.

Journal: Mutagenesis20040701

Title: Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation.

Journal: Journal of medicinal chemistry20040422

Title: Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage.

Journal: The Journal of biological chemistry20040402

Title: Application of field methods to assess isometamidium resistance of trypanosomes in cattle in western Ethiopia.

Journal: Acta tropica20040401

Title: The effects of diminazene aceturate and ceftriaxone on ram sperm.

Journal: Theriogenology20040115

Title: A large-scale trial to evaluate the efficacy of a 1% pour-on formulation of cyfluthrin (Cylence, Bayer) in controlling bovine trypanosomosis in Eastern Zambia.

Journal: Tropical animal health and production20040101

Title: RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate.

Journal: Experimental parasitology20040101

Title: Efficacy of Trypan: a diminazene based drug as antileishmanial agent.

Journal: Acta tropica20040101

Title: The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes.

Journal: Chemico-biological interactions20031215

Title: Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter.

Journal: Parasitology20031201

Title: The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.

Journal: Journal of the South African Veterinary Association20030901

Title: Chemotherapy of surra in horses and mules with diminazene aceturate.

Journal: Veterinary parasitology20030102

Title: The pathogenicity of diminazene aceturate-resistant Trypanosoma brucei in rats after treatment with the drug.

Journal: Journal of comparative pathology20030101

Title: The rare human fragile site 16B.

Journal: Cytogenetic and genome research20030101

Title: Liquid chromatographic determination of diminazene diaceturate (Berenil) in raw bovine milk.

Journal: Journal of AOAC International20030101

Title: Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.

Journal: Biochemistry20021217

Title: Determination of diminazene aceturate in pharmaceutical formulations by HPLC and identification of related substances by LC/MS.

Journal: Journal of pharmaceutical and biomedical analysis20021107

Title: Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda.

Journal: Acta tropica20021001

Title: Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate.

Journal: Journal of drug targeting20020801

Title: Inhibition of DNA replication by berenil in plasmids containing Poly(dA)poly(dT) sequences.

Journal: Plasmid20020301

Title: Effect of strand orientation on the interaction of berenil with DNA triple helices.

Journal: European biophysics journal : EBJ20020201

Title: Discriminating small molecule DNA binding modes by single molecule force spectroscopy.

Journal: FEBS letters20020116

Title: Inhibition of DNA replication by berenil of bacterial plasmids containing poly(dA)-poly(dT) sequences. 2D gel analysis of replicative intermediates.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20020101

Title: Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy.

Journal: Veterinary parasitology20011213

Title: Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia.

Journal: Veterinary parasitology20010831

Title: Heterogeneous DNA binding modes of berenil.

Journal: Biochimica et biophysica acta20010628

Title: Concentration-dependent inhibition of sheep erythrocyte ghost plasma membrane Ca2+-ATPase activity by Berenil.

Journal: Journal of veterinary pharmacology and therapeutics20010601

Title: DNA minor-groove recognition by small molecules.

Journal: Natural product reports20010601

Title: Effect of clindamycin therapy on phagocytic and oxidative activity profiles of spleen mononuclear cells in Babesia rodhaini-infected mice.

Journal: The Journal of veterinary medical science20010501

Title: Validation of a polymerase chain reaction assay for monitoring the therapeutic efficacy of diminazene aceturate in trypanosome-infected sheep.

Journal: Veterinary parasitology20010320

Title: Cytokines and the acute phase response in post-treatment reactive encephalopathy of Trypanosoma brucei brucei infected mice.

Journal: Parasitology international20010301

Title: Enhanced lipid peroxide levels in the erythrocytes of calves with haemoglobinuria.

Journal: Veterinary research communications20010101

Title: In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.

Journal: Drugs under experimental and clinical research20010101

Title: Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer.

Journal: Biochemistry19961203

Title: Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy19880801

Title: Kuriakose S, et al. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS One. 2012;7(11):e48696.

Title: Kuriakose S, et al. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21(2):342-5.

Title: Castardeli C, et al. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218.

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