4261-42-1,MFCD00017433
Catalog No.:AA00IKJ9

4261-42-1 | Isoorientin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98% by HPLC
in stock  
$89.00   $62.00
- +
5mg
≥95%
in stock  
$139.00   $97.00
- +
10mg
>98.0%(HPLC)
in stock  
$239.00   $168.00
- +
25mg
≥95%
in stock  
$550.00   $385.00
- +
50mg
≥95%
in stock  
$893.00   $625.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00IKJ9
Chemical Name:
Isoorientin
CAS Number:
4261-42-1
Molecular Formula:
C21H20O11
Molecular Weight:
448.3769
MDL Number:
MFCD00017433
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1c(O)cc2c(c1O)c(=O)cc(o2)c1ccc(c(c1)O)O
Properties
Computed Properties
 
Complexity:
729  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
8  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.2  

Downstream Synthesis Route

[1]ChemistryofNaturalCompounds,1985,vol.21,p.385    KhimiyaPrirodnykhSoedinenii,1985,vol.21,p.410

[1]ChemicalandPharmaceuticalBulletin,1990,vol.38,p.2277-2280

[1]ChemistryofNaturalCompounds,1985,vol.21,p.385    KhimiyaPrirodnykhSoedinenii,1985,vol.21,p.410

Literature

Title: Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line.

Journal: Toxicology letters 20140303

Title: Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay.

Journal: Food chemistry 20121215

Title: Effect of salinity stress on phenolic compounds and carotenoids in buckwheat (Fagopyrum esculentum M.) sprout.

Journal: Food chemistry 20121201

Title: Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells.

Journal: Toxicology and applied pharmacology 20121115

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: An in vitro perspective to cholinesterase inhibitory and antioxidant activity of five Gentiana species and Gentianella caucasea.

Journal: International journal of food sciences and nutrition 20121101

Title: Isoorientin reverts TNF-α-induced insulin resistance in adipocytes activating the insulin signaling pathway.

Journal: Endocrinology 20121101

Title: Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats.

Journal: Pharmaceutical biology 20121101

Title: Enzymatic acylation of isoorientin and isovitexin from bamboo-leaf extracts with fatty acids and antiradical activity of the acylated derivatives.

Journal: Journal of agricultural and food chemistry 20121031

Title: TLC screening for antioxidant activity of extracts from fifteen bamboo species and identification of antioxidant flavone glycosides from leaves of Bambusa. textilis McClure.

Journal: Molecules (Basel, Switzerland) 20121019

Title: Variation in phenolic content and antioxidant activity of fermented rooibos herbal tea infusions: role of production season and quality grade.

Journal: Journal of agricultural and food chemistry 20120912

Title: Simultaneous determination of alkaloids and flavonoids from aerial parts of Passiflora species and dietary supplements using UPLC-UV-MS and HPTLC.

Journal: Natural product communications 20120901

Title: Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents.

Journal: Archives of pharmacal research 20120801

Title: Accumulation of phenylpropanoids and correlated gene expression during the development of tartary buckwheat sprouts.

Journal: Journal of agricultural and food chemistry 20120606

Title: Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

Journal: European journal of medicinal chemistry 20120601

Title: Protective effect of isoorientin-2″-O-α-L-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

Title: Effects of green tea or Sasa quelpaertensis bamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats.

Journal: Nutrition research and practice 20120401

Title: [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

Title: Kinetic optimisation of the reversed phase liquid chromatographic separation of rooibos tea (Aspalathus linearis) phenolics on conventional high performance liquid chromatographic instrumentation.

Journal: Journal of chromatography. A 20120106

Title: Phytochemical screening and biological activities of Eminium spiculatum (Blume) Kuntze (family Araceae).

Journal: Natural product research 20120101

Title: Analysis of C-glycosyl flavonoids from South American Passiflora species by HPLC-DAD and HPLC-MS.

Journal: Phytochemical analysis : PCA 20120101

Title: Greco-arab and islamic herbal-derived anticancer modalities: from tradition to molecular mechanisms.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells.

Journal: International journal of molecular sciences 20120101

Title: Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves.

Journal: International journal of molecular sciences 20120101

Title: A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China.

Journal: Pharmacognosy magazine 20120101

Title: A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms.

Journal: Pharmacognosy reviews 20120101

Title: Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC.

Journal: Pharmacognosy reviews 20120101

Title: Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD.

Journal: International journal of analytical chemistry 20120101

Title: Biophytum sensitivum: Ancient medicine, modern targets.

Journal: Journal of advanced pharmaceutical technology & research 20120101

Title: Chemical constituents of the methanolic extract of leaves of Leiothrix spiralis Ruhland and their antimicrobial activity.

Journal: Molecules (Basel, Switzerland) 20111216

Title: [Study of flavonoids from leaves of Santalum album].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Title: [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Title: Gallates of isoorientin and (2S)-1,2-propanediol glucoside from the leaves of Schoepfia jasminodora.

Journal: Journal of natural medicines 20110701

Title: Metabolomic analysis of phenolic compounds in buckwheat (Fagopyrum esculentum M.) sprouts treated with methyl jasmonate.

Journal: Journal of agricultural and food chemistry 20110525

Title: Edible neotropical blueberries: antioxidant and compositional fingerprint analysis.

Journal: Journal of agricultural and food chemistry 20110413

Title: Comparative studies on anxiolytic activities and flavonoid compositions of Passiflora edulis 'edulis' and Passiflora edulis 'flavicarpa'.

Journal: Journal of ethnopharmacology 20110216

Title: Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa.

Journal: Bioorganic & medicinal chemistry letters 20110115

Title: Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae).

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Role of phenolic compounds in peptic ulcer: An overview.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities.

Journal: Scientia pharmaceutica 20110101

Title: Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass).

Journal: Journal of advanced pharmaceutical technology & research 20110101

Title: Effect of Gentiana olivieri on experimental epilepsy models.

Journal: Pharmacognosy magazine 20110101

Title: Spectroscopic characterization and antiproliferative activity on HepG2 human hepatoblastoma cells of flavonoid C-glycosides from Petrorhagia velutina.

Journal: Journal of natural products 20101227

Title: Antiedematogenic activity and phytochemical composition of preparations from Echinodorus grandiflorus leaves.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

Title: Antioxidant flavone glycosides from the leaves of Fargesia robusta.

Journal: Journal of natural products 20100924

Title: Gluconeogenesis inhibition and phytochemical composition of two Cecropia species.

Journal: Journal of ethnopharmacology 20100706

Title: Secondary plant substances in various extracts of the leaves, fruits, stem and bark of Caraipa densifolia Mart.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

Title: The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

Title: Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis.

Journal: Planta medica 20100501

Title: Natural products from Scorzonera aristata (Asteraceae).

Journal: Natural product communications 20100501

Title: [Determination of five active constituents in aerial part of Tibetan medicine Gentiana straminea by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100501

Title: Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats.

Journal: Journal of ethnopharmacology 20100421

Title: Sasa borealis leaves extract improves insulin resistance by modulating inflammatory cytokine secretion in high fat diet-induced obese C57/BL6J mice.

Journal: Nutrition research and practice 20100401

Title: Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa.

Journal: Journal of ethnopharmacology 20100302

Title: Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum.

Journal: Journal of experimental botany 20100201

Title: A new flavone C-glycoside from Clematis rehderiana.

Journal: Molecules (Basel, Switzerland) 20100129

Title: Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation.

Journal: BMC complementary and alternative medicine 20100101

Title: Molecular biology, phytochemistry and bioactivity of three endemic Aloe species from Mauritius and Réunion Islands.

Journal: Phytochemical analysis : PCA 20100101

Title: Development and validation of an HPTLC method for simultaneous quantitation of isoorientin, isovitexin, orientin, and vitexin in bamboo-leaf flavonoids.

Journal: Journal of AOAC International 20100101

Title: Phytochemical and pharmacological review of Lagenaria sicereria.

Journal: Journal of Ayurveda and integrative medicine 20100101

Title: [Simultaneous determination of four constituents in wild Gentiana lawrencei from Qinghai province by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Title: Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on human low density lipoprotein oxidation.

Journal: Molecules (Basel, Switzerland) 20090930

Title: Bioassay-guided isolation of anti-inflammatory C-glucosylflavones from Passiflora edulis.

Journal: Planta medica 20090901

Title: Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma.

Journal: Fitoterapia 20090901

Title: Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds.

Journal: Journal of agricultural and food chemistry 20090826

Title: Ulmosides A and B: flavonoid 6-C-glycosides from Ulmus wallichiana, stimulating osteoblast differentiation assessed by alkaline phosphatase.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Neuropharmacological activity of the pericarp of Passiflora edulis flavicarpa degener: putative involvement of C-glycosylflavonoids.

Journal: Experimental biology and medicine (Maywood, N.J.) 20090801

Title: Neural cell protective compounds isolated from Phoenix hanceana var. formosana.

Journal: Phytochemistry 20090601

Title: Phenolic contribution of South African herbal teas to a healthy diet.

Journal: Natural product communications 20090501

Title: Rapid identification of polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS.

Journal: Journal of chromatographic science 20090301

Title: Gastric anti-ulcer activity of leaf fractions obtained of polar extract from Wilbrandia ebracteata in mice.

Journal: Natural product research 20090101

Title: Protection against neurodegenerative diseases of Iris pseudopumila extracts and their constituents.

Journal: Fitoterapia 20090101

Title: Verticilliside, a new flavone C-glucoside from Enicostemma verticillatum.

Journal: Journal of Asian natural products research 20090101

Title: Further studies on the chemical constituents of Chinese folk medicine Gentiana apiata N.E. Br.

Journal: Journal of Asian natural products research 20090101

Title: [Studies on glycosides from Gentiana veitchiorum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

Title: [Chemical constituents from herbs of Swertia delavayi].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

Title: Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity.

Journal: Journal of natural medicines 20080701

Title: Characterization of phenolic compounds in rooibos tea.

Journal: Journal of agricultural and food chemistry 20080514

Title: Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor.

Journal: Journal of ethnopharmacology 20080328

Title: Further knowledge on barley (Hordeum vulgare L.) leaves O-glycosyl-C-glycosyl flavones by liquid chromatography-UV diode-array detection-electrospray ionisation mass spectrometry.

Journal: Journal of chromatography. A 20080222

Title: Compounds from Vitex polygama active against kidney diseases.

Journal: Journal of ethnopharmacology 20080117

Title: Two new 11alpha,12alpha-epoxy-ursan-28,13beta-olides and other triterpenes from Cecropia catharinensis.

Journal: Natural product research 20080101

Title: 4'''-Acetylvitexin-2''-O-rhamnoside, isoorientin, orientin, and 8-methoxykaempferol-3-O-glucoside as markers for the differentiation of Crataegus monogyna and Crataegus pentagyna from Crataegus laevigata (Rosaceae).

Journal: Chemistry & biodiversity 20071201

Title: Resistance to Spodoptera frugiperda (Lepidoptera: Noctuidae) and Euxesta stigmatias (Diptera: Ulidiidae) in sweet corn derived from exogenous and endogenous genetic systems.

Journal: Journal of economic entomology 20071201

Title: Isoorientin induces Nrf2 pathway-driven antioxidant response through phosphatidylinositol 3-kinase signaling.

Journal: Archives of pharmacal research 20071201

Title: Use of cyclic voltammetry, photochemiluminescence, and spectrophotometric methods for the measurement of the antioxidant capacity of buckwheat sprouts.

Journal: Journal of agricultural and food chemistry 20071128

Title: Trace element water improves the antioxidant activity of buckwheat (Fagopyrum esculentum Moench) sprouts.

Journal: Journal of agricultural and food chemistry 20071031

Title: A new pyrrole alkaloid isolated from Arum palaestinum Boiss. and its biological activities.

Journal: Archives of pharmacal research 20070801

Title: The antimutagenic activity of the major flavonoids of rooibos (Aspalathus linearis): some dose-response effects on mutagen activation-flavonoid interactions.

Journal: Mutation research 20070728

Title: Induction of flavonoid production by UV-B radiation in Passiflora quadrangularis callus cultures.

Journal: Fitoterapia 20070701

Title: Phenolic constituents in dried flowers of aloe vera (Aloe barbadensis) and their in vitro antioxidative capacity.

Journal: Planta medica 20070601

Title: An anthocyanin compound in buckwheat sprouts and its contribution to antioxidant capacity.

Journal: Bioscience, biotechnology, and biochemistry 20070201

Title: Antioxidant flavone glycosides from the leaves of Sasa borealis.

Journal: Archives of pharmacal research 20070201

Title: New antifungal flavonoid glycoside from Vitex negundo.

Journal: Bioorganic & medicinal chemistry letters 20070101

Title: Isovitexin-2'-O-beta-[6-O-E-p-coumaroylglucopyranoside] from UV-B irradiated leaves of rice, Oryza sativa L. inhibits fertility of Helicoverpa armigera.

Journal: Photochemistry and photobiology 20070101

Title: [Simultaneous determination of six main constituents in Swertia of Qinghai Province and Sichuan Province by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Title: [Study on quality for Herba Polygoni Orientalis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Activity of Cecropia lyratiloba extract on contractility of cardiac and smooth muscles in Wistar rats.

Journal: Clinical and experimental pharmacology & physiology 20060101

Title: [Studies on chemical constituents of Patrinia villosa].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060101

Title: Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides.

Journal: Phytotherapy research : PTR 20050901

Title: Preparative separation of isovitexin and isoorientin from Patrinia villosa Juss by high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20050513

Title: [Studies on the chemical constituents in seeds of Atriplex centralasiatica].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501

Title: [HPLC fingerprinting of total glycosides of Swertia franchetiana].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050501

Title: Free radical scavengers and antioxidants from Lemongrass (Cymbopogon citratus (DC.) Stapf.).

Journal: Journal of agricultural and food chemistry 20050406

Title: An analysis of flavonoid compounds in leaves of Japonolirion (Petrosaviaceae).

Journal: Journal of plant research 20050201

Title: Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques.

Journal: Life sciences 20050128

Title: Distinction of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin using HPLC-MS exact mass measurement and in-source CID.

Journal: Phytochemical analysis : PCA 20050101

Title: Salmon silk genes contribute to the elucidation of the flavone pathway in maize (Zea mays L.).

Journal: The Journal of heredity 20040101

Title: A HPTLC densitometric determination of flavonoids from Passiflora alata, P. edulis, P. incarnata and P. caerulea and comparison with HPLC method.

Journal: Phytochemical analysis : PCA 20040101

Title: Evaluation of in vivo biological activity profile of isoorientin.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

Title: Unfermented rooibos tea: quantitative characterization of flavonoids by HPLC-UV and determination of the total antioxidant activity.

Journal: Journal of agricultural and food chemistry 20031203

Title: Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle.

Journal: Life sciences 20030404

Title: Antioxidative compounds from Crotalaria sessiliflora.

Journal: Bioscience, biotechnology, and biochemistry 20030201

Title: Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments.

Journal: Journal of agricultural and food chemistry 20030129

Title: Flavonoids from Achillea nobilis L.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: High-speed countercurrent chromatography as a valuable tool to isolate C-glycosylflavones from Cecropia lyratiloba Miquel.

Journal: Phytochemical analysis : PCA 20030101

Title: Xanthones from Swertia punctata.

Journal: Phytochemistry 20021001

Title: Naphthalene glucoside and other phenolics from the shoot and callus cultures of Drosophyllum lusitanicum.

Journal: Phytochemistry 20021001

Title: In vitro anti-Neisseria gonorrhoeae activity of Terminalia macroptera leaves.

Journal: FEMS microbiology letters 20020604

Title: O-Galloyl-C-glycosylflavones from Pelargonium reniforme.

Journal: Phytochemistry 20020201

Title: Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms.

Journal: Plant physiology 20020201

Title: Phenolic compounds from Hypericum perforatum.

Journal: Planta medica 20020101

Title: Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats.

Journal: Journal of ethnopharmacology 20011201

Title: Glochiflavanosides A-D: flavanol glucosides from the leaves of Glochidion zeylanicum (Gaertn) A. Juss.

Journal: Chemical & pharmaceutical bulletin 20010701

Title: Antimicrobial evaluation of coumarins and flavonoids from the stems of Daphne gnidium L.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010701

Title: Characterization of the polyphenolic composition of purple loosestrife (Lythrum salicaria).

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

Title: Sumalatha M, et al. Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. Nat Prod Commun. 2015 Oct;10(10):1703-4.

Title: Ye T, et al. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. Onco Targets Ther. 2016 Dec 12;9:7481-7492.

Title: Anilkumar K, et al. Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa. Oxid Med Cell Longev. 2017;2017:5498054.

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SDS
Tags:4261-42-1 Molecular Formula|4261-42-1 MDL|4261-42-1 SMILES|4261-42-1 Isoorientin
Catalog No.: AA00IKJ9
4261-42-1,MFCD00017433
4261-42-1 | Isoorientin
Pack Size: 1mg
Purity: 98% by HPLC
in stock
$89.00 $62.00
Pack Size: 5mg
Purity: ≥95%
in stock
$139.00 $97.00
Pack Size: 10mg
Purity: >98.0%(HPLC)
in stock
$239.00 $168.00
Pack Size: 25mg
Purity: ≥95%
in stock
$550.00 $385.00
Pack Size: 50mg
Purity: ≥95%
in stock
$893.00 $625.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00IKJ9
Chemical Name: Isoorientin
CAS Number: 4261-42-1
Molecular Formula: C21H20O11
Molecular Weight: 448.3769
MDL Number: MFCD00017433
SMILES: OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1c(O)cc2c(c1O)c(=O)cc(o2)c1ccc(c(c1)O)O
Properties
Complexity: 729  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 5  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 8  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.2  
Downstream Synthesis Route
1163725-44-7    4261-42-1 

[1]ChemistryofNaturalCompounds,1985,vol.21,p.385    KhimiyaPrirodnykhSoedinenii,1985,vol.21,p.410

131507-98-7    4261-42-1 

[1]ChemicalandPharmaceuticalBulletin,1990,vol.38,p.2277-2280

4261-42-1    1163725-44-7 

[1]ChemistryofNaturalCompounds,1985,vol.21,p.385    KhimiyaPrirodnykhSoedinenii,1985,vol.21,p.410

Literature fold

Title: Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line.

Journal: Toxicology letters20140303

Title: Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay.

Journal: Food chemistry20121215

Title: Effect of salinity stress on phenolic compounds and carotenoids in buckwheat (Fagopyrum esculentum M.) sprout.

Journal: Food chemistry20121201

Title: Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells.

Journal: Toxicology and applied pharmacology20121115

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: An in vitro perspective to cholinesterase inhibitory and antioxidant activity of five Gentiana species and Gentianella caucasea.

Journal: International journal of food sciences and nutrition20121101

Title: Isoorientin reverts TNF-α-induced insulin resistance in adipocytes activating the insulin signaling pathway.

Journal: Endocrinology20121101

Title: Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats.

Journal: Pharmaceutical biology20121101

Title: Enzymatic acylation of isoorientin and isovitexin from bamboo-leaf extracts with fatty acids and antiradical activity of the acylated derivatives.

Journal: Journal of agricultural and food chemistry20121031

Title: TLC screening for antioxidant activity of extracts from fifteen bamboo species and identification of antioxidant flavone glycosides from leaves of Bambusa. textilis McClure.

Journal: Molecules (Basel, Switzerland)20121019

Title: Variation in phenolic content and antioxidant activity of fermented rooibos herbal tea infusions: role of production season and quality grade.

Journal: Journal of agricultural and food chemistry20120912

Title: Simultaneous determination of alkaloids and flavonoids from aerial parts of Passiflora species and dietary supplements using UPLC-UV-MS and HPTLC.

Journal: Natural product communications20120901

Title: Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents.

Journal: Archives of pharmacal research20120801

Title: Accumulation of phenylpropanoids and correlated gene expression during the development of tartary buckwheat sprouts.

Journal: Journal of agricultural and food chemistry20120606

Title: Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

Journal: European journal of medicinal chemistry20120601

Title: Protective effect of isoorientin-2″-O-α-L-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association20120601

Title: Effects of green tea or Sasa quelpaertensis bamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats.

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Title: [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS].

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Title: Kinetic optimisation of the reversed phase liquid chromatographic separation of rooibos tea (Aspalathus linearis) phenolics on conventional high performance liquid chromatographic instrumentation.

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Title: Phytochemical screening and biological activities of Eminium spiculatum (Blume) Kuntze (family Araceae).

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Title: Analysis of C-glycosyl flavonoids from South American Passiflora species by HPLC-DAD and HPLC-MS.

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Title: Greco-arab and islamic herbal-derived anticancer modalities: from tradition to molecular mechanisms.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells.

Journal: International journal of molecular sciences20120101

Title: Seasonal variations of the antioxidant composition in ground bamboo Sasa argenteastriatus leaves.

Journal: International journal of molecular sciences20120101

Title: A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China.

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Title: A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms.

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Journal: International journal of analytical chemistry20120101

Title: Biophytum sensitivum: Ancient medicine, modern targets.

Journal: Journal of advanced pharmaceutical technology & research20120101

Title: Chemical constituents of the methanolic extract of leaves of Leiothrix spiralis Ruhland and their antimicrobial activity.

Journal: Molecules (Basel, Switzerland)20111216

Title: [Study of flavonoids from leaves of Santalum album].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20111101

Title: [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20111101

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Title: Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae).

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line.

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Title: Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass).

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Journal: Pharmacognosy magazine20110101

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Title: Antioxidant flavone glycosides from the leaves of Fargesia robusta.

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Title: The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death.

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Title: Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis.

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Title: Natural products from Scorzonera aristata (Asteraceae).

Journal: Natural product communications20100501

Title: [Determination of five active constituents in aerial part of Tibetan medicine Gentiana straminea by HPLC].

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Title: Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats.

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Title: Sasa borealis leaves extract improves insulin resistance by modulating inflammatory cytokine secretion in high fat diet-induced obese C57/BL6J mice.

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Title: Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa.

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Title: [Simultaneous determination of four constituents in wild Gentiana lawrencei from Qinghai province by RP-HPLC].

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Title: Further studies on the chemical constituents of Chinese folk medicine Gentiana apiata N.E. Br.

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Title: [Studies on glycosides from Gentiana veitchiorum].

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Title: [Chemical constituents from herbs of Swertia delavayi].

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Title: Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity.

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Title: Resistance to Spodoptera frugiperda (Lepidoptera: Noctuidae) and Euxesta stigmatias (Diptera: Ulidiidae) in sweet corn derived from exogenous and endogenous genetic systems.

Journal: Journal of economic entomology20071201

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Title: Use of cyclic voltammetry, photochemiluminescence, and spectrophotometric methods for the measurement of the antioxidant capacity of buckwheat sprouts.

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Title: Salmon silk genes contribute to the elucidation of the flavone pathway in maize (Zea mays L.).

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