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57-15-8,MFCD00149293
Catalog No.:AA00ILKZ

57-15-8 | 1,1,1-Trichloro-2-methylpropan-2-ol

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10mg
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25mg
98%
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$7.00   $5.00
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50mg
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$11.00   $8.00
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100mg
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1g
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5g
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25g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ILKZ
Chemical Name:
1,1,1-Trichloro-2-methylpropan-2-ol
CAS Number:
57-15-8
Molecular Formula:
C4H7Cl3O
Molecular Weight:
177.4568
MDL Number:
MFCD00149293
SMILES:
CC(C)(C(Cl)(Cl)Cl)O
Properties
Properties
 
BP:
173°C  
Form:
Solid  
MP:
~78 °C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
83.8  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
2  

Literature

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Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120215

Title: Interaction of antimicrobial preservatives with blow-fill-seal packs: correlating sorption with solubility parameters.

Journal: Pharmaceutical development and technology 20120101

Title: Calbindin-D32k is localized to a subpopulation of neurons in the nervous system of the sea cucumber Holothuria glaberrima (Echinodermata).

Journal: PloS one 20120101

Title: Diversity of the strongly rheophilous tadpoles of Malagasy tree frogs, genus Boophis (Anura, Mantellidae), and identification of new candidate species via larval DNA sequence and morphology.

Journal: ZooKeys 20120101

Title: The Effectiveness of GECB Pastille in Reducing Complications of Dry Socket Syndrome.

Journal: International journal of dentistry 20120101

Title: Differential pharmacology and clinical utility of preservative-free tafluprost in the treatment of ocular hypertension and glaucoma.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20120101

Title: Corneal injury secondary to accidental Surgilube exposure.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110901

Title: Cell viability of four corneoconjunctival cell lines exposed to five preservatives and a surfactant used for infection control in eyedrops.

Journal: Biocontrol science 20110901

Title: Quantitative characterization of planarian wild-type behavior as a platform for screening locomotion phenotypes.

Journal: The Journal of experimental biology 20110401

Title: Preparation of dry reconstituted liposomal powder by freeze-drying at room temperature.

Journal: Journal of liposome research 20110301

Title: Cerumen removal: comparison of cerumenolytic agents and effect on cognition among the elderly.

Journal: Archives of gerontology and geriatrics 20110101

Title: Effectiveness of ophthalmic solution preservatives: a comparison of latanoprost with 0.02% benzalkonium chloride and travoprost with the sofZia preservative system.

Journal: BMC ophthalmology 20110101

Title: A new Gephyromantis (Phylacomantis) frog species from the pinnacle karst of Bemaraha, western Madagascar.

Journal: ZooKeys 20110101

Title: The herpetofauna of Timor-Leste: a first report.

Journal: ZooKeys 20110101

Title: Cell dedifferentiation and epithelial to mesenchymal transitions during intestinal regeneration in H. glaberrima.

Journal: BMC developmental biology 20110101

Title: Constitutive expression of a grapevine polygalacturonase-inhibiting protein affects gene expression and cell wall properties in uninfected tobacco.

Journal: BMC research notes 20110101

Title: Modeling myocardial infarction in mice: methodology, monitoring, pathomorphology.

Journal: Acta naturae 20110101

Title: [Chlorobutanol poisoning: about a case].

Journal: Annales francaises d'anesthesie et de reanimation 20101001

Title: Interactions at human ether-à-go-go-related gene channels.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100401

Title: Modification of cell wall properties in lettuce improves shelf life.

Journal: Journal of experimental botany 20100201

Title: Evaluation of acute corneal barrier change induced by topically applied preservatives using corneal transepithelial electric resistance in vivo.

Journal: Cornea 20100101

Title: The world's richest tadpole communities show functional redundancy and low functional diversity: ecological data on Madagascar's stream-dwelling amphibian larvae.

Journal: BMC ecology 20100101

Title: High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccines.

Journal: BMC genomics 20100101

Title: Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Cytotoxicity of five fluoroquinolone and two nonsteroidal anti-inflammatory benzalkonium chloride-free ophthalmic solutions in four corneoconjunctival cell lines.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Therapeutic approaches to cerebral vasospasm complicating ruptured aneurysm.

Journal: Neurology international 20091116

Title: Development of Calcitonin Salmon Nasal Spray: similarity of peptide formulated in chlorobutanol compared to benzalkonium chloride as preservative.

Journal: Journal of pharmaceutical sciences 20091001

Title: Allergy to ophthalmic preservatives.

Journal: Current opinion in allergy and clinical immunology 20091001

Title: Randomized, placebo-controlled evaluation of chlorobutanol, potassium carbonate, and irrigation in cerumen removal.

Journal: The Annals of otology, rhinology, and laryngology 20090801

Title: Methadone-associated Q-T interval prolongation and torsades de pointes.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090501

Title: A Freshwater clam (Corbicula fluminea) extract reduces cholesterol level and hepatic lipids in normal rats and xenobiotics-induced hypercholesterolemic rats.

Journal: Journal of agricultural and food chemistry 20090422

Title: In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays: the enhancing effect of potassium sorbate.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090411

Title: Comparative toxicity of preservatives on immortalized corneal and conjunctival epithelial cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090401

Title: Reichardt's dye and its reactions with the alkylating agents 4-chloro-1-butanol, ethyl methanesulfonate, 1-bromobutane and Fast Red B - a potentially useful reagent for the detection of genotoxic impurities in pharmaceuticals.

Journal: The Journal of pharmacy and pharmacology 20090401

Title: GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture.

Journal: Journal of chromatographic science 20090401

Title: Atlantic salmon eggs favour sperm in competition that have similar major histocompatibility alleles.

Journal: Proceedings. Biological sciences 20090207

Title: Minimally invasive strabismus surgery (MISS) for inferior obliquus recession.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090201

Title: Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima.

Journal: BMC developmental biology 20090101

Title: Ocular preservatives: associated risks and newer options.

Journal: Cutaneous and ocular toxicology 20090101

Title: Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization.

Journal: BMC developmental biology 20090101

Title: Minimally invasive strabismus surgery for horizontal rectus muscle reoperations.

Journal: The British journal of ophthalmology 20081201

Title: Cytotoxicity of ophthalmic solutions with and without preservatives to human corneal endothelial cells, epithelial cells and conjunctival epithelial cells.

Journal: Clinical & experimental ophthalmology 20080801

Title: Ototoxicity of triethanolamine polypeptide (cerumenex) in the chinchilla.

Journal: The Laryngoscope 20080301

Title: DNA damage in preserved specimens and tissue samples: a molecular assessment.

Journal: Frontiers in zoology 20080101

Title: Development and evaluation of a chloramphenicol hypertonic ophthalmic solution.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Equimolar mixture of 2,2,2-trifluoroethanol and 4-chloro-1-butanol is a stronger inducer of molten globule state: isothermal titration calorimetric and spectroscopic studies.

Journal: The protein journal 20071001

Title: [The treatment of hyperemesis gravidarum with chlorobutanol-caffeine rectal suppositories in Denmark: practice and evidence].

Journal: Ugeskrift for laeger 20070528

Title: Medication administered to children from 0 to 7.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC).

Journal: European journal of clinical pharmacology 20070201

Title: Development and validation of a stability-indicating analytical method for the quantitation of oxytocin in pharmaceutical dosage forms.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Effect of ophthalmic solution components on acrylic intraocular lenses.

Journal: Journal of cataract and refractive surgery 20070101

Title: Conjunctival provocation test for the diagnosis of ocular hypersensitivity to chlorobutanol.

Journal: Cornea 20070101

Title: Vitamin C. Biosynthesis, recycling and degradation in mammals.

Journal: The FEBS journal 20070101

Title: [Contact allergy to triethanolamine in ear drops and shampoo].

Journal: Annales de dermatologie et de venereologie 20070101

Title: Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage.

Journal: Critical care (London, England) 20070101

Title: Common cellular events occur during wound healing and organ regeneration in the sea cucumber Holothuria glaberrima.

Journal: BMC developmental biology 20070101

Title: [Efficacy of an antiseptic dialysis of purulent wounds in the dentofacial region with hyvalix].

Journal: Likars'ka sprava 20070101

Title: Are multidose over-the-counter artificial tears adequately preserved?

Journal: Cornea 20060501

Title: Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver.

Journal: The FEBS journal 20060401

Title: An efficient synthesis of a dual PPAR alpha/gamma agonist and the formation of a sterically congested alpha-aryloxyisobutyric acid via a Bargellini reaction.

Journal: The Journal of organic chemistry 20051014

Title: Preventing exposure keratopathy in the critically ill: a prospective study comparing eye care regimes.

Journal: The British journal of ophthalmology 20050801

Title: Allergic contact dermatitis from triethanolamine polypeptide oleate condensate in eardrops and shampoo.

Journal: Contact dermatitis 20050401

Title: Assessment of corneal epitheliopathy in the critically ill.

Journal: Intensive care medicine 20050201

Title: Application of a capillary electrophoresis method for simultaneous determination of preservatives in pharmaceutical formulations.

Journal: Journal of separation science 20050201

Title: Cerumen removal products.

Journal: Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 20050101

Title: Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.

Journal: Stroke 20041101

Title: Randomized, placebo-controlled evaluation of Cerumenex and Murine earwax removal products.

Journal: Archives of otolaryngology--head & neck surgery 20041001

Title: Management of earwax in primary care--postal survey of UK GPs and practice nurses.

Journal: Family practice 20040801

Title: A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient.

Journal: Intensive care medicine 20040601

Title: 4-Chlorobutanol induces unusual reversible and irreversible thermal unfolding of ribonuclease A: thermodynamic, kinetic, and conformational characterization.

Journal: International journal of biological macromolecules 20040401

Title: Chronic tinnitus resulting from cerumen removal procedures.

Journal: The international tinnitus journal 20040101

Title: Randomized clinical trial of docusate, triethanolamine polypeptide, and irrigation in cerumen removal in children.

Journal: Archives of pediatrics & adolescent medicine 20031201

Title: Review of a randomized trial comparing 2 cerumenolytic agents.

Journal: Archives of pediatrics & adolescent medicine 20031201

Title: Epithelial activity of hexokinase and glucose-6-phosphate dehydrogenase in cultured bovine lenses recovering from pharmaceutical-induced optical damage.

Journal: Molecular vision 20031103

Title: Convenient preparation of L-arabino-hexos-5-ulose derivatives from lactose.

Journal: Carbohydrate research 20031031

Title: QTc interval prolongation associated with intravenous methadone.

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Title: Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes.

Journal: The Journal of biological chemistry 20030919

Title: Development of a multidose formulation for a humanized monoclonal antibody using experimental design techniques.

Journal: AAPS pharmSci 20030601

Title: Ear drops for the removal of ear wax.

Journal: The Cochrane database of systematic reviews 20030101

Title: Clinical inquiries. What is the best treatment for impacted cerumen?

Journal: The Journal of family practice 20020201

Title: Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells.

Journal: Investigative ophthalmology & visual science 20010301

Title: Structural elucidation of disinfection by-products in treated drinking water.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Effects of common ophthalmic preservatives on ocular health.

Journal: Advances in therapy 20010101

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Title: Chlorobutanol toxicity.

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Title: Anaphylactoid reaction to Syntocinon.

Journal: Anaesthesia and intensive care 19930401

Title: Is ketamine or its preservative responsible for neurotoxicity in the rabbit?

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Journal: Lancet (London, England) 19820109

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Tags:57-15-8 Molecular Formula|57-15-8 MDL|57-15-8 SMILES|57-15-8 1,1,1-Trichloro-2-methylpropan-2-ol