[1]Atwell,GrahamJ.;Rewcastle,GordonW.;Baguley,BruceC.;Denny,WilliamA.[JournalofMedicinalChemistry,1987,vol.30,#4,p.652-658]
[2]CurrentPatentAssignee:GOVERNMENTOFTHEUNITEDSTATES-US4258191,1981,A
[1]Atwell,GrahamJ.;Rewcastle,GordonW.;Baguley,BruceC.;Denny,WilliamA.[JournalofMedicinalChemistry,1987,vol.30,#4,p.652-658]
[1]JournalofMedicinalChemistry,1987,vol.30,p.652-658
[1]Atwell,GrahamJ.;Rewcastle,GordonW.;Baguley,BruceC.;Denny,WilliamA.[JournalofMedicinalChemistry,1987,vol.30,#4,p.652-658]
Title: Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors.
Journal: European journal of medicinal chemistry 20121001
Title: Assessment of amsacrine binding with DNA using UV-visible, circular dichroism and Raman spectroscopic techniques.
Journal: Journal of photochemistry and photobiology. B, Biology 20120903
Title: Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation.
Journal: Bioorganic & medicinal chemistry 20120701
Title: Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives.
Journal: Bioorganic & medicinal chemistry 20120601
Title: Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120301
Title: Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.
Journal: Biochemistry 20120227
Title: AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group.
Journal: Cancer 20120201
Title: Early allo-SCT for AML with a complex aberrant karyotype--results from a prospective pilot study.
Journal: Bone marrow transplantation 20120101
Title: Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery.
Journal: International journal of nanomedicine 20120101
Title: Poor-risk cytogenetics may be associated with inferior outcome after fludarabine, cytarabine, and amsacrine reduced intensity conditioning in patients with high-risk acute myeloid leukemia.
Journal: Leukemia & lymphoma 20111001
Title: A validated stability-indicating RP-HPLC assay method for Amsacrine and its related substances.
Journal: Journal of chromatographic science 20110801
Title: Benzoquinazoline derivatives as new agents affecting DNA processing.
Journal: Bioorganic & medicinal chemistry 20110201
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Assisted sonodynamic damage of bovine serum albumin by metronidazole under ultrasonic irradiation combined with photosensitive antitumor drug-Amsacrine.
Journal: Journal of photochemistry and photobiology. B, Biology 20100121
Title: Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients.
Journal: Pediatric blood & cancer 20091215
Title: Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents.
Journal: Bioorganic & medicinal chemistry letters 20091215
Title: Fludarabine, amsacrine, high-dose cytarabine and 12 Gy total body irradiation followed by allogeneic hematopoietic stem cell transplantation is effective in patients with relapsed or high-risk acute lymphoblastic leukemia.
Journal: Bone marrow transplantation 20091201
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Partial purification and characterization of Trichomonas vaginalis DNA topoisomerase II.
Journal: The Southeast Asian journal of tropical medicine and public health 20090901
Title: Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings.
Journal: European journal of medicinal chemistry 20090701
Title: Treatment-subgroup interaction: an example from a published, phase II clinical trial.
Journal: Contemporary clinical trials 20090501
Title: Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery.
Journal: International journal of pharmaceutics 20090209
Title: Synthesis and antitumor activity of novel amsacrine analogs: the critical role of the acridine moiety in determining their biological activity.
Journal: Bioorganic & medicinal chemistry 20090115
Title: Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks.
Journal: The Journal of biological chemistry 20081024
Title: An experimental and theoretical study of dipole moments of N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080901
Title: Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.
Journal: Bioorganic & medicinal chemistry 20080515
Title: Is MutaMouse insensitive to clastogens?
Journal: Mutation research 20080430
Title: Detecting genotoxic effects of potential clastogens: an in vivo study using the transgenic lacZ plasmid and the MutaMouse model.
Journal: Mutation research 20080430
Title: The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice.
Journal: Mutation research 20080312
Title: Amsacrine containing induction therapy in elderly AML patients: comparison to standard induction regimens in a matched-pair analysis.
Journal: Leukemia research 20080301
Title: Development and validation of bioanalytical method for the determination of asulacrine in plasma by liquid chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20080122
Title: Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death.
Journal: Anti-cancer drugs 20080101
Title: Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives.
Journal: Current medicinal chemistry 20080101
Title: [A case of unclassified B-cell lymphosarcoma].
Journal: Terapevticheskii arkhiv 20080101
Title: Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A.
Journal: The Southeast Asian journal of tropical medicine and public health 20071101
Title: Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
Journal: Cancer research 20070615
Title: Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity.
Journal: Bioorganic & medicinal chemistry letters 20070515
Title: The high incidence of varicella herpes zoster with the use of bortezomib in 10 patients.
Journal: American journal of hematology 20070501
Title: Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.
Journal: Pediatric blood & cancer 20070301
Title: Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia: a trial by the Acute Leukemia French Association (ALFA) Group.
Journal: Leukemia 20070301
Title: Autologous stem cell transplantation after complete remission and first consolidation in acute myeloid leukemia patients aged 61-70 years: results of the prospective EORTC-GIMEMA AML-13 study.
Journal: Haematologica 20070301
Title: Synthesis and structure-activity studies of peptide-acridine/acridone conjugates.
Journal: Current medicinal chemistry 20070101
Title: Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes.
Journal: Molecular cancer therapeutics 20061201
Title: AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets.
Journal: Bioinformatics (Oxford, England) 20060715
Title: Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.
Journal: Leukemia research 20060701
Title: Bioactive principles in the bark of Pilidiostigma tropicum.
Journal: Journal of molecular modeling 20060701
Title: Roles of nonhomologous end-joining pathways in surviving topoisomerase II-mediated DNA damage.
Journal: Molecular cancer therapeutics 20060601
Title: A novel interaction [corrected] of nucleolin with Rad51.
Journal: Biochemical and biophysical research communications 20060526
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials.
Journal: British journal of haematology 20060301
Title: Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance.
Journal: Molecular pharmacology 20060101
Title: mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity.
Journal: Nucleic acids research 20060101
Title: Zygomycosis in the immunocompromised patient: a case report.
Journal: Acta bio-medica : Atenei Parmensis 20060101
Title: Type II topoisomerase activities in both the G1 and G2/M phases of the dinoflagellate cell cycle.
Journal: Chromosoma 20051201
Title: Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Journal: Haematologica 20051201
Title: The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells.
Journal: Mutation research 20051015
Title: Phase II trial of amsacrine plus intermediate-dose Ara-C (IDAC) with or without etoposide as salvage therapy for refractory or relapsed acute leukemia.
Journal: Japanese journal of clinical oncology 20051001
Title: Synthesis of a novel series of 2-methylsulfanyl fatty acids and their toxicity on the human K-562 and U-937 leukemia cell lines.
Journal: Lipids 20051001
Title: Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050820
Title: BAVC regimen and autologous bone marrow transplantation for APL patients in second molecular remission: updated results.
Journal: Bone marrow transplantation 20050701
Title: Highly sensitive analysis of the anti-tumor agent 1-[4-(furo[2,3-b]-quinolin-4-ylamino)phenyl]ethanone in rat plasma by high-performance liquid chromatography using electrochemical detection.
Journal: Journal of pharmaceutical and biomedical analysis 20050701
Title: Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity.
Journal: Bioorganic & medicinal chemistry 20050602
Title: [Disseminated cutaneous and visceral fusariosis in an aplastic patient: an unusual digestive entry].
Journal: Annales de dermatologie et de venereologie 20050301
Title: Random mutagenesis of the B'A' core domain of yeast DNA topoisomerase II and large-scale screens of mutants resistant to the anticancer drug etoposide.
Journal: Biochemical and biophysical research communications 20050211
Title: Induction chemotherapy for acute myelogenous leukemia.
Journal: Current hematology reports 20050101
Title: Synthesis and antitumor activity of sulfur-containing 9-anilinoacridines.
Journal: Molecular pharmaceutics 20050101
Title: Usefulness of PKH fluorescent labelling to study leukemic cell proliferation with various cytostatic drugs or acetyl tetrapeptide--AcSDKP.
Journal: BMC cancer 20050101
Title: Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation.
Journal: Bioorganic & medicinal chemistry letters 20040920
Title: Mutation E522K in human DNA topoisomerase IIbeta confers resistance to methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide.
Journal: Molecular pharmacology 20040901
Title: Intensive chemotherapy with idarubicin, cytarabine, etoposide, and G-CSF priming in patients with advanced myelodysplastic syndrome and high-risk acute myeloid leukemia.
Journal: Annals of hematology 20040801
Title: Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
Journal: The Journal of biological chemistry 20040702
Title: Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
Journal: Cancer research 20040701
Title: Risk-adapted induction and consolidation therapy in adults with de novo AML aged </= 60 years: results of a prospective multicenter trial.
Journal: Annals of hematology 20040601
Title: Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.
Journal: British journal of pharmacology 20040601
Title: Structure-activity relationships for the 9-(pyridin-2'-yl)- aminoacridines.
Journal: Molecules (Basel, Switzerland) 20040227
Title: Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity.
Journal: Cancer chemotherapy and pharmacology 20040201
Title: Comparison of BAVC to BuCy regimens in autologous stem cell transplantation for adult patients with acute myeloid leukemia.
Journal: Haematologica 20040101
Title: Rescue therapy combining intermediate-dose cytarabine with amsacrine and etoposide in relapsed adult acute lymphoblastic leukemia.
Journal: The hematology journal : the official journal of the European Haematology Association 20040101
Title: Maintenance therapy in childhood acute myeloid leukemia.
Journal: Annals of hematology 20040101
Title: Investigations into the biological relevance of in vitro clastogenic and aneugenic activity.
Journal: Cytogenetic and genome research 20040101
Title: Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells.
Journal: BMC pharmacology 20040101
Title: A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia.
Journal: Blood 20031215
Title: Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?
Journal: Current medicinal chemistry 20031201
Title: More efficient mobilisation of peripheral blood stem cells with HiDAC+AMSA+G-CSF than with mini-ICE+G-CSF in patients with AML.
Journal: Bone marrow transplantation 20031201
Title: Stem cell transplantation after salvage therapy with high-dose cytarabine and amsacrine in adults with high-risk leukaemia.
Journal: Bone marrow transplantation 20030801
Title: Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia.
Journal: British journal of haematology 20030801
Title: Salvage therapy in refractory acute myeloid leukemia: prediction of outcome based on analysis of prognostic factors.
Journal: Leukemia research 20030301
Title: Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission.
Journal: Blood 20030215
Title: Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.
Journal: Mutation research 20030205
Title: [Effect of etoposide and amsacrine on mitotic progression of GM-130 and Hep-2 cell lines. The flow cytometry assay].
Journal: Tsitologiia 20030101
Title: Dinucleoside monophosphates containing AZT and 1-methyladenosine or 7-methylguanosine.
Journal: Nucleosides, nucleotides & nucleic acids 20030101
Title: Favorable outcome with STI571 (imatinib mesylate) and allogeneic stem cell transplantation in a case of Ph+ chemorefractory acute lymphocytic leukaemia.
Journal: Bone marrow transplantation 20021201
Title: Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
Journal: Journal of medicinal chemistry 20021010
Title: Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.
Journal: The Biochemical journal 20020901
Title: Point of attachment and sequence of immobilized peptide-acridine conjugates control affinity for nucleic acids.
Journal: Journal of the American Chemical Society 20020724
Title: Tetrakis-acridinyl peptide: a novel fluorometric reagent for nucleic acid analysis based on the fluorescence dequenching upon DNA binding.
Journal: The Analyst 20020701
Title: A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.
Journal: Biochemistry 20020625
Title: Impact of addition of maintenance therapy to intensive induction and consolidation chemotherapy for childhood acute myeloblastic leukemia: results of a prospective randomized trial, LAME 89/91. Leucámie Aiqüe Myéloïde Enfant.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020615
Title: High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.
Journal: Carcinogenesis 20020601
Title: Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Journal: Blood 20020101
Title: Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination.
Journal: International journal of cancer 20020101
Title: A study of amsalog (CI-921) administered orally on a 5-day schedule, with bioavailability and pharmacokinetically guided dose escalation.
Journal: Cancer chemotherapy and pharmacology 20020101
Title: Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.
Journal: Molecular cancer therapeutics 20020101
Title: Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines.
Journal: Japanese journal of cancer research : Gann 20011001
Title: FAB M4 and high CD14 surface expression is associated with high cellular resistance to Ara-C and daunorubicin: implications for clinical outcome in acute myeloid leukaemia.
Journal: European journal of haematology 20011001
Title: Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta.
Journal: British journal of cancer 20010901
Title: Altered topoisomerase IIalpha and multidrug resistance-associated protein levels during drug selection: adaptations to increasing drug pressure.
Journal: Japanese journal of cancer research : Gann 20010901
Title: Amsacrine and cisplatin in poor prognosis patients with metastatic transitional cell carcinoma of the urothelium: a phase-II study.
Journal: European urology 20010901
Title: Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha.
Journal: Gene 20010711
Title: Expression of drug resistance genes in VP-16 and mAMSA-selected human carcinoma cells.
Journal: Japanese journal of cancer research : Gann 20010701
Title: Atp-bound topoisomerase ii as a target for antitumor drugs.
Journal: The Journal of biological chemistry 20010511
Title: Repair of topoisomerase-mediated DNA damage in bacteriophage T4.
Journal: Genetics 20010501
Title: Improved efficiency of remission induction facilitates autologous BMT harvesting and improves overall survival in adults with AML: 108 patients treated at a single institution.
Journal: Bone marrow transplantation 20010501
Title: Selection of an unnatural peptide library for dsDNA binding.
Journal: Current medicinal chemistry 20010401
Title: A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule.
Journal: Cancer chemotherapy and pharmacology 20010401
Title: Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
Journal: Cytometry 20010301
Title: Pretreatment leukaemia cell drug resistance is correlated to clinical outcome in acute myeloid leukaemia.
Journal: European journal of haematology 20010301
Title: Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon.
Journal: American journal of clinical pathology 20010201
Title: Analysis of cleavage complexes using reactive inhibitor derivatives.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: Cell-cycle analysis of drug-treated cells.
Journal: Methods in molecular biology (Clifton, N.J.) 20010101
Title: Targeting DNA through-covalent interactions of reversible binding drugs.
Journal: Methods in enzymology 20010101
Title: Inhibition of apoptotic proteins causes multidrug resistance in renal carcinoma cells.
Journal: Anticancer research 20010101
Title: Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells.
Journal: Molecular pharmacology 20000401
Title: Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.
Journal: Mutation research 20000320
Title: Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs.
Journal: Cancer chemotherapy and pharmacology 20000101
Title: [Studies on programmed cell death induced by amsacrine and expression of bcl-2 in leukemia cell lines].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 19970901
Title: Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
Journal: Biochemistry 19970311
Title: [Venous protection of acute leukemia treatment with amsacrine].
Journal: Zhonghua hu li za zhi = Chinese journal of nursing 19960901
Title: Steroid-free chemotherapy decreases the risk of hepatitis flare-up in hepatitis B virus carriers with non-Hodgkin's lymphoma.
Journal: Blood 19960201
Title: Induction of small intestinal adenocarcinomas in Wistar rats administered amsacrine.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 19941001
Title: Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay.
Journal: Toxicology letters 19930401
Title: Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.
Journal: Cancer 19910915
Title: Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.
Journal: Cancer research 19910901
Title: Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.
Journal: European journal of cancer (Oxford, England : 1990) 19910101
Title: Preventing amsacrine-induced cardiac arrhythmias.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19871201
Title: Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
Journal: Cancer chemotherapy and pharmacology 19860101
Title: Sequentially administered 5-azacitidine and amsacrine in refractory adult acute leukemia: a phase I-II trial of the Southeastern Cancer Study Group.
Journal: Cancer treatment reports 19850101
Title: Prevention of amsacrine-induced phlebitis with heparin.
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