405165-61-9,MFCD14636632
Catalog No.:AA00ILN0

405165-61-9 | Besifloxacin HCl

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$9.00   $7.00
- +
10mg
98%
in stock  
$34.00   $24.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ILN0
Chemical Name:
Besifloxacin HCl
CAS Number:
405165-61-9
Molecular Formula:
C19H22Cl2FN3O3
Molecular Weight:
430.3007
MDL Number:
MFCD14636632
SMILES:
NC1CCCCN(C1)c1c(F)cc2c(c1Cl)n(cc(c2=O)C(=O)O)C1CC1.Cl
Properties
Computed Properties
 
Complexity:
656  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route

[1]CurrentPatentAssignee:VYOMETHERAPEUTICSLIMITED-WO2021/250635,2021,A1Locationinpatent:Page/Pagecolumn90

[2]CurrentPatentAssignee:VYOMETHERAPEUTICSLIMITED-WO2021/250635,2021,A1Locationinpatent:Page/Pagecolumn90

Literature

Title: Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high-performance liquid chromatography with precolumn derivatization.

Journal: Chirality 20120701

Title: Besifloxacin ophthalmic suspension, 0.6%: a novel topical fluoroquinolone for bacterial conjunctivitis.

Journal: Advances in therapy 20120601

Title: Besifloxacin ophthalmic suspension 0.6% administered twice daily for 3 days in the treatment of bacterial conjunctivitis in adults and children.

Journal: Clinical drug investigation 20120501

Title: Microbiological etiology and susceptibility of bacterial conjunctivitis isolates from clinical trials with ophthalmic, twice-daily besifloxacin.

Journal: Advances in therapy 20120501

Title: Challenges in assessing microbial susceptibility and predicting clinical response to newer-generation fluoroquinolones.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120201

Title: Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats.

Journal: Environmental toxicology and pharmacology 20110701

Title: Human aqueous humor concentrations of besifloxacin, moxifloxacin, and gatifloxacin after topical ocular application.

Journal: Journal of cataract and refractive surgery 20110601

Title: In vitro time-kill experiments with besifloxacin, moxifloxacin and gatifloxacin in the absence and presence of benzalkonium chloride.

Journal: The Journal of antimicrobial chemotherapy 20110401

Title: Evaluation of the effect of bacterial efflux pumps on the antibacterial activity of the novel fluoroquinolone besifloxacin.

Journal: Journal of chemotherapy (Florence, Italy) 20110401

Title: Comparison of besifloxacin, gatifloxacin, and moxifloxacin against strains of pseudomonas aeruginosa with different quinolone susceptibility patterns in a rabbit model of keratitis.

Journal: Cornea 20110101

Title: Relevance of aqueous humor concentrations of fluoroquinolones.

Journal: Journal of cataract and refractive surgery 20110101

Title: Efficacy and tolerability of besifloxacin ophthalmic suspension 0.6% administered twice daily for 3 days in the treatment of bacterial conjunctivitis: a multicenter, randomized, double-masked, vehicle-controlled, parallel-group study in adults and children.

Journal: Clinical therapeutics 20110101

Title: Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin.

Journal: Chemotherapy 20110101

Title: Penetration and effectiveness of prophylactic fluoroquinolones in experimental methicillin-sensitive or methicillin-resistant Staphylococcus aureus anterior chamber infections.

Journal: Journal of cataract and refractive surgery 20101201

Title: An anterior chamber toxicity study evaluating Besivance, AzaSite, and Ciprofloxacin.

Journal: American journal of ophthalmology 20101001

Title: Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101001

Title: Aqueous penetration of moxifloxacin 0.5% ophthalmic solution and besifloxacin 0.6% ophthalmic suspension in cataract surgery patients.

Journal: Journal of cataract and refractive surgery 20100901

Title: Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

Journal: The Journal of antimicrobial chemotherapy 20100701

Title: Comparative effects of besifloxacin and other fluoroquinolones on corneal reepithelialization in the rabbit.

Journal: Journal of cataract and refractive surgery 20100601

Title: Comparative efficacy of besifloxacin and other fluoroquinolones in a prophylaxis model of penicillin-resistant Streptococcus pneumoniae rabbit endophthalmitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100601

Title: Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials.

Journal: Paediatric drugs 20100401

Title: Efficacy of besifloxacin in an early treatment model of methicillin-resistant Staphylococcus aureus keratitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100401

Title: Besifloxacin: a topical fluoroquinolone for the treatment of bacterial conjunctivitis.

Journal: Clinical therapeutics 20100301

Title: New Drugs2010, PART 1.

Journal: Nursing 20100201

Title: Besifloxacin ophthalmic suspension 0.6%.

Journal: Drugs 20100101

Title: Safety and tolerability of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis: data from six clinical and phase I safety studies.

Journal: Clinical drug investigation 20100101

Title: Efficacy of besifloxacin in a rabbit model of methicillin-resistant Staphylococcus aureus keratitis.

Journal: Cornea 20091001

Title: Besifloxacin, a new ophthalmic fluoroquinolone for the treatment of bacterial conjunctivitis.

Journal: Expert opinion on pharmacotherapy 20091001

Title: Efficacy and safety of besifloxacin ophthalmic suspension 0.6% compared with moxifloxacin ophthalmic solution 0.5% for treating bacterial conjunctivitis.

Journal: Ophthalmology 20090901

Title: Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090801

Title: Besifloxacin ophthalmic suspension for bacterial conjunctivitis.

Journal: Drugs of today (Barcelona, Spain : 1998) 20090801

Title: Phase III efficacy and safety study of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis.

Journal: Current medical research and opinion 20090501

Title: Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli.

Journal: The Journal of antimicrobial chemotherapy 20090301

Title: Besifloxacin ophthalmic suspension 0.6% in patients with bacterial conjunctivitis: A multicenter, prospective, randomized, double-masked, vehicle-controlled, 5-day efficacy and safety study.

Journal: Clinical therapeutics 20090301

Title: New drugs: golimumab, besifloxacin hydrochloride, and artemether/lumefantrine.

Journal: Journal of the American Pharmacists Association : JAPhA 20090101

Title: Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells.

Journal: Current eye research 20081101

Title: Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

Title: Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes.

Journal: The Journal of antimicrobial chemotherapy 20080101

Title: Nonclinical pharmacodynamics, pharmacokinetics, and safety of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601

Title: Wang Z, Wang S, Zhu F, Chen Z, Yu L, Zeng S.Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high-performance liquid chromatography with precolumn derivatization.Chirality. 2012 Jul;24(7):526-31. doi: 10.1002/chir.22042.

Title: Hussar DA.New drugs: golimumab, besifloxacin hydrochloride, and artemether/lumefantrine.J Am Pharm Assoc (2003). 2009 Jul-Aug;49(4):570-4.

Title: Nafziger AN, Bertino JS Jr.Besifloxacin ophthalmic suspension for bacterial conjunctivitis.Drugs Today (Barc). 2009 Aug;45(8):577-88.

Title: Proksch JW, Ward KW.Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.J Ocul Pharmacol Ther. 2010 Oct;26(5):449-58.

Title: Comstock TL, Paterno MR, Usner DW, Pichichero ME.Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials.Paediatr Drugs. 2010 Apr 1;12(2):105-12. doi: 10.2165/11534380-000000000-00000.

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SDS
Tags:405165-61-9 Molecular Formula|405165-61-9 MDL|405165-61-9 SMILES|405165-61-9 Besifloxacin HCl
Catalog No.: AA00ILN0
405165-61-9,MFCD14636632
405165-61-9 | Besifloxacin HCl
Pack Size: 1mg
Purity: 98%
in stock
$9.00 $7.00
Pack Size: 10mg
Purity: 98%
in stock
$34.00 $24.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00ILN0
Chemical Name: Besifloxacin HCl
CAS Number: 405165-61-9
Molecular Formula: C19H22Cl2FN3O3
Molecular Weight: 430.3007
MDL Number: MFCD14636632
SMILES: NC1CCCCN(C1)c1c(F)cc2c(c1Cl)n(cc(c2=O)C(=O)O)C1CC1.Cl
Properties
Complexity: 656  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
405165-61-9    141388-76-3 

[1]CurrentPatentAssignee:VYOMETHERAPEUTICSLIMITED-WO2021/250635,2021,A1Locationinpatent:Page/Pagecolumn90

[2]CurrentPatentAssignee:VYOMETHERAPEUTICSLIMITED-WO2021/250635,2021,A1Locationinpatent:Page/Pagecolumn90

Literature fold

Title: Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high-performance liquid chromatography with precolumn derivatization.

Journal: Chirality20120701

Title: Besifloxacin ophthalmic suspension, 0.6%: a novel topical fluoroquinolone for bacterial conjunctivitis.

Journal: Advances in therapy20120601

Title: Besifloxacin ophthalmic suspension 0.6% administered twice daily for 3 days in the treatment of bacterial conjunctivitis in adults and children.

Journal: Clinical drug investigation20120501

Title: Microbiological etiology and susceptibility of bacterial conjunctivitis isolates from clinical trials with ophthalmic, twice-daily besifloxacin.

Journal: Advances in therapy20120501

Title: Challenges in assessing microbial susceptibility and predicting clinical response to newer-generation fluoroquinolones.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20120201

Title: Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats.

Journal: Environmental toxicology and pharmacology20110701

Title: Human aqueous humor concentrations of besifloxacin, moxifloxacin, and gatifloxacin after topical ocular application.

Journal: Journal of cataract and refractive surgery20110601

Title: In vitro time-kill experiments with besifloxacin, moxifloxacin and gatifloxacin in the absence and presence of benzalkonium chloride.

Journal: The Journal of antimicrobial chemotherapy20110401

Title: Evaluation of the effect of bacterial efflux pumps on the antibacterial activity of the novel fluoroquinolone besifloxacin.

Journal: Journal of chemotherapy (Florence, Italy)20110401

Title: Comparison of besifloxacin, gatifloxacin, and moxifloxacin against strains of pseudomonas aeruginosa with different quinolone susceptibility patterns in a rabbit model of keratitis.

Journal: Cornea20110101

Title: Relevance of aqueous humor concentrations of fluoroquinolones.

Journal: Journal of cataract and refractive surgery20110101

Title: Efficacy and tolerability of besifloxacin ophthalmic suspension 0.6% administered twice daily for 3 days in the treatment of bacterial conjunctivitis: a multicenter, randomized, double-masked, vehicle-controlled, parallel-group study in adults and children.

Journal: Clinical therapeutics20110101

Title: Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin.

Journal: Chemotherapy20110101

Title: Penetration and effectiveness of prophylactic fluoroquinolones in experimental methicillin-sensitive or methicillin-resistant Staphylococcus aureus anterior chamber infections.

Journal: Journal of cataract and refractive surgery20101201

Title: An anterior chamber toxicity study evaluating Besivance, AzaSite, and Ciprofloxacin.

Journal: American journal of ophthalmology20101001

Title: Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20101001

Title: Aqueous penetration of moxifloxacin 0.5% ophthalmic solution and besifloxacin 0.6% ophthalmic suspension in cataract surgery patients.

Journal: Journal of cataract and refractive surgery20100901

Title: Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

Journal: The Journal of antimicrobial chemotherapy20100701

Title: Comparative effects of besifloxacin and other fluoroquinolones on corneal reepithelialization in the rabbit.

Journal: Journal of cataract and refractive surgery20100601

Title: Comparative efficacy of besifloxacin and other fluoroquinolones in a prophylaxis model of penicillin-resistant Streptococcus pneumoniae rabbit endophthalmitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20100601

Title: Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials.

Journal: Paediatric drugs20100401

Title: Efficacy of besifloxacin in an early treatment model of methicillin-resistant Staphylococcus aureus keratitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20100401

Title: Besifloxacin: a topical fluoroquinolone for the treatment of bacterial conjunctivitis.

Journal: Clinical therapeutics20100301

Title: New Drugs2010, PART 1.

Journal: Nursing20100201

Title: Besifloxacin ophthalmic suspension 0.6%.

Journal: Drugs20100101

Title: Safety and tolerability of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis: data from six clinical and phase I safety studies.

Journal: Clinical drug investigation20100101

Title: Efficacy of besifloxacin in a rabbit model of methicillin-resistant Staphylococcus aureus keratitis.

Journal: Cornea20091001

Title: Besifloxacin, a new ophthalmic fluoroquinolone for the treatment of bacterial conjunctivitis.

Journal: Expert opinion on pharmacotherapy20091001

Title: Efficacy and safety of besifloxacin ophthalmic suspension 0.6% compared with moxifloxacin ophthalmic solution 0.5% for treating bacterial conjunctivitis.

Journal: Ophthalmology20090901

Title: Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20090801

Title: Besifloxacin ophthalmic suspension for bacterial conjunctivitis.

Journal: Drugs of today (Barcelona, Spain : 1998)20090801

Title: Phase III efficacy and safety study of besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis.

Journal: Current medical research and opinion20090501

Title: Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli.

Journal: The Journal of antimicrobial chemotherapy20090301

Title: Besifloxacin ophthalmic suspension 0.6% in patients with bacterial conjunctivitis: A multicenter, prospective, randomized, double-masked, vehicle-controlled, 5-day efficacy and safety study.

Journal: Clinical therapeutics20090301

Title: New drugs: golimumab, besifloxacin hydrochloride, and artemether/lumefantrine.

Journal: Journal of the American Pharmacists Association : JAPhA20090101

Title: Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells.

Journal: Current eye research20081101

Title: Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20080501

Title: Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes.

Journal: The Journal of antimicrobial chemotherapy20080101

Title: Nonclinical pharmacodynamics, pharmacokinetics, and safety of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20070601

Title: Wang Z, Wang S, Zhu F, Chen Z, Yu L, Zeng S.Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high-performance liquid chromatography with precolumn derivatization.Chirality. 2012 Jul;24(7):526-31. doi: 10.1002/chir.22042.

Title: Hussar DA.New drugs: golimumab, besifloxacin hydrochloride, and artemether/lumefantrine.J Am Pharm Assoc (2003). 2009 Jul-Aug;49(4):570-4.

Title: Nafziger AN, Bertino JS Jr.Besifloxacin ophthalmic suspension for bacterial conjunctivitis.Drugs Today (Barc). 2009 Aug;45(8):577-88.

Title: Proksch JW, Ward KW.Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.J Ocul Pharmacol Ther. 2010 Oct;26(5):449-58.

Title: Comstock TL, Paterno MR, Usner DW, Pichichero ME.Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials.Paediatr Drugs. 2010 Apr 1;12(2):105-12. doi: 10.2165/11534380-000000000-00000.

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