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61422-45-5,MFCD00866284
Catalog No.:AA00IMC2

61422-45-5 | Carmofur

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1mg
98%
in stock  
$7.00   $5.00
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25mg
98%
in stock  
$22.00   $15.00
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100mg
98%
in stock  
$47.00   $33.00
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250mg
≥98%
in stock  
$52.00   $36.00
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500mg
≥98%
in stock  
$95.00   $66.00
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1g
>98.0%(HPLC)
in stock  
$129.00   $90.00
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5g
>98.0%(HPLC)
in stock  
$327.00   $229.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IMC2
Chemical Name:
Carmofur
CAS Number:
61422-45-5
Molecular Formula:
C11H16FN3O3
Molecular Weight:
257.2614
MDL Number:
MFCD00866284
SMILES:
CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O
NSC Number:
758963
Properties
Computed Properties
 
Complexity:
382  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.6  

Literature

Title: Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin allocation by dietary lipids and environmental toxicants.

Journal: PloS one 20170101

Title: Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives.

Journal: Surgery today 20120101

Title: [Effect of tagalsin on p53 and Bcl-2 expression in hepatoma H(22) tumor-bearing mice].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110701

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Co-polymeric hydrophilic nanospheres for drug delivery: release kinetics, and cellular uptake.

Journal: Indian journal of experimental biology 20101001

Title: Minute liver metastases from a rectal carcinoid: A case report and review.

Journal: World journal of gastrointestinal surgery 20100327

Title: Anti-tumor activity of carmofur water-solubilized by lactic acid oligomer-grafted pullulan nanogels.

Journal: Journal of nanoscience and nanotechnology 20090801

Title: Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action.

Journal: Molecular cancer 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.

Journal: Cancer biotherapy & radiopharmaceuticals 20080801

Title: Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.

Journal: Journal of neurology, neurosurgery, and psychiatry 20080501

Title: [Leukoencephalopathy caused by antineoplastic drugs].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20080201

Title: [Drug-induced leukoencephalopathy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: [Drug-induced leukoencephalopathy].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070810

Title: An individual patient data meta-analysis of adjuvant therapy with uracil-tegafur (UFT) in patients with curatively resected rectal cancer.

Journal: British journal of cancer 20070423

Title: Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil.

Journal: Langenbeck's archives of surgery 20060801

Title: Significance of histologic type of primary lesion and metastatic lymph nodes as a prognostic factor in stage III colon cancer.

Journal: Diseases of the colon and rectum 20060701

Title: [Adjuvant chemotherapy for colorectal cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20060301

Title: Delivery of hydrophobised 5-fluorouracil derivative to brain tissue through intravenous route using surface modified nanogels.

Journal: Journal of drug targeting 20060201

Title: S-1 (TS-1) maintained complete response for approximately 10 years in a case of metastatic breast cancer.

Journal: Breast cancer (Tokyo, Japan) 20060101

Title: An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer.

Journal: Japanese journal of clinical oncology 20050901

Title: A multicenter randomized study comparing 5-fluorouracil continuous infusion (ci) plus 1-hexylcarbamoyl-5-fluorouracil and 5-FU ci alone in colorectal cancer.

Journal: Oncology reports 20050701

Title: [Multicenter comparative study of the recurrence-inhibitory effect of oral fluoropyrimidine drugs in patients with colorectal cancer following curative resection].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20050701

Title: 1-hexylcarbamoyl-5-fluorouracil + cyclophosphamide + tamoxifen versus CMF + tamoxifen in women with lymph node-positive breast cancer after primary surgery: a randomized controlled trial.

Journal: Oncology reports 20041001

Title: [Postoperative changes in serum lipid levels of breast cancer and adjuvant chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20041001

Title: Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-fluorouracil and uracil/tegafur.

Journal: International journal of clinical oncology 20040401

Title: [Analysis of microsatellite instability and p53 LOH in advanced colorectal cancers--first report of the No. 3 protocol].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040301

Title: Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040201

Title: [Appropriate duration of postoperative oral adjuvant chemotherapy with HCFU for colorectal cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040101

Title: Postoperative adjuvant use of carmofur for early breast cancer.

Journal: Osaka city medical journal 20031201

Title: [Neo-adjuvant chemotherapy with carmofur for colorectal cancer--a multi-institutional randomized controlled study].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20021101

Title: Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma.

Journal: British journal of cancer 20020909

Title: Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.

Journal: Biological & pharmaceutical bulletin 20011101

Title: [A case of reversible carmofur-induced leukoencephalopathy].

Journal: No to shinkei = Brain and nerve 20011001

Title: Randomized, controlled trial of lateral node dissection vs. nerve-preserving resection in patients with rectal cancer after preoperative radiotherapy.

Journal: Diseases of the colon and rectum 20010901

Title: Docetaxel alone or orally combined with 5-fluorouracil and its derivatives: effects on mouse mammary tumor cell line MM2 in vitro and in vivo.

Journal: Anti-cancer drugs 20010901

Title: Optimal duration of oral adjuvant chemotherapy with Carmofur in the colorectal cancer patients: the Kansai Carmofur Study Group trial III.

Journal: International journal of oncology 20010801

Title: Postoperative chemoendocrine therapy for women with node-positive stage II breast cancer with combined cyclophosphamide, tamoxifen, and 1-hexylcarbamoyl-5-fluorouracil.

Journal: The European journal of surgery = Acta chirurgica 20010801

Title: Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trials.

Journal: Cancer 20010615

Title: 5-fluorouracil-induced leukoencephalopathy in patients with breast cancer.

Journal: Journal of Korean medical science 20010601

Title: [Inhibition of HCFU absorption after resection for gastric cancer--application of hydroxyaluminium gel].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20010601

Title: An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer.

Journal: Oncology reports 20010101

Title: Oral HCFU for prevention of hepatic metastasis in an experimental colorectal carcinoma.

Journal: Anticancer research 20010101

Title: Apoptosis and p53 overexpression in human rectal cancer; relationship with response to hyperthermo-chemo-radiotherapy.

Journal: Anticancer research 20010101

Title: A phase I study of raltitrexed (Tomudex) combined with carmofur in metastatic colorectal cancer.

Journal: Oncology 20010101

Title: Diffusion-weighted MR imaging of Carmofur-induced leukoencephalopathy.

Journal: European radiology 20010101

Title: Post-operative adjuvant chemotherapy for colorectal cancer with 5-fluorouracil (5-FU) infusion combined with 1-hexylcarbamoyl-5-fluorouracil (HCFU) oral administration after curative resection.

Journal: Anticancer research 20010101

Title: Carmofur-induced leukoencephalopathy: MRI.

Journal: Neuroradiology 19951101

Title: [Clinical effects of carmofur (Mifurol) on advanced and recurrent breast cancer in a cooperative study. Research association for re-evaluation of direct effects of Mifurol on breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19950301

Title: Carmofur-induced organic mental disorders.

Journal: The Japanese journal of psychiatry and neurology 19901201

Title: A case of carmofur-induced leukoencephalopathy--MR images and CT findings.

Journal: The Tokai journal of experimental and clinical medicine 19890901

Title: Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature.

Journal: Asia-Oceania journal of obstetrics and gynaecology 19890601

Title: [A case of leukoencephalopathy caused by HCFU].

Journal: Gan no rinsho. Japan journal of cancer clinics 19880501

Title: Subacute leucoencephalopathy induced by carmofur, a 5-fluorouracil derivative.

Journal: Journal of neurology 19870801

Title: Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism.

Journal: Surgical neurology 19860301

Title: [A case of toxic leucoencephalopathy induced by 5FU derivatives].

Journal: No shinkei geka. Neurological surgery 19851101

Title: [Clinical evaluation of 1-hexylcarbamoyl-5-fluorouracil (HCFU) in hepatocellular carcinoma].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 19841101

Title: Phase I study of a new antitumor drug, 1-hexylcarbamoyl-5-fluorouracil (HCFU), administered orally: an HCFU clinical study group report.

Journal: Cancer treatment reports 19800101

Title: Realini N, et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep. 2013;3:1035.

Title: Jin Z, et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020;27(6):529-532.

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