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217500-96-4,MFCD09838804
Catalog No.:AA00IMJ2

217500-96-4 | Tulathromycin A

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5mg
≥95%
in stock  
$82.00   $57.00
- +
25mg
95%
in stock  
$126.00   $88.00
- +
100mg
95%
in stock  
$278.00   $195.00
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250mg
95%
in stock  
$411.00   $288.00
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1g
95%
in stock  
$1,009.00   $706.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IMJ2
Chemical Name:
Tulathromycin A
CAS Number:
217500-96-4
Molecular Formula:
C41H79N3O12
Molecular Weight:
806.0789
MDL Number:
MFCD09838804
SMILES:
CCCNC[C@]1(O)[C@H](C)O[C@H](C[C@@]1(C)OC)O[C@@H]1[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H](NC[C@@H](C[C@@]([C@@H]([C@H]1C)O[C@@H]1O[C@H](C)C[C@@H]([C@H]1O)N(C)C)(C)O)C)C
Properties
Computed Properties
 
Complexity:
1240  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
18  
Heavy Atom Count:
56  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
11  
XLogP3:
3.8  

Literature

Title: Comparative minimum inhibitory and mutant prevention drug concentrations of enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin against bovine clinical isolates of Mannheimia haemolytica.

Journal: Veterinary microbiology 20121109

Title: Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats.

Journal: American journal of veterinary research 20121001

Title: The effect of respiratory disease and a preventative antibiotic treatment on growth, survival, age at first calving, and milk production of dairy heifers.

Journal: Journal of dairy science 20120901

Title: Pharmacokinetics of tulathromycin and its metabolite in swine administered with an intravenous bolus injection and a single gavage.

Journal: Journal of veterinary pharmacology and therapeutics 20120601

Title: Failure of antimicrobial therapy to accelerate spontaneous healing of subclinical pulmonary abscesses on a farm with endemic infections caused by Rhodococcus equi.

Journal: Veterinary journal (London, England : 1997) 20120601

Title: Antimicrobial susceptibility patterns and sensitivity to tulathromycin in goat respiratory bacterial isolates.

Journal: Veterinary microbiology 20120423

Title: Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats.

Journal: Journal of veterinary pharmacology and therapeutics 20120401

Title: Tulathromycin assay validation and tissue residues after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus).

Journal: Journal of veterinary pharmacology and therapeutics 20120401

Title: Pharmacodynamics of antimicrobials against Mycoplasma mycoides mycoides small colony, the causative agent of contagious bovine pleuropneumonia.

Journal: PloS one 20120101

Title: Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus).

Journal: Journal of veterinary pharmacology and therapeutics 20111001

Title: Assessment of the cardiotoxicity of tulathromycin in rabbits.

Journal: Acta veterinaria Hungarica 20110901

Title: Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats.

Journal: Research in veterinary science 20110601

Title: Determination and confirmation of tulathromycin residues in bovine liver and porcine kidney via their common hydrolytic fragment using high-performance liquid chromatography/tandem mass spectrometry.

Journal: Journal of AOAC International 20110101

Title: Safety evaluation of tulathromycin use in the caprine species: tulathromycin toxicity assessment in goats.

Journal: Journal of veterinary pharmacology and therapeutics 20101001

Title: Genetic diversity of Mycoplasma hyopneumoniae isolates from conventional farrow-to-finish pig farms in Serbia.

Journal: Acta veterinaria Hungarica 20100901

Title: Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves.

Journal: Australian veterinary journal 20100601

Title: Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100201

Title: The effect of treatment with long-acting antibiotic at postweaning movement on respiratory disease and on growth in commercial dairy calves.

Journal: Journal of dairy science 20100201

Title: Antimicrobial activity of tulathromycin and 14 other antimicrobials against virulent Rhodococcus equi in vitro.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20100101

Title: Comparison of three treatment regimens for sheep and goats with caseous lymphadenitis.

Journal: Journal of the American Veterinary Medical Association 20090501

Title: A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20090101

Title: Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of undifferentiated fever in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20090101

Title: Effect of tulathromycin on the carrier status of Actinobacillus pleuropneumoniae serotype 2 in the tonsils of pigs.

Journal: The Veterinary record 20081011

Title: Ultratrace analysis of nine macrolides, including tulathromycin A (Draxxin), in edible animal tissues with minicolumn liquid chromatography tandem mass spectrometry.

Journal: Journal of agricultural and food chemistry 20081008

Title: Susceptibility testing of tulathromycin: interpretative breakpoints and susceptibility of field isolates.

Journal: Veterinary microbiology 20080622

Title: A comparison of florfenicol and tulathromycine for the treatment of undifferentiated fever in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Comparison of short-term health and performance effects related to prophylactic administration of tulathromycin versus tilmicosin in long-hauled, highly stressed beef stocker calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: In vitro activities of tulathromycin and ceftiofur combined with other antimicrobial agents using bovine Pasteurella multocida and Mannheimia haemolytica isolates.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Comparison of florfenicol and tulathromycin for the treatment of undifferentiated fever in Alberta feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20080101

Title: Evaluation of tulathromycin in the treatment of pulmonary abscesses in foals.

Journal: Veterinary journal (London, England : 1997) 20070901

Title: Meta-analysis of treatment of cattle with bovine respiratory disease with tulathromycin.

Journal: Journal of veterinary pharmacology and therapeutics 20070601

Title: The safety of tulathromycin administration in goats.

Journal: Journal of veterinary pharmacology and therapeutics 20070601

Title: An evaluation of the relative efficacy of tulathromycin for the treatment of undifferentiated fever in feedlot calves in Nebraska.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20070601

Title: Quantitative determination of the macrolide antibiotic tulathromycin in plasma and broncho-alveolar cells of foals using tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: Efficacy of tulathromycin or enrofloxacin for initial treatment of naturally occurring bovine respiratory disease in feeder calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Evaluation of the efficacy of tulathromycin as a metaphylactic antimicrobial in feedlot calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Efficacy of tulathromycin for treatment of cattle with acute ocular Moraxella bovis infections.

Journal: Journal of the American Veterinary Medical Association 20060815

Title: Efficacy of tulathromycin in the treatment of respiratory disease in pigs caused by Actinobacillus pleuropneumoniae.

Journal: The Veterinary record 20060401

Title: Tulathromycin: an overview of a new triamilide antibiotic for livestock respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Clinical effectiveness of tulathromycin, a novel triamilide antimicrobial, for the control of respiratory disease in cattle at high risk for developing bovine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Evaluation of tulathromycin for the treatment of pneumonia following experimental infection of swine with Mycoplasma hyopneumoniae.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Evaluation of the therapeutic activity of tulathromycin against swine respiratory disease on farms in Europe.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Efficacy of tulathromycin injectable solution for the treatment of naturally occurring Swine respiratory disease.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20050101

Title: Pharmacokinetics and lung tissue concentrations of tulathromycin in swine.

Journal: Journal of veterinary pharmacology and therapeutics 20040801

Title: [Tulathromycin, a new antibiotic for farm animals].

Journal: Tijdschrift voor diergeneeskunde 20040501

Title: An analytical method for the analysis of tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung.

Journal: Journal of agricultural and food chemistry 20040421

Title: Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20040101

Title: Villarino N, et al. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally with lipopolysaccharide from Escherichia coli. Antimicrob Agents Chemother. 2012;56(8):4078-4086.

Title: Andersen NM, et al. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob Agents Chemother. 2012;56(11):6033-6036.

Title: Duquette SC, et al. Immunomodulatory effects of tulathromycin on apoptosis, efferocytosis, and proinflammatory leukotriene B4 production in leukocytes from Actinobacillus pleuropneumoniae-or zymosan-challenged pigs. Am J Vet Res. 2015;76(6):507-519.

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Tags:217500-96-4 Molecular Formula|217500-96-4 MDL|217500-96-4 SMILES|217500-96-4 Tulathromycin A