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5011-34-7,MFCD00868263
Catalog No.:AA00JC4R

5011-34-7 | 1-(2,3,4-trimethoxybenzyl)piperazine

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Purity
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1g
96%
in stock  
$95.00   $67.00
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5g
96%
in stock  
$261.00   $183.00
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10g
96%
in stock  
$378.00   $264.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00JC4R
Chemical Name:
1-(2,3,4-trimethoxybenzyl)piperazine
CAS Number:
5011-34-7
Molecular Formula:
C14H22N2O3
Molecular Weight:
266.3361
MDL Number:
MFCD00868263
SMILES:
COc1c(ccc(c1OC)OC)CN1CCNCC1
Properties
Properties
 
Storage:
2-8℃;Keep in dry area;  

Computed Properties
 
Complexity:
259  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
1  

Literature

Title: Trimetazidine protects cardiomyocytes against hypoxia-induced injury through ameliorates calcium homeostasis.

Journal: Chemico-biological interactions 20150705

Title: Food effect on bioavailability of modified-release trimetazidine tablets.

Journal: Journal of clinical pharmacology 20121001

Title: Effects of sheath injury and trimetazidine on endothelial dysfunction of radial artery after transradial catheterization.

Journal: Journal of interventional cardiology 20120801

Title: Trimetazidine and inflammatory response in coronary artery bypass grafting.

Journal: Arquivos brasileiros de cardiologia 20120801

Title: Long-term beta blockers for stable angina: systematic review and meta-analysis.

Journal: European journal of preventive cardiology 20120601

Title: The cardioprotective effect of TG-6, a newly synthesized compound, on ischemia-reperfusion injury in rats.

Journal: European journal of pharmacology 20120515

Title: Randomized clinical trial France DMLA2: effect of trimetazidine on exudative and nonexudative age-relatedmacular degeneration.

Journal: Retina (Philadelphia, Pa.) 20120401

Title: Extrapyramidal adverse drug reactions associated with trimetazidine: a series of 21 cases.

Journal: Fundamental & clinical pharmacology 20120401

Title: Trimetazidine in the prevention of contrast induced nephropathy after coronary angiogram.

Journal: Mymensingh medical journal : MMJ 20120401

Title: Additional use of trimetazidine in patients with chronic heart failure: a meta-analysis.

Journal: Journal of the American College of Cardiology 20120306

Title: Reduction of postoperative adhesions by trimetazidine: an experimental study in a rat model.

Journal: Archives of gynecology and obstetrics 20120301

Title: Effect of trimetazidine treatment on the transient outward potassium current of the left ventricular myocytes of rats with streptozotocin-induced type 1 diabetes mellitus.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120301

Title: A systematic review of aluminium phosphide poisoning.

Journal: Arhiv za higijenu rada i toksikologiju 20120301

Title: Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120201

Title: Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle.

Journal: Journal of molecular medicine (Berlin, Germany) 20120101

Title: Development of a novel 96-microwell assay with high throughput for determination of olmesartan medoxomil in its tablets.

Journal: Chemistry Central journal 20120101

Title: Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate.

Journal: Chemistry Central journal 20120101

Title: Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery.

Journal: International journal of molecular sciences 20120101

Title: Psychiatric symptoms of patients with primary mitochondrial DNA disorders.

Journal: Behavioral and brain functions : BBF 20120101

Title: Role of acamprosate in sensorineural tinnitus.

Journal: Indian journal of pharmacology 20120101

Title: Impact of normothermic preservation with extracellular type solution containing trehalose on rat kidney grafting from a cardiac death donor.

Journal: PloS one 20120101

Title: Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Stress studies of tenofovir disoproxil fumarate by HPTLC in bulk drug and pharmaceutical formulation.

Journal: TheScientificWorldJournal 20120101

Title: Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms.

Journal: Biochemistry research international 20120101

Title: [Trimetazidine addition to antianginal therapy: effects on efficacy and quality of life in patients with stable angina treated outpatiently].

Journal: Terapevticheskii arkhiv 20120101

Title: Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation.

Journal: PloS one 20120101

Title: Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment.

Journal: Journal of biomedical science 20120101

Title: [Contrast nephropathy and prevention].

Journal: Vnitrni lekarstvi 20120101

Title: Trimetazidine effect on burn-induced intestinal mucosal injury and kidney damage in rats.

Journal: International journal of burns and trauma 20120101

Title: Optimization of cardiac metabolism in heart failure.

Journal: Current pharmaceutical design 20111201

Title: Abstracts of the 6th cachexia conference, milan, Italy, december 8-10, 2011.

Journal: Journal of cachexia, sarcopenia and muscle 20111201

Title: Metabolic modulation: a new therapeutic target in treatment of heart failure.

Journal: American journal of therapeutics 20111101

Title: Effect of diabetes on alteration of metabolism in cardiac myocytes: therapeutic implications.

Journal: Diabetes technology & therapeutics 20111101

Title: Drug-induced parkinsonism: a review of 17 years' experience in a regional pharmacovigilance center in France.

Journal: Movement disorders : official journal of the Movement Disorder Society 20111001

Title: Update on the medical treatment of stable angina.

Journal: Archives of cardiovascular diseases 20111001

Title: Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis.

Journal: European journal of drug metabolism and pharmacokinetics 20110901

Title: Effect of partial inhibition of fatty acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failure.

Journal: Heart (British Cardiac Society) 20110901

Title: Trimetazidine on ischemic injury and reperfusion in coronary artery bypass grafting.

Journal: Arquivos brasileiros de cardiologia 20110901

Title: Large-volume injection of sample diluents not miscible with the mobile phase as an alternative approach in sample preparation for bioanalysis: an application for fenspiride bioequivalence.

Journal: Bioanalysis 20110901

Title: Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.

Journal: American journal of physiology. Endocrinology and metabolism 20110701

Title: Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trials.

Journal: Clinical cardiology 20110601

Title: Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.

Journal: Journal of medicinal chemistry 20110512

Title: Modulating fatty acid oxidation in heart failure.

Journal: Cardiovascular research 20110501

Title: Trimetazidine improves exercise performance in patients with peripheral arterial disease.

Journal: Pharmacological research 20110401

Title: Treat the graft to improve the regenerative ability of the host.

Journal: Medical hypotheses 20110401

Title: Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110401

Title: Pulsatile ocular blood flow in subjects with sleep apnoea syndrome.

Journal: Archives of medical science : AMS 20110401

Title: Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.

Journal: Medical hypotheses 20110201

Title: Trimetazidine: a meta-analysis of randomised controlled trials in heart failure.

Journal: Heart (British Cardiac Society) 20110201

Title: Metabolic modulation in heart failure: high time for a definitive clinical trial.

Journal: Heart (British Cardiac Society) 20110201

Title: Myrica rubra Extracts Protect the Liver from CCl(4)-Induced Damage.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Would coronary collaterals to the infarct-related artery serve as a marker of viability in patients with prior myocardial infarction? A study with trimetazidine-(99m)Tc-sestamibi imaging.

Journal: Cardiovascular revascularization medicine : including molecular interventions 20110101

Title: Analysis of machine perfusion benefits in kidney grafts: a preclinical study.

Journal: Journal of translational medicine 20110101

Title: Outcome predictors for treatment success with 5% lidocaine medicated plaster in low back pain with neuropathic components and neuropathic pain after surgical and nonsurgical trauma.

Journal: Journal of pain research 20110101

Title: Contribution of large pig for renal ischemia-reperfusion and transplantation studies: the preclinical model.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.

Journal: Frontiers in physiology 20110101

Title: [Stabilization of cellular membranes as a target of vascular therapy].

Journal: Kardiologiia 20110101

Title: Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial.

Journal: Trials 20110101

Title: Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair.

Journal: Journal of inflammation (London, England) 20110101

Title: Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules.

Journal: Chemistry Central journal 20110101

Title: Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms.

Journal: International journal of analytical chemistry 20110101

Title: [The (PRIMA) Study. Comparison of clinical effect of trimetazidine MR in men and women].

Journal: Kardiologiia 20110101

Title: Managing aluminum phosphide poisonings.

Journal: Journal of emergencies, trauma, and shock 20110101

Title: Relative bioavailability and pharmacokinetic study of two trimetazidine modified release formulations in healthy Bangladeshi male volunteers.

Journal: Arzneimittel-Forschung 20110101

Title: A simple and sensitive liquid chromatography method for the determination of low dihydrocodeine concentrations in human plasma: its application in Chinese healthy volunteers.

Journal: Arzneimittel-Forschung 20110101

Title: N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats.

Journal: PloS one 20110101

Title: [Myocardial cytoprotectors, a reserve therapeutic modality for patients with stable angina of effort].

Journal: Klinicheskaia meditsina 20110101

Title: [Clinico-economical aspects of application of trimetazidine MB in patients with chronic heart failure and cardiac rhythm disturbances].

Journal: Kardiologiia 20110101

Title: Spectrofluorimetric determination of sertraline in dosage forms and human plasma through derivatization with 9-fluorenylmethyl chloroformate.

Journal: Chemistry Central journal 20110101

Title: Novel microwell-based spectrophotometric assay for determination of atorvastatin calcium in its pharmaceutical formulations.

Journal: Chemistry Central journal 20110101

Title: Myocardial perfusion imaging with (99 m)Tc-tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study.

Journal: Radiation oncology (London, England) 20110101

Title: Comparative study between trimetazidine and ice slush hypothermia in protection against renal ischemia/reperfusion injury in a porcine model.

Journal: International braz j urol : official journal of the Brazilian Society of Urology 20110101

Title: Tai chi enhances the effects of endurance training in the rehabilitation of elderly patients with chronic heart failure.

Journal: Rehabilitation research and practice 20110101

Title: Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analysis.

Journal: Cardiology 20110101

Title: Protective effect of lisinopril on hepatic ischemia/reperfusion injury in rats.

Journal: Indian journal of pharmacology 20110101

Title: Hepatoprotection through regulation of voltage dependent anion channel expression by Amomum subulatum Roxb seeds extract.

Journal: Indian journal of pharmacology 20110101

Title: Trimetazidine blocks store-operated Ca(2+) channels in HL-60 and THP-1 cell lines and inhibits the secretion of tumor necrosis factor.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20110101

Title: Structural and functional characterization of the recombinant human mitochondrial trifunctional protein.

Journal: Biochemistry 20101005

Title: Trimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase-ROS-CTGF pathway.

Journal: Cardiovascular research 20101001

Title: [Is ejection fraction the best parameter for the assessment of ventricular function?].

Journal: Arquivos brasileiros de cardiologia 20101001

Title: Capecitabine cardiac toxicity presenting as effort angina: a case report.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20100901

Title: Floating tablet of trimetazidine dihydrochloride: an approach for extended release with zero-order kinetics.

Journal: AAPS PharmSciTech 20100901

Title: Effects of trimetazidine, a partial inhibitor of fatty acid oxidation, on ventricular function and survival after myocardial infarction and reperfusion in the rat.

Journal: Fundamental & clinical pharmacology 20100801

Title: Imaging and modeling of myocardial metabolism.

Journal: Journal of cardiovascular translational research 20100801

Title: Hypoxia inducible factor-1alpha accumulation in steatotic liver preservation: role of nitric oxide.

Journal: World journal of gastroenterology 20100728

Title: Modulation of myocardial metabolism: an emerging therapeutic principle.

Journal: Current opinion in cardiology 20100701

Title: Allopurinol for chronic stable angina: old drug, new tricks?

Journal: Lancet (London, England) 20100619

Title: Effects of trimetazidine on endothelial dysfunction after sheath injury of radial artery.

Journal: The American journal of cardiology 20100615

Title: Emerging medical treatment for angina pectoris.

Journal: Expert opinion on emerging drugs 20100601

Title: Trimetazidine exerts protection against increasing current electroshock seizure test in mice.

Journal: Seizure 20100601

Title: [Evaluation of the myocardial protection of trimetazidine during percutaneous coronary intervention: a multi-center randomized and controlled clinical study].

Journal: Zhonghua nei ke za zhi 20100601

Title: Attenuation of gentamicin-induced nephrotoxicity: trimetazidine versus N-acetyl cysteine.

Journal: Journal of applied toxicology : JAT 20100501

Title: Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling.

Journal: The Journal of pharmacology and experimental therapeutics 20100501

Title: Improvement of mechanical heart function by trimetazidine in db/db mice.

Journal: Acta pharmacologica Sinica 20100501

Title: Development and validation of a simple and sensitive liquid chromatography-tandem mass spectrometry method for quantifying trimetazidine in human plasma.

Journal: Clinical and experimental pharmacology & physiology 20100401

Title: Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401

Title: Trimetazidine: new French pharmacovigilance data.

Journal: Prescrire international 20100401

Title: Characterization of an ambulatory population with stable coronary artery disease and importance of heart rate: the PULSAR registry.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20100401

Title: Trimetazidine shortens QTc interval in patients with ischemic heart failure.

Journal: Journal of cardiovascular pharmacology and therapeutics 20100301

Title: Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure.

Journal: Journal of cardiovascular pharmacology and therapeutics 20100301

Title: Pharmacological strategies against cold ischemia reperfusion injury.

Journal: Expert opinion on pharmacotherapy 20100301

Title: Neuropharmacology of vestibular system disorders.

Journal: Current neuropharmacology 20100301

Title: Systematic review of randomized controlled trials of pharmacological interventions to reduce ischaemia-reperfusion injury in elective liver resection with vascular occlusion.

Journal: HPB : the official journal of the International Hepato Pancreato Biliary Association 20100201

Title: Naproxen aggravates doxorubicin-induced cardiomyopathy in rats.

Journal: Indian journal of pharmacology 20100201

Title: Angina in Women without Obstructive Coronary Artery Disease.

Journal: Current cardiology reviews 20100201

Title: [Acute coronary syndrome with ST segment depression on ECG: novel outlook of an old problem].

Journal: Kardiologiia 20100101

Title: [A clinical experience of taurine and trimetazidine use in premenopausal women with chronic heart failure].

Journal: Kardiologiia 20100101

Title: Trimetazidine for prevention of induced ischemia and reperfusion of guinea pig retina.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: [Effect of therapy with trimetazidine modified release on quality of life of patients with stable effort angina survivors after acute myocardial infarction. Results of PRIMA study].

Journal: Kardiologiia 20100101

Title: Chick embryo partial ischemia model: a new approach to study ischemia ex vivo.

Journal: PloS one 20100101

Title: Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.

Journal: Vascular health and risk management 20100101

Title: Trimetazidine activates paraoxonase.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

Title: Preservation on calcium homeostasis is involved in mitochondrial protection of Limonium sinense against liver damage in mice.

Journal: Pharmacognosy magazine 20100101

Title: Emerging clinical role of ranolazine in the management of angina.

Journal: Therapeutics and clinical risk management 20100101

Title: Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure.

Journal: Cardiovascular diabetology 20100101

Title: Preparation and in vitro Evaluation of Ethylcellulose Coated Egg Albumin Microspheres of Diltiazem Hydrochloride.

Journal: Journal of young pharmacists : JYP 20100101

Title: [Efficacy of ramipril, carvedilol, and trimetazidine MR in improvement of quality of life of patients after myocardial infarction].

Journal: Kardiologiia 20100101

Title: Formulation and evaluation of trimetazidine dihydrochloride extended release tablets by melt congealing method.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.

Journal: Heart failure reviews 20091201

Title: The adrenergic-fatty acid load in heart failure.

Journal: Journal of the American College of Cardiology 20091027

Title: Pharmacological interventions versus no pharmacological intervention for ischaemia reperfusion injury in liver resection surgery performed under vascular control.

Journal: The Cochrane database of systematic reviews 20091007

Title: [Effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury evaluated by (18)F-fluorodeoxyglucose positron emission tomography/computed tomography].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20091001

Title: Trimetazidine and N-acetylcysteine in attenuating hind-limb ischemia and reperfusion injuries: experimental study in rats.

Journal: International angiology : a journal of the International Union of Angiology 20091001

Title: Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation.

Journal: Chinese medical journal 20090920

Title: Trimetazidine: the future of cardiac function?

Journal: Future cardiology 20090901

Title: Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity.

Journal: Experimental neurology 20090801

Title: The effects of trimetazidine on heart rate variability in patients with heart failure.

Journal: Arquivos brasileiros de cardiologia 20090801

Title: Improved left and right ventricular functions with trimetazidine in patients with heart failure: a tissue Doppler study.

Journal: Heart and vessels 20090701

Title: Cardiac lesions induced by testosterone: protective effects of dexrazoxane and trimetazidine.

Journal: Cardiovascular toxicology 20090601

Title: Trimetazidine may protect the myocardium during cardiac surgery.

Journal: The heart surgery forum 20090601

Title: [Clinical outcomes of trimetazidine in patients with acute ST segment elevation myocardial infarction without ST segment resolution after primary percutaneous coronary intervention].

Journal: Zhonghua yi xue za zhi 20090526

Title: [Effects of Trimetazidine upon ventricular remodeling and GLUT4 in diabetic rats after myocardial infarction].

Journal: Zhonghua yi xue za zhi 20090512

Title: Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: Diabetic cardiomyopathy.

Journal: Clinical science (London, England : 1979) 20090501

Title: Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy.

Journal: Advances in therapy 20090401

Title: Trimetazidine: abnormal movements and hallucinations. Should be withdrawn from the market.

Journal: Prescrire international 20090401

Title: An animal model of testicular toxicity by cyclosporine: evaluation and protection.

Journal: Fundamental & clinical pharmacology 20090401

Title: Re: Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.

Journal: Circulation 20090324

Title: [A new possible strategy for prevention and preventive treatment of age-related macular degeneration resting on recent clinical and pathophysiological observations].

Journal: Orvosi hetilap 20090315

Title: Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial.

Journal: European heart journal 20090301

Title: S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function.

Journal: European journal of pharmacology 20090214

Title: The effects of trimetazidine on p-wave duration and dispersion in heart failure patients.

Journal: Pacing and clinical electrophysiology : PACE 20090201

Title: Effects of carvedilol, losartan and trimetazidin on functional parameters of isolated heart of rats at oxidative stress.

Journal: Georgian medical news 20090201

Title: Effects of trimetazidine on crush injury of the sciatic nerve in rats: a biochemical and stereological study.

Journal: Brain research 20090109

Title: [Clinical-pharmacoeconomic aspects of trimetazidine modified release use in patients with ischemic heart disease undergoing coronary artery bypass grafting].

Journal: Kardiologiia 20090101

Title: The metabolic treatment of coronary artery disease and heart failure.

Journal: Current pharmaceutical design 20090101

Title: The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.

Journal: Current pharmaceutical design 20090101

Title: The metabolic approach in patients with heart failure: effects on left ventricle remodeling.

Journal: Current pharmaceutical design 20090101

Title: Effects of metabolic approach in diabetic patients with coronary artery disease.

Journal: Current pharmaceutical design 20090101

Title: Prognostic relevance of metabolic approach in patients with heart failure.

Journal: Current pharmaceutical design 20090101

Title: [Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].

Journal: Giornale italiano di cardiologia (2006) 20090101

Title: Trimetazidine selectively inhibits SOC channels in plasma membranes of human HL-60 cells and does not affect the intracellular Ca2+ stores.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

Title: Preservation and modulation of peritoneal function. A potential role of pyruvate and betaine.

Journal: Contributions to nephrology 20090101

Title: Percutaneous coronary revascularization in patients with formerly 'refractory angina pectoris in end-stage coronary artery disease' - not 'end-stage' after all.

Journal: BMC cardiovascular disorders 20090101

Title: Effect of liver hypothermic preservation: exploration and protection.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20090101

Title: Effect of antianginal drugs in stable angina on predicted mortality risk after surviving a myocardial infarction: a preliminary study (METRO).

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: [Coronary-ventricular sinusoid communications].

Journal: Medicina 20090101

Title: New nonextractive and highly sensitive high-performance liquid chromatographic method for determination of paroxetine in plasma after offline precolumn derivatization with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.

Journal: Journal of AOAC International 20090101

Title: Low use of statins and other coronary secondary prevention therapies in primary and secondary care in India.

Journal: Vascular health and risk management 20090101

Title: Simple spectrophotometric method for determination of paroxetine in tablets using 1,2-naphthoquinone-4-sulphonate as a chromogenic reagent.

Journal: International journal of analytical chemistry 20090101

Title: New spectrophotometric and fluorimetric methods for determination of fluoxetine in pharmaceutical formulations.

Journal: International journal of analytical chemistry 20090101

Title: Kinetic spectrophotometric determination of certain cephalosporins in pharmaceutical formulations.

Journal: International journal of analytical chemistry 20090101

Title: Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate.

Journal: International journal of analytical chemistry 20090101

Title: Effects of topical mitomycin and trimetazidine on myringosclerosis.

Journal: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 20081201

Title: The effects of trimetazidine on lipid peroxidation in patients with end-stage renal disease.

Journal: Methods and findings in experimental and clinical pharmacology 20081201

Title: Trimetazidine: transparency. Information withheld from patients.

Journal: Prescrire international 20081201

Title: Characterization of mitochondrial trifunctional protein and its inactivation study for medicine development.

Journal: Biochimica et biophysica acta 20081101

Title: Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area.

Journal: Epilepsy research 20081001

Title: Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation.

Journal: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20081001

Title: The role of trimetazidine after acute myocardial infarction.

Journal: Current vascular pharmacology 20081001

Title: Neuropharmacology.

Journal: Indian journal of pharmacology 20081001

Title: Autonomic nervous system and cardiovascular system.

Journal: Indian journal of pharmacology 20081001

Title: Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.

Journal: Circulation 20080916

Title: Chronic stable angina pectoris.

Journal: Disease-a-month : DM 20080901

Title: Utility of ranolazine in chronic stable angina patients.

Journal: Vascular health and risk management 20080801

Title: Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.

Journal: Bulletin of experimental biology and medicine 20080801

Title: 4-Benzyl-piperazin-1-ium chloride chloro-form solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: Suppression of arsenic trioxide-induced apoptosis in HeLa cells by N-acetylcysteine.

Journal: Molecules and cells 20080731

Title: Metabolic agents in the management of diabetic coronary patients: a new era.

Journal: International journal of cardiology 20080623

Title: Metabolic agents in the management of diabetic coronary patients: a new era.

Journal: International journal of cardiology 20080623

Title: [Trimetazidine-induced encephalopathy with choreiform disorders: a case report].

Journal: La Revue de medecine interne 20080601

Title: Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats.

Journal: Endocrinology 20080601

Title: Apoptosis in arsenic trioxide-treated Calu-6 lung cells is correlated with the depletion of GSH levels rather than the changes of ROS levels.

Journal: Journal of cellular biochemistry 20080601

Title: Pyrogallol as a glutathione depletor induces apoptosis in HeLa cells.

Journal: International journal of molecular medicine 20080601

Title: Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy.

Journal: Journal of cardiovascular pharmacology 20080601

Title: Pharmacotherapy in patients with stable coronary artery disease treated on an outpatient basis in Poland. Results of the multicentre RECENT study.

Journal: Kardiologia polska 20080601

Title: Retraction to 'Effect of trimetazidine on renal ischemia/reperfusion injury in rats' [Pharmacol. Res. 50 (2004) 623-629].

Journal: Pharmacological research 20080601

Title: [Effects of chronic trimetazidine treatment on atrial energy metabolism in a canine model of chronic atrial fibrillation].

Journal: Zhonghua xin xue guan bing za zhi 20080601

Title: Ivabradine: the evidence of its therapeutic impact in angina.

Journal: Core evidence 20080601

Title: Anti-oxidant activity mediated neuroprotective potential of trimetazidine on focal cerebral ischaemia-reperfusion injury in rats.

Journal: Clinical and experimental pharmacology & physiology 20080501

Title: Effect of trimetazidine on xanthine oxidoreductase expression in rat kidney with ischemia--reperfusion injury.

Journal: Archives of medical research 20080501

Title: Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: a dose effect study.

Journal: Journal of vascular surgery 20080401

Title: The pathophysiology of heart failure: a tale of two old paradigms revisited.

Journal: Clinical medicine (London, England) 20080401

Title: Apoptosis in pyrogallol-treated Calu-6 cells is correlated with the changes of intracellular GSH levels rather than ROS levels.

Journal: Lung cancer (Amsterdam, Netherlands) 20080301

Title: Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigs.

Journal: Cardiovascular drugs and therapy 20080201

Title: Management of the metabolic syndrome in cardiovascular disease.

Journal: Current treatment options in cardiovascular medicine 20080201

Title: [Effect of combination therapy with preduktal and prestarium on the left ventricular function in the postinfarction period].

Journal: Georgian medical news 20080201

Title: [New possibilities in the pharmacologic prevention of age-related macular degeneration].

Journal: Orvosi hetilap 20080120

Title: Intracellular GSH levels rather than ROS levels are tightly related to AMA-induced HeLa cell death.

Journal: Chemico-biological interactions 20080110

Title: Does trimetazidine prevent myocardial injury after percutaneous coronary intervention?

Journal: Nature clinical practice. Cardiovascular medicine 20080101

Title: Transdermal permeation of trimetazidine from nerodilol-based HPMC gel drug reservoir system across rat epidermis.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

Title: Limonene enhances the in vitro and in vivo permeation of trimetazidine across a membrane-controlled transdermal therapeutic system.

Journal: Current drug delivery 20080101

Title: [Efficacy of long-term therapy with trimetazidine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].

Journal: Kardiologiia 20080101

Title: Trimetazidine revisited: a comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine.

Journal: Cardiovascular therapeutics 20080101

Title: Computer-assisted optimization and validation of LC analysis of trimetazidine dihydrochloride and its impurities.

Journal: Journal of chromatographic science 20080101

Title: Sensitive and rapid method to determine trimetazidine in human plasma by liquid chromatography/tandem mass spectrometry.

Journal: Journal of AOAC International 20080101

Title: Importance and limits of ischemia in renal partial surgery: experimental and clinical research.

Journal: Advances in urology 20080101

Title: The effect of trimetazidine added to maximal anti-ischemic therapy in patients with advanced coronary artery disease.

Journal: Cardiology journal 20080101

Title: [Clinicopathogenetic features of coronary heart disease combined with chronic obstructive pulmonary diseases and efficiency of therapy with trimetazidin].

Journal: Klinicheskaia meditsina 20080101

Title: [Oxidative stress in myocardial infarction and the efficiency of its correction with the drug Trimetazidine].

Journal: Klinicheskaia meditsina 20080101

Title: Trimetazidine as cardioplegia addictive without pre-treatment does not improve myocardial protection: study in a swine working heart model.

Journal: Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular 20080101

Title: Liquid chromatography-tandem mass spectrometry method for the determination of trimetazidine in human plasma.

Journal: Arzneimittel-Forschung 20080101

Title: Nonextractive procedure and precolumn derivatization with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole for trace determination of trimetazidine in plasma by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20080101

Title: Modulation of cardiac metabolism during myocardial ischemia.

Journal: Current pharmaceutical design 20080101

Title: Metabolic therapy of heart failure.

Journal: Current pharmaceutical design 20080101

Title: [The PRIMA study: trimetazidin in the treatment of patients with stable angina pectoris after myocardial infarction. Epidemiological and clinical phases].

Journal: Kardiologiia 20080101

Title: [Effects of trimetazidine on myocardial metabolism evaluated by PET-CT in patients with ischemic cardiomyopathy].

Journal: Zhonghua xin xue guan bing za zhi 20080101

Title: [Principle energy substrate changing as a technique of myocardium protection against ischemic damage in experimental mechanic cardiac contusion].

Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20080101

Title: [Genesis of systemic changes in hemodynamics in cardiac contusion].

Journal: Anesteziologiia i reanimatologiia 20080101

Title: Herbal excipients in novel drug delivery systems.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Trimetazidine modulates AMPA/kainate receptors in rat vestibular ganglion neurons.

Journal: European journal of pharmacology 20071121

Title: The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats.

Journal: Pediatric surgery international 20071101

Title: Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial.

Journal: Journal of cardiovascular pharmacology 20071101

Title: The effect of trimetazidine on left ventricular systolic function and physical tolerance in patients with ischaemic cardiomyopathy.

Journal: Acta cardiologica 20071001

Title: Sensitive determination of trimetazidine in spiked human plasma by HPLC with fluorescence detection after pre-column derivatization with 9-fluorenylmethyl chloroformate.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Beneficial effects of trimetazidine treatment on exercise tolerance and B-type natriuretic peptide and troponin T plasma levels in patients with stable ischemic cardiomyopathy.

Journal: American heart journal 20070901

Title: Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolase.

Journal: Current clinical pharmacology 20070901

Title: Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.

Journal: International journal of cardiology 20070809

Title: [Clinical study of trimetazidine for myocardial protection in acute myocardial infarction].

Journal: Zhonghua nei ke za zhi 20070801

Title: Betahistine in the treatment of Ménière's disease.

Journal: Neuropsychiatric disease and treatment 20070801

Title: Trimetazidine added to combined hemodynamic antianginal therapy in patients with type 2 diabetes: a randomized crossover trial.

Journal: American heart journal 20070701

Title: Sensitive and rapid LC-ESI-MS method for the determination of trimetazidine in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20070628

Title: Trimetazidine in the prevention of contrast-induced nephropathy after coronary procedures.

Journal: Heart (British Cardiac Society) 20070601

Title: A superoxide anion generator, pyrogallol induces apoptosis in As4.1 cells through the depletion of intracellular GSH content.

Journal: Mutation research 20070601

Title: Protective effect of an acute oral loading dose of trimetazidine on myocardial injury following percutaneous coronary intervention.

Journal: Heart (British Cardiac Society) 20070601

Title: Trimetazidine to reverse ischemia in patients with class I or II angina: a randomized, double-blind, placebo-controlled dobutamine-atropine stress echocardiography study.

Journal: Coronary artery disease 20070601

Title: Preventing contrast nephropathy in catheter laboratory.

Journal: Heart (British Cardiac Society) 20070601

Title: Measurement and prevention of myocardial injury during percutaneous coronary intervention.

Journal: Heart (British Cardiac Society) 20070601

Title: Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect.

Journal: European heart journal 20070501

Title: The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts.

Journal: Canadian journal of physiology and pharmacology 20070501

Title: Bupivacaine induced cardiac toxicity mimicking an acute non-ST segment elevation myocardial infarction.

Journal: Yonsei medical journal 20070430

Title: LC/ESI-MS method for the determination of trimetazidine in human plasma: application to a bioequivalence study on Chinese volunteers.

Journal: Journal of pharmaceutical and biomedical analysis 20070411

Title: A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: Trimetazidine improves post-ischemic recovery by preserving endothelial nitric oxide synthase expression in isolated working rat hearts.

Journal: Nitric oxide : biology and chemistry 20070301

Title: Trimetazidine inhibits cardiomyocyte apoptosis in a rabbit model of ischemia-reperfusion.

Journal: Translational research : the journal of laboratory and clinical medicine 20070301

Title: Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: a way of protecting rat steatotic livers.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301

Title: Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.

Journal: American journal of physiology. Renal physiology 20070301

Title: Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.

Journal: Clinical cardiology 20070201

Title: Quantification of trimetazidine in human plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to a bioequivalence study.

Journal: Die Pharmazie 20070101

Title: [The best of cardiac rehabilitation in 2006].

Journal: Archives des maladies du coeur et des vaisseaux 20070101

Title: [Comparative trial of efficacy of trimethasidine MB and 3-(2,2,2-trimethylhydrasine) propionate dihydrate in chronic heart failure].

Journal: Terapevticheskii arkhiv 20070101

Title: Protective effects of trimetazidine on testicular ischemia-reperfusion injury in rats.

Journal: Urologia internationalis 20070101

Title: [Derangements of contractility of left ventricular myocardium in patients subjected to coronary bypass surgery. Methods of their correction].

Journal: Kardiologiia 20070101

Title: Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

Title: [Program for detection of patients with ineffective therapy with beta-adrenoblockers and comparative assessment of efficacy of addition of trimetazidine MB or isosorbide dinitrate in stable angina. Results of a Russian Study Parrallel].

Journal: Kardiologiia 20070101

Title: Trimetazidine decreases Ca2+ response to thapsigargin in differentiated and undifferentiated human HL-60 cells.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101

Title: [Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus].

Journal: Kardiologiia 20070101

Title: [The efficacy of complex therapy of ventricular arrhythmias with emoxipin and preductal in combination with antiarrhythmic agents].

Journal: Klinicheskaia meditsina 20070101

Title: Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents.

Journal: Journal of clinical biochemistry and nutrition 20070101

Title: Metabolic modulation as a target for heart failure treatment: current perspective.

Journal: Indian heart journal 20070101

Title: Menière's disease.

Journal: BMJ clinical evidence 20070101

Title: Meta-analysis of antiplatelet therapy for IgA nephropathy.

Journal: Clinical and experimental nephrology 20061201

Title: Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation.

Journal: Life sciences 20061012

Title: Effects of chronic trimetazidine treatment on myocardial preconditioning in anesthetized rats.

Journal: Fundamental & clinical pharmacology 20061001

Title: Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure.

Journal: Fundamental & clinical pharmacology 20061001

Title: A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure.

Journal: Journal of the American College of Cardiology 20060905

Title: Metabolic approach in heart failure: rethinking how we translate from theory to clinical practice.

Journal: Journal of the American College of Cardiology 20060905

Title: Clinical benefits of a metabolic approach with trimetazidine in revascularized patients with angina.

Journal: The American journal of cardiology 20060904

Title: Metabolic therapy for patients with diabetes mellitus and coronary artery disease.

Journal: The American journal of cardiology 20060904

Title: Role of trimetazidine in management of ischemic cardiomyopathy.

Journal: The American journal of cardiology 20060904

Title: Clinical benefits of a metabolic approach in the cardiac rehabilitation of patients with coronary artery disease.

Journal: The American journal of cardiology 20060904

Title: Modification of myocardial substrate use as a therapy for heart failure.

Journal: Nature clinical practice. Cardiovascular medicine 20060901

Title: Trimetazidine reduces oxidative stress in cardiac surgery.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20060901

Title: Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.

Journal: Seminars in cardiothoracic and vascular anesthesia 20060901

Title: Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Trimetazidine-induced enhancement of myocardial recovery during reperfusion: a comparative study in diabetic and non-diabetic rat hearts.

Journal: Archives of medical research 20060801

Title: Metabolic approach to heart failure - evidence that trimetazidine improves symptoms, left ventricular function and possibly prognosis.

Journal: International journal of clinical practice 20060801

Title: Reversible Parkinsonism linked to trimetazidine (continued).

Journal: Prescrire international 20060801

Title: Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

Journal: Journal of medicinal chemistry 20060713

Title: Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060701

Title: Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Metabolic therapeutics in angina pectoris: history revisited with perhexiline.

Journal: European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20060601

Title: The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.

Journal: American heart journal 20060601

Title: [Adverse drug events in out-patients as the cause of an initial consultation to neurology].

Journal: Neurologia (Barcelona, Spain) 20060601

Title: [Treatment of stable angina pectoris with trimetazidine].

Journal: Vnitrni lekarstvi 20060601

Title: [Modulation of myocardial metabolism with trimetazidine].

Journal: Vnitrni lekarstvi 20060601

Title: [Trimetazidine in the treatment of stable angina pectoris TRIADA-(trimetazidine in stable angina twice daily)].

Journal: Vnitrni lekarstvi 20060601

Title: Trimetazidine improved Ca2+ handling in isoprenaline-mediated myocardial injury of rats.

Journal: Experimental physiology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure.

Journal: European heart journal 20060401

Title: The effects of trimetazidine on heart rate variability in patients with slow coronary artery flow.

Journal: Journal of electrocardiology 20060401

Title: Rare cases of Ménière's disease in children.

Journal: The Journal of laryngology and otology 20060401

Title: Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.

Journal: Journal of medicinal chemistry 20060309

Title: Effect of trimetazidine on the nucleotide profile in rat kidney with ischemia-reperfusion injury.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060301

Title: Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.

Journal: The Tohoku journal of experimental medicine 20060301

Title: Trimetazidine: is it a promising drug for use in steatotic grafts?

Journal: World journal of gastroenterology 20060214

Title: Selection of optimal therapy for chronic stable angina.

Journal: Current treatment options in cardiovascular medicine 20060201

Title: Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.

Journal: Molecular and cellular biochemistry 20060201

Title: Evolving treatment strategies for chronic refractory angina.

Journal: Expert opinion on pharmacotherapy 20060201

Title: [Effect of trimitazidine on insulin resistance in patients with coronary heart disease].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201

Title: [Effects of metabolic triad (25% polarizing solution, mildronat, preductal MR) in acute myocardial infarction].

Journal: Georgian medical news 20060201

Title: Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.

Journal: American journal of physiology. Endocrinology and metabolism 20060101

Title: Placebo or trimetazidine (99m)Tc tetrofosmin myocardial SPECT and low-dose dobutamine echocardiography in hibernating myocardium.

Journal: Archives of medical research 20060101

Title: [Therapy of patients with heart failure--do we owe anything to our patients?].

Journal: Casopis lekaru ceskych 20060101

Title: [Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance].

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Title: Trimetazidine increases [3H]glucose uptake in rat brain.

Journal: Pharmacological reports : PR 20060101

Title: [Possibilities of myocardial cytoprotection in complex treatment of patients with chronic heart failure].

Journal: Kardiologiia 20060101

Title: Protective effect of astragalosides on myocardial injury by isoproterenol in SD rats.

Journal: The American journal of Chinese medicine 20060101

Title: [The effects of trimetazidine on left ventricular function and physical exercise tolerance in patients with ischemic cardiomyopathy].

Journal: Klinicheskaia meditsina 20060101

Title: Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats.

Journal: Mediators of inflammation 20060101

Title: Effects of antioxidant therapy on leukocyte myeloperoxidase and Cu/Zn-superoxide dismutase and plasma malondialdehyde levels in experimental colitis.

Journal: Mediators of inflammation 20051214

Title: Trimetazidine inhibits mitochondrial permeability transition pore opening and prevents lethal ischemia-reperfusion injury.

Journal: Journal of molecular and cellular cardiology 20051201

Title: Metabolic modulators for chronic cardiac ischemia.

Journal: Journal of cardiovascular pharmacology and therapeutics 20051201

Title: Cardiac mitochondrial alterations induced by insulin deficiency and hyperinsulinaemia in rats: targeting membrane homeostasis with trimetazidine.

Journal: Clinical and experimental pharmacology & physiology 20051201

Title: Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation.

Journal: Heart failure reviews 20051201

Title: Metabolic therapy for heart disease: impact of trimetazidine.

Journal: Heart failure reviews 20051201

Title: Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.

Journal: Pharmacology 20051101

Title: Rationale for a metabolic approach in diabetic coronary patients.

Journal: Coronary artery disease 20051101

Title: Metabolic therapy for the diabetic patients with ischaemic heart disease.

Journal: Coronary artery disease 20051101

Title: Meeting the challenge of chronic ischaemic heart disease with trimetazidine.

Journal: Coronary artery disease 20051101

Title: Trimetazidine for stable angina.

Journal: The Cochrane database of systematic reviews 20051019

Title: Evaluation of the effect of trimetazidine on Tc-99m methoxyisobutyl isonitrile gated scintigraphy in patients with coronary artery ectasia.

Journal: Saudi medical journal 20051001

Title: Non-extractive procedure followed by LC/APCI MS/MS analysis of trimetazidine in plasma samples for assessing bioequivalence of immediate/modified release formulations.

Journal: Biomedical chromatography : BMC 20050901

Title: [Observation on effect of compound danshen droplet-pill combined with trimetazidine in treating senile unstable angina pectoris].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050901

Title: [Therapeutic value of trimetazidine in patients with coronary heart disease and left ventricular dysfunction].

Journal: Zhonghua xin xue guan bing za zhi 20050901

Title: Trimetazidine: a new cause for drug-induced parkinsonism?

Journal: Movement disorders : official journal of the Movement Disorder Society 20050801

Title: [Trimetazidine, oxidative stress, and cell injury during myocardial reperfusion].

Journal: Revista espanola de cardiologia 20050801

Title: [Ischemia-reperfusion injury during experimental heart transplantation. Evaluation of trimetazidine's cytoprotective effect].

Journal: Revista espanola de cardiologia 20050801

Title: Trimetazidine normalizes postischemic function of hypertrophied rat hearts.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury.

Journal: Journal of cardiovascular pharmacology 20050701

Title: Mitochondrial changes induced by trimetazidine in the myocardium.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20050601

Title: Reversible Parkinsonism linked to trimetazidine.

Journal: Prescrire international 20050401

Title: Silent myocardial ischaemia: clinical relevance and treatment.

Journal: Expert opinion on investigational drugs 20050401

Title: Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.

Journal: FEBS letters 20050314

Title: Trimetazidine protects isolated rat hearts against ischemia-reperfusion injury in an experimental timing-dependent manner.

Journal: Basic research in cardiology 20050301

Title: Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus.

Journal: Journal of pediatric surgery 20050301

Title: Prevention of gentamicin induced ototoxicity by trimetazidine in animal model.

Journal: International journal of pediatric otorhinolaryngology 20050201

Title: Myocardial metabolic manipulation: a new therapeutic approach in heart failure?

Journal: Heart (British Cardiac Society) 20050201

Title: Long term cardioprotective action of trimetazidine and potential effect on the inflammatory process in patients with ischaemic dilated cardiomyopathy.

Journal: Heart (British Cardiac Society) 20050201

Title: Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease.

Journal: The American journal of cardiology 20050201

Title: Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis.

Journal: Current atherosclerosis reports 20050201

Title: [A prospective study on trimetazidine effectiveness and tolerability in diabetic patients in association to the previous treatment of their coronary disease. DIETRIC study].

Journal: Revista clinica espanola 20050201

Title: Trimetazidine in Angina Combination Therapy--the TACT study: trimetazidine versus conventional treatment in patients with stable angina pectoris in a randomized, placebo-controlled, multicenter study.

Journal: American journal of therapeutics 20050101

Title: [Limited application of prevention measures in patients with diabetes mellitus type 2 and coronary artery disease in Spain. DIETRIC study].

Journal: Revista clinica espanola 20050101

Title: Effectors of fatty acid oxidation reduction: promising new anti-ischaemic agents.

Journal: Current pharmaceutical design 20050101

Title: Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month study.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: [Anti-ischemic efficacy of combination of trimetazidine with enalapril in patients with stable effort angina and metabolic syndrome].

Journal: Kardiologiia 20050101

Title: [Use of preductal in therapy of hemodynamic complications in patients with tuberculosis].

Journal: Problemy tuberkuleza i boleznei legkikh 20050101

Title: Treatment of stable angina pectoris with trimetazidine modified release in Indian primary-care practice.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: Modified-release formulation of trimetazidine for exceptional control of angina pectoris: fact or fiction.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: Chronic angina: new medical options for treatment.

Journal: Reviews in cardiovascular medicine 20050101

Title: [Trimetazidine effects on postinfarction remodeling of the left ventricle].

Journal: Terapevticheskii arkhiv 20050101

Title: [Clinical efficacy of combined therapy with enalapril + trimetazidine in patients with hypertension comorbid with ischemic heart disease and metabolic disturbances].

Journal: Terapevticheskii arkhiv 20050101

Title: Trimetazidine induces parkinsonism, gait disorders and tremor.

Journal: Therapie 20050101

Title: Effects of trimetazidine on lipid peroxidation, antioxidant enzyme activities and plasma brain natriuretic peptide levels in patients with chronic cor pulmonale.

Journal: The Journal of international medical research 20050101

Title: [Trimetazidine-a new aetiology for extrapyramidal disorders: A case of parkinsonism and akathisia].

Journal: Therapie 20050101

Title: Therapy of hearing disorders - conservative procedures.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20050101

Title: Effect of trimetazidine on renal ischemia/reperfusion injury in rats.

Journal: Pharmacological research 20041201

Title: The potential benefits of trimetazidine in patients with diabetes and ischemic cardiomyopathy.

Journal: American heart journal 20041201

Title: Comparison of the effects of trimetazidine and diltiazem on exercise performance in patients with coronary heart disease. The Turkish trimetazidine study (TTS).

Journal: Acta cardiologica 20041201

Title: Inhibitory effect of trimetazidine on cardiac myocyte apoptosis in rabbit model of ischemia-reperfusion.

Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20041201

Title: Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia.

Journal: European journal of pharmacology 20041025

Title: Effects of trimetazidine on myocardial preconditioning in anesthetized rats.

Journal: European journal of pharmacology 20041025

Title: Metabolic therapy for heart failure.

Journal: European heart journal 20041001

Title: Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease.

Journal: European heart journal 20041001

Title: [Trimetazidine-induced parkinsonism].

Journal: Neurologia (Barcelona, Spain) 20040901

Title: Myocardial energy metabolism during ischemia and the mechanisms of metabolic therapies.

Journal: Journal of cardiovascular pharmacology and therapeutics 20040901

Title: Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials.

Journal: Journal of cardiovascular pharmacology and therapeutics 20040901

Title: Efficacy of trimetazidine in patients with recurrent angina: a subgroup analysis of the TRIMPOL II study.

Journal: Current medical research and opinion 20040901

Title: Influence of colloid, preservation medium and trimetazidine on renal medulla injury.

Journal: Biochimica et biophysica acta 20040804

Title: Ischemic heart disease: metabolic approaches to management.

Journal: Clinical cardiology 20040801

Title: The acute administration of trimetazidine modified myocardial perfusion and left ventricular function in 31 patients with ischaemic ventricular dysfunction.

Journal: The international journal of cardiovascular imaging 20040801

Title: Evidence for protective roles of polyethylene glycol plus high sodium solution and trimetazidine against consequences of renal medulla ischaemia during cold preservation and reperfusion in a pig kidney model.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040701

Title: Effects of trimetazidine on left ventricular function in patients with type 2 diabetes and heart failure.

Journal: Journal of cardiovascular pharmacology 20040701

Title: The acute effect of trimetazidine on the high frequency fatigue in the isolated rat diaphragm muscle.

Journal: Archives of pharmacal research 20040601

Title: Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion.

Journal: Pharmacology 20040501

Title: Recurrent angina after revascularization: an emerging problem for the clinician.

Journal: Coronary artery disease 20040501

Title: Clinical benefits of trimetazidine in patients with recurrent angina.

Journal: Coronary artery disease 20040501

Title: Protective roles of polyethylene glycol and trimetazidine against cold ischemia and reperfusion injuries of pig kidney graft.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040401

Title: Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.

Journal: European heart journal 20040401

Title: [Heart disease and diabetes: from pathophysiology to therapeutic options].

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

Title: [Quality of life in elderly patients with ischemic cardiopathy].

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

Title: [Ischemic heart disease and left ventricular dysfunction: the role of trimetazidine].

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

Title: [Trimetazidine and cardioprotection during ischemia-reperfusion].

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

Title: ['Persistent' angina: rationale for a metabolic approach].

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

Title: How brain influences neuro-cardiovascular dysfunction.

Journal: The Journal of the Association of Physicians of India 20040301

Title: Trimetazidine improves myocardial perfusion and left ventricular function in ischemic left ventricular dysfunction.

Journal: Clinical nuclear medicine 20040201

Title: Anti-excitotoxic activity of trimetazidine in the retina.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040201

Title: Quantitative structure-activity relationship analysis of the substituent effects on the binding affinity of derivatives of trimetazidine.

Journal: Arzneimittel-Forschung 20040101

Title: [Clinical and hemodynamic efficacy of selective beta-blocker bisoprolol and cytoprotector trimetazidine in the treatment of chronic cardiac failure in patients with ischemic heart disease].

Journal: Terapevticheskii arkhiv 20040101

Title: Assessment of the sustained release properties of a new oral formulation of trimetazidine in pigs and dogs and confirmation in healthy human volunteers.

Journal: European journal of drug metabolism and pharmacokinetics 20040101

Title: [Clinical Efficacy of Combination Therapy With Trimetazidine and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension and Ischemic Heart Disease Associated With Type II Diabetes].

Journal: Kardiologiia 20040101

Title: [The protective effect of trimetazidine on the myocardium against reperfusion injury during thrombolytic therapy of acute infarction].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101

Title: Nonsynergistic effects of trimetazidine and selenium combination therapy on renal ischemic-reperfusion injury in rats.

Journal: Advances in therapy 20040101

Title: [Anti-ischemic effects of trimetazidine in patients with post-infarction heart failure].

Journal: Klinicheskaia meditsina 20040101

Title: Determination of trimetazidine dihydrochloride in the presence of its acid-induced degradation products.

Journal: Journal of AOAC International 20040101

Title: [Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.].

Journal: Kardiologiia 20040101

Title: [Favorable effect of trimetazidine on clinical state and left ventricular function postinfarction period.].

Journal: Kardiologiia 20040101

Title: [Potentialities of cytoprotection in the treatment of chronic heart failure in patients with coronary heart disease].

Journal: Klinicheskaia meditsina 20040101

Title: [Usefulness of trimetazidine in ischemia-reperfusion lesion. Experimental study in myocardial stunning model].

Journal: Archivos de cardiologia de Mexico 20040101

Title: Evaluation of various therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma.

Journal: Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat 20040101

Title: Trimetazidine Modified Release in the Treatment of Stable Angina : TRIUMPH StudyTRImetazidine MR in Patients with Stable Angina: Unique Metabolic PatH.

Journal: Clinical drug investigation 20040101

Title: Evidence for a protective role of trimetazidine during cold ischemia: targeting inflammation and nephron mass.

Journal: Biochemical pharmacology 20031201

Title: Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20031201

Title: Trimetazidine in geriatric patients with stable angina pectoris: the tiger study.

Journal: International journal of clinical practice 20031201

Title: Attenuation of renal ischemia-reperfusion injury by trimetazidine: evidence of an in vivo antioxidant effect.

Journal: Methods and findings in experimental and clinical pharmacology 20031201

Title: [Regulation of myocardial metabolism: possibilities and application in cardiac surgery].

Journal: Kardiologia polska 20031201

Title: Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.

Journal: American heart journal 20031101

Title: Preconditioning and metabolic anti-ischaemic agents.

Journal: European heart journal 20031001

Title: Carvedilol and trimetazidine attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats.

Journal: Toxicology 20030930

Title: The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

Journal: Circulation research 20030808

Title: Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

Journal: Circulation research 20030808

Title: Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride.

Journal: Farmaco (Societa chimica italiana : 1989) 20030801

Title: Effect of trimetazidine on exercise performance in patients with coronary artery ectasia.

Journal: Japanese heart journal 20030701

Title: Effects of trimetazidine on submaximal exercise test in patients with acute myocardial infarction.

Journal: Cardiovascular drugs and therapy 20030701

Title: [Protective effect of trimetazidine on rabbit myocardium during ischemia- reperfusion].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20030601

Title: S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties.

Journal: European journal of pharmacology 20030509

Title: Pharmacokinetic profile of a modified release formulation of trimetazidine (TMZ MR 35 mg) in the elderly and patients with renal failure.

Journal: Biopharmaceutics & drug disposition 20030501

Title: Trimetazidine reduces basal cytosolic Ca2+ concentration during hypoxia in single Xenopus skeletal myocytes.

Journal: Experimental physiology 20030501

Title: Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation.

Journal: Journal of the American College of Cardiology 20030416

Title: Efficacy and tolerability of trimetazidine in stable angina: a meta-analysis of randomized, double-blind, controlled trials.

Journal: Coronary artery disease 20030401

Title: Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine.

Journal: Fundamental & clinical pharmacology 20030401

Title: Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: effects of trimetazidine in rats.

Journal: The International journal of neuroscience 20030401

Title: Prevention of heart failure in rats by trimetazidine treatment: a consequence of accelerated phospholipid turnover?

Journal: The Journal of pharmacology and experimental therapeutics 20030301

Title: Treatment of stable angina with low dose diltiazem in combination with the metabolic agent trimetazidine.

Journal: International journal of cardiology 20030301

Title: Metabolic modulation and optimization of energy consumption in heart failure.

Journal: The Medical clinics of North America 20030301

Title: Trimetazidine effect on phospholipid synthesis in ventricular myocytes: consequences in alpha-adrenergic signaling.

Journal: Fundamental & clinical pharmacology 20030201

Title: Effects of trimetazidine on acetic acid-induced colitis in female Swiss rats.

Journal: Journal of toxicology and environmental health. Part A 20030124

Title: Attenuation of glycerol-induced acute renal failure in rats by trimetazidine and deferoxamine.

Journal: Pharmacology 20030101

Title: Myocardial cytoprotection by trimetazidine against anthracycline-induced cardiotoxicity in anticancer chemotherapy.

Journal: Angiology 20030101

Title: [Effect of treatment with trimethazidine on characteristics of arrhythmia and indicators of heart rhythm in patients with chronic cardiac failure].

Journal: Terapevticheskii arkhiv 20030101

Title: The effect of oxidative stress inhibition with trimetazidine on the peritoneal alterations induced by hypertonic peritoneal dialysis solution.

Journal: Journal of nephrology 20030101

Title: The effect of trimetazidine on liver regeneration after partial hepatectomy under hepatic blood inflow occlusion.

Journal: Hepato-gastroenterology 20030101

Title: [Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina].

Journal: Kardiologiia 20030101

Title: [Efficacy and tolerability of trimetazidine in the treatment of stable effort angina (TRIUMPH Study in Russia)].

Journal: Kardiologiia 20030101

Title: [Oxygen-dependent metabolism of neutrophils and monocytes in patients with unstable angina pectoris and its correction with preductal].

Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20030101

Title: [Effect of trimetazidine and perindopril on myocardial function and metabolism in patients with low cardiac output during postinfarction period].

Journal: Terapevticheskii arkhiv 20030101

Title: [Effect of acetyl-CoA C-acyltransferase inhibitor trimetazidine on parameters of global and local systolic and diastolic functions of left ventricular myocardium in patients with combined postinfarction ischemic syndrome].

Journal: Kardiologiia 20030101

Title: [Clinical efficacy of myocardial cytoprotector trimetazidine in peri- and postmenopausal women with ischemic heart disease].

Journal: Kardiologiia 20030101

Title: Cardioprotective effects of trimetazidine: a review.

Journal: Current medical research and opinion 20030101

Title: Trimetazidine diminishes fasting glucose in rats with fasting hyperglycemia: a preliminary study.

Journal: American journal of therapeutics 20030101

Title: Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study.

Journal: Cardiovascular diabetology 20030101

Title: Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20030101

Title: [Ischemia-reperfusion myocardial injury].

Journal: Archivos de cardiologia de Mexico 20030101

Title: Effects of trimetazidine and selenium on high-frequency fatigue in isolated rat diaphragm muscle.

Journal: Advances in therapy 20030101

Title: [Effects of trimetazidine on serum oxygen free radicals in congestive heart failure].

Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20021228

Title: Cardioprotective effect of trimetazidine during thrombolytic therapy in patients with acute myocardial infarction.

Journal: Bulletin of experimental biology and medicine 20021201

Title: The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.

Journal: Herz 20021101

Title: [Coronary artery disease observed in general hospitals: ETTIC study. Comparison between trimetazidine and mononitrate isosorbide for patients receiving betablockers].

Journal: Annales de cardiologie et d'angeiologie 20021101

Title: Bioavailability studies on guar gum-based three-layer matrix tablets of trimetazidine dihydrochloride in human volunteers.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20021004

Title: Effects of trimetazidine on tissue damage in kidney after hindlimb ischemia-reperfusion.

Journal: Pharmacological research 20021001

Title: Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning.

Journal: Journal of molecular and cellular cardiology 20020901

Title: Trimetazidine: a second look. Still no efficacy in visual disorders.

Journal: Prescrire international 20020801

Title: [The role of endogenous modulators of chemoreactivity in the regulation of coronary blood flow].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020701

Title: Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20020517

Title: Partial fatty acid oxidation inhibitors for stable angina.

Journal: Expert opinion on investigational drugs 20020501

Title: Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity.

Journal: Biochemical pharmacology 20020501

Title: Oxidative stress-mediated renal dysfunction by cyclosporine A in rats: attenuation by trimetazidine.

Journal: Renal failure 20020501

Title: New concepts in organ preservation.

Journal: Transplant immunology 20020501

Title: Energy metabolism in the hypertrophied heart.

Journal: Heart failure reviews 20020401

Title: Metabolic approaches to the treatment of ischemic heart disease: the clinicians' perspective.

Journal: Heart failure reviews 20020401

Title: Gateways to Clinical Trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020401

Title: Cardioprotection of trimetazidine and anthracycline-induced acute cardiotoxic effects.

Journal: Lancet (London, England) 20020330

Title: Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample.

Journal: Forensic science international 20020328

Title: Trimetazidine as a potential neuroprotectant in transient global ischemia in gerbils: a behavioral and histological study.

Journal: Brain research 20020222

Title: Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: evaluation of the protective role of the metabolic modulator trimetazidine.

Journal: Journal of the American College of Cardiology 20020206

Title: Prolonged survival after experimental paraquat intoxication: role of alternative antioxidants.

Journal: Veterinary and human toxicology 20020201

Title: Determination of trimetazidine HCl by adsorptive stripping square-wave voltammetry at a glassy carbon electrode.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: Increase of adenosine plasma levels after oral trimetazidine: a pharmacological preconditioning?

Journal: Pharmacological research 20020101

Title: [Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].

Journal: Klinicheskaia meditsina 20020101

Title: [Oxygen dependent metabolism of neutrophils and monocytes in patients with unstable angina and its correction with preductal].

Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20020101

Title: [Effect of atenolol and trimetazidine on dispersion of cardiac rhythm in patients with moderately expressed postinfarction left ventricular dysfunction].

Journal: Terapevticheskii arkhiv 20020101

Title: Protective effect of trimetazidine in a model of ischemia-reperfusion in the rat retina.

Journal: Ophthalmic research 20020101

Title: [Decrease in the sensitivity to the anti-ischemic effect of propranolol and prospects for correcting it in patients with stable angina pectoris].

Journal: Terapevticheskii arkhiv 20020101

Title: Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty.

Journal: Current medical research and opinion 20020101

Title: [Significance of trimetazidine for out of hospital physical rehabilitation after myocardial infarction].

Journal: Kardiologiia 20020101

Title: [Use of trimetazidine in the combined therapy of myocardial infarction with left ventricular dysfunction].

Journal: Kardiologiia 20020101

Title: [Trimetazidine in pectoris patients older than 65 years with stable angina].

Journal: Kardiologiia 20020101

Title: [Trimetazidine in correction of chronic heart failure in patients with ischemic heart disease].

Journal: Kardiologiia 20020101

Title: [Efficacy of trimetazidine in stable angina pectoris refractory to traditional treatment].

Journal: Kardiologiia 20020101

Title: [Antiischemic efficacy of trimetazidine in patients with ischemic heart disease, stable angina pectoris and disturbances of carbohydrate metabolism].

Journal: Kardiologiia 20020101

Title: [The study and comparative evaluation of the actoprotective activity of ATF-LONG in experiment].

Journal: Likars'ka sprava 20020101

Title: Antianginal effects of trimetazidine and left ventricular function improvement in patients with stable angina pectoris.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

Title: Trimetazidine protects the energy status after ischemia and reduces reperfusion injury in a rat single lung transplant model.

Journal: The Journal of thoracic and cardiovascular surgery 20011201

Title: Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand.

Journal: European heart journal 20011201

Title: Can metabolic manipulation reverse myocardial dysfunction?

Journal: European heart journal 20011201

Title: Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy.

Journal: European heart journal 20011201

Title: Scavenger effect of experimental and clinically used cardiovascular drugs.

Journal: Journal of cardiovascular pharmacology 20011101

Title: [Metabolic considerations in the treatment of coronary disease in diabetic patients].

Journal: Diabetes & metabolism 20011101

Title: Recipient treatment with trimetazidine improves graft function and protects energy status after lung transplantation.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20011001

Title: Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine.

Journal: American journal of physiology. Heart and circulatory physiology 20010901

Title: Attenuation of liver normothermic ischemia--reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative.

Journal: Biochemical pharmacology 20010815

Title: Comments on EMIP-FR study's editorial.

Journal: European heart journal 20010801

Title: The effect of trimetazidine on the survival of rat island skin flaps subjected to ischemia-reperfusion injury.

Journal: Annals of plastic surgery 20010801

Title: Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176.

Journal: Pharmacological research 20010801

Title: Influence of trimetazidine on the synthesis of complex lipids in the heart and other target organs.

Journal: Fundamental & clinical pharmacology 20010801

Title: Does trimetazidine exert cytoprotective activity on astrocytes subjected to hypoxia in vitro?

Journal: Neurotoxicology 20010801

Title: Mitochondria as target for antiischemic drugs.

Journal: Advanced drug delivery reviews 20010702

Title: QT dispersion--what does it mean?

Journal: Cardiovascular drugs and therapy 20010701

Title: Metabolic management of coronary heart disease: adjunctive treatment with trimetazidine decreases QT dispersion in patients with a first acute myocardial infarction.

Journal: Cardiovascular drugs and therapy 20010701

Title: Trimetazidine protects low-density lipoproteins from oxidation and cultured cells exposed to H(2)O(2) from DNA damage.

Journal: Free radical biology & medicine 20010615

Title: About EMIP-FR and reperfusion damage in AMI: a comment to the comment.

Journal: European heart journal 20010601

Title: The EMIP-FR Study: the evolution of scientific background as a non-controlled parameter.

Journal: European heart journal 20010601

Title: Trimetazidine and reperfusion injury.

Journal: European heart journal 20010601

Title: Trimetazidine in AMI.

Journal: European heart journal 20010601

Title: Trimetazidine: stability indicating RPLC assay method.

Journal: Journal of pharmaceutical and biomedical analysis 20010501

Title: Trimetazidine for stable angina pectoris.

Journal: Expert opinion on pharmacotherapy 20010501

Title: Combination therapy in angina: a review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents.

Journal: International journal of clinical practice 20010501

Title: Stability indicating HPTLC determination of Trimetazidine as bulk drug and in pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20010401

Title: The effects of trimetazidine on heart rate variability and signal-averaged electrocardiography in early period of acute myocardial infarction.

Journal: International journal of cardiology 20010201

Title: A randomized double-blind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction.

Journal: International journal of cardiology 20010201

Title: Dobutamine stress echocardiography and the effects of trimetazidine on left ventricular dysfunction in patients with coronary artery disease.

Journal: Coronary artery disease 20010201

Title: Haemodynamic and metabolic agents in the treatment of stable angina: publication review.

Journal: Coronary artery disease 20010201

Title: Anti-ischaemic efficacy and tolerability of trimetazidine administered to patients with angina pectoris: results of three studies.

Journal: Coronary artery disease 20010201

Title: Metabolic energy metabolism in diabetes: therapeutic implications.

Journal: Coronary artery disease 20010201

Title: Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?

Journal: Coronary artery disease 20010201

Title: S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes.

Journal: Fundamental & clinical pharmacology 20010201

Title: [Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].

Journal: Klinicheskaia meditsina 20010101

Title: [Therapy perspectives in subjective tinnitus].

Journal: Anales otorrinolaringologicos ibero-americanos 20010101

Title: The efficacy of medication on tinnitus due to acute acoustic trauma.

Journal: Scandinavian audiology. Supplementum 20010101

Title: Effect of trimetazidine on retinal ischemia/reperfusion injury in rats.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

Title: [Aspects of diastolic function of the heart in vibration disease].

Journal: Terapevticheskii arkhiv 20010101

Title: [Antioxidant effects of amtizol and trimetazidine in brain ischemia].

Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia 20010101

Title: [Are sigma receptors implicated in ischemic injury?].

Journal: Therapie 20010101

Title: [Effect of preservation of the kidney on the long-term function following autotransplantation].

Journal: Therapie 20010101

Title: [Trimetazidine prevents ischemia-reperfusion injury in hepatic surgery under vascular clamping].

Journal: Therapie 20010101

Title: [Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].

Journal: Therapie 20010101

Title: [Therapeutic perspectives in the treatment of stable angina].

Journal: Therapie 20010101

Title: The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction.

Journal: Acta medica (Hradec Kralove) 20010101

Title: Management of ischaemic heart disease in diabetic patients--is there a role for cardiac metabolic agents?

Journal: Current medical research and opinion 20010101

Title: Role of metabolically active drugs in the management of ischemic heart disease.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

Title: The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

Journal: Circulation research 20000317

Title: Trimetazidine counteracts tacrolimus nephrotoxicity in a hypertensive liver transplant patient.

Journal: Transplantation 19991027

Title: Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions.

Journal: Drugs 19990701

Title: Cytoprotective effects of trimetazidine in carmustine cholestasis.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 19990701

Title: The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis.

Journal: Pharmaceutical research 19990501

Title: Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease.

Journal: The American journal of cardiology 19981001

Title: Effect of trimetazidine on early and delayed doxorubicin myocardial toxicity.

Journal: Archives internationales de pharmacodynamie et de therapie 19890101

Title: Antiarrhythmic effects of coronary vasodilators on canine ventricular arrhythmia models.

Journal: Japanese journal of pharmacology 19850501

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Tags:5011-34-7 Molecular Formula|5011-34-7 MDL|5011-34-7 SMILES|5011-34-7 1-(2,3,4-trimethoxybenzyl)piperazine