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1859053-21-6,MFCD31382198
Catalog No.:AA00JSA1

1859053-21-6 | Rucaparib Camsylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%(HPLC)
in stock  
$181.00   $127.00
- +
10mg
≥98%(HPLC)
in stock  
$268.00   $188.00
- +
25mg
≥98%(HPLC)
in stock  
$532.00   $373.00
- +
50mg
≥98%(HPLC)
in stock  
$588.00   $412.00
- +
100mg
≥98%(HPLC)
in stock  
$852.00   $597.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00JSA1
Chemical Name:
Rucaparib Camsylate
CAS Number:
1859053-21-6
Molecular Formula:
C29H34FN3O5S
Molecular Weight:
555.6608
MDL Number:
MFCD31382198
SMILES:
O=C1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)O)(C)C.CNCc1ccc(cc1)c1[nH]c2c3c1CCNC(=O)c3cc(c2)F
Properties
Computed Properties
 
Complexity:
869  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  

Literature

Title: Thomas HD, et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther, 2007, 6(3), 945-956.

Title: J Murray, et al. Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. Br J Cancer. 2014 Apr 15;110(8):1977-84.

Title: Matt Shirley, et al. Rucaparib: A Review in Ovarian Cancer. Target Oncol. 2019 Apr;14(2):237-246.

Title: Jianneng Li, et al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13(595):eabe8226.

Title: Hunter JE, et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene, 2012, 31(2), 251-264.

Title: Daniel RA, et al. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res, 2009, 15(4), 1241-1249.

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SDS
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