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58-54-8,MFCD00056693
Catalog No.:AA0186HY

58-54-8 | Ethacrynic acid

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5mg
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$43.00   $30.00
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1g
≥98%
in stock  
$99.00   $69.00
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5g
≥98%
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10g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0186HY
Chemical Name:
Ethacrynic acid
CAS Number:
58-54-8
Molecular Formula:
C13H12Cl2O4
Molecular Weight:
303.1380
MDL Number:
MFCD00056693
SMILES:
CCC(=C)C(=O)c1ccc(c(c1Cl)Cl)OCC(=O)O
Properties
Properties
 
Form:
Solid  
MP:
123-126°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
370  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.8  

Literature

Title: Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1.

Journal: Toxicology and applied pharmacology 20160415

Title: Genotoxic effect of ethacrynic acid and impact of antioxidants.

Journal: Toxicology and applied pharmacology 20150701

Title: FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.

Journal: Chemico-biological interactions 20130905

Title: Characterization and functional analysis of four glutathione S-transferases from the migratory locust, Locusta migratoria.

Journal: PloS one 20130101

Title: Alpha-class glutathione S-transferases in wild turkeys (Meleagris gallopavo): characterization and role in resistance to the carcinogenic mycotoxin aflatoxin B1.

Journal: PloS one 20130101

Title: Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20121215

Title: Antioxidant responses and whole-organism changes in Daphnia magna acutely and chronically exposed to endocrine disruptor bisphenol A.

Journal: Ecotoxicology and environmental safety 20121201

Title: Review: ototoxic characteristics of platinum antitumor drugs.

Journal: Anatomical record (Hoboken, N.J. : 2007) 20121101

Title: Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20121001

Title: Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Journal: Journal of medicinal chemistry 20120823

Title: Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS.

Journal: Analytical and bioanalytical chemistry 20120801

Title: Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo.

Journal: Hearing research 20120701

Title: New insights into redox response modulation in Fanconi's anemia cells by hydrogen peroxide and glutathione depletors.

Journal: The FEBS journal 20120701

Title: Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.

Journal: Biochemical pharmacology 20120615

Title: Synthesis and evaluation of [18F]Fluorobutyl ethacrynic amide: a potential PET tracer for studying glutathione transferase.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: The second sodium pump: from the function to the gene.

Journal: Pflugers Archiv : European journal of physiology 20120601

Title: Some physicochemical properties of two major soluble hepatic glutathione transferases of tilapia (Tilapia zilli).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20120515

Title: A novel molluscan sigma-like glutathione S-transferase from Manila clam, Ruditapes philippinarum: cloning, characterization and transcriptional profiling.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120501

Title: In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma.

Journal: Leukemia research 20120501

Title: [Research progress of acute kanamycin sulfate-induced deafness in guinea pig].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20120501

Title: [Inner ear morphological study of guinea pigs with acoustically evoked short latency negative response].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20120501

Title: The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors.

Journal: Bioorganic & medicinal chemistry 20120401

Title: Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.

Journal: Neurobiology of disease 20120301

Title: Cl anion-dependent Mg-ATPase.

Journal: The Journal of membrane biology 20120301

Title: Heterologous expression and characterization of a sigma glutathione S-transferase involved in carbaryl detoxification from oriental migratory locust, Locusta migratoria manilensis (Meyen).

Journal: Journal of insect physiology 20120201

Title: Virtual screening and in vitro assay of potential drug like inhibitors from spices against glutathione-S-transferase of filarial nematodes.

Journal: Journal of molecular modeling 20120101

Title: Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons.

Journal: BMC neuroscience 20120101

Title: Combined effects of salicylic acid and furosemide and noise on hearing.

Journal: Journal of occupational medicine and toxicology (London, England) 20120101

Title: [Comparison of different deafening strategies based on ototoxic drugs on mouse animals model].

Journal: Otolaryngologia polska = The Polish otolaryngology 20120101

Title: Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.

Journal: PloS one 20120101

Title: Role of leukotrienes on protozoan and helminth infections.

Journal: Mediators of inflammation 20120101

Title: Blood Magnesium levels in migraineurs within and between the headache attacks: a case control study.

Journal: The Pan African medical journal 20120101

Title: The bad, the good, and the ugly about oxidative stress.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Relationship between human aging muscle and oxidative system pathway.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Evaluation of hematological parameters in partial exchange and packed cell transfusion in treatment of severe anemia in pregnancy.

Journal: Anemia 20120101

Title: Ototoxicity of cisplatin administered to guinea pigs via the round window membrane.

Journal: The Journal of toxicological sciences 20120101

Title: Evaluation of platinum-ethacrynic acid conjugates in the treatment of mesothelioma.

Journal: ChemMedChem 20111209

Title: Purification and biochemical characterization of glutathione S-transferases from four field populations of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae).

Journal: Archives of insect biochemistry and physiology 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Distribution and mechanism of α-amanitin tolerance in mycophagous Drosophila (Diptera: Drosophilidae).

Journal: Environmental entomology 20111201

Title: Functional characterization of alpha-class glutathione s-transferases from the Turkey (meleagris gallopavo).

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111101

Title: Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance.

Journal: Molecular pharmaceutics 20111003

Title: Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats.

Journal: Journal of Zhejiang University. Science. B 20111001

Title: Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy.

Journal: The Analyst 20110921

Title: Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.

Journal: Environmental health perspectives 20110801

Title: Older blood pressure medications-do they still have a place?

Journal: The American journal of cardiology 20110715

Title: Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110704

Title: Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent.

Journal: Biophysical chemistry 20110701

Title: The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.

Journal: Chemico-biological interactions 20110630

Title: Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis.

Journal: Dental materials : official publication of the Academy of Dental Materials 20110501

Title: Oesophagostomum dentatum: effect of glutathione S-transferase (GST) inhibitors on GST activity and larval development.

Journal: Experimental parasitology 20110401

Title: [Origin of acoustically evoked short latency negative response in guinea pigs].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20110401

Title: Association of GSTM1 null polymorphism with isosorbide-5-mononitrate cardiovascular response and involvement of CGRP in healthy Chinese male volunteers.

Journal: Pharmacogenetics and genomics 20110301

Title: Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Depressogenic effects of medications: a review.

Journal: Dialogues in clinical neuroscience 20110301

Title: Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.

Journal: Bioorganic & medicinal chemistry letters 20110201

Title: Involvement of anion channels in mediating elicitor-induced ATP efflux in Salvia miltiorrhiza hairy roots.

Journal: Journal of plant physiology 20110115

Title: Organometallic anticancer compounds.

Journal: Journal of medicinal chemistry 20110113

Title: Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.

Journal: Journal of molecular recognition : JMR 20110101

Title: Cellular iron depletion weakens induction of heme oxygenase-1 by cadmium.

Journal: The international journal of biochemistry & cell biology 20110101

Title: Identification of ligand binding sites of proteins using the Gaussian Network Model.

Journal: PloS one 20110101

Title: Acoustic trauma increases cochlear and hair cell uptake of gentamicin.

Journal: PloS one 20110101

Title: Increased in vivo efficacy of lenalidomide and thalidomide by addition of ethacrynic acid.

Journal: In vivo (Athens, Greece) 20110101

Title: Na(+)/K(+)-ATPase in the lacrimal glands of rabbits and its changes during induced autoimmune dacryoadenitis.

Journal: Molecular vision 20110101

Title: Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study.

Journal: Pharmaceutical development and technology 20110101

Title: Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye.

Journal: Molecular vision 20110101

Title: Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection.

Journal: International journal of otolaryngology 20110101

Title: Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin.

Journal: PloS one 20110101

Title: Glutathione s-transferases in pediatric cancer.

Journal: Frontiers in oncology 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme glutathione transferase P1-1.

Journal: Molecular pharmacology 20101001

Title: Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.

Journal: Biochemical and biophysical research communications 20100820

Title: Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics.

Journal: Toxins 20100801

Title: Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells.

Journal: Brain research 20100716

Title: Ethacrynic acid as potential drug for diuretic renography in instance of sulfonamide allergy.

Journal: Clinical nuclear medicine 20100701

Title: Mechanistic study of the reaction of thiol-containing enzymes with alpha,beta-unsaturated carbonyl substrates by computation and chemoassays.

Journal: ChemMedChem 20100607

Title: Effect of ethacrynic acid on the sodium- and potassium-activated adenosine triphosphatase activity and expression in Old Order Amish bipolar individuals.

Journal: Journal of affective disorders 20100601

Title: Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.

Journal: Journal of natural products 20100528

Title: Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice.

Journal: Antiviral chemistry & chemotherapy 20100414

Title: Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

Journal: Journal of neuroscience research 20100401

Title: Biochemical analysis of a recombinant glutathione transferase from the cestode Echinococcus granulosus.

Journal: Acta tropica 20100401

Title: Ethacrynic acid analogues lacking the alpha,beta-unsaturated carbonyl unit--potential anti-metastatic drugs.

Journal: Bioorganic & medicinal chemistry letters 20100315

Title: Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork.

Journal: Annals of biomedical engineering 20100301

Title: Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation.

Journal: Journal of medicinal chemistry 20100211

Title: The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: I. Dimer formation in sodium ethacrynate.

Journal: Journal of pharmaceutical sciences 20100201

Title: Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.

Journal: European journal of medicinal chemistry 20100201

Title: Application of diffusion-edited NMR spectroscopy for the structural characterization of drug metabolites in mixtures.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid.

Journal: Hearing research 20100101

Title: New in vitro dermal absorption database and the prediction of dermal absorption under finite conditions for risk assessment purposes.

Journal: Regulatory toxicology and pharmacology : RTP 20100101

Title: Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.

Journal: PloS one 20100101

Title: In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids.

Journal: BMC complementary and alternative medicine 20100101

Title: A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder.

Journal: BMC systems biology 20100101

Title: Influence of ethacrynic acid on the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock seizure model.

Journal: Pharmacological reports : PR 20100101

Title: Light-induced photoreceptor and RPE degeneration involve zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light.

Journal: Molecular vision 20100101

Title: Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.

Journal: Clinical pharmacology : advances and applications 20100101

Title: Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.

Journal: Protein science : a publication of the Protein Society 20091201

Title: Effect of ethacrynic acid on the anticonvulsant activity of the second-generation antiepileptics against maximal electroshock-induced seizures in mice.

Journal: Epilepsy research 20091201

Title: Effects of neonatal partial deafness and chronic intracochlear electrical stimulation on auditory and electrical response characteristics in primary auditory cortex.

Journal: Hearing research 20091101

Title: A comprehensive review of the loop diuretics: should furosemide be first line?

Journal: The Annals of pharmacotherapy 20091101

Title: In vitro antifilarial activity of glutathione S-transferase inhibitors.

Journal: Parasitology research 20091001

Title: Enhanced survival of spiral ganglion cells after cessation of treatment with brain-derived neurotrophic factor in deafened guinea pigs.

Journal: Journal of the Association for Research in Otolaryngology : JARO 20090901

Title: Comparing the role of glutathione-S-transferase and mitochondrial aldehyde dehydrogenase in nitroglycerin biotransformation and the correlation with calcitonin gene-related peptide.

Journal: European journal of pharmacology 20090901

Title: The characterization of cytosolic glutathione transferase from four species of sea turtles: loggerhead (Caretta caretta), green (Chelonia mydas), olive ridley (Lepidochelys olivacea), and hawksbill (Eretmochelys imbricata).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090801

Title: Combining a solution-phase derived library with in-situ cellular bioassay: prompt screening of amide-forming minilibraries using MTT assay.

Journal: Chemical & pharmaceutical bulletin 20090701

Title: Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.

Journal: Toxicology and applied pharmacology 20090615

Title: Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601

Title: Na+, K+-ATPase activity in gill microsomes from the blue crab, Callinectes danae, acclimated to low salinity: novel perspectives on ammonia excretion.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20090601

Title: Glutathione participates in the regulation of mitophagy in yeast.

Journal: The Journal of biological chemistry 20090529

Title: Hepatic and branchial glutathione S-transferases of two fish species: substrate specificity and biotransformation of microcystin-LR.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090501

Title: Targeting Wnt pathway in lymphoma and myeloma cells.

Journal: British journal of haematology 20090301

Title: Olfactory host finding, intermediate memory and its potential ecological adaptation in Nasonia vitripennis.

Journal: Die Naturwissenschaften 20090301

Title: Attenuation of cadmium-induced necrotic cell death by necrostatin-1: potential necrostatin-1 acting sites.

Journal: Toxicology and applied pharmacology 20090301

Title: The role of chloride channels in rat corpus cavernosum: in vivo study.

Journal: The journal of sexual medicine 20090301

Title: Molecular cloning and thermal stress-induced expression of a pi-class glutathione S-transferase (GST) in the Antarctic bivalve Laternula elliptica.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20090201

Title: cAMP-dependent chloride secretion mediates tubule enlargement and cyst formation by cultured mammalian collecting duct cells.

Journal: American journal of physiology. Renal physiology 20090201

Title: Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression.

Journal: Antiviral research 20090201

Title: Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Purification and partial characterization of glutathione S-transferase from insecticide-resistant field populations of Liposcelis paeta Pearman (Psocoptera: Liposcelididae).

Journal: Archives of insect biochemistry and physiology 20090201

Title: [Correlation between reduction of distortion product otoacoustic emission and percentage of outer hair cell missing in chinchillas].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20090201

Title: The management of acute heart failure and diuretic therapy.

Journal: American journal of therapeutics 20090101

Title: The pleiotropic effects of ethacrynic acid.

Journal: American journal of therapeutics 20090101

Title: The clinical pharmacology of ethacrynic acid.

Journal: American journal of therapeutics 20090101

Title: Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability.

Journal: Molecular vision 20090101

Title: A novel method for screening the glutathione transferase inhibitors.

Journal: BMC biochemistry 20090101

Title: Formation and efflux of ATP-binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments.

Journal: Molecular pharmaceutics 20090101

Title: Human papillomavirus-16 E7 interacts with glutathione S-transferase P1 and enhances its role in cell survival.

Journal: PloS one 20090101

Title: Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.

Journal: PloS one 20090101

Title: Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid.

Journal: Molecules (Basel, Switzerland) 20081223

Title: Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.

Journal: Archives of toxicology 20081201

Title: 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress.

Journal: Antioxidants & redox signaling 20081201

Title: Novel mitochondrial extensions provide evidence for a link between microtubule-directed movement and mitochondrial fission.

Journal: Biochemical and biophysical research communications 20081107

Title: Molecular cloning and characterization of three sigma glutathione S-transferases from disk abalone (Haliotis discus discus).

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20081101

Title: Characterization of the binding of 8-anilinonaphthalene sulfonate to rat class Mu GST M1-1.

Journal: Biophysical chemistry 20081001

Title: LC-high-resolution multiple stage spectrometric analysis of diuretic compounds Unusual mass fragmentation pathways.

Journal: Journal of pharmaceutical and biomedical analysis 20080929

Title: Capillary electrophoresis of diuretics and probenecid in methanol.

Journal: Journal of chromatography. A 20080711

Title: Extrinsic fluorescent dyes as tools for protein characterization.

Journal: Pharmaceutical research 20080701

Title: Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase.

Journal: Cancer investigation 20080701

Title: The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.

Journal: Journal of molecular biology 20080627

Title: Molecular characterization of mu class glutathione-S-transferase from disk abalone (Haliotis discus discus), a potential biomarker of endocrine-disrupting chemicals.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20080601

Title: In vitro characterization of the enzymes involved in the metabolism of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound.

Journal: Archives of pharmacal research 20080601

Title: DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra.

Journal: Experimental neurology 20080401

Title: Deafferentation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor.

Journal: The Journal of comparative neurology 20080401

Title: The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes.

Journal: Neuroscience 20080124

Title: Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation.

Journal: Pflugers Archiv : European journal of physiology 20080101

Title: Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs.

Journal: ChemMedChem 20071201

Title: Effects of metals and detergents on biotransformation and detoxification enzymes of leaping mullet (Liza saliens).

Journal: Ecotoxicology and environmental safety 20071101

Title: Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition.

Journal: Cancer research 20070815

Title: Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway.

Journal: Biochemical and biophysical research communications 20070803

Title: Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.

Journal: Archives of toxicology 20070801

Title: A high pressure liquid chromatography-based assay for glutathione-S-transferase class distinction assay.

Journal: Journal of biochemical and biophysical methods 20070801

Title: Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.

Journal: Biological & pharmaceutical bulletin 20070801

Title: Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons.

Journal: Hearing research 20070601

Title: Curcumin-induced GADD153 upregulation: modulation by glutathione.

Journal: Journal of cellular biochemistry 20070515

Title: A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo.

Journal: Journal of neuroscience research 20070515

Title: MALDI mass sequencing and characterization of filarialglutathione-S-transferase.

Journal: Biochemical and biophysical research communications 20070504

Title: Glutathione S-transferase cytosolic isoform in the pink-shrimp, Farfantepenaeus brasiliensis, from Conceição Lagoon, Santa Catarina Island, SC, Brazil.

Journal: Environment international 20070501

Title: Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.

Journal: Investigative ophthalmology & visual science 20070501

Title: Cell death after co-administration of cisplatin and ethacrynic acid.

Journal: Hearing research 20070401

Title: The synthesis of alpha,beta-unsaturated carbonyl derivatives with the ability to inhibit both glutathione S-transferase P1-1 activity and the proliferation of leukemia cells.

Journal: Bioorganic & medicinal chemistry 20070401

Title: Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.

Journal: Journal of biomolecular screening 20070401

Title: Neuropsychiatric consequences of cardiovascular medications.

Journal: Dialogues in clinical neuroscience 20070301

Title: Characterization of hepatic glutathione S-transferases in coho salmon (Oncorhynchus kisutch).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20070227

Title: Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.

Journal: Neuroscience 20070209

Title: Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway.

Journal: Journal of agricultural and food chemistry 20070207

Title: Transscleral diffusion of ethacrynic acid and sodium fluorescein.

Journal: Molecular vision 20070101

Title: Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.

Journal: Retrovirology 20070101

Title: Non-sensory cells in the deafened organ of Corti: approaches for repair.

Journal: The International journal of developmental biology 20070101

Title: Bench-to-bedside review: High-mobility group box 1 and critical illness.

Journal: Critical care (London, England) 20070101

Title: Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis.

Journal: Journal of chromatography. A 20061201

Title: Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli.

Journal: FEMS immunology and medical microbiology 20061201

Title: Involvement of Na(+)-K(+)-2Cl(-) cotransporters in hypertonicity-induced rise in intracellular calcium concentration.

Journal: The International journal of neuroscience 20061201

Title: In vitro degradation of hexanitrohexaazaisowurtzitane (CL-20) by cytosolic enzymes of Japanese quail and the rabbit.

Journal: Environmental toxicology and chemistry 20061201

Title: Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.

Journal: Bioorganic & medicinal chemistry letters 20061115

Title: Antiepileptic effect of loop diuretics? Comment to 'Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy' by Margineanu, Klitgaard, Epilepsy Res. 69 (2006) 93-99.

Journal: Epilepsy research 20061001

Title: Inducible nitric oxide synthase up-regulation and mitochondrial glutathione depletion mediate cyanide-induced necrosis in mesencephalic cells.

Journal: Journal of neuroscience research 20061001

Title: Coupling between chemical reactivity and structural relaxation in pharmaceutical glasses.

Journal: Pharmaceutical research 20061001

Title: Efficacy and safety of a furosemide continuous infusion following cardiac surgery.

Journal: The Annals of pharmacotherapy 20061001

Title: Inhibition of human glutathione transferases by multidrug resistance chemomodulators in vitro.

Journal: Journal of enzyme inhibition and medicinal chemistry 20061001

Title: Changes in hepatic cytosolic glutathione S-transferase activity and expression of its class-P during prenatal and postnatal period in rats treated with aflatoxin B1.

Journal: Archives of toxicology 20060901

Title: The fate of outer hair cells after acoustic or ototoxic insults.

Journal: Hearing research 20060801

Title: Bivalent inhibitors of glutathione S-transferase: the effect of spacer length on isozyme selectivity.

Journal: Bioorganic & medicinal chemistry letters 20060715

Title: Garlic allyl sulfides display differential modulation of rat cytochrome P450 2B1 and the placental form glutathione S-transferase in various organs.

Journal: Journal of agricultural and food chemistry 20060712

Title: Discovery of glutathione S-transferase inhibitors using dynamic combinatorial chemistry.

Journal: Journal of the American Chemical Society 20060705

Title: Optimization of bivalent glutathione S-transferase inhibitors by combinatorial linker design.

Journal: Journal of the American Chemical Society 20060705

Title: Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo.

Journal: Cell and tissue research 20060701

Title: Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo.

Journal: Neuroscience 20060619

Title: Oxidative stress and Mrp2 internalization.

Journal: Free radical biology & medicine 20060615

Title: Reported medication use in the neonatal intensive care unit: data from a large national data set.

Journal: Pediatrics 20060601

Title: Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney.

Journal: Amino acids 20060601

Title: Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060601

Title: Differential effects of cation-chloride co-transport-blocking diuretics in a rat hippocampal slice model of epilepsy.

Journal: Epilepsy research 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Analysis of major intracellular proteins of Aspergillus fumigatus by MALDI mass spectrometry: identification and characterisation of an elongation factor 1B protein with glutathione transferase activity.

Journal: Biochemical and biophysical research communications 20060324

Title: Proliferation and apoptosis of HeLa cells induced by in vitro stimulation with digitalis.

Journal: European journal of pharmacology 20060318

Title: The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo.

Journal: Hearing research 20060301

Title: Indirect laser-induced fluorescence detection of diuretics separated by capillary electrophoresis.

Journal: Journal of separation science 20060301

Title: The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo.

Journal: Chemico-biological interactions 20060201

Title: Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20060201

Title: Salinity effects on activity and expression of glutathione S-transferases in white sturgeon and Chinook salmon.

Journal: Ecotoxicology and environmental safety 20060201

Title: Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling.

Journal: Biochemical pharmacology 20060112

Title: Two glutathione S-transferase isoenzymes purified from Bulinus truncatus (Gastropoda: Planorbidae).

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20060101

Title: Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient.

Journal: The Annals of pharmacotherapy 20060101

Title: Inhibitors of cysteine proteases.

Journal: Current topics in medicinal chemistry 20060101

Title: [Diuretic therapy in heart failure].

Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20060101

Title: Cardiomyopathy, familial dilated.

Journal: Orphanet journal of rare diseases 20060101

Title: Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity.

Journal: Cutaneous and ocular toxicology 20060101

Title: Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.

Journal: Biological & pharmaceutical bulletin 20051201

Title: A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods.

Journal: Journal of medicinal chemistry 20051103

Title: Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1.

Journal: Cell death and differentiation 20050801

Title: Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.

Journal: Bioorganic & medicinal chemistry letters 20050801

Title: Selective modifiers of glutathione prevent restoration of photorelaxations in mouse gastric fundus.

Journal: Fundamental & clinical pharmacology 20050801

Title: Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.

Journal: Therapeutic drug monitoring 20050801

Title: Combined effects of GSTP1 and MRP1 in melanoma drug resistance.

Journal: British journal of cancer 20050725

Title: Characterization of cytosolic glutathione S-transferases in juvenile Chinook salmon (Oncorhynchus tshawytscha).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20050701

Title: Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050701

Title: New non-peptidic inhibitors of papain derived from etacrynic acid.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20050701

Title: Synthesis and structure-activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition.

Journal: Bioorganic & medicinal chemistry 20050602

Title: Engineering the substrate specificity of cytochrome P450 CYP102A2 by directed evolution: production of an efficient enzyme for bioconversion of fine chemicals.

Journal: Biomolecular engineering 20050601

Title: A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major.

Journal: The Biochemical journal 20050515

Title: Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells.

Journal: Journal of the neurological sciences 20050515

Title: Augmentation of cisplatin sensitivity in cisplatin-resistant human bladder cancer cells by modulating glutathione concentrations and glutathione-related enzyme activities.

Journal: BJU international 20050501

Title: Purification and biochemical properties of glutathione S-transferase from Lactuca sativa.

Journal: Journal of biochemistry and molecular biology 20050331

Title: Induction of mitochondrial fusion by cysteine-alkylators ethacrynic acid and N-ethylmaleimide.

Journal: Journal of cellular physiology 20050301

Title: Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals.

Journal: Nature medicine 20050301

Title: Characterization of glutathione S-transferases in juvenile white sturgeon.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20050210

Title: Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance.

Journal: Journal of the American Chemical Society 20050209

Title: In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood.

Journal: Mutation research 20050207

Title: Precision improvement for the analysis of flavonoids in selected Thai plants by capillary zone electrophoresis.

Journal: Electrophoresis 20050201

Title: Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway.

Journal: Shock (Augusta, Ga.) 20050101

Title: The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO).

Journal: BMC neuroscience 20050101

Title: Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.

Journal: In vivo (Athens, Greece) 20050101

Title: Filarial glutathione S-transferase: its induction by xenobiotics and potential as drug target.

Journal: Acta biochimica Polonica 20050101

Title: Molecular cloning and characterization of alpha-class glutathione S-transferase genes from the hepatopancreas of red sea bream, Pagrus major.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050101

Title: Multidrug resistance-associated protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine sulfoximine.

Journal: Cancer cell international 20050101

Title: Therapy of hearing disorders - conservative procedures.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20050101

Title: Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver.

Journal: Free radical biology & medicine 20041201

Title: Clofibric and ethacrynic acids prevent experimental pyelonephritis by Escherichia coli in mice.

Journal: FEMS immunology and medical microbiology 20041101

Title: The interaction of selected natural products with human recombinant glutathione transferases.

Journal: Phytotherapy research : PTR 20041101

Title: Molecular cloning, expression and characterization of glutathione S-transferase from Mytilus edulis.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20041001

Title: Engineering the xenobiotic substrate specificity of maize glutathione S-transferase I.

Journal: Protein engineering, design & selection : PEDS 20041001

Title: Process control and drug analysis with an on-line capillary electrophoresis system.

Journal: Journal of biochemical and biophysical methods 20040930

Title: Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040915

Title: Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040901

Title: Biochemical characterization and distribution of glutathione S-transferases in leaping mullet (Liza saliens).

Journal: Biochemistry. Biokhimiia 20040901

Title: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

Journal: Cancer research 20040815

Title: Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.

Journal: Biomaterials 20040801

Title: Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus.

Journal: Neuropharmacology 20040801

Title: Conformation of poly(sodium ethacrylate) in solution studied by small-angle X-ray scattering.

Journal: Biophysical chemistry 20040701

Title: Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.

Journal: Biological & pharmaceutical bulletin 20040701

Title: Glutathione induces helical formation in the carboxy terminus of human glutathione transferase A1-1.

Journal: Biochemistry 20040615

Title: Volume-sensitive chloride channels do not mediate activation-induced chloride efflux in human neutrophils.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040601

Title: New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells.

Journal: Biological & pharmaceutical bulletin 20040601

Title: Glutathione-S-transferases from chloroquine-resistant and -sensitive strains of Plasmodium falciparum: what are their differences?

Journal: The Southeast Asian journal of tropical medicine and public health 20040601

Title: Differential response of bipolar and normal control lymphoblastoid cell sodium pump to ethacrynic acid.

Journal: Journal of affective disorders 20040501

Title: Renal accumulation and excretion of radioiodinated 3-iodo-alpha-methyl-L-tyrosine.

Journal: Annals of nuclear medicine 20040501

Title: Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents.

Journal: European journal of pharmacology 20040405

Title: Glutathione S-transferases and esterases in placenta after normal and pre-eclamptic pregnancies.

Journal: Placenta 20040401

Title: Characterization and molecular cloning of a glutathione S-transferase from the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae).

Journal: Insect biochemistry and molecular biology 20040401

Title: Interactions of human organic anion transporters with diuretics.

Journal: The Journal of pharmacology and experimental therapeutics 20040301

Title: Cellular glutathione prevents cytolethality of monomethylarsonic acid.

Journal: Toxicology and applied pharmacology 20040301

Title: Antioxidant gene therapy can protect hearing and hair cells from ototoxicity.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20040201

Title: The influence of anti-irritants on captopril hydrophilic gel.

Journal: Drug development and industrial pharmacy 20040201

Title: Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla.

Journal: Brain research 20040130

Title: Effects of pH and the presence of micelles on the resolution of diuretics by reversed-phase liquid chromatography.

Journal: Journal of chromatography. A 20040102

Title: Co-administration of kanamycin and ethacrynic acid as a deafening method for acute animal experiments.

Journal: Hearing research 20040101

Title: Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040101

Title: Risk of hospitalization for upper gastrointestinal tract bleeding.

Journal: Journal of clinical epidemiology 20040101

Title: Pretreatment of human epidermal keratinocytes in vitro with ethacrynic Acid reduces sulfur mustard cytotoxicity.

Journal: Toxicology mechanisms and methods 20040101

Title: Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

Journal: Chemical research in toxicology 20031201

Title: Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells.

Journal: Hearing research 20031101

Title: Ethacrynic acid can be effective for refractory congestive heart failure and ascites.

Journal: Southern medical journal 20031101

Title: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.

Journal: Cancer science 20031001

Title: Desynchronization of electrically evoked auditory-nerve activity by high-frequency pulse trains of long duration.

Journal: The Journal of the Acoustical Society of America 20031001

Title: Improved neural representation of vowels in electric stimulation using desynchronizing pulse trains.

Journal: The Journal of the Acoustical Society of America 20031001

Title: Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice.

Journal: Neuroscience letters 20030925

Title: Changes in cell proliferation in rat and guinea pig cochlea after aminoglycoside-induced damage.

Journal: Neuroscience letters 20030828

Title: Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia.

Journal: Schizophrenia research 20030801

Title: Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems.

Journal: Biochemical and biophysical research communications 20030627

Title: Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: thiol ester hydrolysis and inhibitor maturation.

Journal: Archives of biochemistry and biophysics 20030615

Title: Analysis of energy metabolism and mechanism of loop diuretics in the thick ascending limb of Henle's loop in dog kidneys.

Journal: Acta physiologica Scandinavica 20030501

Title: Neurotrophic factor effects on oxidative stress-induced neuronal death.

Journal: Neurochemical research 20030501

Title: Modulation of pumpkin glutathione S-transferases by aldehydes and related compounds.

Journal: Plant & cell physiology 20030501

Title: Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum.

Journal: Proteins 20030401

Title: Effect of ethacrynic acid on sodium pump alpha isoforms in SH-SY5Y cells.

Journal: Bipolar disorders 20030401

Title: Characterization of an ectonucleoside triphosphate diphosphohydrolase 1 activity in alkaline phosphatase-depleted rat osseous plate membranes: possible functional involvement in the calcification process.

Journal: Biochimica et biophysica acta 20030321

Title: Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid.

Journal: Journal of the neurological sciences 20030315

Title: A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase.

Journal: British journal of pharmacology 20030301

Title: A novel Cl- inward-rectifying current in the plasma membrane of the calcifying marine phytoplankton Coccolithus pelagicus.

Journal: Plant physiology 20030301

Title: Cytosolic and mitochondrial glutathione in microglial cells are differentially affected by oxidative/nitrosative stress.

Journal: Nitric oxide : biology and chemistry 20030201

Title: Substrate specificity of mouse aldo-keto reductase AKR7A5.

Journal: Chemico-biological interactions 20030201

Title: Ethacrynic acid and the sulfa-sensitive patient.

Journal: Archives of internal medicine 20030113

Title: Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.

Journal: Journal of molecular biology 20030103

Title: Interaction between metamizol and tramadol in a model of acute visceral pain in rats.

Journal: European journal of pain (London, England) 20030101

Title: Effects of glutathione S-transferase inhibitors on nitroglycerin action in pig isolated coronary arteries.

Journal: Clinical and experimental pharmacology & physiology 20021201

Title: Rapid spectrophotometric method for serum glutathione S-transferases activity.

Journal: Clinica chimica acta; international journal of clinical chemistry 20021201

Title: Chinchilla models of selective cochlear hair cell loss.

Journal: Hearing research 20021201

Title: Ethacrynic acid rapidly and selectively abolishes blood flow in vessels supplying the lateral wall of the cochlea.

Journal: Hearing research 20021101

Title: Complementary DNA cloning, protein expression, and characterization of alpha-class GSTs from Macaca fascicularis liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20021101

Title: Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs.

Journal: Molecular pharmacology 20021101

Title: Combined effects of cadmium and nickel on testicular xenobiotic metabolizing enzymes in rats.

Journal: Biological trace element research 20021101

Title: Induction of cytosolic glutathione S-transferases from Atlantic eel (Anguilla Anguilla) after intraperitoneal treatment with polychlorinated biphenyls.

Journal: The Science of the total environment 20021007

Title: Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme.

Journal: The Biochemical journal 20020915

Title: A putative role for S-nitrosoglutathione as the source of nitric oxide in photorelaxation of the mouse gastric fundus.

Journal: European journal of pharmacology 20020830

Title: Nipradilol induces vasodilation of canine isolated posterior ciliary artery via stimulation of the guanylyl cyclase-cGMP pathway.

Journal: Life sciences 20020726

Title: Purification and characterization of a novel glutathione S-transferase from Asaphis dichotoma.

Journal: Archives of biochemistry and biophysics 20020715

Title: Disparity between ionic mediators of volume regulation and apoptosis in N1E 115 mouse neuroblastoma cells.

Journal: Brain research 20020712

Title: A possible effect of sulfhydryl reagents on the contractile activity of the rat detrusor muscle.

Journal: European journal of pharmacology 20020510

Title: A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis.

Journal: Chemical research in toxicology 20020501

Title: Influence of temperature, pH, oxygenation, water-type and substrate on biomarker responses in the freshwater clam Corbicula fluminea (Müller).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020501

Title: Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target.

Journal: Biological chemistry 20020501

Title: Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig.

Journal: Hearing research 20020501

Title: [The role of thiol oxidants in inhibition of pancreatic exocrine secretory function and glutathione].

Journal: Zhonghua nei ke za zhi 20020501

Title: Toxicity of ethacrynic acid in isolated rat hepatocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020401

Title: Analysis of myogenic mechanisms in renal autoregulation.

Journal: Acta physiologica Scandinavica 20020401

Title: Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020315

Title: The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?

Journal: Breast cancer research and treatment 20020301

Title: Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance.

Journal: International journal of cancer 20020210

Title: Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers.

Journal: International journal of oncology 20020201

Title: Influence of antioxidant depletion on nitrergic relaxation in the pig gastric fundus.

Journal: British journal of pharmacology 20020201

Title: Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats.

Journal: Journal of agricultural and food chemistry 20020116

Title: Peptidomimetic glutathione analogues as novel gammaGT stable GST inhibitors.

Journal: Bioorganic & medicinal chemistry 20020101

Title: Glutathione might exert an important function in caerulein-stimulated amylase release in isolated rat pancreatic acini.

Journal: Pancreas 20020101

Title: Solutol and cremophor products as new additives in suppository formulation.

Journal: Drug development and industrial pharmacy 20020101

Title: Characteristics of the plasma membrane Cl(-)-ATPase of the bream (Abramis brama) brain sensitive to the inhibitory receptor ligands.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20020101

Title: The glutathione system in alkylator resistance.

Journal: Cancer treatment and research 20020101

Title: DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration.

Journal: British journal of pharmacology 20011201

Title: Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane.

Journal: Journal of neuroscience research 20011201

Title: Decreased glutathione S-transferase expression and activity and altered sex steroids in Lake Apopka brown bullheads (Ameiurus nebulosus).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20011112

Title: Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity.

Journal: Journal of cell science 20011101

Title: Ethacrynic acid inhibits pancreatic exocrine secretion.

Journal: Acta pharmacologica Sinica 20011101

Title: Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20011001

Title: Brain energy metabolism in Alzheimer's disease: 99mTc-HMPAO SPECT imaging during verbal fluency and role of astrocytes in the cellular mechanism of 99mTc-HMPAO retention.

Journal: Brain research. Brain research reviews 20011001

Title: Purification and characterization of a glutathione S-transferase from the fungus Cunninghamella elegans.

Journal: FEMS microbiology letters 20010925

Title: Sensitization to the cytotoxicity of melphalan by ethacrynic acid and hyperthermia in drug-sensitive and multidrug-resistant Chinese hamster ovary cells.

Journal: Radiation research 20010901

Title: Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic.

Journal: Molecular pharmacology 20010801

Title: Heterologous expression and characterization of alternatively spliced glutathione S-transferases from a single Anopheles gene.

Journal: Insect biochemistry and molecular biology 20010726

Title: Chloride channel antagonists perturb growth and morphology of Neurospora crassa.

Journal: FEMS microbiology letters 20010724

Title: Induction of glutathione S-transferase activity and protein expression in brown bullhead (Ameiurus nebulosus) liver by ethoxyquin.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010701

Title: 3-Methyleneoxindole: an affinity label of glutathione S-transferase pi which targets tryptophan 38.

Journal: Biochemistry 20010626

Title: Purification and characterization of multiple glutathione S-transferase isozymes from Chironomidae larvae.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010601

Title: Determination and characterization of diuretics in human urine by liquid chromatography coupled to pneumatically assisted electrospray ionization mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20010601

Title: Determination and multivariate statistical analysis of biochemical responses to environmental contaminants in feral freshwater fish Leuciscus cephalus, L.

Journal: Environmental toxicology and chemistry 20010501

Title: Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.

Journal: Molecular pharmacology 20010401

Title: Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve.

Journal: British journal of pharmacology 20010401

Title: Overexpression of glutathione-S-transferase A1 in benign adrenocortical adenomas from patients with Cushing's syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20010401

Title: Rat liver microsomal lipid peroxidation produced during the oxidative metabolism of ethacrynic acid.

Journal: Pharmacology & toxicology 20010401

Title: Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401

Title: Detection of drug-induced apoptosis and necrosis in human cervical carcinoma cells using 1H NMR spectroscopy.

Journal: Cell death and differentiation 20010301

Title: Differential induction of glutathione S-transferases in the clam Ruditapes decussatus exposed to organic compounds.

Journal: Environmental toxicology and chemistry 20010301

Title: Glutathione S-transferases from rainbow trout liver and freshly isolated hepatocytes: purification and characterization.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010201

Title: Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta.

Journal: Chemico-biological interactions 20010130

Title: Glutathione transferase activities in renal carcinomas and adjacent normal renal tissues: factors influencing renal carcinogenesis induced by xenobiotics.

Journal: Archives of toxicology 20010101

Title: Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20010101

Title: The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance.

Journal: The Journal of pharmacology and experimental therapeutics 20000801

Title: Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

Journal: Pharmacogenetics 20000201

Title: Long-lasting c-fos and NGF mRNA expressions and loss of perikaryal parvalbumin immunoreactivity in the development of epileptogenesis after ethacrynic acid-induced seizure.

Journal: Brain research 19990710

Title: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.

Journal: Cancer research 19990201

Title: GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid.

Journal: FEBS letters 19981211

Title: Recombinant human glutathione S-transferases catalyse enzymic isomerization of 13-cis-retinoic acid to all-trans-retinoic acid in vitro.

Journal: The Biochemical journal 19981115

Title: Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element.

Journal: Archives of biochemistry and biophysics 19981101

Title: Zeta, a novel class of glutathione transferases in a range of species from plants to humans.

Journal: The Biochemical journal 19971215

Title: Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1.

Journal: Chemico-biological interactions 19971212

Title: A sensitive animal model to assess acute and chronic ototoxic effects.

Journal: Archives of otolaryngology--head & neck surgery 19960801

Title: Onset of ototoxicity in the cat is related to onset of auditory function.

Journal: Hearing research 19951201

Title: Cochlear pathology following chronic electrical stimulation of the auditory nerve: II. Deafened kittens.

Journal: Hearing research 19941201

Title: Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid.

Journal: Hearing research 19940101

Title: Profound hearing loss in the cat following the single co-administration of kanamycin and ethacrynic acid.

Journal: Hearing research 19931101

Title: Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.

Journal: European journal of pharmacology 19921006

Title: Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene.

Journal: Cancer research 19910115

Title: A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols.

Journal: The Journal of biological chemistry 19900715

Title: Ethacrynic acid-induced convulsions and brain noradrenaline in mice.

Journal: European journal of pharmacology 19900410

Title: Interaction of rat glutathione S-transferases 7-7 and 8-8 with gamma-glutamyl- or glycyl-modified glutathione analogues.

Journal: The Biochemical journal 19891215

Title: Intracerebroventricular injection of ethacrynic acid induces status epilepticus.

Journal: European journal of pharmacology 19890704

Title: Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.

Journal: Molecular pharmacology 19890701

Title: Characterization of antibody and selection of alternative drug therapy in hydrochlorothiazide-induced immune hemolytic anemia.

Journal: Transfusion 19880101

Title: [Effect of diuretics on the course of experimental arrhythmias].

Journal: Farmakologiia i toksikologiia 19860101

Title: Acute effects of alkylating agents on canine renal function and ultrastructure: high-dose ethacrynic acid vs. dihydroethacrynic acid and ticrynafen.

Journal: The Journal of pharmacology and experimental therapeutics 19840301

Title: Ultrastructural histopathology in a case of human ototoxicity due to loop diuretics.

Journal: Acta oto-laryngologica 19810101

Title: Ethacrynic acid-induced deafness accompanied by nystagmus.

Journal: The New England journal of medicine 19800918

Title: Furosemide-induced ototoxicity.

Journal: Annals of internal medicine 19791101

Title: Quantitative relationships of the ototoxic interaction of kanamycin and ethacrynic acid.

Journal: Archives of otolaryngology (Chicago, Ill. : 1960) 19790501

Title: Combined effect of 3', 4'-dideoxykanamycin B and potent diuretics on the cochlea. (A scanning and transmission electron microscopic evaluation).

Journal: The Laryngoscope 19770901

Title: Drug-induced anaphylaxis, convulsions, deafness, and extrapyramidal symptoms.

Journal: Lancet (London, England) 19770312

Title: Mechanisms in acute oliguric renal failure induced by tetracycline infusion.

Journal: Scandinavian journal of clinical and laboratory investigation 19751101

Title: Methoxyflurane nephropathy.

Journal: Human pathology 19740501

Title: Diuretics and renal pain.

Journal: British medical journal 19730922

Title: Laboratory testing for ototoxic effects of drugs.

Journal: British journal of pharmacology 19730601

Title: Reversible hearing loss due to ethacrynic acid in occult renal failure. Case report.

Journal: Missouri medicine 19730501

Title: Drug-induced deafness.

Journal: JAMA 19730423

Title: Deafness after ethacrynic acid.

Journal: The New England journal of medicine 19711101

Title: Complications from diuretic therapy with ethacrynic acid and furosemide.

Journal: Southern medical journal 19710701

Title: Diuretics and ototoxicity.

Journal: The New England journal of medicine 19710610

Title: Deafness following standard intravenous dose of ethacrynic acid.

Journal: JAMA 19710503

Title: The extrarenal effects of ethacrynic acid on ouabain-induced tachyarrhythmias.

Journal: Research communications in chemical pathology and pharmacology 19710501

Title: Kanamycin ototoxicity--possible potentiation by other drugs.

Journal: Southern medical journal 19700501

Title: [Hearing disorders after treatment with ethacrynic acid (Edecrin) in patients with reduced kidney function].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19700101

Title: Ototoxicity of ethacrynic acid. Demonstrated in a human temporal bone.

Journal: Archives of otolaryngology (Chicago, Ill. : 1960) 19690801

Title: Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia.

Journal: The New England journal of medicine 19690529

Title: Deafness after ethacrynic acid.

Journal: Lancet (London, England) 19690329

Title: Deafness after ethacrynic acid.

Journal: Lancet (London, England) 19690222

Title: Transient and permanent deafness following treatment with ethacrynic acid in renal failure.

Journal: Lancet (London, England) 19690111

Title: Ototoxic drugs and poor renal function.

Journal: JAMA 19681125

Title: Use of ethacrynic acid in mannitol-resistant oliguric renal failure.

Journal: JAMA 19681021

Title: Recurrent ventricular fibrillation precipitated by quinidine. Report of a patient with recovery after 28 paroxysms.

Journal: Archives of internal medicine 19680701

Title: Influence of drugs, implanted into the hypothalamus, on the water consumption of rats.

Journal: The Journal of pharmacology and experimental therapeutics 19680101

Title: [Transient deafness-a rare complication of ethacrynic acid therapy].

Journal: Duodecim; laaketieteellinen aikakauskirja 19680101

Title: Acute transient hearing loss after ethacrynic acid therapy.

Journal: Archives of internal medicine 19660501

Title: Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256.

Title: Harada T, et al. Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. Clinics (Sao Paulo). 2018 Oct 18;73:e332.

Title: Zhao XX, et al. Ethacrynic acid inhibits airway smooth muscle contraction in mice. Sheng Li Xue Bao. 2019 Dec 25;71(6):863-873.

Title: Byun HJ, et al. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. Biomol Ther (Seoul). 2013 Sep 30;21(5):338-42.

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Tags:58-54-8 Molecular Formula|58-54-8 MDL|58-54-8 SMILES|58-54-8 Ethacrynic acid