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Home Other Building Blocks 1334493-07-0
1334493-07-0,MFCD29477477
Catalog No.:AA01A2DL

1334493-07-0 | BP-1-102

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$12.00   $8.00
- +
2mg
99+%
in stock  
$17.00   $12.00
- +
5mg
99+%
in stock  
$33.00   $23.00
- +
10mg
99+%
in stock  
$55.00   $39.00
- +
25mg
99+%
in stock  
$110.00   $77.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01A2DL
Chemical Name:
BP-1-102
CAS Number:
1334493-07-0
Molecular Formula:
C29H27F5N2O6S
Molecular Weight:
626.5915
MDL Number:
MFCD29477477
SMILES:
O=C(N(c1ccc(c(c1)O)C(=O)O)Cc1ccc(cc1)C1CCCCC1)CN(S(=O)(=O)c1c(F)c(F)c(c(c1F)F)F)C
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
6.4  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,#18,p.5605-5609

[2]ACSMedicinalChemistryLetters,2013,vol.4,#11,p.1102-1107

[3]JournalofMedicinalChemistry,2013,vol.56,#18,p.7190-7200

[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,#18,p.5605-5609

[2]JournalofMedicinalChemistry,2013,vol.56,#18,p.7190-7200

[3]ACSMedicinalChemistryLetters,2013,vol.4,#11,p.1102-1107

[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,#18,p.5605-5609

[2]JournalofMedicinalChemistry,2013,vol.56,#18,p.7190-7200

[3]ACSMedicinalChemistryLetters,2013,vol.4,#11,p.1102-1107

[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,#18,p.5605-5609

[2]ACSMedicinalChemistryLetters,2013,vol.4,#11,p.1102-1107

[1]ACSMedicinalChemistryLetters,2013,vol.4,#11,p.1102-1107

Literature

Title: Zhang X, et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8.

Title: De Simone V, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015 Jul;34(27):3493-503.

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SDS
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Tags:1334493-07-0 Molecular Formula|1334493-07-0 MDL|1334493-07-0 SMILES|1334493-07-0 BP-1-102