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882697-00-9,MFCD30146410
Catalog No.:AA01BZZY

882697-00-9 | Anle138b

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$21.00   $15.00
- +
5mg
≥98%
in stock  
$46.00   $32.00
- +
10mg
98%
in stock  
$70.00   $49.00
- +
25mg
98%
in stock  
$111.00   $78.00
- +
50mg
98%
in stock  
$169.00   $118.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01BZZY
Chemical Name:
Anle138b
CAS Number:
882697-00-9
Molecular Formula:
C16H11BrN2O2
Molecular Weight:
343.1747
MDL Number:
MFCD30146410
SMILES:
Brc1cccc(c1)c1[nH]nc(c1)c1ccc2c(c1)OCO2
Properties
Computed Properties
 
Complexity:
370  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
4  

Downstream Synthesis Route
882697-00-9    74-88-4   
sery392A 
 
sery392B 

[1]Patent:WO2010/372,2010,A2.Locationinpatent:Page/Pagecolumn32

[1]Patent:WO2010/372,2010,A2.Locationinpatent:Page/Pagecolumn32

1-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-propan-1,3-dione 
  882697-00-9 

[1]Patent:WO2010/372,2010,A2.Locationinpatent:Page/Pagecolumn47

127039-03-6    882697-00-9    74-88-4   
C24H19BrN3O4(1+)*I(1-) 
 
C24H19BrN3O4(1+)*I(1-) 

[1]Patent:WO2017/102893,2017,A1.Locationinpatent:Page/Pagecolumn18;19

127039-03-6    882697-00-9   
C23H16BrN3O4 
 
C23H16BrN3O4 

[1]Patent:WO2017/102893,2017,A1.Locationinpatent:Page/Pagecolumn18;19

Literature

Title: Wagner J, et al. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 Jun;125(6):795-813.

Title: Martinez Hernandez A, et al. The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Mol Med. 2018;10(1):32-47.

Title: Heras-Garvin A, et al. Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov Disord. 2019;34(2):255-263.

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SDS
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