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50-90-8,MFCD00006531
Catalog No.:AA01CB25

50-90-8 | Uridine, 5-chloro-2'-deoxy-

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25mg
≥98%
in stock  
$58.00   $40.00
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50mg
≥98%
in stock  
$92.00   $64.00
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100mg
≥98%
in stock  
$138.00   $96.00
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1g
98%
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$146.00   $103.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CB25
Chemical Name:
Uridine, 5-chloro-2'-deoxy-
CAS Number:
50-90-8
Molecular Formula:
C9H11ClN2O5
Molecular Weight:
262.6470
MDL Number:
MFCD00006531
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cc(Cl)c(=O)[nH]c1=O
Properties
Properties
 
Form:
Solid  
MP:
>171°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
386  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-0.7  

Literature

Title: Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

Journal: The Biochemical journal 20120701

Title: Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

Title: Polymerase incorporation and miscoding properties of 5-chlorouracil.

Journal: Chemical research in toxicology 20100419

Title: Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.

Journal: Journal of neurochemistry 20100301

Title: Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Journal: Molecular cell 20100226

Title: Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.

Journal: PloS one 20100101

Title: Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue.

Journal: Journal of visualized experiments : JoVE 20100101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Noggin expands neural stem cells in the adult hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080910

Title: Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.

Journal: Bioorganic & medicinal chemistry 20080601

Title: A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

Journal: Nature chemical biology 20080601

Title: Label-retaining cells in the rat submandibular gland.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080101

Title: Use of halogenated precursors for simultaneous DNA and RNA detection by means of immunoelectron and immunofluorescence microscopy.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080101

Title: Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.

Journal: Antiviral chemistry & chemotherapy 20080101

Title: Replication labeling with halogenated thymidine analogs.

Journal: Current protocols in cell biology 20070601

Title: High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.

Journal: PLoS biology 20070501

Title: Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney.

Journal: American journal of physiology. Cell physiology 20070201

Title: Absence of an immediate G1/S checkpoint in primary MEFs following gamma-irradiation identifies a novel checkpoint switch.

Journal: Cell cycle (Georgetown, Tex.) 20060801

Title: Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.

Journal: Bioorganic & medicinal chemistry 20051215

Title: Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20051101

Title: Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells.

Journal: DNA repair 20050302

Title: Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218

Title: Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol.

Journal: Toxicology and applied pharmacology 20031001

Title: Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

Journal: Chembiochem : a European journal of chemical biology 20030804

Title: Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Changes in nuclear matrix proteins during the senescence-like phenomenon induced by 5-chlorodeoxyuridine in HeLa cells.

Journal: Experimental gerontology 20020701

Title: 5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.

Journal: Bioorganic & medicinal chemistry letters 20020211

Title: [Chromosomal abnormalities in lymphocytes from a patient with Werner's syndrome in intact culture and after treatment with halogenated analogs of thymidine].

Journal: Tsitologiia 20020101

Title: Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections.

Journal: Clinical microbiology reviews 20010401

Title: Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.

Journal: Journal of medicinal chemistry 19860701

Title: Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.

Journal: Journal of medicinal chemistry 19770701

Title: Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.

Journal: Journal of medicinal chemistry 19660501

Title: Kim CH, et al. Polymerase incorporation and miscoding properties of 5-chlorouracil. Chem Res Toxicol. 2010 Apr 19;23(4):740-8.

Title: Yuan CJ, et al. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav. 2011 Nov;100(1):98-108.

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Tags:50-90-8 Molecular Formula|50-90-8 MDL|50-90-8 SMILES|50-90-8 Uridine, 5-chloro-2'-deoxy-