Home Amines 64544-07-6
64544-07-6,MFCD00864991
Catalog No.:AA01CCFX

64544-07-6 | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$50.00   $35.00
- +
250mg
745 - 875 µg/mg (Cefuroxime , C16H16N4O8S Assay on the anhydrous basis)
in stock  
$115.00   $80.00
- +
1g
745 - 875 µg/mg (Cefuroxime , C16H16N4O8S Assay on the anhydrous basis)
in stock  
$265.00   $185.00
- +
5g
745 - 875 µg/mg (Cefuroxime , C16H16N4O8S Assay on the anhydrous basis)
in stock  
$550.00   $385.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CCFX
Chemical Name:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-
CAS Number:
64544-07-6
Molecular Formula:
C20H22N4O10S
Molecular Weight:
510.4745
MDL Number:
MFCD00864991
SMILES:
CO/N=C(/c1ccco1)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)OC(OC(=O)C)C)COC(=O)N
Properties
Computed Properties
 
Complexity:
968  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.9  

Literature

Title: Thrombotic thrombocytopenic purpura after prophylactic cefuroxime axetil administered in relation to a liposuction procedure.

Journal: Aesthetic plastic surgery 20120401

Title: A probable association of panic attack with cephuroxime (cefuroxime) axetil administration.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20120110

Title: Preformulation studies for direct compression suitability of cefuroxime axetil and paracetamol: a graphical representation using SeDeM diagram.

Journal: Acta poloniae pharmaceutica 20120101

Title: Cefuroxime-axetil induced allergic angina: an insight into classification management of Kounis syndrome.

Journal: International journal of cardiology 20110901

Title: Comparison of single-dose and multiple-dose antibiotics for lower urinary tract infection in pregnancy.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20110901

Title: Comparative bioavailability study of cefuroxime axetil (equivalent to 500 mg cefuroxime/tablet) tablets (Zednad® versus Zinnat®) in healthy male volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20110901

Title: Liquid antisolvent preparation of amorphous cefuroxime axetil nanoparticles in a tube-in-tube microchannel reactor.

Journal: International journal of pharmaceutics 20100816

Title: HPTLC determination of cefuroxime axetil and ornidazole in combined tablet dosage form.

Journal: Journal of chromatographic science 20100101

Title: Subjective symptoms after treatment of early Lyme disease.

Journal: The American journal of medicine 20100101

Title: Comparative bioavailability of cefuroxime axetil suspension formulations administered with food in healthy subjects.

Journal: Arzneimittel-Forschung 20100101

Title: Chiral separation of diastereoisomers of cefuroxime axetil by high-performance thin-layer chromatography.

Journal: Journal of AOAC International 20100101

Title: Cefuroxime axetil-induced liver failure.

Journal: Annals of hepatology 20100101

Title: Kounis Syndrome secondary to cefuroxime axetil use in an asthmatic patient.

Journal: International journal of cardiology 20091112

Title: [Lyme borreliosis: How should erythema migrans be treated in pregnant women?].

Journal: Deutsche medizinische Wochenschrift (1946) 20091101

Title: Improvement of psoriasis after antibiotic therapy with cefuroxime axetil.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20090801

Title: Cefuroxime axetil solid dispersion with polyglycolized glycerides for improved stability and bioavailability.

Journal: The Journal of pharmacy and pharmacology 20090601

Title: Synthesis and antibacterial activity of some new 2,3-dimethoxy-3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chromanones.

Journal: European journal of medicinal chemistry 20090401

Title: Infections as complications of neuroleptic malignant syndrome.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: Antibacterial activities of amorphous cefuroxime axetil ultrafine particles prepared by high gravity antisolvent precipitation (HGAP).

Journal: Pharmaceutical development and technology 20090101

Title: Simultaneous determination of cefuroxime axetil and ornidazole in tablet dosage form using reversed-phase high performance liquid chromatography.

Journal: Se pu = Chinese journal of chromatography 20081101

Title: Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080901

Title: [Studies on the action features between cefuroxime axetil and bovine serum albumin].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20080901

Title: Kounis syndrome secondary to cefuroxime-axetil use in an octogenarian.

Journal: Journal of the American Geriatrics Society 20080901

Title: Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model.

Journal: Langmuir : the ACS journal of surfaces and colloids 20080715

Title: What is a suitable dissolution method for drug nanoparticles?

Journal: Pharmaceutical research 20080701

Title: Neurological picture. Horner syndrome due to jugular vein thrombosis (Lemierre syndrome).

Journal: Journal of neurology, neurosurgery, and psychiatry 20080301

Title: Sequential therapy with cefuroxime and cefuroxime-axetil for community-acquired lower respiratory tract infection in the oldest old.

Journal: Aging clinical and experimental research 20080201

Title: Stability of cefuroxime axetil oral suspension at different temperature storage conditions.

Journal: Bosnian journal of basic medical sciences 20080201

Title: Effect of malnutrition on the pharmacokinetics of cefuroxime axetil in young rats.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

Title: Fatal toxic epidermal necrolysis and severe granulocytopenia following therapy with cefuroxime.

Journal: Acta dermatovenerologica Croatica : ADC 20080101

Title: A randomized study of sequential intravenous/oral moxifloxacin in comparison to sequential intravenous ceftriaxone/oral cefuroxime axetil in patients with hospital-acquired pneumonia.

Journal: Infection 20071201

Title: Nosocomial pneumonia - are economical considerations important?

Journal: Infection 20071201

Title: Anaphylactic shock associated with cefuroxime axetil: structure-activity relationships.

Journal: The Annals of pharmacotherapy 20070601

Title: Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy?

Journal: International urogynecology journal and pelvic floor dysfunction 20070501

Title: [Sudden lameness in an afebrile infant].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20070401

Title: Designing a self-associated cationic polymer for enhanced compatibility, palatability, and gastric release of cefuroxime axetil.

Journal: Biomacromolecules 20070201

Title: Comparison of two oral regimens for the outpatient treatment of low-risk cancer patients with chemotherapy-induced neutropenia and fever: ciprofloxacin plus cefuroxime axetil versus ciprofloxacin plus amoxicillin/clavulanate.

Journal: Scandinavian journal of infectious diseases 20070101

Title: Antabuse reaction with ceftin.

Journal: The American journal of psychiatry 20061101

Title: Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants.

Journal: International journal of pharmaceutics 20061012

Title: Randomized double-blind study comparing 7- and 10-day regimens of faropenem medoxomil with a 10-day cefuroxime axetil regimen for treatment of acute bacterial sinusitis.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20061001

Title: A stability indicating assay method for cefuroxime axetil and its application to analysis of tablets exposed to accelerated stability test conditions.

Journal: Journal of chromatography. A 20060630

Title: The stability of the amorphous form of cefuroxime axetil in solid state.

Journal: Journal of pharmaceutical and biomedical analysis 20060607

Title: Intragastric floating drug delivery system of cefuroxime axetil: in vitro evaluation.

Journal: AAPS PharmSciTech 20060601

Title: Disappearance of middle ear effusion in acute otitis media monitored daily with tympanometry.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20060301

Title: Deep neck infection complicating lymphadenitis caused by Streptococcus intermedius in an immunocompetent child.

Journal: BMC infectious diseases 20060101

Title: Cefuroxime axetil solid dispersions prepared using solution enhanced dispersion by supercritical fluids.

Journal: The Journal of pharmacy and pharmacology 20051201

Title: Telithromycin for the treatment of acute bacterial maxillary sinusitis: a review of a new antibacterial agent.

Journal: Southern medical journal 20050901

Title: Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: a randomized, controlled trial.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20050901

Title: [Chronic sinusitis therapy with antibiotics (axetyl cefuroxym, clarithromycin) and steroid (prednisone)].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050901

Title: Treatment of Lyme disease.

Journal: The Medical letter on drugs and therapeutics 20050523

Title: Clinical and bacteriological efficacy of 5-day telithromycin in acute maxillary sinusitis: a pooled analysis.

Journal: The Journal of infection 20050401

Title: Postcoital allergic reaction in a woman.

Journal: The Journal of emergency medicine 20050201

Title: The stability of Cefuroxime axetil in tablets.

Journal: Acta poloniae pharmaceutica 20050101

Title: [Pharmacoeconomic analysis of patients with acute exacerbation of chronic bronchitis treated with telithromycin or cefuroxime-axetil].

Journal: Revista clinica espanola 20041101

Title: Cholestatic attack due to ampicillin and cross-reactivity to cefuroxime.

Journal: The Annals of pharmacotherapy 20040901

Title: Bioequivalence evaluation of 2 brands of cefuroxime axetil 250 mg tablets in healthy human volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20040701

Title: Streptococcal-A tonsillopharyngitis: a 5-day course of cefuroxime axetil versus a 10-day course of penicillin V. results depending on the children's age.

Journal: Chemotherapy 20040401

Title: Short-term and long-term outcomes of moxifloxacin compared to standard antibiotic treatment in acute exacerbations of chronic bronchitis.

Journal: Chest 20040301

Title: Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs).

Journal: Advanced drug delivery reviews 20040223

Title: Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040205

Title: Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201

Title: A bioequivalence study of the cefuroxime axetil in healthy volunteers.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20031101

Title: Evaluation of stability of cefuroxime axetil in solid state.

Journal: Journal of pharmaceutical and biomedical analysis 20030821

Title: Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis.

Journal: Thorax 20030801

Title: Comparison of the efficacy and safety of faropenem daloxate and cefuroxime axetil for the treatment of acute bacterial maxillary sinusitis in adults.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20030401

Title: Oral gemifloxacin once daily for 5 days compared with sequential therapy with i.v. ceftriaxone/oral cefuroxime (maximum of 10 days) in the treatment of hospitalized patients with acute exacerbations of chronic bronchitis.

Journal: Respiratory medicine 20030301

Title: Oral telithromycin 800 mg once daily for 5 days versus cefuroxime axetil 500 mg twice daily for 10 days in adults with acute exacerbations of chronic bronchitis.

Journal: The Journal of international medical research 20030101

Title: A comparison of the efficacy of telithromycin versus cefuroxime axetil in the treatment of acute bacterial maxillary sinusitis.

Journal: American journal of rhinology 20030101

Title: [Evaluation of drug sensitivity of the microorganisms isolated from chronic sinusitis treated by beta lactam antibiotics].

Journal: Otolaryngologia polska = The Polish otolaryngology 20030101

Title: Open-label, randomized comparison of the efficacy and tolerability of clarithromycin, levofloxacin, and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis.

Journal: Clinical therapeutics 20020901

Title: Comparative study of cefuroxime axetil versus amoxicillin in children with early Lyme disease.

Journal: Pediatrics 20020601

Title: Intestinal transport of cefuroxime axetil in rats: absorption and hydrolysis processes.

Journal: International journal of pharmaceutics 20020302

Title: Comparative study of cefaclor AF vs. cefuroxime axetil in acute exacerbations of chronic bronchitis.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020101

Title: Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial.

Journal: JAMA 20011226

Title: Effects of cefuroxime axetil on Staphylococcus aureus colonization and superantigen production in atopic dermatitis.

Journal: The Journal of allergy and clinical immunology 20011001

Title: Evaluation of oral antimicrobial agent levels in tooth extraction sites.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010601

Title: Ecological effects on the oro- and nasopharyngeal microflora in children after treatment of acute otitis media with cefuroxime axetil or amoxycillin-clavulanate as suspensions.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20010501

Title: Isolation of Borrelia burgdorferi sensu lato from blood of children with solitary erythema migrans.

Journal: The Pediatric infectious disease journal 20010301

Title: Computed tomography imaging of the maxillary and ethmoid sinuses in children with short-duration purulent rhinorrhea.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20010201

Title: Cefuroxime axetil: an updated review of its use in the management of bacterial infections.

Journal: Drugs 20010101

Title: [Comparative clinical efficacy and tolerance of cefuroxime axetil (zinnat) and ceftibuten (cedex) in patients with acute sinusitis].

Journal: Vestnik otorinolaringologii 20010101

Title: Bilateral renal cortical necrosis associated with cefuroxime axetil.

Journal: Clinical nephrology 19980401

Title: Sequential therapy with cefuroxime followed by cefuroxime axetil in acute exacerbations of chronic bronchitis.

Journal: The Journal of antimicrobial chemotherapy 19971201

Title: Cefuroxime axetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.

Journal: Drugs 19960701

Title: Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells.

Journal: Biochimica et biophysica acta 19940420

Title: Scott LJ, et al. Cefuroxime axetil: an updated review of its use in the management of bacterial infections. Drugs. 2001;61(10):1455-500.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:64544-07-6 Molecular Formula|64544-07-6 MDL|64544-07-6 SMILES|64544-07-6 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, 1-(acetyloxy)ethyl ester, (6R,7R)-