Title: Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model.

Journal: Toxicology letters20180515

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.

Journal: Bioorganic & medicinal chemistry letters20130301

Title: Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.

Journal: Behavioural brain research20121201

Title: Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor.

Journal: Synapse (New York, N.Y.)20121201

Title: Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development.

Journal: Bioorganic & medicinal chemistry letters20121115

Title: Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats.

Journal: Neuroscience letters20121114

Title: The suppressive effect of metabotropic glutamate receptor 5 (mGlu5) inhibition on hepatocarcinogenesis.

Journal: Biochimie20121101

Title: Epileptic stimulus increases Homer 1a expression to modulate endocannabinoid signaling in cultured hippocampal neurons.

Journal: Neuropharmacology20121101

Title: Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.

Journal: Molecular pharmacology20121101

Title: Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: role of brain-derived neurotrophic factor.

Journal: Neuroscience20121025

Title: Electrophysiological and behavioral effects of group I metabotropic glutamate receptors on pallidal neurons in rats.

Journal: Brain research20121005

Title: Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum.

Journal: Neuroscience20120906

Title: Role of metabotropic glutamate receptors in the mechanisms of experimental parkinsonism development.

Journal: Bulletin of experimental biology and medicine20120901

Title: Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells.

Journal: Stem cells and development20120810

Title: Involvement of metabotropic glutamate receptor 5 signaling in activity-related proliferation of adult hippocampal neural stem cells.

Journal: The European journal of neuroscience20120801

Title: Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20120711

Title: Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model.

Journal: Pharmacology, biochemistry, and behavior20120701

Title: Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice.

Journal: The European journal of neuroscience20120601

Title: Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20120501

Title: The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug.

Journal: Neuropharmacology20120401

Title: Structure-activity relationships for negative allosteric mGluR5 modulators.

Journal: ChemMedChem20120305

Title: Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity.

Journal: Biochimie20120301

Title: Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear.

Journal: Neuropharmacology20120301

Title: Action of molecular switches in GPCRs--theoretical and experimental studies.

Journal: Current medicinal chemistry20120301

Title: Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model.

Journal: CNS & neurological disorders drug targets20120301

Title: New perspectives on glutamate receptor antagonists as antidepressants.

Journal: Archives of pharmacal research20120301

Title: Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.

Journal: Psychopharmacology20120201

Title: Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways.

Journal: Neuroscience letters20120117

Title: Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c.

Journal: Neurobiology of learning and memory20120101

Title: Differential involvement of mGluR1 and mGluR5 in memory reconsolidation and retrieval in a passive avoidance task in 1-day old chicks.

Journal: Neurobiology of learning and memory20120101

Title: Hemodynamic responses evoked by neuronal stimulation via channelrhodopsin-2 can be independent of intracortical glutamatergic synaptic transmission.

Journal: PloS one20120101

Title: Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73.

Journal: Frontiers in psychiatry20120101

Title: Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.

Journal: Scientific reports20120101

Title: Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.

Journal: PloS one20120101

Title: The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro.

Journal: BMC medical genetics20120101

Title: Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception.

Journal: Molecular pain20120101

Title: mGlu5 Receptor Functional Interactions and Addiction.

Journal: Frontiers in pharmacology20120101

Title: Inhibition mechanism and model of an angiotensin I-converting enzyme (ACE)-inhibitory hexapeptide from yeast (Saccharomyces cerevisiae).

Journal: PloS one20120101

Title: Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats.

Journal: International journal of nanomedicine20120101

Title: Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome.

Journal: Neural plasticity20120101

Title: Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice.

Journal: Behavioral and brain functions : BBF20120101

Title: Modulation of endocannabinoid-mediated long-lasting disinhibition of striatal output by cholinergic interneurons.

Journal: Neuropharmacology20111201

Title: Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

Journal: Neuropharmacology20111201

Title: Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain.

Journal: Behavioural pharmacology20111201

Title: Early, time-dependent disturbances of hippocampal synaptic transmission and plasticity after in utero immune challenge.

Journal: Biological psychiatry20111115

Title: Polymodal activation of the endocannabinoid system in the extended amygdala.

Journal: Nature neuroscience20111106

Title: CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics20111101

Title: Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.

Journal: Journal of neurophysiology20111101

Title: Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats.

Journal: The Chinese journal of physiology20111031

Title: Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disorders.

Journal: Brain research bulletin20111010

Title: The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl) pyridine decreases striatal VGlut2 expression in association with an attenuation of L-DOPA-induced dyskinesias.

Journal: Synapse (New York, N.Y.)20111001

Title: Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats.

Journal: Behavioural brain research20111001

Title: The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors.

Journal: Addiction biology20111001

Title: Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro.

Journal: Neuroscience20110929

Title: Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.

Journal: The Journal of pharmacology and experimental therapeutics20110901

Title: Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase.

Journal: Disease models & mechanisms20110901

Title: Discriminative stimulus effects of NMDA, AMPA, and mGluR5 glutamate receptor ligands in methamphetamine-trained rats.

Journal: Behavioural pharmacology20110901

Title: Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation.

Journal: Neuroscience letters20110818

Title: Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801's antiseizure potency in the genetically inbred Balb/c mouse.

Journal: Epilepsy & behavior : E&B20110801

Title: Progress in structure based drug design for G protein-coupled receptors.

Journal: Journal of medicinal chemistry20110714

Title: A role for glutamate in subjective response to smoking and its action on inhibitory control.

Journal: Psychopharmacology20110701

Title: Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110615

Title: The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain.

Journal: Behavioural brain research20110601

Title: A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

Journal: Neurobiology of disease20110601

Title: Group I mGluR-regulated translation of the neuronal glutamate transporter, excitatory amino acid carrier 1.

Journal: Journal of neurochemistry20110601

Title: Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series.

Journal: Bioorganic & medicinal chemistry letters20110601

Title: Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice.

Journal: Psychopharmacology20110501

Title: Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome.

Journal: Psychopharmacology20110501

Title: Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.

Journal: Bioorganic & medicinal chemistry letters20110501

Title: Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

Journal: Neuropharmacology20110501

Title: Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.

Journal: Molecular pharmacology20110501

Title: Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110413

Title: Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110413

Title: Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine.

Journal: Psychopharmacology20110401

Title: Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20110401

Title: Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110316

Title: Blockade of mGLUR5 receptors differentially alters amphetamine-induced enhancement of locomotor activity and of brain stimulation reward.

Journal: Journal of psychopharmacology (Oxford, England)20110301

Title: Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses.

Journal: Cerebral cortex (New York, N.Y. : 1991)20110301

Title: Effects of CNQX and MPEP on sensitization to the rewarding effects of morphine.

Journal: European journal of pharmacology20110301

Title: Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons.

Journal: The European journal of neuroscience20110301

Title: Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist produces anxiolytic-like effects and reverses abnormal firing activity of projection neurons in the basolateral nucleus of the amygdala in rats with bilateral 6-OHDA lesions.

Journal: Brain research bulletin20110227

Title: Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.

Journal: Journal of medicinal chemistry20110210

Title: Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking.

Journal: Alcohol (Fayetteville, N.Y.)20110201

Title: The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats.

Journal: Addiction biology20110101

Title: Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse.

Journal: Neurobiology of disease20110101

Title: Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20110101

Title: Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.

Journal: Journal of biomedical science20110101

Title: [Effects of chronic, systemic treatment with metabotropic glutamate receptor 5 antagonist on behavioral activity and neuroprotection in a preclinical rat model of Parkinson's disease].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20110101

Title: Metabotropic glutamate receptors as novel therapeutic targets on visceral sensory pathways.

Journal: Frontiers in neuroscience20110101

Title: Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses.

Journal: Frontiers in cellular neuroscience20110101

Title: Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression.

Journal: PloS one20110101

Title: Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.

Journal: PloS one20110101

Title: mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism.

Journal: PloS one20110101

Title: Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

Journal: PloS one20110101

Title: Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.

Journal: Frontiers in pharmacology20110101

Title: Validating γ oscillations and delayed auditory responses as translational biomarkers of autism.

Journal: Biological psychiatry20101215

Title: Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.

Journal: Molecular pharmacology20101201

Title: Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20101117

Title: Regional differences in neurovascular coupling in rat brain as determined by fMRI and electrophysiology.

Journal: NeuroImage20101101

Title: A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca(v)2.3 R-type calcium channels in CA1 pyramidal neurons.

Journal: PLoS biology20101101

Title: Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20101020

Title: Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats.

Journal: European journal of pharmacology20101010

Title: Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes.

Journal: Neuron20101006

Title: The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.

Journal: Pharmacogenetics and genomics20100901

Title: Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.

Journal: Dialogues in clinical neuroscience20100901

Title: Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.

Journal: European journal of pharmacology20100810

Title: Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator.

Journal: European journal of pharmacology20100810

Title: The HIV-1 viral protein Tat increases glutamate and decreases GABA exocytosis from human and mouse neocortical nerve endings.

Journal: Cerebral cortex (New York, N.Y. : 1991)20100801

Title: Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20100801

Title: Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20100801

Title: D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

Journal: Neuroscience letters20100712

Title: Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain.

Journal: Journal of neurochemistry20100701

Title: The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine.

Journal: Psychopharmacology20100701

Title: Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.

Journal: The European journal of neuroscience20100701

Title: Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats.

Journal: Epilepsia20100701

Title: Modulators of metabotropic glutamate receptors microinfused into perirhinal cortex: anticonvulsant effects in rats challenged with soman.

Journal: European journal of pharmacology20100625

Title: Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100616

Title: Delayed stabilization of dendritic spines in fragile X mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100609

Title: Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys.

Journal: Neuropharmacology20100601

Title: Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20100601

Title: Beyond acid suppression: new pharmacologic approaches for treatment of GERD.

Journal: Current gastroenterology reports20100601

Title: Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake.

Journal: Biological psychiatry20100501

Title: The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.

Journal: Psychopharmacology20100501

Title: Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

Journal: Bioorganic & medicinal chemistry20100501

Title: Effects of early and delayed treatment with an mGluR5 antagonist on motor impairment, nigrostriatal damage and neuroinflammation in a rodent model of Parkinson's disease.

Journal: Brain research bulletin20100429

Title: An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.

Journal: PLoS biology20100401

Title: The modified Geller-Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5-HT1A receptor activation.

Journal: Behavioural brain research20100317

Title: Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20100301

Title: Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100224

Title: Nicotine-induced conditioned place preference in rats: sex differences and the role of mGluR5 receptors.

Journal: Neuropharmacology20100201

Title: Developmental alteration of endocannabinoid retrograde signaling in the hippocampus.

Journal: Journal of neurophysiology20100201

Title: Reduction of increased repetitive self-grooming in ASD mouse model by metabotropic 5 glutamate receptor antagonism; randomized controlled trial of Early Start Denver Model.

Journal: Autism research : official journal of the International Society for Autism Research20100201

Title: Electrophysiological characterization of the rat trigeminal caudalis (Vc) neurons following intramuscular injection of capsaicin.

Journal: Neuroscience letters20100129

Title: Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-).

Journal: Toxicology and applied pharmacology20100115

Title: Repeated cocaine administration increases B-cell leukemia/lymphoma 2 phosphorylation in the rat dorsal striatum.

Journal: Neuroscience letters20100104

Title: Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20100101

Title: Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain.

Journal: Journal of neurochemistry20100101

Title: MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta.

Journal: International journal of clinical and experimental pathology20100101

Title: Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.

Journal: Molecular brain20100101

Title: The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia.

Journal: International journal of molecular sciences20100101

Title: Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.

Journal: PloS one20100101

Title: Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).

Journal: PloS one20100101

Title: Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.

Journal: The open medicinal chemistry journal20100101

Title: Metabotropic glutamate receptors: their therapeutic potential in anxiety.

Journal: Current topics in behavioral neurosciences20100101

Title: Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells.

Journal: Neuroscience letters20091225

Title: Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain.

Journal: Pain20091215

Title: Effects of mGluR5 and mGluR1 antagonists on anxiety-like behavior and learning in developing rats.

Journal: Behavioural brain research20091201

Title: Synaptic plasticity in the adult visual cortex is regulated by the metabotropic glutamate receptor, mGluR5.

Journal: Experimental brain research20091201

Title: Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS.

Journal: Bioorganic & medicinal chemistry letters20091201

Title: Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats.

Journal: Neuroscience20091110

Title: Non-competitive metabotropic glutamate 1 receptor antagonists block activity of slowly adapting type I mechanoreceptor units in the rat sinus hair follicle.

Journal: Neuroscience20091020

Title: Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats.

Journal: Toxicology and applied pharmacology20091015

Title: Dopamine D1 receptor-dependent modifications in the dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa phosphorylation pattern in striatal areas of morphine-sensitized rats.

Journal: Neuroscience20091006

Title: Effect of the metabotropic glutamate antagonist MPEP on striatal expression of the Homer family proteins in levodopa-treated hemiparkinsonian rats.

Journal: Psychopharmacology20091001

Title: Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking.

Journal: Behavioural brain research20090914

Title: Depolarization-induced slow current in cerebellar Purkinje cells does not require metabotropic glutamate receptor 1.

Journal: Neuroscience20090901

Title: A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.

Journal: Gut20090901

Title: Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats.

Journal: Epilepsia20090901

Title: The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

Journal: The Journal of pharmacology and experimental therapeutics20090901

Title: Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist in 6-hydroxydopamine partially lesioned rats reverses abnormal firing of dopaminergic neurons.

Journal: Brain research20090825

Title: Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription.

Journal: Neuroscience letters20090821

Title: [Expression of metabotropic glutamate receptor 5 in spinal cord of morphine tolerant rats].

Journal: Zhonghua yi xue za zhi20090818

Title: Pharmacological characterization of harmaline-induced tremor activity in mice.

Journal: European journal of pharmacology20090815

Title: A role for SNAP25 in internalization of kainate receptors and synaptic plasticity.

Journal: Neuron20090813

Title: Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

Journal: Molecular pharmacology20090801

Title: Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20090729

Title: Limbic epileptogenesis in a mouse model of fragile X syndrome.

Journal: Cerebral cortex (New York, N.Y. : 1991)20090701

Title: Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice.

Journal: Journal of neurochemistry20090701

Title: DHPG activation of group 1 mGluRs in BLA enhances fear conditioning.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20090701

Title: Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

Journal: Journal of medicinal chemistry20090611

Title: Differential effects of MPEP and diazepam in tests of conditioned emotional response and Pavlovian-to-instrumental transfer suggests 'anxiolytic' effects are mediated by different mechanisms.

Journal: Psychopharmacology20090601

Title: Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey.

Journal: The Journal of physiology20090601

Title: Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability.

Journal: The European journal of neuroscience20090601

Title: Selective blockade of mGlu5 metabotropic glutamate receptors is hepatoprotective against fulminant hepatic failure induced by lipopolysaccharide and D-galactosamine in mice.

Journal: Journal of applied toxicology : JAT20090501

Title: The mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) supports intravenous self-administration and induces conditioned place preference in the rat.

Journal: European journal of pharmacology20090401

Title: Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats.

Journal: Neuroscience letters20090320

Title: 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates ketamine and heroin reward as assessed by acquisition, extinction, and reinstatement of conditioned place preference in the rat.

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Title: Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol A.

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Title: CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20090301

Title: Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor.

Journal: Neuropharmacology20090301

Title: Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system.

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Title: Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease.

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Title: Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.

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Title: Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.

Journal: PloS one20090101

Title: Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG.

Journal: PloS one20090101

Title: Activity-dependent modulation of neural circuit synaptic connectivity.

Journal: Frontiers in molecular neuroscience20090101

Title: Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus oralis of the rat.

Journal: Molecular pain20090101

Title: Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.

Journal: Frontiers in neural circuits20090101

Title: Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.

Journal: Journal of biomedical science20090101

Title: Fragile X syndrome -- from genes to cognition.

Journal: Developmental disabilities research reviews20090101

Title: Effect of MPEP on rat's behavioral activity in experimental episodes of hypoxia.

Journal: Advances in medical sciences20090101

Title: mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum.

Journal: Frontiers in neuroscience20090101

Title: D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20081224

Title: Role of metabotropic glutamate receptor 5 in the procholinergic effects of neuropsychotherapeutic compounds.

Journal: Synapse (New York, N.Y.)20081201

Title: The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice.

Journal: Neuroscience20081119

Title: Focal degeneration of astrocytes in amyotrophic lateral sclerosis.

Journal: Cell death and differentiation20081101

Title: Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.

Journal: Epilepsy research20081101

Title: Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice.

Journal: Alcoholism, clinical and experimental research20081101

Title: Glutamate: the new frontier in pharmacotherapy for cocaine addiction.

Journal: CNS & neurological disorders drug targets20081101

Title: Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine.

Journal: Psychopharmacology20081001

Title: Effect of a metabotropic glutamate receptor 5 antagonist, MPEP, on the nociceptive response induced by intrathecal injection of excitatory aminoacids, substance P, bradykinin or cytokines in mice.

Journal: Pharmacology, biochemistry, and behavior20081001

Title: Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology20081001

Title: Activation of metabotropic glutamate 5 (mGlu5) receptors induces spontaneous excitatory synaptic currents in layer V pyramidal cells of the rat prefrontal cortex.

Journal: Neuroscience letters20080919

Title: In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080910

Title: Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions.

Journal: The international journal of neuropsychopharmacology20080901

Title: Effect of selective antagonists of group I metabotropic glutamate receptors on the micturition reflex in rats.

Journal: BJU international20080901

Title: Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro.

Journal: Neuroscience research20080901

Title: Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor.

Journal: Neuropharmacology20080901

Title: Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

Journal: Neuropharmacology20080901

Title: Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP.

Journal: Neuropharmacology20080901

Title: Functional interaction between adenosine A2A and group III metabotropic glutamate receptors to reduce parkinsonian symptoms in rats.

Journal: Neuropharmacology20080901

Title: MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats.

Journal: Behavioural brain research20080822

Title: Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080801

Title: Wiring and volume transmission in rat amygdala. Implications for fear and anxiety.

Journal: Neurochemical research20080801

Title: Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide].

Journal: The Journal of pharmacology and experimental therapeutics20080801

Title: Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region.

Journal: Journal of neurophysiology20080801

Title: Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway.

Journal: Organic letters20080703

Title: Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.

Journal: Neurobiology of disease20080701

Title: Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.

Journal: European journal of pharmacology20080531

Title: Inhibition of MPEP on the development of morphine antinociceptive tolerance and the biosynthesis of neuronal nitric oxide synthase in rat spinal cord.

Journal: Neuroscience letters20080509

Title: Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro.

Journal: Neuroscience letters20080509

Title: Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice.

Journal: Psychopharmacology20080501

Title: Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice.

Journal: Alcohol (Fayetteville, N.Y.)20080501

Title: Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP.

Journal: European journal of pharmacology20080428

Title: Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons.

Journal: Cell death and differentiation20080401

Title: Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens.

Journal: Neuropharmacology20080401

Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Journal: Nature chemical biology20080401

Title: Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena.

Journal: Bioorganic & medicinal chemistry letters20080315

Title: Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.

Journal: Brain research20080310

Title: Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model.

Journal: Neuroreport20080305

Title: Metabotropic glutamate receptors subtype 5 are necessary for the enhancement of auditory evoked potentials in the lateral nucleus of the amygdala by tetanic stimulation of the auditory thalamus.

Journal: Neuroscience20080303

Title: N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

Journal: Molecular pharmacology20080301

Title: Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

Journal: The European journal of neuroscience20080301

Title: Alcohol related changes in regulation of NMDA receptor functions.

Journal: Current neuropharmacology20080301

Title: Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats.

Journal: European journal of pharmacology20080212

Title: Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner.

Journal: Journal of neurophysiology20080201

Title: Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.

Journal: Alcoholism, clinical and experimental research20080201

Title: Auditory fear conditioning modulates prepulse inhibition in socially reared rats and isolation-reared rats.

Journal: Behavioral neuroscience20080201

Title: Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor.

Journal: European journal of pharmacology20080128

Title: Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080123

Title: mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.

Journal: Brain research20080102

Title: Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus.

Journal: Neuroscience20080102

Title: Modulation of defensive responses and anxiety-like behaviors by group I metabotropic glutamate receptors located in the dorsolateral periaqueductal gray.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20080101

Title: Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson's disease.

Journal: Neurobiology of disease20080101

Title: Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice.

Journal: Alcoholism, clinical and experimental research20080101

Title: Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors.

Journal: BMC bioinformatics20080101

Title: Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents.

Journal: PloS one20080101

Title: MGluR5 mediates the interaction between late-LTP, network activity, and learning.

Journal: PloS one20080101

Title: Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo.

Journal: PloS one20080101

Title: FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20071226

Title: Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5.

Journal: Synapse (New York, N.Y.)20071201

Title: Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus.

Journal: Neuropharmacology20071201

Title: Effect of 2-methyl-6-(phenylethynyl) pyridine on intravenous self-administration of ketamine and heroin in the rat.

Journal: Behavioural pharmacology20071201

Title: Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway.

Journal: Journal of neurochemistry20071101

Title: Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.

Journal: Journal of neurochemistry20071101

Title: Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning.

Journal: Neurobiology of learning and memory20071001

Title: Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20071001

Title: Different effects of ionotropic and metabotropic glutamate receptor antagonists on attention and the attentional properties of nicotine.

Journal: Neuropharmacology20070901

Title: Allosteric modulators for mGlu receptors.

Journal: Current neuropharmacology20070901

Title: Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.

Journal: Current neuropharmacology20070901

Title: Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.

Journal: Bioorganic & medicinal chemistry letters20070815

Title: Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery.

Journal: European journal of pain (London, England)20070801

Title: Stress-induced hyperthermia: effects of acute and repeated dosing of MPEP.

Journal: European journal of pharmacology20070730

Title: Water T-maze, an improved method to assess spatial working memory in rats: Pharmacological validation.

Journal: Neuroscience letters20070718

Title: Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.

Journal: Journal of medicinal chemistry20070712

Title: Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats.

Journal: Psychopharmacology20070701

Title: Differential activation of protein kinases in the dorsal horn in vitro of normal and inflamed rats by group I metabotropic glutamate receptor subtypes.

Journal: Neuropharmacology20070701

Title: Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20070701

Title: Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat.

Journal: Neuroscience letters20070613

Title: Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity.

Journal: Journal of neurophysiology20070601

Title: Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.

Journal: Bioorganic & medicinal chemistry letters20070601

Title: mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption.

Journal: European journal of pharmacology20070521

Title: Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

Journal: Molecular pharmacology20070501

Title: Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition.

Journal: Journal of neuroscience research20070501

Title: mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons.

Journal: Neuropharmacology20070501

Title: (+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.

Journal: Journal of psychopharmacology (Oxford, England)20070501

Title: Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus.

Journal: European journal of pharmacology20070430

Title: Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms.

Journal: Neuroscience20070425

Title: The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation.

Journal: Neuroscience letters20070412

Title: Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists.

Journal: Bioorganic & medicinal chemistry letters20070401

Title: Effects of MPEP on avoidance learning in rats.

Journal: Methods and findings in experimental and clinical pharmacology20070401

Title: Cocaine increases endoplasmic reticulum stress protein expression in striatal neurons.

Journal: Neuroscience20070316

Title: Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation.

Journal: Cerebral cortex (New York, N.Y. : 1991)20070301

Title: The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.

Journal: Neuropharmacology20070301

Title: Stimulation of group I mGlu receptors in the ventrotegmental area enhances extracellular dopamine in the rat medial prefrontal cortex.

Journal: Journal of neurochemistry20070301

Title: Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters20070301

Title: Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists.

Journal: Neuroscience letters20070202

Title: Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20070201

Title: Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats.

Journal: Neuropharmacology20070201

Title: Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5.

Journal: American journal of physiology. Gastrointestinal and liver physiology20070201

Title: ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies.

Journal: Bioorganic & medicinal chemistry20070115

Title: Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats.

Journal: European journal of pharmacology20070112

Title: Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo.

Journal: European journal of pharmacology20070105

Title: Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression?

Journal: Biological psychiatry20070101

Title: Effect of MPEP in Morris water maze in adult and old rats.

Journal: Pharmacological reports : PR20070101

Title: Arthritis and pain. Future targets to control osteoarthritis pain.

Journal: Arthritis research & therapy20070101

Title: Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol.

Journal: Visual neuroscience20070101

Title: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.

Journal: BMC structural biology20070101

Title: Recent developments of the PET imaging agents for metabotropic glutamate receptor subtype 5.

Journal: Current topics in medicinal chemistry20070101

Title: Metabotropic glutamate receptors differentially regulate GABAergic inhibition in thalamus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20061227

Title: Mechanisms of glutamate receptor induced proliferation of astrocytes.

Journal: Neuroreport20061218

Title: Participation of peripheral group I and II metabotropic glutamate receptors in the development or maintenance of IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats.

Journal: Neuroscience letters20061206

Title: mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats.

Journal: European journal of pharmacology20061203

Title: Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice.

Journal: European journal of pharmacology20061203

Title: Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome.

Journal: Human molecular genetics20061201

Title: Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.

Journal: Drug and alcohol dependence20061108

Title: Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats.

Journal: Brain research bulletin20061016

Title: A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants.

Journal: European journal of pharmacology20061010

Title: Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice.

Journal: The Journal of pharmacology and experimental therapeutics20061001

Title: Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells.

Journal: Journal of neurochemistry20061001

Title: Changes in mGlu5 receptor expression in the basal ganglia of reserpinised rats.

Journal: European journal of pharmacology20060918

Title: A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).

Journal: Bioorganic & medicinal chemistry letters20060915

Title: Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.

Journal: Neuropharmacology20060901

Title: Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression.

Journal: Neuron20060817

Title: mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones.

Journal: The Journal of physiology20060815

Title: A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.

Journal: Molecular pharmacology20060801

Title: Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

Journal: Journal of neurochemistry20060701

Title: Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists.

Journal: Behavioural pharmacology20060601

Title: Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060503

Title: Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.

Journal: Bioorganic & medicinal chemistry letters20060501

Title: Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors.

Journal: British journal of anaesthesia20060501

Title: The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.

Journal: European journal of pharmacology20060501

Title: Spike-timing-dependent plasticity at resting and conditioned lateral perforant path synapses on granule cells in the dentate gyrus: different roles of N-methyl-D-aspartate and group I metabotropic glutamate receptors.

Journal: The European journal of neuroscience20060501

Title: Anxiolytic-like effects of the selective metabotropic glutamate receptor 5 antagonist MPEP after its intra-amygdaloid microinjection in three different non-conditioned rat models of anxiety.

Journal: The European journal of neuroscience20060501

Title: Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20060401

Title: Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease.

Journal: Neurobiology of disease20060401

Title: Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression.

Journal: Journal of neurophysiology20060401

Title: Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors.

Journal: Molecular pharmacology20060401

Title: A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20060301

Title: Regulation of phosphorylation of NMDA receptor NR1 subunits in the rat neostriatum by group I metabotropic glutamate receptors in vivo.

Journal: Neuroscience letters20060220

Title: Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Journal: Journal of medicinal chemistry20060209

Title: Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors.

Journal: Current opinion in pharmacology20060201

Title: Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.

Journal: Journal of neurochemistry20060201

Title: Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060125

Title: Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.

Journal: European journal of pharmacology20060104

Title: Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors.

Journal: Cerebral cortex (New York, N.Y. : 1991)20060101

Title: Nicotine has a permissive role on the activation of metabotropic glutamate 5 receptors coexisting with nicotinic receptors on rat hippocampal noradrenergic nerve terminals.

Journal: Neurochemistry international20060101

Title: The metabotropic glutamate receptor subtype 5 antagonist MPEP and the Na+ channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions.

Journal: Neuroscience20060101

Title: The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

Journal: Psychopharmacology20060101

Title: Blockade of mGluR glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease.

Journal: The European journal of neuroscience20060101

Title: The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks.

Journal: Neurochemistry international20060101

Title: Effect of MPEP treatment on brain-derived neurotrophic factor gene expression.

Journal: Pharmacological reports : PR20060101

Title: Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

Journal: CNS drug reviews20060101

Title: Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation.

Journal: Neuroscience letters20051230

Title: Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

Journal: Neuropharmacology20051201

Title: A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.

Journal: Molecular pharmacology20051201

Title: The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides.

Journal: Journal of neurochemistry20051201

Title: Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20051109

Title: The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.

Journal: Cerebral cortex (New York, N.Y. : 1991)20051101

Title: Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

Journal: The Journal of pharmacology and experimental therapeutics20051101

Title: Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects.

Journal: Journal of neurochemistry20051101

Title: Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease.

Journal: The European journal of neuroscience20051001

Title: Cochlear dopamine release is modulated by group II metabotropic glutamate receptors via GABAergic neurotransmission.

Journal: Neuroscience letters20050909

Title: Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist.

Journal: European journal of pharmacology20050905

Title: Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception.

Journal: Journal of neurochemistry20050901

Title: Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats.

Journal: Addiction biology20050901

Title: Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands.

Journal: Gastroenterology20050901

Title: Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence.

Journal: The European journal of neuroscience20050901

Title: Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors.

Journal: Nuclear medicine and biology20050801

Title: Activation of group I metabotropic glutamate receptors depresses recurrent inhibition of motoneurons in the neonatal rat spinal cord in vitro.

Journal: Experimental brain research20050701

Title: Retrograde endocannabinoid signaling in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050629

Title: Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.

Journal: British journal of pharmacology20050601

Title: Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson's disease.

Journal: Journal of neuroscience research20050601

Title: Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock.

Journal: The European journal of neuroscience20050601

Title: Behavioral sensitization due to social defeat stress in mice: antagonism at mGluR5 and NMDA receptors.