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138579-66-5,MFCD00144384
Catalog No.:AA01DBL7

138579-66-5 | Galantide

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1mg
≥90% (HPLC)
2 weeks  
$281.00   $197.00
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5mg
≥90% (HPLC)
2 weeks  
$656.00   $460.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01DBL7
Chemical Name:
Galantide
CAS Number:
138579-66-5
Molecular Formula:
C104H151N25O26S
Molecular Weight:
2199.5286
MDL Number:
MFCD00144384
SMILES:
CSCC[C@@H](C(=O)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)CN)CC(C)C)CC(=O)N)CO)C)CC(C)C)CC(C)C)CCC(=O)N)CCC(=O)N)Cc1ccccc1)Cc1ccccc1)CC(C)C
Properties
Computed Properties
 
Complexity:
4770  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
17  
Heavy Atom Count:
156  
Hydrogen Bond Acceptor Count:
28  
Hydrogen Bond Donor Count:
27  
Rotatable Bond Count:
67  
XLogP3:
-0.9  

Literature

Title: Octreotide negates the benefit of galantide when used in the treatment of caerulein-induced acute pancreatitis in mice.

Journal: HPB : the official journal of the International Hepato Pancreato Biliary Association 20100801

Title: The efficacy of combining feG and galantide in mild caerulein-induced acute pancreatitis in mice.

Journal: Peptides 20100601

Title: Galanin mediates the pathogenesis of cerulein-induced acute pancreatitis in the mouse.

Journal: Pancreas 20100301

Title: Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.

Journal: Journal of medicinal chemistry 20100225

Title: The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice.

Journal: Peptides 20100201

Title: Galanin potentiates supramaximal caerulein-stimulated pancreatic amylase secretion via its action on somatostatin secretion.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091201

Title: Galanin modulates vagally induced contractions in the mouse oesophagus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090201

Title: Interactions of galanin with endomorphin-2, vasopressin and oxytocin in nociceptive modulation of the trigemino-hypoglossal reflex in rats.

Journal: Physiological research 20080101

Title: Galanin stimulates hCG induced testicular steroidogenesis in adult but not in immature male rats.

Journal: Indian journal of experimental biology 20070401

Title: Inhibitory effects of different galanin compounds and fragments on osmotically and histamine-induced enhanced vasopressin secretion in rats.

Journal: European journal of pharmacology 20050601

Title: Pro-nociceptive role of peripheral galanin in inflammatory pain.

Journal: Pain 20040701

Title: Direct inhibitory action of galanin on hypothalamic arcuate nucleus neurones expressing galanin receptor Gal-r1 mRNA.

Journal: Neuroendocrinology 20030801

Title: Inhibitory effect of galanin on dopamine-induced enhanced vasopressin secretion in rat neurohypophyseal tissue cultures.

Journal: Regulatory peptides 20021231

Title: Functional and immunocytochemical evidence that galanin is a physiological regulator of human jejunal motility.

Journal: Journal of physiology, Paris 20010101

Title: Langel U, et al. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int J Pept Protein Res. 1992;39(6):516-522.

Title: Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188.

Title: Mulvaney JM, et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100.

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Tags:138579-66-5 Molecular Formula|138579-66-5 MDL|138579-66-5 SMILES|138579-66-5 Galantide