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10378-06-0,MFCD28992015
Catalog No.:AA01DK1B

10378-06-0 | (3aR,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate

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Purity
Availability
Price(USD)
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5mg
98% by HPLC
in stock  
$285.00   $200.00
- +
10mg
98% by HPLC
in stock  
$438.00   $306.00
- +
25mg
98% by HPLC
in stock  
$855.00   $598.00
- +
250mg
75%
in stock  
$1,046.00   $732.00
- +
1g
75%
in stock  
$2,041.00   $1,429.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01DK1B
Chemical Name:
(3aR,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate
CAS Number:
10378-06-0
Molecular Formula:
C14H19NO8
Molecular Weight:
329.3026
MDL Number:
MFCD28992015
SMILES:
CC(=O)OCC1O[C@@H]2OC(=N[C@@H]2C(C1OC(=O)C)OC(=O)C)C
Properties

Downstream Synthesis Route

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[4]CurrentPatentAssignee:JOHNSON&JOHNSONINC-WO2019/53661,2019,A2Locationinpatent:Paragraph0114;0133

[5]CurrentPatentAssignee:UNIVERSITYOFCHICAGO;ANOKIONSA-WO2018/232176,2018,A1Locationinpatent:Paragraph0309;0310

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[17]CurrentPatentAssignee:SUZHOURIBOLIFESCIENCECOLTD-CN111377984,2020,ALocationinpatent:Paragraph0389;0392;0395-0397

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[1]Bernardes,GonaloJ.L.;Kikkeri,Raghavendra;Maglinao,Maha;Laurino,Paola;Collot,Mayeul;Hong,SungYou;Lepenies,Bernd;Seeberger,PeterH.[OrganicandBiomolecularChemistry,2010,vol.8,#21,p.4987-4996]

[2]Yamazaki,Tatsumi;Warren,ChristopherD.;Herscovics,Annette;Jeanloz,RogerW.[CanadianJournalofChemistry,1981,vol.59,p.2247-2252]

[1]Pertel',S.S.;Chirva,V.Ya.[RussianJournalofOrganicChemistry,1993,vol.29,#5.2,p.867-869][ZhurnalOrganicheskoiKhimii,1993,vol.29,#5,p.1051-1053]

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[4]CurrentPatentAssignee:HEBEIUNIVERSITY-CN111748005,2020,ALocationinpatent:Paragraph0050;0052

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[7]Srinivasan,Selvi;Roy,Debashish;Chavas,ThomasE.J.;Vlaskin,Vladimir;Ho,Duy-Khiet;Pottenger,Ayumi;LeGuyader,ClareL.M.;Maktabi,Mahdi;Strauch,Pamela;Jackson,Conner;Flaherty,SiobhanM.;Lin,Hsiuling;Zhang,Jing;Pybus,Brandon;Li,Qigui;Huber,HansE.;Burke,PaulA.;Wesche,David;Rochford,Rosemary;Stayton,PatrickS.[JournalofControlledRelease,2021,vol.331,p.213-227]

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[13]Ivanenkov,YanA.;Majouga,AlexanderG.;Petrov,RostislavA.;Petrov,StanislavA.;Kovalev,SergeyV.;Maklakova,SvetlanaYu.;Yamansarov,EmilYu.;Saltykova,IrinaV.;Deyneka,EkaterinaV.;Filkov,GlebI.;Kotelianski,VictorE.;Zatsepin,TimofeyS.;Beloglazkina,ElenaK.[BioorganicandMedicinalChemistryLetters,2018,vol.28,#3,p.503-508]

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[16]Yamazaki,Tatsumi;Warren,ChristopherD.;Herscovics,Annette;Jeanloz,RogerW.[CanadianJournalofChemistry,1981,vol.59,p.2247-2252]

[17]Bernardes,GonaloJ.L.;Kikkeri,Raghavendra;Maglinao,Maha;Laurino,Paola;Collot,Mayeul;Hong,SungYou;Lepenies,Bernd;Seeberger,PeterH.[OrganicandBiomolecularChemistry,2010,vol.8,#21,p.4987-4996]

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[20]CurrentPatentAssignee:SOLSTICEBIOLOGICSLLC-WO2015/188197,2015,A2Locationinpatent:Page/Pagecolumn157;157

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[22]CurrentPatentAssignee:ARROWHEADRESEARCHCORP-US9249179,2016,B2Locationinpatent:Page/Pagecolumn40;41

[23]CurrentPatentAssignee:NOVONORDISKA/S-WO2016/100401,2016,A1Locationinpatent:Paragraph00551-00552

[24]CurrentPatentAssignee:SOLSTICEBIOLOGICSLLC-WO2017/100461,2017,A1Locationinpatent:Page/Pagecolumn60;61

[25]CurrentPatentAssignee:ALNYLAMPHARMACEUTICALSINC-WO2018/136620,2018,A2Locationinpatent:Paragraph00509

[26]CurrentPatentAssignee:SANOFI;TranslateBio(in:Sanofi)-WO2019/140102,2019,A1Locationinpatent:Page/Pagecolumn82

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53765-90-5    171973-79-8    10378-06-0   
Aceticacid(2R,3R,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-diacetylamino-6-((2R,3S,4S,5R,6S)-3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-4-ylester 

[1]Castro-Palomino;Schmidt[TetrahedronLetters,1995,vol.36,#38,p.6871-6874]

Literature

Title: Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

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Tags:10378-06-0 Molecular Formula|10378-06-0 MDL|10378-06-0 SMILES|10378-06-0 (3aR,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate